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Results 401 - 450 of 2851
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Dey Michelle - - 2012
PURPOSE: To systematically review studies about the quality of life (QOL) of children with various mental disorders relative to healthy controls and to describe limitations in these studies. METHODS: Relevant articles were searched using different databases, by checking reference lists and contacting experts. We included articles that either compared children ...
Pun Carson - - 2012
Although significant advances in our understanding of the cognitive and neural processes involved in conscious awareness have occurred in recent years, the precise mechanisms that support consciousness remain elusive. Examining the neural correlates associated with the moment a stimulus enters or exits conscious awareness is one way to potentially identify ...
Wikan Arild - - 2012
Discrete stage-structured density-dependent and discrete age-structured density-dependent population models are considered. Regarding the former, we prove that the model at hand is permanent (i.e., that the population will neither go extinct nor exhibit explosive oscillations) and given density dependent fecundity terms we also show that species with delayed semelparous life ...
Gong Yan - - 2012
Adeno-associated virus vector plasmid carrying the expression cassette of brain-derived neurotrophic factor (BDNF), pAAV-BDNF, was constructed and packaged into recombinant adeno-associated virus (rAAV-BDNF). The rAAV-BDNF was intravitreally injected into streptzotocin (STZ)-induced diabetic Sprague-Dawley (SD) Rats. Data showed that over-expression of BDNF could increase alive retinal ganglion cell (RGC) number and ...
McMullen Roger L - - 2012
There are numerous chromophores present throughout the strata of human skin, which present many challenges and opportunities to probe molecular events. Fluorescence spectroscopy is principally employed to identify important biochemical components of the skin including endogenous tryptophan, tyrosine, pepsin digestible collagen cross-links, collagenase digestible collagen cross-links, NADH, etc. Over the ...
Yu Mei-Ching - - 2012
People with type 1 diabetes mellitus are at an increased risk of cardiovascular mortality. Studies comparing arterial stiffness between subjects with type 1 diabetes and nondiabetic controls have provided controversial findings. We investigated brachial-ankle pulse wave velocity (baPWV) in 87 teenagers with type 1 diabetes mellitus and in 21 matched ...
Boleij Annemarie - - 2012
A healthy human body contains at least tenfold more bacterial cells than human cells and the most abundant and diverse microbial community resides in the intestinal tract. Intestinal health is not only maintained by the human intestine itself and by dietary factors, but is also largely supported by this resident ...
Agar Guleray - - 2012
Northeastern Turkey is recognized as one of the most important germplasm centers for the grape in the world. In the present study, simple sequence repeat markers were used to investigate the genetic diversity between four Vitis vinifera cv. Kabarcik populations sampled from the Coruh Valley in Turkey, at altitudes of ...
Krejci M - - 2012
Graft-versus-host disease (GVHD) is the most frequent complication after allogeneic hematopoietic cell transplantation. We analyzed the kinetics of bilirubin and liver enzymes in 47 cases with liver GVHD and in 47 cases without GVHD after allogeneic transplantation for various hematological malignancies. The duration of an liver GVHD episode (LGVHD) was ...
Bonabi Sharouz - - 2012
To evaluate the prevalence of thyroid FDG-PET/CT incidentalomas and the risk of malignancy in focal findings. A retrospective study of 3,062 PET scans was performed between 05/2006 and 09/2009. Prevalence of thyroid incidentalomas, risk of malignancy and correlation between standard uptake value (SUV) and cancer risk were analysed. The overall ...
Du Bin - - 2012
Three different S(1) and T(1) energy donors are linked onto a central zinc(ii) porphyrin acceptor and the rates for energy transfers show evidence for cooperativity.
Sacornrattana O - - 2012
The purpose of this study was to describe abdominal ultrasonographic findings present at diagnosis of osteosarcoma (OSA) in dogs and to investigate for associations with treatment outcome. Medical records from 118 dogs diagnosed with OSA that had abdominal ultrasonography performed as part of their initial evaluation were reviewed. Fifty-seven percent ...
Alhumaidan Hiba - - 2012
The storage of platelets in additive solution (PAS) had lagged behind red cell concentrates, especially in North America. The partial or complete removal of anticoagulated plasma and storage of platelet concentrates in AS presents many advantages. The PAS can be formulated to optimize aerobic metabolism or decrease platelet activation, thus ...
Li Yun - - 2012
BACKGROUND: The goal of the present study was to differentiate between benign and malignant solitary pulmonary nodules (SPN) by developing a mathematical prediction model. METHODS: Records from 371 patients (197 male, 174 female) with SPN between January 2000 and September 2009 were reviewed (group A). Clinical data were collected to ...
Theocharis G - - 2012
Over the last decade, travel medicine was mainly focused on the epidemiology of diseases among travelers to developing countries. However, less is known about travel-related morbidity in Europe. We evaluated the demographic and clinical characteristics of foreign travelers to Greece during a 5-year period (01/01/2005 - 31/12/2009) who sought medical ...
Jiang Qiao-Ying - - 2012
Endometriosis is a common gynecological disease defined by extrauterine growth of endometrial glands and stroma. A variety of theories have been proposed to account for the pathogenesis of this disease, including retrograde transplantation theory, metaplasia of coelomic epithelium, hematogenic and lymphogenic spread, and remnants of the MÅ­llerian duct. However, the ...
Cardoso Juliano C - - 2012
We report on low-cost, all solution fabrication of efficient air-stable nanostructured thin film photovoltaics comprised of n-type Sb(2)S(3) chemically deposited onto TiO(2) nanowire array films, forming coaxial Sb(2)S(3)/TiO(2) nanowire hybrids vertically oriented from the SnO(2):F coated glass substrate, which are then intercalated with poly(3-hexylthiophene) (P3HT) for hole transport and enhanced ...
Watanabe Tatsuro - - 2012
PURPOSE: To understand how nanomechanical stiffness affects metastatic potential, we studied the relationship between cell migration, a characteristic of metastasis, and cell stiffness using atomic force microscopy (AFM), which can measure stiffness (elasticity) of individual living cells. METHODS: Migration and cell stiffness of three metastatic B16 melanoma variants (B16-F10, B16-BL6, ...
Huddle Thomas S - - 2012
Opponents of physician-assisted suicide (PAS) maintain that physician withdrawal-of-life-sustaining-treatment cannot be morally equated to voluntary active euthanasia. PAS opponents generally distinguish these two kinds of act by positing a possible moral distinction between killing and allowing-to-die, ceteris paribus. While that distinction continues to be widely accepted in the public discourse, ...
Wang Qun - - 2012
The ubiquitin/proteasome pathway plays an important role in gametogenesis. Ubiquitin/ribosomal fusion protein is the precursor of mono-ubiquitin. We identified two ubiquitin/ribosomal fusion proteins genes in testis of Eriocheir sinensis. The ubiquitin-ribosomal proteins S27 and L40 are denoted as UBS27 and UBL40, respectively. The full length Es-UBS27 cDNA (565 bp) was cloned ...
Sacristan Carlos - - 2012
Yeast cells normally grow by budding, but under certain specific conditions they are also able to grow in hyperpolarized forms reminiscent of hyphal growth. During vegetative growth, the synthesis of the septum that physically separates yeast cells during cytokinesis depends on the correct assembly of the septin ring. Septins and ...
Li Gebin - - 2012
Continuous high intensity training may induce alterations to enzyme activities related to glucose and lipid metabolism in horses. In our study, five Thoroughbred race horses (3 male and 2 female, avg age = 5 yrs old) were compared against five riding horses (1 male, 1 female, 3 gelding, avg age = 13 yrs old) in terms ...
Lanier Anne P - - 2012
The Alaska Education and Research Towards Health (EARTH) Study assessed cancer risk among 3,821 Alaska Native people (AN). We present the prevalence of selected cancer risk factors and comparison with Healthy People 2010 goals. Participants completed extensive computer-assisted self-administered questionnaires on diet, physical activity, tobacco and alcohol use, cancer screening, ...
Matsui Yoshio - - 2012
Thromboxane A(2) (TXA(2) ) is a prostanoid formed by thromboxane synthase using the cyclooxygenase product, prostaglandin H(2), as the substrate. TXA(2) was shown to enhance tumor metastasis, but the underlying mechanism remains unclear. B16F1 melanoma cells were intravenously injected into TXA(2) receptor (TP) knockout mice (TP(-/-) ) and wild-type littermates ...
Fischmann Arne - - 2012
Oculopharyngeal muscular dystrophy (OPMD) is a rare autosomal dominant muscular dystrophy with late onset and slow progression. The aim of this study was to compare different methods of quantitative MRI in the follow-up of OPMD to semiquantitative evaluation of MRI images and to functional parameters. We examined 8 patients with genetically ...
Lotufo Paulo A - - 2012
BACKGROUND: Brazil has one of the highest cerebrovascular death rates in the Western Hemisphere. We investigated temporal trends according to gender and stroke subtypes. METHODS: We analyzed mortality rates between 1979 and 2009 for different stroke subtypes. Data were stratified by gender and age (35-74 years). The annual percent change and ...
Kozlowski Tomasz - - 2012
There is a paucity of data concerning the correlation of C4d staining in liver allografts with antibody mediated rejection (AMR). Data regarding location and character of C4d deposits in native and allograft liver tissue are inconsistent. We performed C4d immunofluorescence (IF) on 141 fresh frozen liver allograft biopsies and native ...
Pallesen Lone Tjener - - 2012
Sortilin and SorLA are members of the Vps10p domain receptor family, the Sortilins, which comprise five type I transmembrane receptors differentially expressed in neuronal tissues of the central and peripheral nervous system. Since the identification of sortilin in 1997, members of this receptor family are recognized as sorting receptors primarily ...
Kalogjera Livije - - 2012
Olfaction is an essential chemosensory system in the living world. Although less appreciated in humans, smell impairment significantly affects many aspects of quality of life. Smell disorders may be caused by an impaired nasal airway or by lesions in the olfactory system, leading to reduced or distorted smell perception. The ...
Kearley Gordon J - - 2012
We analyze the interplay between proton-transfer in the hydrogen-bond bridge, O…H…O, and lattice dynamics in the model system tetraacetylethane (TAE) (CH3CO)2CH=CH(COCH3)2, using density functional theory. Lattice dynamics calculations and molecular dynamics simulations are validated against neutron scattering data. Hindrance to the cooperative reorientation of neighboring methyl groups at low temperatures ...
Tian Chungui - - 2012
Zinc oxide with excellent photocatalytic performance for the photodegradation of dyes (superior to Degussa P25 TiO(2)) could be easily prepared in large quantity by direct calcination of zinc acetate (Zn(Ac)(2)·2H(2)O).
Occhino John A - - 2012
Mentor Corporation's ObTape has been associated with considerable morbidity. An unacceptably high exposure rate has been noted, and in some cases, multiple procedures may be necessary for complete mesh removal. We evaluated a patient who had prior ObTape placement complicated with persistent vaginal discharge and granulation tissue formation related to ...
Wurst Martin - - 2012
When Trypanosoma brucei differentiates from the bloodstream form to the procyclic form, there are decreases in the levels of many mRNAs encoding proteins required for the glycolytic pathway, and the mRNA encoding the RNA Recognition Motif protein RBP10 decreases in parallel. We show that RBP10 is a cytoplasmic protein that ...
Bhaktha Geetha - - 2012
Objective: Our study attempted to evaluate the diagnostic value of HbA1c in predicting diabetic dyslipidemia and cardiovascular diseases (CVD). Methods: Study comprised 229 subjects (156 males and 73 females) with diabetic dyslipidemia without any micro and macro vascular disorders. Fasting blood samples were taken to analyse biochemical parameters like HbA1c, ...
Stafinski Tania - - 2012
Background  Interest in citizens' juries for eliciting the views of the public to inform coverage decisions on new health technologies has grown. However, evaluative information, particularly regarding their short- and/or longer-term impact on participants' views is limited. As citizens' juries can be resource intensive, such information is required to make ...
Zhou Fang - - 2012
Porcine reproductive and respiratory syndrome (PRRS) is now considered to be one of the most important diseases in countries with intensive swine industries. The two major membrane-associated proteins of porcine reproductive and respiratory syndrome virus (PRRSV), GP5 and M (encoded by ORF5 and ORF6 genes, respectively), are associated as disulfide-linked ...
Redondo Analía - - 2012
Abstract Dietary flavonoids, present in different amount in foods, are associated with the prevention of hypertension, but little is known about the interactions between them. The aim of this study was to explore the effect of quercetin (Q), catechin (C) and the mixture, on Angiotensin II (AngII)-induced redox-dependent signaling pathways ...
Girolomoni Giampiero - - 2012
The efficacy and favorable safety profile of anti-tumor necrosis factor (TNF) agents in the treatment of psoriasis and psoriatic arthritis (PsA) are supported by several randomized controlled studies and meta-analyses. However, some concerns on the long-term safety of these drugs still exist, as these studies generally included small patient numbers ...
Rodriguez B Leticia - - 2012
Previously, it was shown that treatment of tumor-bearing mice with an RNA replicase-based plasmid that produces dsRNA when transfected into tumor cells significantly inhibited the tumor growth. In the present study, the feasibility of further improving the anti-tumor activity of the RNA replicase-based plasmid by targeting it into tumors cells ...
Parajuli Nirmal - - 2012
The inflammatory cytokines interleukin (IL)-10 and tumor necrosis factor (TNF)-α play an important role in left ventricular (LV) remodeling after myocardial infarction (MI). Phosphatase and tensin homolog deleted on chromosome ten (PTEN) inactivates protein kinase Akt and promotes cell death in the heart. However, it is not known whether PTEN ...
Jang Dong Pyo - - 2012
Although fast-scan cyclic voltammetry (FSCV) has contributed to important advances in neuroscience research, the technique is encumbered by significant analytical challenges. Confounding factors such as pH change and transient effects at the microelectrode surface make it difficult to discern the analytes represented by complex voltammograms. Here we introduce paired-pulse voltammetry ...
Sen Yi-Heng - - 2012
Nanofluidic sensing elements have been the focus of recent experiments for numerous applications ranging from nucleic acid fragment sizing to single-molecule DNA sequencing. These applications critically rely on high measurement fidelity, and methods to increase resolution are required. Herein, we describe fabrication and testing of a nanochannel device that enhances ...
Skibola C F - - 2012
Follicular lymphoma (FL) is an indolent, sometimes, fatal disease characterized by recurrence at progressively shorter intervals and is frequently refractive to therapy. Genome-wide association studies have identified single nucleotide polymorphisms (SNPs) in the human leukocyte antigen (HLA) region on chromosome 6p21.32-33 that are statistically significantly associated with FL risk. Low ...
Nikpay Majid - - 2012
Links between substance use habits, obesity, stress and the related cardiovascular outcomes can be, in part, because of loci with pleiotropic effects. To investigate this hypothesis, we performed genome-wide mapping in 119 multigenerational families from a population in the Saguenay-Lac-St-Jean region with a known founder effect using 58,000 single-nucleotide polymorphisms ...
Chen Xia - - 2012
This birth cohort study was conducted to investigate the contribution of prenatal and antenatal environmental exposures to later-life hypertensive status. Two thousand five hundred and three individuals born in 1921-1954 at the Peking Union Medical College Hospital (PUMCH) were targeted; 2,081 (83.1%) participated. Clinical examinations included an interview, blood pressure ...
Fekete Natalie - - 2012
The clinical use of human mesenchymal stromal cells (MSC) requires ex vivo expansion in media containing supplements such as fetal bovine serum or, alternatively, human platelet lysate (PL). Platelet concentrates were frozen, quarantine stored, thawed and sterile filtered to obtain PL. PL content and its effect on fibroblast-colony-forming unit (CFU-F) ...
Harris John E - - 2012
Vitiligo is an autoimmune disease of the skin causing disfiguring patchy depigmentation of the epidermis and, less commonly, hair. Therapeutic options for vitiligo are limited, reflecting in part limited knowledge of disease pathogenesis. Existing mouse models of vitiligo consist of hair depigmentation but lack prominent epidermal involvement, which is the ...
Liu Michael - - 2012
Sponges harbour complex communities of diverse microorganisms, which have been postulated to form intimate symbiotic relationships with their host. Here we unravel some of these interactions by characterising the functional features of the microbial community of the sponge Cymbastela concentrica through a combined metagenomic and metaproteomic approach. We discover the ...
Delmont Tom O - - 2012
The soil ecosystem is critical for human health, affecting aspects of the environment from key agricultural and edaphic parameters to critical influence on climate change. Soil has more unknown biodiversity than any other ecosystem. We have applied diverse DNA extraction methods coupled with high throughput pyrosequencing to explore 4.88 × ...
Locatelli Francesco - - 2012
Anemia, a frequent and early complication of chronic kidney disease (CKD), not only impairs quality of life but is also an independent risk factor for adverse cardiovascular outcomes. Erythropoiesis-stimulating agents (ESAs), together with iron, are the main therapeutic tool to correct anemia in CKD patients nowadays. Following a literature search ...
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