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Moon Seung Hwan - - 2012
BACKGROUND: The prognostic significance of volume-based metabolic parameters measured by (18) F-fluorodeoxyglucose positron emission tomography/CT ((18) F-FDG PET/CT) is not established. We evaluated the prognostic value of metabolic parameters in patients with squamous cell carcinoma (SCC) of the tonsil. METHODS: We enrolled a total of 69 patients with SCC of ...
Taki Nizar H - - 2012
BACKGROUND: Salivary gland carcinosarcoma is a rare and aggressive malignant mixed tumor in which carcinomatous and sarcomatous elements coexist and metastasize together. The tumor may occur in the background of a preexisting pleomorphic adenoma or may arise de novo. We report a case of a woman presenting with a carcinosarcoma ...
Nepal Dhriti - - 2012
Colloidal synthetic approaches to discrete, soluble plasmonic architectures, such as nanorod pairs, offer numerous advantages relative to lithographic techniques, including compositionally asymmetric structures, atomically smooth surfaces, and continuous fabrication. Density-driven colloidal assembly, such as by solvent evaporation, produces some intriguing structures, e.g., particle chains; however, controllability and post-processibility of the ...
Bordicchia Marica - - 2012
The ability of mammals to resist body fat accumulation is linked to their ability to expand the number and activity of "brown adipocytes" within white fat depots. Activation of β-adrenergic receptors (β-ARs) can induce a functional "brown-like" adipocyte phenotype. As cardiac natriuretic peptides (NPs) and β-AR agonists are similarly potent ...
Gu Peng P University of Toronto Transplant Institute, Toronto General Research Institute, University Health Network, Toronto, Ontario, - - 2012
Trogocytosis is a process which involves the transfer of membrane fragments and cell surface proteins between cells. Various types of T cells have been shown to be able to acquire membrane-bound proteins from antigen-presenting cells and their functions can be modulated following trogocytosis. However, it is not known whether induced ...
Brown James S - - 2012
BACKGROUND: The aim of this article was to assess the management of the neck and regional recurrence for squamous cell carcinoma of the maxillary alveolus and hard palate (n = 43) and compare that to the rest of the oral cancer sites (n = 465). METHODS: This is a retrospective ...
Lorenz Maria - - 2012
Dapsone is widely used in the treatment of leprosy and several chronic inflammatory dermatological conditions. Hypersensitivity reactions to dapsone are potentially fatal adverse drug reactions with unknown prevalence and risk factors. We performed a systematic review covering all reported cases of hypersensitivity reactions, in order to systematically summarize the published ...
Strauss Harald - - 2012
In this work, the biogeochemistry of marine sediments from the Kiel Bight, coastal SW Baltic Sea, is studied based on the abundance and isotopic composition of organic carbon and different forms of sedimentary sulphur. Active bacterial sulphate reduction, partly under sulphate-limiting conditions, is evident from paired δ(34)S and δ(18)O values ...
Petersen Jens - - 2012
We investigate theoretically the control of the ultrafast excited state dynamics of adenine in water by laser pulse trains, with the aim to extend the excited state lifetime and to suppress nonradiative relaxation processes. For this purpose, we introduce the combination of our field-induced surface hopping method (FISH) with the ...
Braitberg George - - 2012
Is the 4-hour rule achievable - and beneficial - in our current system of health care?
Mohammad S Noor - - 2012
Extensive analyses of thermodynamic imbalance, surface energy, and segregation of nanotubes on nanoparticle surfaces are performed. A model for surface energy i developed. In addition, nanotube growth both by vapor-phase and solid-phase mechanisms is described. Segregation of the nanotube species to the periphery of the nanoparticle, the creation of an ...
Thompson Alex J - - 2012
We present a clinical investigation of diffuse reflectance and time-resolved autofluorescence spectra of skin cancer with an emphasis on basal cell carcinoma. A total of 25 patients were measured using a compact steady-state diffuse reflectance/fluorescence spectrometer and a fibre-optic-coupled multispectral time-resolved spectrofluorometer. Measurements were performed in vivo prior to surgical ...
Pfeiffer Dietrich - - 2012
Most patients with hypertension will require treatment with at least two antihypertensive agents to achieve blood pressure (BP) control. This double-blind study evaluated the efficacy and safety of aliskiren/amlodipine single-pill combination (SPC) therapy in patients with mild-to-moderate hypertension who are inadequately responsive to amlodipine monotherapy. Patients with mean sitting diastolic ...
Snethen Gretchen - - 2012
Purpose: The Independence through Community Access and Navigation (I-CAN) intervention was developed to increase community participation in adults with schizophrenia spectrum disorders (SSD) through identification of interest-based recreation activities and supported participation. Method: Ten individuals consented to participate in a 10-week pilot intervention. Eight individuals participated in the intervention, during ...
Das Priyadip - - 2012
A newly designed phosphonium derivative (L) having active methylene functionality, shows unusual preference towards F(-) over all other anions. The binding process through C-HF(-) hydrogen bond formation was probed by monitoring the changes in either electronic or luminescence spectra. Changes in both cases are significant enough to allow visual detection. ...
van den Hurk Corina J - - 2012
Background. Chemotherapy-induced alopecia is a frequently occurring side effect of cancer treatment with a high psychological impact which can be prevented by scalp cooling. With this multi-centre patient series we estimated the results of scalp cooling for currently used chemotherapies to provide patient information and we identified characteristics associated with ...
Taira Naoe - - 2012
Dysregulation of the G(1)/S transition in the cell cycle contributes to tumor development. The oncogenic transcription factors c-Jun and c-Myc are indispensable regulators at this transition, and their aberrant expression is associated with many malignancies. Degradation of c-Jun/c-Myc is a critical process for the G(1)/S transition, which is initiated upon ...
Reynolds Luke X - - 2012
We demonstrate that blend films containing poly(3-hexylthiophene-2,5-diyl) and in situ grown CdS display a greater yield of photogenerated charges than a blend containing an equivalent amount of pre-synthesised CdS quantum dots. Moreover, we show that the greater charge yield in the in situ grown films leads to an improvement in ...
Devillier R - - 2012
We previously reported that reduced intensity conditioning (RIC) regimen with fludarabine, BU and 2.5 mg/kg of rabbit anti-thymocyte globulin (r-ATG) was effective but associated with a high rate of acute and chronic GVHD. Therefore, we increased the dose of r-ATG to 5 mg/kg. In this report, we analyzed 87 patients with AML ...
Kreppel Matthias - - 2012
BACKGROUND: The purpose of this study was to evaluate the prognostic impact of the sixth edition of the Union Internationale Contre le Cancer (UICC) classification and different TNM-based stage groupings for malignant tumors of the ethmoid sinuses and the nasal cavity. METHODS: We conducted a retrospective analysis of 98 patients ...
Singh Narendra - - 2012
Here, we report the facile preparation of tunable magnetic Ni-doped near-infrared (NIR) quantum dots (MNIR-QDs) as an efficient probe for targeting, imaging and cellular sorting applications. We synthesized the MNIR-QDs via hot colloidal synthesis approach to yield monodisperse and tunable QDs. These hydrophobic QDs were structurally and compositionally characterized and ...
Virji-Babul Naznin - - 2012
ABSTRACT Research on facial expressions in individuals with Down syndrome (DS) has been conducted using photographs. Our goal was to examine the effect of motion on perception of emotional expressions. Adults with DS, adults with typical development matched for chronological age (CA), and children with typical development matched for developmental ...
Fadeev Victor V - - 2012
We use an advanced fluorescence method of Nonlinear Laser Fluorimetry in combination with Fluorescence Induction and Relaxation technique to study the influence of excess-light conditions on the physiological state of the green alga Chlorella pyrenoidosa. We demonstrate that zeaxanthin-dependent non-photochemical quenching leads to a significant increase in the rate constant ...
León Xavier X Department of Otorhinolaryngology, Institut d'Investigacions Biomèdiques Sant Pau, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain. - - 2012
Patients with a first head and neck carcinoma have a high risk of successive neoplasms, many of which appear again in the head and neck. Second head and neck tumors have a poorer prognosis than first tumors, but data about the prognosis of third and fourth tumors in the head ...
Zagmutt Francisco J - - 2012
Abstract The comparative safety profiles of monotherapeutic treatments against Parkinson's disease(PD) can provide valuable therapeutic information. The objective of this study was to perform an indirect comparison of Adverse Events(AEs) and Dropout Rates(DRs) among clinical trials of pramipexole, ropinirole, and rasagiline. Outcomes analyzed included DRs, total AEs, and AE categories ...
Peveling-Oberhag J - - 2012
The precise molecular pathogenesis of splenic marginal zone lymphoma (SMZL) is still unknown. Clinical and epidemiological data suggest that chronic hepatitis C virus (HCV) infection may have an etiological role in a subset of cases.We performed a large-scale microRNA (miRNA) expression profiling analysis of 381 miRNAs by quantitative reverse transcription ...
Xia Shu-Jie - - 2012
In this paper, we reviewed the features of common prostate diseases, such as benign prostatic hyperplasia (BPH), prostate cancer (PCa) and chronic prostatitis (CP) that are specific to Asian men. Compared to the Westerners, Asians exhibit particular characteristics of prostate diseases. Through summarizing the epidemiology, symptomatology, diagnostics and therapeutics of ...
Manna Anamika - - 2012
We report an interesting pH tunable energy transfer between an acceptor ionic styryl dye 2-(4-(dimethylamino) styryl)-1-methylpyridinium iodide and a donor charge transfer dye 1, 8 naphthalimide in a vesicular medium. The polyethylene-b-polyethylene glycol block-copolymer intercalates with the sodium dodecyl sulphate anionic surfactant to form self-aggregated nano-composites. These nano-composites interact with ...
Liu Monan - - 2012
Atomic layer deposition (ALD) provides a tool for conformal coating on high aspect-ratio nanostructures with excellent uniformity. It has become a technique for both template-directed nanofabrications and engineering of surface properties. This Feature Article highlights the application of ALD in selected fields including photonics, SERS and energy materials. Specifically, the ...
van de Giessen Elsmarieke E Department of Nuclear Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands. - - 2012
Different types of high-fat (HF) diets are used to study diet-induced obesity (DIO) in rodents and this has led to different phenotypes. This study assesses whether different HF diets differentially affect striatal dopamine D(2/3) receptor (DRD(2/3)) availability, as decreased striatal DRD(2/3) availability has been implicated in obesity in relation to ...
Zhang Lei - - 2012
To effectively treat articular cartilage defect with tissue engineering there is an urgent need to develop safe and cheap drugs that can substitute or cooperate with growth factors for chondrogenesis promotion. Here, we demonstrate the chondrogenic effect of icariin, the major pharmacological active constituent of Herb Epimedium (HEP). Rabbit chondrocytes ...
Salari Pooneh - - 2012
Inflammatory bowel disease (IBD) is fundamentally a relapsing and remitting disease appearing in forms of ulcerative colitis (UC) or Crohn's disease (CD) with a non-well-known etiology. With the hope to prevent adverse drug events and to increase the efficacy of therapies for IBD, in the recent years, other than new ...
Paximadis Peter A PA Department of Radiation Oncology, Wayne State University/Detroit Medical Center, Detroit, Michigan, USA. - - 2012
The appropriate management of the neck in patients with regionally advanced head and neck cancer remains controversial. The purpose of this study was to retrospectively analyze our institutional experience with up-front neck dissection followed by definitive chemoradiotherapy. Fifty-five patients with radiographic evidence of large or necrotic lymph nodes underwent up-front ...
Lu Yiliang - - 2012
In visual prosthesis research, electrically evoked potentials (EEPs) can be elicited by one or more biphasic current pulses delivered to the optic nerve (ON) through penetrating electrodes. Multi-channel EEPs recorded from the visual cortex usually contain large stimulus artifacts caused by instantaneous electrotonic current spread through the brain tissue. These ...
Sahoo Amaresh Kumar - - 2012
Rapid, simple and sensitive detection of bacterial contamination is critical for safeguarding public health and the environment. Herein, we report an easy method of detection as well as enumeration of the bacterial cell number on the basis of fluorescence quenching of a non-antibacterial fluorescent nanocomposite, consisting of paracetamol dimer (PD) ...
Glorioso Nicola - - 2012
Many patients with hypertension will require multiple antihypertensive drugs to achieve blood pressure (BP) control. This double-blind study evaluated the efficacy and safety of aliskiren/amlodipine single-pill combinations (SPCs) in patients with mild-to-moderate hypertension who were non-responsive to aliskiren monotherapy. After a 4-week run-in with aliskiren 300 mg, patients with mean ...
Jones Simon - - 2012
Chiral amines are key components in numerous bioactive molecules. The development of efficient and economical ways to access molecules containing this functional group still remains a challenge at the forefront of synthetic chemistry. Of the methods that do exist, the trichlorosilane mediated organocatalytic reduction of ketimines offers significant potential as ...
Prosenjak Claudia - - 2012
Thermal desorption spectra of a number of metal-organic frameworks were studied using grand canonical Monte Carlo simulation. Our simulation results are in qualitative agreement with experimental results but also show that great care must be taken when choosing the force field to describe the hydrogen/framework interaction. As the simulations additionally ...
Husson Olga - - 2012
BACKGROUND: The aim of this study was to provide insight into the relationship between information provision and illness perceptions among cancer survivors. METHODS: All individuals diagnosed with lymphoma, multiple myeloma, endometrial or colorectal cancer between 1998 and 2008, as registered in the Eindhoven Cancer Registry, were eligible for participation. In ...
Wang Zhen-He - - 2012
Background: Epoxyeicosatrienoic acids (EETs) have been shown to play a role in cardiovascular protection by reducing ischemia reperfusion injury, producing anti-inflammatory effects, and promoting angiogenesis. EETs are regulated through conversion to less active corresponding diols by soluble epoxide hydrolase (sEH). Inhibition of sEH enhances the beneficial properties of EETs and ...
Karasawa Fumitoshi - - 2012
Gastric gland mucin secreted from the lower portion of the gastric mucosa contains unique O-linked oligosaccharides (O-glycans) having terminal α1,4-linked N-acetylglucosamine residues (αGlcNAc). Previously, we identified human α1,4-N-acetylglucosaminyltransferase (α4GnT), which is responsible for the O-glycan biosynthesis and characterized αGlcNAc function in suppressing Helicobacter pylori in vitro. In the present study, ...
Peter Inga I Department of Genetics and Genomic Sciences, Mount Sinai School of Medicine, New York, NY, USA. - - 2012
The importance of lifestyle intervention for the prevention and treatment of type 2 diabetes (T2D) has been underscored by the limited benefit of pharmacologic therapies. We sought to determine whether genetic variants that contribute to T2D risk modify the response of weight and waist circumference to an intensive lifestyle intervention ...
Trijolet J P - - 2012
BACKGROUND: Lipoleiomyosarcoma is a rare tumor consisting of well-differentiated liposarcoma and leiomyosarcoma. The ear-nose-throat location of lipoleiomyosarcoma has not been previously described. METHODS AND RESULTS: A 37-year-old man with a dysphagia had a dyspnea after an endoscopy. A large tumor was exteriorized from the man's mouth. The lesion was pedicled ...
Nanan Ralph K - - 2012
Is canonical thinking inhibiting the flexibility and innovation required for expert clinical reasoning?
Casimiro Mathew C - - 2012
Chromosomal instability (CIN) in tumors is characterized by chromosomal abnormalities and an altered gene expression signature; however, the mechanism of CIN is poorly understood. CCND1 (which encodes cyclin D1) is overexpressed in human malignancies and has been shown to play a direct role in transcriptional regulation. Here, we used genome-wide ...
Jin Wei W Immunology Program, Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA. - - 2012
E3 ubiquitin ligases play a crucial role in regulating immune receptor signaling and modulating immune homeostasis and activation. One emerging family of such E3s is the Pelle-interacting (Peli) proteins, characterized by the presence of a cryptic forkhead-associated domain involved in substrate binding and an atypical RING domain mediating formation of ...
Percec Virgil - - 2012
The synthesis and structural analysis of polymers dendronized with self-assembling Janus dendrimers containing one fluorinated and one hydrogenated dendrons are reported. Janus dendrimers were attached to the polymer backbone both from the hydrogenated and from the fluorinated parts of the Janus dendrimer. Structural analysis of these dendronized polymers and of ...
Jorm Anthony F - - 2012
To assemble what is known about the mental health of Indigenous Australians from community surveys. A systematic search was carried out of publications and data sources since 2000 using PubMed, PsycINFO, Australian Medical Index, the National Library of Australia and datasets known to the authors. Surveys had to involve representative sampling ...
Oertli Mathias - - 2012
Persistent colonization with the gastric bacterial pathogen Helicobacter pylori causes gastritis and predisposes infected individuals to gastric cancer. Conversely, it is also linked to protection from allergic, chronic inflammatory, and autoimmune diseases. We demonstrate here that H. pylori inhibits LPS-induced maturation of DCs and reprograms DCs toward a tolerance-promoting phenotype. ...
Wang Wenzhuo Y WY Center for Inflammation, Immunity and Infection, and Department of Biology, Georgia State University, Atlanta, GA 30302, - - 2012
Pneumonia, the most typical and frequent lower respiratory tract infection (LRTI), is a leading cause of health problems in the United States. Bacteria represent the most prevailing cause of pneumonia in both children and adults. Although pneumonia with a single bacterial infection is common, a significant portion of patients with ...
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