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Hawkins Alice K AK Centre for Applied Ethics, University of British Columbia, 227-6356 Agricultural Road, Vancouver, BC V6T1Z2, Canada. - - 2012
Over the last several years, direct to consumer(DTC) genetic testing has received increasing attention in the public, healthcare and academic realms. DTC genetic testing companies face considerable criticism and scepticism,particularly from the medical and genetic counseling community. This raises the question of what specific aspects of DTC genetic testing provoke ...
Ponce Lucido L LL Department of Neurosurgery, Baylor College of Medicine, Houston, Texas 77030, - - 2012
Monitoring brain tissue PO2 (PbtO2) is part of multimodality monitoring of patients with traumatic brain injury (TBI). However, PbtO2 measurement is a sampling of only a small area of tissue surrounding the sensor tip. To examine the effect of catheter location on the relationship between PbtO2 and neurological outcome. A ...
Park Serk In - - 2012
Prostate cancer remains a leading cause of cancer-related death in men, largely attributable to distant metastases, most frequently to bones. Despite intensive investigations, molecular mechanisms underlying metastasis are not completely understood. Among prostate cancer-derived factors, parathyroid hormone-related peptide (PTHrP), first discovered as an etiologic factor for malignancy-induced hypercalcemia, regulates many ...
Liu Limei - - 2012
Oocyte maturation is a complex process during which epigenetic modifications are dramatically changed, especially histone acetylation and phosphorylation. We have investigated the effects of NaBu (sodium butyrate), a natural HDAC (histone deacetylase) inhibitor, on porcine oocyte maturation at different stages and subsequent embryonic development to improve IVF (in vitro fertilization) ...
Ratto C - - 2012
The surgical treatment of a complex anal fistula remains controversial, although 'sphincter-saving' operations are desirable. The Gore Bio-A® Fistula Plug is a new bioprosthetic plug that has been proposed for the treatment of complex anal fistula. This study reports preliminary data following implantation of this plug. Eleven patients with a ...
Pedersen Mette - - 2012
This study examined efficacy of the innate immune defence via the mannose binding lectin (MBL) in a cohort of 55 dystonic patients prospectively referred to the clinic with laryngeal mucosal complaints, who were placed on local steroids (budesonid inhaler, 400 μg 2 times daily) and antihistamines (fexofenadin 180 mg mostly ...
Zaidi Habib - - 2012
Several methods have been proposed for the segmentation of ¹⁸F-FDG uptake in PET. In this study, we assessed the performance of four categories of ¹⁸F-FDG PET image segmentation techniques in pharyngolaryngeal squamous cell carcinoma using clinical studies where the surgical specimen served as the benchmark. Nine PET image segmentation techniques ...
Sadurska Elżbieta - - 2012
We report a 16-year-old girl in whom Takayasu arteritis (TA) was manifested mainly by severe arterial hypertension on her right arm, which was detected during a routine examination at school. Her systolic blood pressure on the right arm was significantly higher than that on the left one. There was also ...
Thiadens Alberta A H J - - 2012
Danon disease is a neuromuscular disorder with variable expression in the eye. We describe a family with Danon disease and cone-rod dystrophy (CRD). Affected males of one family with Danon were invited for an extensive ophthalmologic examination, including color vision testing, fundus photography, Goldmann perimetry, full-field electroretinogram (ERG), and SD-OCT. ...
Favoni Roberto E - - 2012
The incidence of human malignant pleural mesothelioma (hMPM) is still increasing worldwide. hMPM prognosis is poor even if the median survival time has been slightly improved after the introduction of the up-to-date chemotherapy. Nevertheless, large phase II/III trials support the combination of platinum derivatives and pemetrexed or raltitrexed, as preferred ...
Harmar Anthony J - - 2012
Vasoactive intestinal peptide (VIP) and pituitary adenylate cyclase-activating polypeptide (PACAP) are members of a superfamily of structurally related peptide hormones that includes glucagon, glucagon-like peptides, secretin, gastric inhibitory peptide (GIP) and growth hormone-releasing hormone (GHRH). VIP and PACAP exert their actions through three GPCRs - PAC(1) , VPAC(1) and VPAC(2) ...
Eirin Alfonso - - 2012
Reno-protective strategies are needed to improve renal outcomes in patients with atherosclerotic renal artery stenosis (ARAS). Adipose tissue-derived mesenchymal stem cells (MSCs) can promote renal regeneration, but their potential for attenuating cellular injury and restoring kidney repair in ARAS has not been explored. We hypothesized that replenishment of MSC as ...
Urao Norifumi - - 2012
Bone marrow (BM) microenvironment, which is regulated by hypoxia and proteolytic enzymes, is crucial for stem/progenitor cell function and mobilization involved in postnatal neovascularization. We demonstrated that NADPH oxidase 2 (Nox2)-derived reactive oxygen species (ROS) are involved in postischemic mobilization of BM cells and revascularization. However, role of Nox2 in ...
Sureshkumar Kalathil K - - 2012
Over last several years, alemtuzumab induction has been increasingly used in kidney transplantation especially in patients maintained on steroid-free immunosuppression. It is unclear which induction agent is associated with better graft and patient outcomes in these patients. Using Organ Procurement and Transplant Network/United Network of Organ Sharing database, graft and ...
Scholtes Caroline - - 2012
Hepatitis C virus (HCV) particles associate viral and lipoprotein moieties to form hybrid lipoviral particles (LVPs). Cell culture-produced HCV (HCVcc) and ex vivo-characterized LVPs primarily differ by their apolipoprotein (apo) B content, which is low for HCVcc, but high for LVPs. Recombinant nucleocapsid-free subviral LVPs are assembled and secreted by ...
Kim Young-Il - - 2012
The physiologic tooth position is determined by interactions between the periodontal tissue and occlusal, tongue, and lip forces. Bone destruction resulting from chronic periodontal disease disturbs the equilibrium of these interactive balances, leading to pathologic tooth migration, often requiring multidisciplinary treatment approaches. The present case demonstrates a systematic periodontal-orthodontic-prosthetic treatment ...
Jankovic Sasha - - 2012
This 6-month randomized controlled clinical study primarily aimed to compare the results achieved by the use of a platelet-rich fibrin (PRF) membrane or connective tissue graft (CTG) in the treatment of gingival recession and to evaluate the clinical impact of PRF on early wound healing and subjective patient discomfort. Use ...
Lee Young-Moo - - 2012
The purpose of this case series was to evaluate secondary soft tissue level changes of a single-stage surgical protocol combining immediate implant placement and connective tissue grafting in maxillary incisors associated with gingival recession defects. Ten patients underwent the proposed combined treatment consisting of 11 single-tooth implant restorations. Peri-implant soft ...
Braut Vedrana - - 2012
This retrospective radiographic study analyzed the dimensions of the alveolar bone in the posterior dentate mandible based on cone beam computed tomography (CBCT) images. A total of 56 CBCT images met the inclusion criteria, resulting in a sample size of 122 cross sections showing posterior mandibular teeth (premolars and molars). ...
Thoma Daniel S - - 2012
The aim of this study was to test whether recombinant human platelet-derived growth factor BB (rhPDGF-BB) enhances bone regeneration in combination with Β-tricalcium phosphate (Β-TCP) granules or deproteinized bovine bone mineral (DBBM) compared to empty defects and Β-TCP granules alone. Four titanium cylinders were placed on the external cortical plates ...
Tinti Carlo - - 2012
This article describes a soft tissue surgical modification--the trap door technique--used to enhance contemporary patient esthetic expectations and preserve periodontal health longitudinally. This surgical modification is greatly indicated for single-stage single and multiple implant surgery to preserve the integrity of the papillae and eliminate buccal soft tissue concavity. This procedure ...
Minoretti Roger - - 2012
Excessive cantilever lengths of fixed implant-supported prostheses may have functional and biomechanical disadvantages. This study reports the clinical outcomes of unconventional implants placed for distal support of a fixed implant-supported prostheses. Seven extraoral implants with intraosseous lengths of 2.5 to 4.0 mm were placed in four patients. Distal cantilevers had ...
Vela Xavier - - 2012
Because of the peri-implant bone resorption that occurs when a non-platform switched implant is exposed to the oral environment, it has been recommended to maintain 1.5 mm between the tooth and implant to preserve the bone adjacent to the teeth. Several studies have documented that platform-switched implants have less peri-implant ...
Perez Fabiano - - 2012
This study evaluated factors that may influence the presence or absence of interproximal papillae. Clinical evaluation consisted of visual determination, and quantitative analyses were made using millimeter grids on radiographs. Patients (n = 45) were divided into three groups according to age. Data were analyzed using the chi-square test followed ...
Fradeani Mauro - - 2012
Restorative treatment of the severely worn dentition is typically indicated to replace deficient tooth structure, limit the advancement of tooth destruction, improve oral function, and enhance the appearance of the teeth. Minimizing removal of additional tooth structure while also fulfilling the desire of patients to have highly esthetic restorations can ...
Verdugo Fernando - - 2012
Periodontal regeneration in patients with advanced periodontitis and severe attachment loss has classically presented some of the greatest challenges to the practitioner. The purpose of this article is to describe the staged treatment approach and long-term follow-up of a case with generalized advanced chronic periodontitis. Microbial sampling for suspected periodontopathogens ...
Petruzzi Massimo - - 2012
The use of a hydropneumatic balloon for the elevation of the sinus membrane is a new technique for sinus floor augmentation procedures. Few cases using such a technique are reported in the English medical literature. This report describes 40 patients who were treated with this technique and studied retrospectively. Forty ...
Margossian Patrice - - 2012
While immediate loading in the edentulous mandible is a well-documented procedure, there are limited scientific data on immediate loading in the partially edentulous mandible. Two-year success rates of immediate loading and conventional delayed loading of dental implants in partially dentate mandibles were compared. Patients were randomized into three groups: group ...
Rotunno Fabrizio - - 2012
Ten similarly sized extracted maxillary central incisors were treated endodontically; carbon fiber posts were fit to five specimens and zirconia ceramic posts were fit to the other five. The same cement was used for fixation and core reconstruction. The purpose of this study was to test the strength of the ...
Camelo Marcelo - - 2012
The connective tissue graft (CTG) in conjunction with a coronally advanced flap is still regarded as the gold standard treatment for gingival recession defects. Increased surgical morbidity as well as limited tissue availability continues to spur interest in alternatives to the CTG. The current case report examines a porcine-derived, double-layer ...
Gely-Pernot Aurore - - 2012
Neural stem cells (NSC) persist in the adult mammalian brain, within the subventricular zone (SVZ). The endogenous mechanisms underpinning SVZ stem and progenitor cell proliferation are not fully elucidated. Vitamin K-dependent proteins (VKDPs) are mainly secreted factors that were initially discovered as major regulators of blood coagulation. Warfarin ((S(-)-3-acetonylbenzyl)-4-hydroxycoumarin)), a ...
Zhao Chen - - 2012
RelB and nuclear factor κB (NF-κB2) are the main effectors of NF-κB noncanonical signaling and play critical roles in many physiological processes. However, their role in hematopoietic stem/progenitor cell (HSPC) maintenance has not been characterized. To investigate this, we generated RelB/NF-κB2 double-knockout (dKO) mice and found that dKO HSPCs have ...
Lamb Allen N - - 2012
SOX5 encodes a transcription factor involved in the regulation of chondrogenesis and the development of the nervous system. Despite its important developmental roles, SOX5 disruption has yet to be associated with human disease. We report one individual with a reciprocal translocation breakpoint within SOX5, eight individuals with intragenic SOX5 deletions ...
Rumachik Neil G - - 2012
We implemented negative electron-transfer dissociation (NETD) on a hybrid ion trap/Orbitrap mass spectrometer to conduct ion/ion reactions using peptide anions and radical reagent cations. In addition to sequence-informative ladders of a•- and x-type fragment ions, NETD generated intense neutral loss peaks corresponding to the entire or partial side-chain cleavage from ...
Kwong Ava - - 2012
BRCA1/2 mutation prediction models (BRCAPRO, Myriad II, Couch, Shattuck-Eidens, BOADICEA) are well established in western cohorts to estimate the probability of BRCA1/2 mutations. Results are conflicting in Asian populations. Most studies did not account for gender-specific prediction. We evaluated the performance of these models in a Chinese cohort, including males, ...
Quinto Guilherme G GG Wilmer Ophthalmological Institute, Department of Ophthalmology, Johns Hopkins University, Baltimore, MD 21287-0005, - - 2012
To compare the effects of topical human amniotic fluid (HAF), topical human serum (HS), and topical artificial tears in a mouse model of dry eye. Thirty C57BL/6 mice were divided into 3 treatment groups: HAF, HS, and preservative-free artificial tears. Dry eye was induced by an injection of botulinum toxin ...
Yamamoto Hideyuki H Department of Veterinary Science, Graduate School of Life and Environmental Sciences, Osaka Prefecture University, Izumisano, Osaka 598-8531, - - 2012
The botulinum neurotoxin light chain (BoNT-LC) is a zinc-dependent metalloprotease that cleaves neuronal SNARE proteins such as SNAP-25, VAMP2, and Syntaxin1. This cleavage interferes with the neurotransmitter release of peripheral neurons and results in flaccid paralysis. SNAP, VAMP, and Syntaxin are representative of large families of proteins that mediate most ...
Latham Heath E HE Division of Pulmonary and Critical Care Medicine, TheUniversity of Kansas Medical Center, 3901 Rainbow Blvd,MS 3007, Kansas City, KS 66160, USA. - - 2012
To determine the equivalency of pressure measurements from peripherally inserted central catheters(PICCs) versus centrally inserted central venous catheters(CVCs) in vitro as well as in vivo. The in vitro study was performed in a clinical laboratory. Static pressure measurements from PICCs and CVCs were obtained in vitro over a physiologic range ...
Parekh Chintan C Department of Pathology and Laboratory Medicine, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California 90095-1732, - - 2012
The cytokine thrombopoietin (Tpo) plays a critical role in hematopoiesis by binding to the extracellular domain and inducing homodimerization of the intracellular signaling domain of its receptor, c-Mpl. Mpl homodimerization can also be accomplished by binding of a synthetic ligand to a constitutively expressed fusion protein F36VMpl consisting of a ...
Mao Haoyu - - 2012
Many mutations in the human rhodopsin gene (RHO) cause autosomal dominant retinitis pigmentosa (ADRP). Our previous studies with a P23H (proline-23 substituted by histidine) RHO transgenic mouse model of ADRP demonstrated significant improvement of retinal function and preservation of retinal structure after transfer of wild-type rhodopsin by AAV. In this ...
Montgomery John R - - 2012
ABO incompatible (ABOi) kidney transplantation is an important modality to facilitate living donor transplant for incompatible pairs. To date, reports of the outcomes from this practice in the United States have been limited to single-center studies. Using the Scientific Registry of Transplant Recipients, we identified 738 patients who underwent live-donor ...
Burrell Jake S - - 2012
The recently described combined carbogen USPIO (CUSPIO) magnetic resonance imaging (MRI) method uses spatial correlations in independent imaging biomarkers to assess specific components of tumor vascular structure and function. Our study aimed to evaluate CUSPIO biomarkers for the assessment of tumor response to antiangiogenic therapy. CUSPIO imaging was performed in ...
Iizumi Toshichika - - 2012
We developed a dataset of local-scale daily climate change scenarios for Japan (called ELPIS-JP) using the stochastic weather generators (WGs) LARS-WG and, in part, WXGEN. The ELPIS-JP dataset is based on the observed (or estimated) daily weather data for seven climatic variables (daily mean, maximum and minimum temperatures; precipitation; solar ...
Crucifix Michel - - 2012
Ice sheets appeared in the northern hemisphere around 3 Ma (million years) ago and glacial-interglacial cycles have paced Earth's climate since then. Superimposed on these long glacial cycles comes an intricate pattern of millennial and sub-millennial variability, including Dansgaard-Oeschger and Heinrich events. There are numerous theories about these oscillations. Here, we ...
Thompson J Michael T - - 2012
The current threat of global warming and the public demand for confident projections of climate change pose the ultimate challenge to science: predicting the future behaviour of a system of such overwhelming complexity as the Earth's climate. This Theme Issue addresses two practical problems that make even prediction of the ...
Beaulieu Claudie - - 2012
Recently, there have been an increasing number of studies using change-point methods to detect artificial or natural discontinuities and regime shifts in climate. However, a major drawback with most of the currently used change-point methods is the lack of flexibility (able to detect one specific type of shift under the ...
Sieber Jan - - 2012
Approaching a dangerous bifurcation, from which a dynamical system such as the Earth's climate will jump (tip) to a different state, the current stable state lies within a shrinking basin of attraction. Persistence of the state becomes increasingly precarious in the presence of noisy disturbances. We argue that one needs ...
Franzke Christian L E - - 2012
Long-range dependence (LRD) and non-Gaussianity are ubiquitous in many natural systems such as ecosystems, biological systems and climate. However, it is not always appreciated that the two phenomena may occur together in natural systems and that self-similarity in a system can be a superposition of both phenomena. These features, which ...
Kwasniok Frank - - 2012
A new approach for data-based stochastic parametrization of unresolved scales and processes in numerical weather and climate prediction models is introduced. The subgrid-scale model is conditional on the state of the resolved scales, consisting of a collection of local models. A clustering algorithm in the space of the resolved variables ...
Ferro Christopher A T - - 2012
A perennial question in modern weather forecasting and climate prediction is whether to invest resources in more complex numerical models or in larger ensembles of simulations. If this question is to be addressed quantitatively, then information is needed about how changes in model complexity and ensemble size will affect predictive ...
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