Objective. We performed a systematic review of the literature to evaluate the effects of alpha lipoic acid for symptomatic peripheral neuropathy in patients with diabetes mellitus. Research design and methods. The databases MEDLINE and EMBASE were searched using the key words "lipoic acid", "thioctic acid", "diabet∗", and the MeSH-terms "thioctic ...

The goal of environmental enrichment for laboratory animals is to improve welfare, but some enrichment practices may affect research in unintended ways or even be harmful to the animals themselves. We previously found that mice raised at a commercial vendor then given multiple enrichment devices upon arrival at our facilities ...

Aim: This study aims to provide information on the accrual rate and to identify the reasons for non-enrollment of oral cancer patients into a clinical trial. Setting and Design: Prospective study conducted at the Tertiary Cancer Centre (India). Materials and Methods: Patients eligible and screened for the oral cancer adjuvant ...

Eliminating racial/ethnic disparities in health and health care is a national priority, and obesity is a prime target. During the last 30 y in the United States, the prevalence of obesity among children has dramatically increased, sparing no age group. Obesity in childhood is associated with adverse cardio-metabolic outcomes such ...

Dynamic circadian rhythms contribute to memory formation, and the hormonal and neurochemical changes that follow circadian patterns are frequently dysregulated with aging. The effect of aging on circadian rhythms is a doubleedged sword; on one hand, poor sleep quality compromises neuronal structure and function in regions that support cognition, and ...

Central serous chorioretinopathy (CSC) has been traditionally treated with laser photocoagulation. We thought that transpupillary thermotherapy (TTT) utilizing a lower temperature than that of conventional laser photocoagulation might minimize permanent retinal and choroidal damage. Studies suggest that undesirable effects on vision due to TTT are minimal even if it is ...

Common explanations for the generally negative relationship between education and ethnic endogamy include (1) education makes immigrants and their children better able to adapt to native culture thereby eliminating the need for a same-ethnicity spouse and (2) education raises the likelihood of leaving ethnic enclaves, thereby decreasing the probability of ...

Annually 1-2 in every 1000 adults will develop a deep venous thrombosis of the lower extremity. A third to half of these patients will develop the post-thrombotic syndrome (PTS). However, predicting which patients will develop the PTS remains elusive. Ipsilateral thrombosis recurrence seems to be the most important risk factor. ...

<span class="subtitle">Summary</span> <span class="subtitle">background </span>It is difficult to do research relating to forensic psychiatric patients because there are a number of methodological problems inherent in systematic measurements in forensic psychiatry. <span class="subtitle">aim </span>To give readers an overview of the rom literature and some information about worthwhile developments in the field. ...

Background: Minor salivary gland tumors (MSGTs) are unusual, accounting for only 15-20% of all salivary gland tumors. The commonest site of MSGTs of the head and neck is oral cavity. Aims: To describe our experience with MSGTs of oral cavity seen over a period of one decade and elucidate their ...

Epidemiological studies beginning in the 1990s have reported that intake of quercetin, a polyphenolic flavonoid found in a wide variety of plant-based foods, such as apples, onions, berries, and red wine, is inversely related to cardiovascular disease. More recent work using hypertensive animals and humans (>140 mm Hg systolic and ...

Two patients with a patent foramen ovale associated with redundant and fenestrated atrial septal aneurysms and a history of multiple transient ischaemic episodes underwent percutaneous device closure using the Atriasept(™) II septal occluders. After release of the devices, the aneurysms were stabilised and no residual shunts were detected. Certain clinical ...

The objectives of this study are to consider the influence of pathophysiology in the treatment of pelvic congestion syndrome (PCS) and to determine the criteria which impact on the long-term results. A classification of venous pathology including three types of pathophysiological conditions, independent of the location of the pelvic venous ...

A simple and sensitive HPLC method was developed to determine cefdinir (CAS 91832-40-5) in human plasma. The method was validated by investigating the accuracy and precision for intra- and inter-day runs in a linear concentration from 0.05-2.0 µg/ml. The object of this study was to compare the bioavailability of cefdinir capsule ...

Obesity has recently become an epidemic. The rise in the childhood obesity incidence is of particular concern. High density caloric diets and physical inactivity are the main causes of obesity. Besides that, is generally accepted that obesity has a genetic predisposition, unchanged for the past few decades. The environment via ...

To compare different methods of assessing energy expenditure (EE) and physical activity (PA) in people with spinal cord injury (SCI) under community-dwelling conditions. A reference standard encompassing the doubly labelled water (DLW) technique, heart rate monitoring (FLEX-HR), a multi-sensor armband (SenseWear Armband (SWA)), and two PA recall questionnaires were employed ...

Chronic venous disease (CVD) is one of the most common diseases in our population. Aside from venous symptoms like heaviness and pain, which are present in about 50% of the general population, signs of CVD include varicose veins (VVs), oedema, eczema, venous eczema, hyperpigmentation, white atrophy, lipodermatosclerosis and venous ulcers. ...

This article summarizes a spatial econometric analysis of local population and employment growth in the Netherlands, with specific reference to impacts of gender and space. The simultaneous equations model used distinguishes between population- and gender-specific employment groups, and includes autoregressive and cross-regressive spatial lags to detect relations both within and ...

The post-thrombotic syndrome (PTS) is a common, debilitating complication following deep venous thrombosis. PTS is a syndrome for which it has been difficult to provide a clear definition. PTS was defined as chronic venous signs/symptoms after a deep venous thrombosis. A number of scales are available to diagnose PTS, but ...

China boasts a rapidly growing economy and is a leading food exporter. Since China has dominated world export markets in food, electronics, and toys, many safety concerns about Chinese exports have emerged. For example, many countries have had problems with Chinese food products and food-processing ingredients. Factors behind food safety ...

Using a representative sample of children all born to unwed parents drawn from the Fragile Families and Child Wellbeing Study and a potential outcome approach to account for self-selection into marriage, we investigate whether marriage after childbearing has a causal effect on early child development. Comparing children with similar background ...

Pelvic congestion syndrome (PCS) is frequent and underestimated as both symptoms and signs are not specific. Furthermore, patients consult general practitioners as well as specialist gynaecologists, urologists, vascular surgeons and phlebologists who are frequently unaware of this condition. Investigation protocol must first eliminate other diseases with similar clinical disorders and ...

Influenza virus is a respiratory pathogen that causes a high degree of morbidity and mortality every year in multiple parts of the world. Therefore, precise diagnosis of the infecting strain and rapid high-throughput screening of vast numbers of clinical samples is paramount to control the spread of pandemic infections. Current ...

<span class="subtitle">summary</span> <span class="subtitle">background</span> An evaluation of the most commonly used <span class="abbreviation">rom</span> measures in Dutch psychiatry is lacking, both for severe mental illnesses and for common psychiatric disorders. <span class="subtitle">aim</span> To provide an overview of the characteristics and quality of outcome measures. <span class="subtitle">method</span> A literature study yielded six ...

Perinatal outcome data for 2010 reveal a continuation of the recent decline in total number of live births in South Dakota and an increase in the percent of low-birth-weight (LBW) newborns. This increase in LBW, apparent in both the very-low-birth-weight and mid-low birth-weight cohorts of newborns, contributed to an increase ...

Two new iridoid glycosides, named williamsoside C (1) and williamsoside D (2) were isolated from the root barks of Sambucus williamsii Hance. Their structures were established on the basis of extensive spectroscopic analysis (1D, 2D NMR and HRESIMS) and chemical studies as α-D-glucopyranosyl (1→2)-β-D-fructofuranosyl (4→6)-β-morroniside (1) and 7β-O-ethyl morroniside-(6'-O-7'')-β-morroniside (2), ...

To describe the background for - and mechanism of - catheter-directed thrombolysis (CDT) for iliofemoral deep venous thrombosis (DVT) accessed via the popliteal vein. Focus is on safety and efficacy. From the Copenhagen experience we have looked into the systematically registrated risk factors, peri- and postprocedure complications for patients consecutively ...

Attention, working memory and long-term memory dysfunctions are the most commonly seen cognitive impairments in schizophrenic patients. Conflicting results exist regarding the effects of antipsychotics on cognitive abnormalities. The aim of this study was to investigate the effects of atypical antipsychotic drugs olanzapine (0.4, 0.8 and 1.25 mg/kg, i.p.) and clozapine ...

Objective. This is a report of an 18 year old black female patient with primary hyperparathyroidism and a sellar/parasellar brown tumor and unusual nonresponsiveness to 1,25 vitamin D administration post parathyroidectomy but responsiveness postoperatively to 25 vitamin D administration.Method. Report the history, physical exam, laboratory, and radiological findings of the patient with ...

The impulse oscillation system (IOS) offers significant value in the assessment of airway dynamics in persons with spinal cord injury (SCI) because of minimal patient effort but measurement reproducibility in SCI is unknown. To evaluate between-day reproducibility and the effect of posture on airway resistance [respiratory resistances at 5 Hz ...

Oral cancers form a significant portion of the cancer burden seen in our country. Typically, they tend to be preceded by a premalignant state for a long time. This article discusses the various types of premalignant disorders commonly seen in daily practice. Also, it is important to screen patients for ...

The International Life Science Institute North America and the American Society for Nutrition annual Functional Foods for Health Symposium was held 9 April 2011. Evidence that foods and their components offer health benefits beyond basic nutrition continues to captivate the interest of the scientific community, government agencies, and the general ...

Ethnobotany encompasses the cultural uses of plants by humans, including their uses as medicines (ethnopharmacology). The reputed medicinal properties of plants have been documented for centuries in different cultures, and there are many plant species that have been traditionally used for memory disorders, which are now being explored to determine ...

Exploiting hitherto unexamined London port book data, this article shows that during the last quarter of the seventeenth century the coastal metropolitan corn import trade was twice the size that historians relying on the work of Gras have assumed it to have been. More significantly, it demonstrates that Gras's failure ...

<span class="subtitle">Summary </span> <span class="subtitle">background</span> In psychiatry <span class="abbreviation">rom </span>is more difficult to use with children and adolescents than with other subject groups. In 2008 a Dutch consortium was set up to study the use of rom with children and adolescents (<span class="abbreviation">romckap</span>). <span class="subtitle">aim</span> To investigate specific problems relating ...

Context: To assess the feasibility of metronomic chemotherapy in the palliative care setting. Aims: To study the toxicity profile and efficacy of metronomic chemotherapy for palliation in oral cavity cancers. Settings and Design: Retrospective analysis of prospectively collected data. Materials and Methods: Subjects receiving metronomic chemotherapy from August 2010 to ...

The present case series describes four patients with asthma, airway hyperresponsiveness and neutrophilic bronchitis who harboured abnormal cystic fibrosis transmembrance conductance regulator (CFTR) gene mutations. It serves both to alert clinicians to consider CFTR-related disease in both young and elderly patients with persistent neutrophilic bronchitis, and to highlight the potential ...

The central objectives of the 'Blair/Brown' reforms of the English NHS in the 2000s were to reduce hospital waiting times and improve the quality of care. However, critics raised concerns that the choice and competition elements of reform might undermine socioeconomic equity in health care. By contrast, the architects of ...

It is increasingly being recognized that oral cavity cancer incidences are rising globally. Furthermore, these tumors represent a high risk group of tumors comparative to other head and neck tumor sub-sites and have a high preponderance of occult nodal metastases. Surgery alone leads to excellent outcomes in early stage disease. ...

Summary.  There are approximately 100 drugs in development to treat hepatitis C. Over the next decade, a number of new therapies will become available. A good understanding of the cost of hepatitis C sequelae is important for assessing the value of new treatments. The objective of this study was to ...

Based on sequence analysis of the mitochondrial gene ND4, we determined the presence in Argentina of 3 haplotypes representing different Aedes (Stegomyia) aegypti lineages previously identified in other countries of the Americas, Africa, and Asia. Haplotype 17, the most frequent in Argentina, was previously detected in Brazil. Haplotype 7, restricted ...

The aim of this study is to analyze biomedical publications on health surveys (HS) in the Catalan territory from documents published in various bibliographic databases to 2010. Analysis of 1,287 HS documents on 3 bibliographic sources of information relating to Catalonia, between 1991 and 2010. Scientific papers on HS in ...

The treatment for patients with locally advanced, resectable rectal cancer has evolved over the years. Various combinations and sequences of chemotherapy, radiation therapy, and total mesorectal excision (TME)-based surgery are the mainstay of current therapy. Preoperative combined chemoradiation, followed by surgery, is now the preferred treatment strategy, with the majority ...

Identification of the molecular structure and novel biophysiological functions of plant cystatins or phytocystatins is of great interest in the field of molecular biology. The important requirements for these are the efficient production, purification and correctly folded forms of these proteins. We report here the cloning, easy expression and characterization ...

Fabry disease is an X-linked disease of glycosphingolipid (GL) metabolism. The accumulation of GL in tissues can affect multiple organ systems. Initial symptoms includes episodes of severe pain in the extremities, cornea verticillata and skin lesions. In late stages, kidney, heart and brain can be involved. This report attempts for ...

During a mosquito collection, a female of the pigeon louse fly, Pseudolynchia canariensis (Diptera: Hippoboscidae), was collected by a mosquito trap baited with dry ice in Ishigaki-jima, Yaeyama Islands, Japan. This is the 1st record of P. canariensis from Yaeyama Islands.

To evaluate the efficacy and the toxicity of 0.15% ganciclovir gel in the treatment of adenoviral conjunctivitis and in preventing ocular complications after adenoviral conjunctivitis, such as corneal infiltrates and pseudomembranes. Double blind, interventional and randomized clinical trial. Thirty-three patients with clinical diagnosis of adenoviral conjunctivitis with onset of symptoms ...

OBJECTIVE: The purpose of this study was to investigate the nutrient intakes of people with mood disorders. Method: A cross-sectional survey using 3-day food records was carried out in 97 adults with bipolar or major depressive disorder to compare nutrient intakes with Dietary Reference Intakes and British Columbia Nutrition Survey ...

Bladder cancer is a heterogeneous disease that carries a significant risk of progression and lethality. Radical cystectomy with pelvic lymph node dissection remains the predominant treatment for patients with muscle-invasive disease and offers the best chance of long-term disease control. However, radical surgery is insufficient in patients with advanced-stage disease. ...

The characteristics of the interaction between reserpine and bovine serum albumin (BSA) were studied by fluorescence, UV-vis absorption and Fourier transform infrared (FT-IR) spectroscopy. Spectroscopic analysis revealed that fluorescence quenching of BSA by reserpine was through a static quenching procedure. The binding constant K(A) of reserpine with BSA at 293, ...