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Alicandri-Ciufelli Matteo - - 2012
BACKGROUND: The purpose of this study was to assess the factors influencing swallowing and phonatory results after partial laryngectomy. METHODS: We carried out a medical chart review of patients who underwent partial laryngectomies between June 2003 and November 2010, focusing on functional outcomes. RESULTS: Thirty-two patients were enrolled. No statistically ...
Forniés Juan - - 2012
The reaction between (NBu(4))[Pt(bzq)(C(6)F(5))(2)] (1, bzq = 7,8-benzoquinolate) and AgClO(4) in a 1 : 1 molar ratio, in acetone, gives the polymer [{Pt(bzq)(C(6)F(5))(2)}Ag](n) (2). The reaction of 2 with equimolecular amounts of PPh(3) and SC(4)H(8) (tht) produces the bimetallic complexes [{Pt(bzq)(C(6)F(5))(2)}AgL] (L = PPh(3) (3), tht (4)). For L = py, decomposition ...
Tanweer Faiz - - 2012
Microfluidics is an emerging multidisciplinary field that has the potential to provide solutions to many of the current challenges in managing head and neck squamous cell carcinoma (HNSCC). Treatment strategies for this disease are often complex and associated with significant morbidity and mortality; furthermore, prediction of response to treatment remains ...
Spurway N C - - 2012
Abstract Three modern views about the factors limiting oxygen uptake in healthy humans are set against the original (early 1920s) concept of A. V. Hill and colleagues. The majority view for most of the intervening time has been that cardiac output is the essential limiting function. Among recent research in ...
Abendstern M - - 2012
Objectives: In the UK and elsewhere, specialist community mental health teams (CMHTs) are central to the provision of comprehensive services for older people with mental ill health. Recent guidance documents suggest a core set of attributes that such teams should encompass. This article reports on a systematic literature review undertaken ...
Zhang Bowu - - 2012
Herein, we report a facile approach to decorate graphene oxide (GO) sheets with poly(vinyl acetate) (PVAc) by γ-ray irradiation-induced graft polymerization. The content of PVAc in the obtained sample, i.e., PVAc grafted GO (GO-g-PVAc) is calculated by the loss weight in thermogravimetric analysis (TGA) curves. A GO-g-PVAc sample with a ...
Richardson Drew B - - 2012
Early evidence is encouraging, but guarded optimism is advised.
Oaklander Anne Louise - - 2012
Patients with chronic itch are diagnosed and treated by dermatologists. However, itch is a neural sensation and some forms of chronic itch are the presenting symptoms of neurological diseases. Dermatologists need some familiarity with the most common neuropathic itch syndromes to initiate diagnostic testing and to know when to refer ...
Takumi Hiroko - - 2012
Hesperetin is an aglycone of citrus flavonoids and is expected to exert a vasodilatation effect in vivo. We developed water-dispersible hesperetin by the process of micronization to enhance the bioavailability of hesperetin. This study aimed to assess the effect of this process on the bioavailability of hesperetin and to estimate ...
Topolnik Lisa - - 2012
Calcium (Ca(2+) ) is a major second messenger in the regulation of different forms of synaptic and intrinsic plasticity. Tightly organized in space and time, postsynaptic Ca(2+) transients trigger the activation of many distinct Ca(2+) signaling cascades, providing a means for a highly specific signal transduction and plasticity induction. High-resolution ...
Zhang Xia - - 2012
A highly diastereoselective three-component tandem 1,4-conjugate addition-cyclization reaction of diazoacetophenones with anilines and unsaturated ketoesters was developed. The reaction provides general, easy, and highly efficient access to multisubstituted pyrrolidines in good yield with high diastereoselectivity.
Gebauer Vera - - 2012
The surface profile of human skin influences characteristically the distribution pattern of topically applied formulations and consequently the efficacy of sunscreens. The volumes of furrows and the spectroscopically determined factors of inhomogeneity are investigated for three sunscreens. A clear correlation between both measurands exists. The average values for younger (<32 ...
Chien Wade - - 2012
BACKGROUND: We describe a novel surgical technique for resection of squamous cell carcinoma in the setting of a massive tongue lymphovascular malformation (LVM). METHODS AND RESULTS: A 75-year-old man with a history of long-standing massive LVM of the tongue presented with a 4-cm squamous cell carcinoma of the involved oral ...
Sahoo Amaresh Kumar - - 2012
Rapid, simple and sensitive detection of bacterial contamination is critical for safeguarding public health and the environment. Herein, we report an easy method of detection as well as enumeration of the bacterial cell number on the basis of fluorescence quenching of a non-antibacterial fluorescent nanocomposite, consisting of paracetamol dimer (PD) ...
Glorioso Nicola - - 2012
Many patients with hypertension will require multiple antihypertensive drugs to achieve blood pressure (BP) control. This double-blind study evaluated the efficacy and safety of aliskiren/amlodipine single-pill combinations (SPCs) in patients with mild-to-moderate hypertension who were non-responsive to aliskiren monotherapy. After a 4-week run-in with aliskiren 300 mg, patients with mean ...
Geelhoed Gary C - - 2012
To assess whether emergency department (ED) overcrowding was reduced after the introduction of the 4-hour rule in Western Australia and whether any changes in overcrowding were associated with significant changes in patient mortality rates. Quasi-experimental intervention study using dependent pretest and post-test samples. Hospital and patient data were obtained for ...
Erovic Boban M - - 2012
BACKGROUND: The purpose of this study was to determine the expression pattern of the Merkel cell polyomavirus (MCPyV) large T-protein antigen in patients with Merkel cell carcinoma. METHODS: A tissue microarray (TMA) containing 30 specimens was constructed and stained for the MCPyV large T protein. Immunohistochemical expression was determined semiquantitively ...
Seo Chang-Seob - - 2012
Objective: Spirodela polyrhiza (L.) Sch. is widely used in Korean traditional medicine. No previous work has investigated in detail the anti-inflammatory activities of S. polyrhiza or assessed in vitro their potential underlying mechanism(s). We assessed the effects of S. polyrhiza ethanolic extract (SPEE) on the production of inflammatory mediators in ...
Grosskopf Courtney C - - 2012
BACKGROUND: Parapharyngeal space (PPS) tumors are rare, accounting for 0.5% of all head and neck neoplasms. PPS tumors are difficult to diagnose due to limited presenting signs and symptoms and because of their location deep within the neck. METHODS AND RESULTS: A 60-year-old woman presented with complaints of otalgia, which ...
Burgstaller Maria - - 2012
In many sensory systems adaptation acts as a gain control mechanism that optimizes sensory performance by trading increased sensitivity to low stimulus intensity for decreased sensitivity to high stimulus intensity. Adaptation of insect antennal olfactory receptor neurons (ORNs) has been studied for strong odour concentrations, either pulsed or constant. Here, ...
Goulston Kerry J - - 2012
The formula for reform works, but is the next review already overdue?
Scott Elizabeth M - - 2012
To assess the extent to which youth-specific, mental health care centres engage young people (12-25 years of age) in treatment, and to report the degree of psychological distress, and the diagnostic type, stage of illness, and psychosocial and vocational impairment evident in these young people. Standardised clinical and self-report assessments of ...
Hajiaghamohammadi Ali Akbar - - 2012
This study was performed to investigate the effects of licorice on non-alcoholic fatty liver disease (NAFLD). In this double blind randomized clinical trial, 66 patients were divided into case and control groups. All patients had elevated liver enzymes and had increased liver echogenicity (lipid accumulation) on sonography. The case group ...
Kang Hyo Jin - - 2012
Various apoptotic signals can activate caspase-3 and -7 by triggering the L2 loop cleavage of their proenzymes. These two enzymes have highly similar structures and functions and serve as apoptotic executioners. The structures of caspase-7 and procaspase-7 differ significantly in the conformation of the loops constituting the active site, indicating ...
Liu Monan - - 2012
Atomic layer deposition (ALD) provides a tool for conformal coating on high aspect-ratio nanostructures with excellent uniformity. It has become a technique for both template-directed nanofabrications and engineering of surface properties. This Feature Article highlights the application of ALD in selected fields including photonics, SERS and energy materials. Specifically, the ...
Zhang Lei - - 2012
To effectively treat articular cartilage defect with tissue engineering there is an urgent need to develop safe and cheap drugs that can substitute or cooperate with growth factors for chondrogenesis promotion. Here, we demonstrate the chondrogenic effect of icariin, the major pharmacological active constituent of Herb Epimedium (HEP). Rabbit chondrocytes ...
Salari Pooneh - - 2012
Inflammatory bowel disease (IBD) is fundamentally a relapsing and remitting disease appearing in forms of ulcerative colitis (UC) or Crohn's disease (CD) with a non-well-known etiology. With the hope to prevent adverse drug events and to increase the efficacy of therapies for IBD, in the recent years, other than new ...
Lu Yiliang - - 2012
In visual prosthesis research, electrically evoked potentials (EEPs) can be elicited by one or more biphasic current pulses delivered to the optic nerve (ON) through penetrating electrodes. Multi-channel EEPs recorded from the visual cortex usually contain large stimulus artifacts caused by instantaneous electrotonic current spread through the brain tissue. These ...
Parker Robert M - - 2012
Broader thinking is needed to restore mental health in a vulnerable population.
Sitzmann Markus - - 2012
We present here a greatly updated version of an earlier study on the conformational energies of protein-ligand complexes in the Protein Data Bank (PDB) [Nicklaus et al., Bioorg. Med. Chem. 1995, 3, 411-428], with the goal of improving on all possible aspects such as number and selection of ligand instances, ...
Geng Baoyou - - 2012
Uniform porous three-dimensional nanoarchitectures of α-Fe(2)O(3) with high yield have been synthesized by a route based on a Ni(2+)/surfactant system. The obtained α-Fe(2)O(3) has a flue-like porous morphology with a rough surface. What is more, spatially ordered nodes and meshes are presented in these networks. By adjusting the experimental parameters ...
Friaa O - - 2012
Antioxidants may affect the outcome of photodynamic therapy (PDT) through the inactivation of reactive oxygen species. Their direct interaction with photosensitizers excited at the triplet state is also worthy of interest. This process is investigated by laser flash photolysis of m-THPC (meso-tetra(3-hydroxyphenyl)chlorin, Foscan) hydroalcoholic solutions added with Trolox (TrOH), a ...
Souvirón R - - 2012
BACKGROUND: Bleeding within the supraglottic region can be a lethal complication after CO(2) laser microsurgery. Our aim was to propose endoluminal anatomical landmarks to locate the superior laryngeal vessels resulting in a safer microsurgery. METHODS: Endoluminal dissections were made in 22 larynges without laryngeal disease. RESULTS: The neurovascular structures were ...
Liu Bin - - 2012
An aqueous ratiometric ESIPT sensor with a 87 nM (15.4 ppb) detection limit was successfully synthesized and applied for detection of all oxidation states of palladium species.
Percec Virgil - - 2012
The synthesis and structural analysis of polymers dendronized with self-assembling Janus dendrimers containing one fluorinated and one hydrogenated dendrons are reported. Janus dendrimers were attached to the polymer backbone both from the hydrogenated and from the fluorinated parts of the Janus dendrimer. Structural analysis of these dendronized polymers and of ...
Hunter Ernest M - - 2012
To describe and characterise treated psychotic disorders in the Indigenous populations of Cape York and the Torres Strait. Cross-sectional analysis of patients with a psychotic disorder identified by treating psychiatrists. Indigenous patients aged ≥ 15 years in Cape York and Torres Strait communities receiving treatment for a psychotic disorder over 3 months in ...
Tizon R - - 2012
Idiopathic Pneumonia Syndrome (IPS) is a common complication after allo-SCT and results in high mortality rates. Conventional treatment for IPS typically includes supportive care and high-dose corticosteroids (CS). Data suggests that TNF-α is important in the pathogenesis of IPS and that the TNF-α inhibitor etanercept may be useful for IPS ...
Dietrich David - - 2012
The biosynthetic gene cluster responsible for the generation of the antibiotic d-cycloserine (DCS) has recently been disclosed. One of the putative enzymes described was DcsC, which showed a high degree of homology to diaminopimelate epimerase (DapF). Based on this homology, the activity of DcsC was presumed to be the racemization ...
Eadie Roslyn - - 2012
5-(2-bromoethyl)phenanthridinium bromide (BEP) undergoes a 3-step-one-pot cyclisation reaction with primary amines allowing the facile synthesis of a vast library of heterocycles. A diverse range of primary aryl amines were explored as reactants to gain insight into the product isolated as a result of the steric and electronic effects of the ...
Barker Dawn - - 2012
The close between the science of medicine and the art of writing.
Roccio Marta - - 2012
To better understand the extrinsic signals that control neural stem cell (NSC) fate, here we applied a microwell array platform which allows high-throughput clonal analyses of NSCs, cultured either as neurospheres or as adherent clones, exposed to poly(ethylene glycol) (PEG) hydrogel substrates functionalized with selected signaling molecules. We analyzed by ...
Madssen Erik - - 2012
Abstract Objectives To assess fatal coronary artery disease (CAD) by gender and glucose regulation status. Design 47951 people were followed up according to fatal CAD identified in the National Cause of Death Registry. Gender-effects of fatal CAD in people with impaired glucose regulation (IGR), newly diagnosed diabetes (NDM) or known ...
Chong Michelle - - 2012
We present a model-based estimation method to reconstruct the unmeasured membrane potential of neuronal populations from a single-channel electroencephalographic (EEG) measurement. We consider a class of neural mass models that share a general structure, specifically the models by Stam et al (1999 Clin. Neurophysiol. 110 1801-13), Jansen and Rit (1995 ...
Jones Daryl A - - 2012
Proactive recognition and response, pre-emptive management.
Xu Hui - - 2012
A novel heterojunction AgBr/BiPO(4) photocatalyst was synthesized with the hydrothermal method. The photocatalyst was characterized by X-Ray powder Diffraction (XRD), Scanning Electron Microscopy (SEM) and Energy Dispersive X-ray Spectrometry (EDS), Transmission Electron Microscopy (TEM), X-ray Photoelectron Spectrscopy (XPS) and Diffuse Reflectance Spectroscopy (DRS). The XRD, SEM-EDS, TEM and XPS analyses ...
Angouridakis Nikolaos - - 2012
BACKGROUND: Neuroendocrine tumors are rare neoplasms arising from neural and epithelial origin. METHODS AND RESULTS: The case records of 4 patients with the diagnosis of neuroendocrine laryngeal tumor were retrospectively reviewed. In this analysis of our medical records, we describe a series of 4 men with neuroendocrine laryngeal tumors treated ...
Fadeev Victor V - - 2012
We use an advanced fluorescence method of Nonlinear Laser Fluorimetry in combination with Fluorescence Induction and Relaxation technique to study the influence of excess-light conditions on the physiological state of the green alga Chlorella pyrenoidosa. We demonstrate that zeaxanthin-dependent non-photochemical quenching leads to a significant increase in the rate constant ...
León Xavier - - 2012
BACKGROUND: Patients with a first head and neck carcinoma have a high risk of successive neoplasms, many of which appear again in the head and neck. Second head and neck tumors have a poorer prognosis than first tumors, but data about the prognosis of third and fourth tumors in the ...
Zagmutt Francisco J - - 2012
Abstract The comparative safety profiles of monotherapeutic treatments against Parkinson's disease(PD) can provide valuable therapeutic information. The objective of this study was to perform an indirect comparison of Adverse Events(AEs) and Dropout Rates(DRs) among clinical trials of pramipexole, ropinirole, and rasagiline. Outcomes analyzed included DRs, total AEs, and AE categories ...
Krasnovsky A A - - 2012
It is shown that the weak IR absorption bands corresponding to the forbidden triplet-singlet transitions in oxygen molecules can be reliably studied in air-saturated solvents under ambient conditions using measurements of the photooxygenation rates of singlet oxygen traps (1,3-diphenylisobenzofuran or uric acid) upon direct excitation of oxygen molecules by IR ...
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