Search Results
Results 251 - 300 of 4120
< 1 2 3 4 5 6 7 8 9 10 11 >
Gopalakrishna Kota N - - 2012
The molecular nature of transducin-α subunits (Gα(t)) may contribute to the distinct physiology of cone and rod photoreceptors. Biochemical properties of mammalian cone Gα(t2) subunits and their differences with rod Gα(t1) are largely unknown. Here, we examined properties of chimeric Gα(t2) in comparison with its rod counterpart. The key biochemical ...
Subelj Vesna - - 2012
OBJECTIVE: The pandemic influenza (H1N1) 2009 virus, which combined genes from swine, human and avian influenza viruses, emerged in April 2009 and spread globally within the next month. The post-pandemic serological response to the influenza A(H1N1) 2009 virus in non-vaccinated individuals from the central part of Slovenia was studied. METHODS: ...
Velnar Tomaz - - 2012
Blepharospasm in connection with chronic subdural haematoma is an uncommon pathology and usually subsides after treatment of the haematoma. Different mechanical and vascular factors may play a role by affecting domapinergic transmission in basal ganglia. A case of a 72-year-old patient is presented, who developed transient blepharospasm as a result ...
Dupont Catherine - - 2012
High frequencies of chromosomal anomalies are reported in human and non-human primate in vitro-produced preimplantation embryos. It is unclear why certain embryos develop aneuploidies while others remain euploid. A differential susceptibility to aneuploidy is most likely a consequence of events that occur before oocyte collection. One hypothesis is that the ...
Asari Sadaki - - 2012
Intraductal papillary mucinous neoplasm (IPMN) of the pancreas is a distinct entity characterized by papillary proliferations of mucin-producing epithelial cells with excessive mucin production and cystic dilatation of the pancreatic ducts. The clinical presentation often involves recurrent episodes of pancreatitis associated with the temporal obstruction of the main pancreatic duct ...
Vaidya Anand - - 2012
Over the past decade, vitamin D has generated considerable interest as potentially having important effects on the vasculature and the kidney. Animal and human data indicate that vitamin D suppresses the activity of the renin-angiotensin system and improves endothelial function. Observational studies in humans suggest that low 25-hydroxyvitamin D (25[OH]D) ...
Kato So - - 2012
PURPOSE: Paralysis in spinal metastasis is often caused by anterior dural compression, and anterior approach has been frequently chosen for decompression despite its dreadful complications. On the other hand, the effectiveness of posterior indirect decompression has not specifically established. The objective of the present study was to investigate the anatomical ...
Santos Roberto Christ Vianna - - 2012
It has been previously showed that fructose-1,6-bisphosphate (FBP) has anti-inflammatory and immunomodulatory effects on several experimental inflammation models. However, the effects and mechanism of FBP on Zymosan-induced acute lung injury (ALI) in mice had not been tested. In this study, our aim was to assess the anti-inflammatory activities of FBP ...
Kouyama Yuichi - - 2012
We conducted an epidemiological study concerning carbapenem-non-susceptible clinical isolates of Acinetobacter spp. in Japan by molecular procedures including carbapenemase gene identification and amplified ribosomal DNA restriction analysis. Among 598 clinically isolated Acinetobacter spp. in 2007, 27 (4.5%) were non-susceptible to carbapenems. Most carbapenem-non-susceptible Acinetobacter baumannii (13/14) belonged to clonal complex ...
Baek Gui-Hyun - - 2012
Fresh rhizome of Rehmannia glutinosa Libosch. (Saeng-jihwang in Korean: SJH) has been prescribed for the treatment of diabetes-associated complications. The purpose of the present study is to investigate the underlying mechanisms of the efficacy of SJH in diabetes-related complications. Decoction was obtained after boiling SJH in water and subsequent lyophilization. ...
Han Chuncho - - 2012
The objective of the present study was to demonstrate the anti-inflammatory and antinociceptive properties of agaricoglycerides of the fermented mushroom of Grifola frondosa (AGF). The effects of AGF on interleukin-1β (IL-1β) levels, tumor necrosis factor-α (TNF-α) levels, nuclear factor kappa B (NF-κB) levels, intercellular adhesion molecule-1 (ICAM-1) levels, cyclooxygenase-2 (COX-2) ...
Han Chun-Chao - - 2012
The roots of Sophora flavescens was reported to possess many pharmacological activities including anti-inflammatory, antiashmatic, antithelmintic, free radical scavenging and antimicrobial activities. However, the low saturated solubility and dissolution velocity of S. flavescens lead to poor bioavailability. The S. flavescens nanoparticles (SFNP) were prepared by a combination of ultrasound and ...
Nishigori Hideaki - - 2012
PURPOSE: To evaluate the diagnosis, epidemiology, risk factors, and treatment of chylous ascites after colorectal cancer surgery. METHODS: Among 907 patients who underwent colorectal cancer resection at our institution between 2006 and 2009, chylous ascites developed in 9. We analyzed the clinical data for these 9 patients. RESULTS: Five of ...
Moon Juhi - - 2012
Gram-negative microorganisms are rarely implicated in causing infective endocarditis (IE). Although the traditionally identified risk factor for Gram-negative endocarditis has been intravenous drug abuse, recent studies have revealed that healthcare contact and the presence of prosthetic cardiac devices are primary risk factors for IE secondary to non-HACEK Gram-negative bacteria. We ...
Levy Dan - - 2012
Migraine is considered one of the most prevalent neurological disorders but its underlying pathophysiology is poorly understood. Over the past two decades, it became widely accepted that activation of primary afferent nociceptive neurons that innervate the intracranial meninges serves as a key process that mediates the throbbing head pain of ...
Singh Ram Sarup - - 2012
Aspartase (L: -aspartate ammonia-lyase; EC 4.3.1.1) catalyzes the reversible amination of fumaric acid to produce L: -aspartic acid. Aspartase coding gene (aspA) of Aeromonas media NFB-5 was cloned, sequenced, and expressed with His tag using pET-21b(+) expression vector in Escherichia coli BL21. Higher expression was obtained with IPTG (1.5 mM) induction ...
Matsuda Ken Ichi - - 2012
Sexual differentiation of the brain can be considered as a process during which effects of sex steroid hormones secreted during early development is maintained into adulthood. Epigenetic regulation is emerging as a potentially important mechanism of conveyance of long-lasting effects of the hormonal and environmental milieu in the developing brain. ...
de Jong E - - 2012
Many laboratories use enzyme immunoassays (EIAs) for the diagnosis of Clostridium difficile infection (CDI). More recently, polymerase chain reaction (PCR)-based diagnosis has been described as a sensitive test. Real-time PCR for the detection of C. difficile toxin A and B genes was evaluated. A prospective evaluation was performed on stool ...
Laborda Mario A - - 2012
We view the response decrement resulting from extinction treatment as an interference effect, in which the reactivated memory from acquisition competes with the reactivated memory from extinction for behavioral expression. For each of these memories, reactivation is proportional to both the strength of the stimulus-outcome association and the quality of ...
Baas Peter W PW Department of Neurobiology and Anatomy, Drexel University College of Medicine, 2900 Queen Lane, Philadelphia, Pennsylvania 19129, USA. - - 2012
Short microtubules move within the axon in both directions. In the past, it had been assumed that all of the short moving microtubules are oriented with their plus-ends distal to the cell body, regardless of their direction of movement. The anterogradely moving microtubules were posited to play critical roles in ...
Yoshizawa Akihiro - - 2012
Patients with dilated cardiomyopathy (DCM) often have autoantibodies against cardiac antigens including the M(2) muscarinic acetylcholine receptor (M(2) R). To elucidate the role of autoimmunity against M(2) R in disease development, we induced an immune response against M(2) R by adoptive transfer into Rag2(-/-) mice of splenocytes from M(2) R(-/-) ...
Wang Min - - 2012
Centrins are conserved calcium-binding proteins important for various regulatory functions. In procyclic Trypanosoma brucei, TbCentrin2 and TbCentrin4 have distinct effects on cell division but both localize to the basal bodies that seed the flagellum, and a bi-lobed structure important for organelle duplication and cell division. Here we show that TbCentrin2 ...
Armengol Jordi - - 2012
Preadipocyte factor -1 (Pref-1) is known to play a central role in regulating white adipocyte differentiation, but the role of Pref-1 in brown adipose tissue (BAT) has not been analyzed. Here we found that Pref-1 expression is high in fetal BAT and declines progressively after birth. However, Pref-1-null mice showed ...
Rittig K - - 2012
AIMS/HYPOTHESIS: We have previously found that the mass of perivascular adipose tissue (PVAT) correlates negatively with insulin sensitivity and post-ischaemic increase in blood flow. To understand how PVAT communicates with vascular vessels, interactions between perivascular, subcutaneous and visceral fat cells with endothelial cells (ECs) were examined with regard to inflammatory, ...
Minev Ivan R - - 2012
Neuroprostheses interfaced with transected peripheral nerves are technological routes to control robotic limbs as well as convey sensory feedback to patients suffering from traumatic neural injuries or degenerative diseases. To maximize the wealth of data obtained in recordings, interfacing devices are required to have intrafascicular resolution and provide high signal-to-noise ...
Robinson Whitney R - - 2012
In countries undergoing nutrition transition and historically poor minority groups in wealthy countries, obesity tends to be more common in women than men. A potential contributor to this female excess of obesity is a mismatch between perinatal nutritional restriction and a later calorie-rich environment. Several epidemiologic and quasi-experimental studies support ...
So Kelvin - - 2012
Neurons in the brain form highly complex networks through synaptic connections. Traditionally, functional connectivity between neurons has been explored using methods such as correlations, which do not contain any notion of directionality. Recently, an information-theoretic approach based on directed information theory has been proposed as a way to infer the ...
Srivastava Sachchidanand - - 2012
A novel and facile approach is developed to synthesize a magnetic nanoparticle (iron oxide)-doped carbogenic nanocomposite (IO-CNC) for magnetic resonance (MR)/fluorescence imaging applications. IO-CNC is synthesized by thermal decomposition of organic precursors in the presence of Fe(3) O(4) nanoparticles with an average size of 6 nm. IO-CNC shows wavelength-tunable fluorescence ...
Villanueva Luis Guillermo - - 2012
A hydrogen sensor based on a novel fabrication process that combines the precision of advanced nano-fabrication techniques with a bottom-up process based on electrochemistry is presented. The sensor allows for reliable detection between 0.1% and 100% of H(2) in air. This fabrication is very versatile, highly reliable, and fully scalable ...
Wu Lili - - 2012
Multiple factors of task difficulty keep problem solvers from finding the crucial thinking steps required to solve insight problems. In this study, we distinguished two difficulty factors, chunk familiarity and chunk tightness, and investigated their effects on chunk decomposition-a specific type of insight that depends on the process of breaking ...
Qin Fengyun - - 2012
γ-Linolenic acid (GLA) has been used as a general nutraceutical for pharmacologic applications, particularly in the treatment of skin conditions such as eczema. Four transgenic soybean lines that produce GLA at high yields (4.21% of total fatty acids, up to 1002-fold) were generated through the stable insertion of the Delta-6-fatty ...
Okada Hiroshi - - 2012
We evaluated sequential dynamic contrast-enhanced CT (DCE-CT) scans to assess the possibility of early prediction of treatment responses by quantifying the tumor size reduction and the change in tumor enhancement during and after a course of radiotherapy (RT). Thirty-nine patients with non-small-cell lung cancer were treated with RT for initial ...
Jagasia M H - - 2012
This prospective, randomized, double-blind, placebo-controlled study evaluated the efficacy of palifermin to reduce the incidence of severe (grade 3-4) acute GVHD after myeloablation and allo-SCT. Adults who received allo-SCT for hematologic malignancies received placebo or palifermin 60 μg/kg daily on three consecutive days before conditioning and a single dose of 180 μg/kg ...
Balansky Roumen - - 2012
Cigarette smoke (CS) and dietary factors play a major role in cancer epidemiology. At the same time, however, the diet is the richest source of anticancer agents. Berries possess a broad array of health protective properties and were found to attenuate the yield of tumors induced by individual carcinogens in ...
Delangle Pascale - - 2012
Wilson's disease is an orphan disease due to copper homeostasis dysfunction. Mutations of the ATP7B gene induces an impaired functioning of a Cu-ATPase, impaired Cu detoxification in the liver and copper overload in the body. Indeed, even though copper is an essential element, which is used as cofactor by many ...
Ohguri Takayuki - - 2012
The purpose of this study was to evaluate the efficacy and toxicity of the postoperative radiotherapy in patients with incompletely resected NSCLC, and to investigate whether the histological subtype is a prognostic factor. Forty-one incompletely resected NSCLC patients who underwent postoperative radiotherapy were retrospectively analyzed. The microscopic residual tumor (R1 ...
Yoshida Daisuke - - 2012
Aim:  Near infrared spectroscopy has been reported to have a high reliability and accuracy in assessing the percentage of body fat. However, whether muscle mass can be accurately estimated using this method has not been established. This study examined whether a near infrared spectroscopy method could estimate appendicular muscle mass ...
Schwartz Alexander - - 2012
Changes in resting EE (energy expenditure) during weight loss are said to be greater than what can be expected from changes of body mass, i.e. fat mass (FM) and fat-free mass (FFM) but controversy persists. The primary focus of this study was to investigate whether there is a greater than ...
Altay Canan - - 2012
Ectopic thyroid tissue may be observed anywhere from the tongue base to the lower neck. It is rarely seen in the mediastinum and abdominal cavity. Computed tomography and magnetic resonance imaging are very sensitive for detection and localization of ectopic thyroid tissue. This pictorial essay presents the radiological characteristics of ...
Mohapatra Hemakesh - - 2012
This Communication describes three small molecule reagents that amplify the signal for a detection event via an autocatalytic reaction. Two signals are obtained from each reagent: (i) the dibenzofulvene chromophore and (ii) piperidine, which can be visualized using a pH indicator dye. The reagents are demonstrated in a model assay ...
Doorley Gerard W - - 2012
Two-colour fluorescence microscopy was used to track the cellular internalization of nanoparticles exposed to extracellular serum proteins. Single particle tracking revealed that nanoparticles and serum proteins are internalized and transported through the cell as a single complex. This study demonstrates the importance of nanoparticle-protein interactions in cellular applications.
Sisó C - - 2012
The purpose of this study was to describe the variation in listeriosis infection incidence during pregnancy over a 25-year period based on salient clinical and laboratory features compiled in a tertiary referral hospital and to depict the clinical characteristics of these cases. A cohort was created of all cases of ...
Zhang Haibin - - 2012
Aims: The purpose of this study was to characterize left ventricular (LV) intracavitary flow during the isovolumic contraction (IVC) period in humans using vector flow mapping. Methods: Color flow Doppler imaging was performed from the apical long-axis view in 61 patients with heart failure and 58 healthy volunteers. Doppler flow ...
Borges Alan Maia - - 2012
PROBLEM: Bacterial infections commonly cause bovine endometritis and infertility via innate immune pathways. However, mechanistic studies using isolated cells or chopped tissue may be compromised by the disruption of endometrial architecture and release of damage-associated molecular patterns. So, this study aimed to establish an ex vivo model of intact bovine ...
Hyllienmark Petra - - 2012
Background: Ventilator-associated pneumonia (VAP), the most common hospital-acquired infection in intensive care unit (ICU) patients, is caused by bacteria in the lower respiratory tract of mechanically ventilated patients. Methods: The current study was focused on 443 bacterial isolates from the lower respiratory tract of mechanically ventilated ICU patients (n = ...
Nikolić Danko - - 2012
When computing a cross-correlation histogram, slower signal components can hinder the detection of faster components, which are often in the research focus. For example, precise neuronal synchronization often co-occurs with slow co-variation in neuronal rate responses. Here we present a method - dubbed scaled correlation analysis - that enables the ...
Jung Yong Chae - - 2012
We report a mechanically strong, electrically and thermally conductive, and optically transparent shape-memory polyurethane composite which was fabricated by introducing a small amount (0.1 wt%) of high-quality graphene as a filler. Geometrically large (≈4.6 μm(2) ), but highly crystallized few-layer graphenes, verified by Raman spectroscopy and transmission electron microscopy, were ...
Erko M - - 2012
A simple explanation is given for the low-temperature density minimum of water confined within cylindrical pores of ordered nanoporous materials of different pore size. The experimental evidence is based on combined data from in-situ small-angle scattering of X-rays (SAXS) and neutrons (SANS), corroborated by additional wide-angle X-ray scattering (WAXS). The ...
Knight Darryl Kenneth - - 2012
The ability of biomaterials to support the adhesion of cells is a necessary condition for their use in scaffold-guided tissue engineering. Waveguide evanescent field fluorescence (WEFF) microscopy is a relatively new microscopic technique that allows the number of cell adhesions to a waveguide surface be measured by imaging the interfacial ...
Casella Michela - - 2012
IntroductionRadiofrequency catheter ablation is the mainstay of therapy for supraventricular tachyarrhythmias. Conventional radiofrequency catheter ablation requires the use of fluoroscopy, thus exposing patients to ionising radiation. The feasibility and safety of non-fluoroscopic radiofrequency catheter ablation has been recently reported in a wide range of supraventricular tachyarrhythmias using the EnSite NavX™ ...
< 1 2 3 4 5 6 7 8 9 10 11 >