Search Results
Results 51 - 100 of 999
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Vanstechelman Sylvie - - 2012
The use of oral fluid (OF) as an alternative matrix for the detection of drugs of abuse has increased over the last decade, leading to the need for a rapid, simple, and reliable on-site OF testing device. Four on-site OF drug testing devices (Dräger DrugTest 5000, Cozart DDS, Mavand Rapid ...
Murali Sowmiya - - 2012
Purpose: To study the rate of isolation and prevalence of drug resistance among bacteria isolated from conjunctival swabs collected from multiorgan donor and Donor corneal rim specimens obtained from a tertiary eye hospital in South India. Methods: Donor corneal rims (DCR) and conjunctival swabs from multiorgan donors collected over a ...
Ikenberg Kristian - - 2012
Background: The mitotic rate was introduced as a major prognostic criterion for the staging of thin (≤1.0 mm) melanoma by the 2009 American Joint Committee on Cancer Staging and Classification (seventh edition). The detection of a single mitotic figure changes the tumor stage in thin melanoma. We sought to address ...
Voetsch Andrew C - - 2012
: During 2003-2005, the National HIV Behavioral Surveillance System (NHBS) enrolled men who have sex with men (MSM) from 12 different venue types in 15 metropolitan areas in the United States. Our goal was to examine whether limiting NHBS enrollment venues to gay bars and dance clubs could increase efficiency ...
Brailsford Alan D - - 2012
Over the last 10-15 years, γ-hydroxybutyrate (GHB) and γ-butyrolactone have become increasingly popular "club drugs", but they have also gained attention as potential agents of drug-facilitated sexual assault (DFSA). Several studies have attempted to characterize GHB's pharmacokinetic properties in humans, and the aim of this paper is to build on ...
Li Yingguo - - 2012
This paper describes the preparation of a novel mixed-bed immunoaffinity chromatography (IAC) column by coupling four monoclonal antibodies against different sulfonamides (SAs) to Sepharose 4B. The IAC column can be used to simultaneously extract and purify 16 SAs in pork muscle. The dynamic column capacities for all SAs in mixed ...
Dry Sarah - - 2012
Personalized medicine and health care reform offer the opportunity for pathologists to have a more central and visible role in patient care. Pathologists face new and more complicated requests for clinical and research testing on tissue specimens, including testing for somatic and inherited mutations. Pathologists must comprehend the applications and ...
- - 2012
A short-cut review was carried out to establish whether early enteral feeding is indicated in acute pancreatitis. A total of 33 papers was found using the reported search, of which four represented the best evidence to answer the clinical question. The author, date and country of publication, patient group studied, ...
- - 2012
A short-cut review was carried out to establish whether intravenous adenosine is effective in the treatment of unstable paroxysmal supraventricular tachycardia. A total of 711 papers was found using the reported search, of which eight represented the best evidence to answer the clinical question. The author, date and country of ...
Deconinck E - - 2012
The use of chromatographic descriptors as alternative for Caco-2 permeability in drug absorption screening was evaluated. Therefore, retentions were measured on 17 Reversed-Phase Liquid Chromatographic systems, considered to be orthogonal or dissimilar, and an Immobilized Artificial Membrane (IAM) system. Retentions on a Micellar Liquid Chromatography system were taken from the ...
Dursun Ozer O Mersin State Hospital, Ophthalmology Clinic, Mersin, - - 2012
To analyze the serum levels and H/L gene polymorphisms of mannose-binding lectin-2 (MBL-2) in primary open angle glaucoma (POAG) cases and control subjects to investigate whether MBL-2 has a possible role in the development and pathogenesis of POAG. In 45 POAG cases and age and sex-matched 45 healthy controls, Elisa ...
Yang Hanjun - - 2012
Background: The diagnosis of early mycosis fungoides (MF) is a big challenge to dermatologists and dermatopathologists because it lacks specific clinicopathologic features. Methods: Fifty-two paraffin-embedded skin samples from 50 patients, including 31 with suspected MF, 10 with typical MF and 9 with benign inflammatory dermatosis (BID), were obtained from our ...
Stumm Michael M - - 2012
Tumor biomarker studies are integral to oncology clinical trials but may yield artifactual results owing to variation in sample procurement and processing. Ethanol, 70% vol/vol, was validated as a sample transport medium using markers of the PI3K/Akt/mTOR pathway. BT474 tumor xenografts were excised and slices were immediately placed into formaldehyde ...
Sampath Janardhan - - 2012
An estimated 610,000 new cases of myocardial infarction (MI) and 325,000 recurrent MIs will occur this year in the United States, accounting for 1 MI every 34 seconds. Despite the advances in acute coronary syndrome management, recurrent events and the mortality associated with acute coronary syndromes are also high. There ...
Cannizzo Elisa - - 2012
We have developed a new statistical diagnostic model that examines the correlation between immunophenotype and clonality as detected by flow cytometry (FC) and histology, defining the diagnostic role of FC in multiple myeloma (MM). The 192 bone marrow samples from patients and control subjects were studied for routine diagnostic analysis ...
Pashikanti Lavanya - - 2012
: The purpose of this review article was to examine the efficacy of an early mobilization protocol in hospitalized medical-surgical inpatient population. : Prolonged immobilization can result in functional decline and heighten the risk for hospital-associated complications such as falls and pressure ulcers. Early mobilization, on the other hand, has ...
Powell Emilie S - - 2012
: A common strategy for excluding coronary artery disease among patients presenting with low-risk chest pain is observation unit (OU) admission with serial cardiac biomarkers and stress testing for cardiac risk stratification. Patients with positive- or indeterminate-stress tests are often admitted for cardiac catheterization despite a low likelihood of disease. ...
Mohrmann Margaret E - - 2012
Welcome is a primary moral obligation of clinicians, essential for appropriate compassionate medical care. Listening to patients' stories requires a prior welcoming disposition that enables the practitioner to listen well.
Prestage Garrett - - 2012
: Measures of HIV treatments optimism were developed in response to increased risk behavior among gay men, but were limited in their capacity to help understand gay men's risk behavior. : We explored current beliefs about HIV health and transmission and sexual desire and risk behavior in an online survey ...
Schnitzbauer Andreas A - - 2012
To evaluate a new 2-step technique for obtaining adequate but short-term parenchymal hypertrophy in oncologic patients requiring extended right hepatic resection with limited functional reserve. Patients presenting with primary or metastatic liver tumors often face the dilemma that the remaining liver tissue may not be sufficient. Preoperative portal vein embolization ...
Pan Ryh-Nan - - 2012
A sensitive and selective liquid chromatography-tandem mass spectrometry (LC-MS-MS) method for the determination of quetiapine was developed and validated over the linearity range 1-1500 ng/mL with 0.1 mL of plasma using clozapine as the internal standard. Detection was performed on a triple-quadrupole tandem mass spectrometer using positive electrospray ionization and ...
Viñuela Eduardo F - - 2012
: To perform a meta-analysis of high-quality published trials, randomized and observational, comparing laparoscopic distal gastrectomy (LDG) and open distal gastrectomy (ODG) for gastric cancer. : Controversy persists about the clinical utility of minimally invasive techniques for the treatment of gastric cancer. Prospective data is limited to a few small ...
Oláh E - - 2012
This paper demonstrates the analysis of levetiracetam, a new chiral antiepileptic drug, at ng/mL levels using an ultra-high-performance liquid chromatography (UHPLC)-photodiode absorbance (PDA) method. Three different sample preparation methods, liquid-liquid extraction with Extrelut, solid phase extraction (SPE) with Oasis HLB and Oasis MAX SPE cartridges, and protein precipitation with organic ...
Vasantha Kumar Sekar - - 2012
A simple, highly repeatable and reproducible method for the estimation of Paclitaxel (TAX) in micro volume amounts of rat plasma is successfully developed and validated. The extraction procedure using 800 µL of ice-cold acetonitrile is very simple and economical with high sensitivity. The rectangular ratiograms and purity curve demonstrate the ...
Arslan Sermal - - 2012
Purpose: The purposes of this study were to investigate the effects of topically administrated Tacrolimus and Octreotide on modulation of postoperative scarring in experimental glaucoma filtration surgery and to compare the antifibrotic properties of these agents with mitomycin-C (MMC). Material and methods: A total of 28 New Zealand rabbits weighing ...
Bansal Mona - - 2012
Current American Society of Colposcopy and Cervical Pathology recommendations about human papillomavirus (HPV) triage and further management for atypical squamous cells are pertinent to cervical Papanicolaou (Pap) tests. There are limited data on HPV detection in vaginal liquid-based cytology (LBC) specimens. The aims of this study were to determine whether ...
Jenke Dennis - - 2012
Substances from packaging systems that are leached into packaged medical products may have a safety impact on patients to whom such medical products are administered. The potential safety impact depends on the identity and concentration of the leached substances. The concentration above which a leachable must be identified in order ...
Luong Jim - - 2012
Various commercially available ultra-fast temperature programming approaches were integrated to silicon micromachined GC (micro-GC) for performance improvement assessment. The combined technique of micro-GC and ultra-fast temperature programming up to a rate of 6°C/second yielded an extended analysis range to undecane (nC(11)), improved signal detectability by at least a factor of ...
Marshall Audrey - - 2012
'Dissertations into Practice' is a new regular feature in the Health Information and Libraries Journal, which aims to encourage students to write for publication. The idea is that students will write an extended abstract of their health-related dissertations, outlining the methods used and commenting on the implications for practice. Co-written ...
Devaraj Sridevi - - 2012
The Klotho gene has been identified as an aging suppressor gene that encodes a transmembrane protein, which is expressed primarily in renal tubules. There are 2 forms of Klotho, membrane and secreted. However, there is a paucity of data on levels of soluble Klotho in diseases like diabetes and kidney ...
Juhascik Matthew - - 2012
In forensic toxicology general alkaline drug screens typically utilize liquid liquid [LLE] or solid phase extraction [SPE] sample preparation techniques. It is expected that different drugs will be detected when a laboratory changes techniques. In this study, when the authors switched from LLE to SPE they were able to detect ...
Sajewicz Mieczyslaw - - 2012
In our earlier studies, a spontaneous chiral conversion of the selected low-molecular-weight carboxylic acids (i.e., amino acids, hydroxy acids, and profen drugs) dissolved in aqueous ethanol medium, running in vitro was described. Then it became clear that this spontaneous chiral conversion is accompanied by the spontaneous condensation of the discussed ...
de Blacam Catherine - - 2012
: The purpose of this study was to examine the incidence of complications of breast cancer surgery in a multi-institutional, prospective, validated database and to identify preoperative risk factors that predispose to these complications. : There is an increased emphasis on clinical outcomes to improve the quality of surgical care. ...
Casale John F - - 2012
Illicit cocaine laboratories in South America have been adding phenyltetrahydroimidazothiazole enantiomers (levamisole and/or tetramisole) to refined illicit cocaine for over 8 years. A chiral capillary gas chromatographic methodology is presented for phenyltetrahydroimidazothiazole enantiomer determination in illicit cocaine samples and in the urine of cocaine abusers. Illicit cocaine samples (N = ...
Raiskup Frederik - - 2012
Purpose: To investigate the influence of osmolarity on the transepithelial permeability of riboflavin solutions in a cross-linking procedure. Methods: Several riboflavin 0.1% solutions that contained different NaCl and benzalkonium chloride (BAC) concentrations were applied to 36 rabbit eyes for 30 min. To serve as a control, the epithelium was removed in ...
Schaff Jason E - - 2012
In cases of death by inert gas asphyxiation, it can be difficult to obtain toxicological evidence supporting assignment of a cause of death. Because of its low mass and high diffusivity, and its common use as a carrier gas, helium presents a particular challenge in this respect. We describe a ...
Tschudin-Sutter Sarah - - 2012
: We studied the impact of residual bacteria at the incision site after disinfection with polyvinylpyrrolidone (PVP or povidone)-iodine-alcohol and the correlation with postoperative surgical site infections (SSIs). : Chlorhexidine-based preparations are significantly more effective for catheter insertion care than povidone-iodine solutions to prevent catheter-associated infections, suggesting that the use ...
Jain Nieraj - - 2012
Although advances in vitreoretinal surgical techniques and technology have helped to minimize the risks associated with surgical manipulation of the retina, retinal pigment epithelium, and optic nerve, unanticipated or unexplained visual loss still occurs. We review causes of vision loss encountered after pars plana vitrectomy, including retinal toxicities, vascular events, ...
Colella Rita - - 2012
The Pelger-Huët anomaly (PHA) is a recognized morphologic variant affecting all granulocytes but is most evident in polymorphonuclear neutrophils (PMNs). PHA is caused by a decreased amount of the lamin B receptor (LBR). Recognition of PHA morphologic features serves as a marker for mutations in the LBR gene. This review ...
- - 2012
A short-cut review was carried out to establish whether rocuronium is as effective as succinylcholine at facilitating laryngoscopy during rapid sequence intubation (RSI). A total of 94 papers was found using the reported search, of which seven represented the best evidence to answer the clinical question. The author, date and ...
Bayyoud Tarek - - 2012
Purpose: To evaluate the potential of decellularized bovine corneas (DBCs) as a carrier matrix for cultivating and transplanting human corneal endothelial cells (HCECs). Methods: Posterior lamellae of ten bovine corneas were decellularized using ethylene diamin tetra-acetic acid (EDTA, 0.1%), aprotinin (10 KIU/mL) and 0.3% sodium dodecyl sulphate (SDS). Hematoxylin-eosin (HE) ...
Castro Arnold R - - 2012
We described the ASiManager-AT digital flocculation reader to demonstrate concordance between visual and digital readings of the rapid plasma reagin test for detection of antibodies in the serum of patients with syphilis. A qualitative and quantitative rapid plasma reagin was performed on each serum samples giving a concordance of 98.6% ...
Martinell Mats - - 2012
Electronic medical records (EMRs) enable analysis of health care data by using data mining techniques to build research databases. Though the reliability of the data extraction process is crucial for the credibility of the final analysis, there are few published validations of this process. In this paper we validate the ...
McMillin Gwendolyn A - - 2012
Patterns of buprenorphine and metabolites were examined in 1946 positive urine samples analyzed by liquid chromatography-tandem mass spectrometry for free (unconjugated) buprenorphine and norbuprenorphine (quantitative, 2 to 1000 ng/mL) and buprenorphine-glucuronide (B3G) and norbuprenorphine-glucuronide (N3G) (semi-quantitative, 5 to 1000 ng/mL). Two distribution patterns predominated with 49.1% positive for norbuprenorphine, B3G, ...
O'Connor N - - 2012
A selective and sensitive method for the analysis of Miconazole and its associated impurities is developed. The separation is carried out using a Thermo Scientific Hypersil Gold C18 Column (50 mm x 4.6 mm i.d., 1.9 µm particle size) with a mobile phase of acetonitrile-methanol-ammonium acetate (1.5 w/v) (30:32:38 v/v) ...
Nobili Cinzia - - 2012
: To generate the first evaluation of risk factors for postoperative pulmonary complications (PPCs) after hepatectomy. : Postoperative pulmonary complications (PPCs) after surgery are associated with significant morbidity and have been shown to increase the length of hospital stays. Several studies have been conducted to identify the risk factors for ...
Majholm B - - 2012
Day surgery is expanding in several countries, and it is important to collect information about quality. The aim of this study was to assess morbidity and unanticipated hospital visits 0-30 days post-operatively in a large cohort. We prospectively recorded data from 57,709 day surgery procedures performed in eight day surgery ...
Froom Paul - - 2012
The purpose of our study was to determine the effect of the elimination of laboratory-initiated reflex testing on physician ordering behavior. In 1999, we stopped laboratory-initiated reflex testing and did microscopic analysis only on physician request. The number of urinalysis dipstick tests, microscopic analysis tests, and urine cultures done during ...
Yarbrough Jason - - 2012
High-performance liquid chromatography method for the determination of propofol has been developed and validated. Following a liquid extraction using ethyl acetate and hexane, samples were separated by reverse-phase high-performance liquid chromatography on an XBridge C(18) column and quantified using fluorescence detection at an excitation of 276 nm and an emission ...
Catania Kimberly - - 2012
The aim of this study was to describe how the clinical nurse specialist (CNS) role can be positioned to proactively plan and facilitate evidenced-based best practices in collaboration with a transdisciplinary, population-focused team that manages the patient across the cancer care continuum. This model capitalizes on the spheres of CNS ...
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