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McGuire Lindsay K LK Memorial Sloan-Kettering Cancer Center, New York, NY 10022, - - 2012
Melanoma of the lentigo maligna subtype presents diagnostic and treatment challenges because of ill-defined clinical margins in cosmetically and functionally sensitive areas of the head and neck with extensive sun damage. This review highlights the natural history, varied clinical presentations, and pitfalls in histologic diagnosis. The focus is on the ...
Clarenbach Christian F - - 2012
The natural course of chronic obstructive pulmonary disease (COPD) is complicated by the development of systemic consequences and comorbidities. COPD has been associated with an increased risk for cardiovascular disease, osteoporosis, cachexia and skeletal muscle weakness. In several large prospective cohort studies, the degree of airflow limitation was an independent ...
Silva Tânia Lúcia de Oliveira - - 2012
OBJECTIVES: To evaluate the alveolar bone density (ABD) in the upper first molars of patients with juvenile idiopathic arthritis (JIA) and to compare their ABD with that of healthy controls. Secondary objectives included the evaluation of the influence of medication and rheumatic disease activity on ABD, in addition to the ...
Shimura Takaya - - 2012
Background/Aim: C-reactive protein (CRP) has been associated with the development of many carcinomas, but the significance of CRP remains unclear for metastatic gastric cancer (MGC). Sixty one patients who received S-1 plus cisplatin for MGC were retrospectively identified and categorized into two groups depending on the serum CRP level before ...
Nishimura Goshi - - 2012
Concurrent chemoradiotherapy (CCRT) is used to treat advanced head and neck cancer. The accuracy of evaluating lymph nodes metastases following CCRT is important for subsequent therapy. Patients were divided into two groups, the complete response (CR) and the non-CR groups, as determined by imaging and fine-needle aspiration cytology (FNAC) performed ...
Harrington Charles R - - 2012
Neurofibrillary pathology in Alzheimer's disease consists of paired helical filaments comprising tau protein. This pathology is correlated with dementia, but can appear in the first two decades of life. Extracellular amyloid β-protein arises through proteolytic processing of a transmembrane precursor, which involves the action of several enzymes. Mutations in the ...
Soares Neelkamal S - - 2012
Autism spectrum disorders (ASDs), also called pervasive developmental disorders in the Diagnostic and Statistical Manual of Mental Disorders (Fourth Edition, Text Revised), constitute a group of neurodevelopmental disorders that coalesce around a common theme of impairments in social functioning, communication abilities, and repetitive or rigid behaviors. The ASDs considered here ...
Shirali Girish S - - 2012
Complex intracardiac anatomy and spatial relationships are inherent to congenital heart defects (CHDs). Recognition of the limitations of two-dimensional echocardiography has stimulated clinical interest in three-dimensional imaging. The current review examines contemporary studies in the following areas where three-dimensional echocardiography has provided additive value in CHD: (1) visualization of morphology, ...
Ko Jason H JH Department of Surgery, Division of Plastic and Reconstructive Surgery, Northwestern University, Feinberg School of Medicine, Chicago, Ill., - - 2012
3-Hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors, also known as statins, are the most commonly prescribed cholesterol-lowering medications in the world. Statins have been shown to inhibit connective tissue growth factor (CTGF) gene and protein expression in vitro, and previous studies in the authors' laboratory have demonstrated that CTGF plays a significant role ...
Singh Meenu - - 2012
Reply to: Peters JL, Moreno SG, Phillips B, Sutton AJ. Are we sure about the evidence for zinc in prophylaxis of the common cold? Expert Rev. Respir. Med. 6(1), 15-16 (2012).
Van Bever Hugo P S HP Department of Paediatrics, Children's Medical Institute, National University Hospital, National University Health System, Singapore. - - 2012
Allergic diseases have been increasing during the last three decades, and exact reasons for this are still debated. Despite intense ongoing research, a lot of aspects of allergic diseases are still poorly understood, resulting in limitations in current therapeutic approach to allergies. In this viewpoint, important unanswered research questions are ...
Hwang Jung Eun JE Systems and Synthetic Agrobiotech Center and PMBBRC, Gyeongsang National University, Jinju 660-701, - - 2012
Dehydration-responsive element-binding proteins (DREBs)regulate plant responses to environmental stresses. In the current study, transcription of DREB2C, a class 2 Arabidopsis DREB, was induced by a superoxide anion propagator, methyl viologen (MV). The oxidative stress tolerance of DREB2C-overexpressing transgenic plants was significantly greater than that of wild-type plants, as measured by ...
Edel Elizabeth Morell - - 2012
Validating existing count practices and reducing individual practice variance are necessary to decrease the risk for retained surgical items. A quality improvement project was undertaken at one large city hospital to identify best practice and eliminate variability in count practices. The project included an analysis of 20 surgical count policies ...
Kaplan Gabriel - - 2012
At present, no evidence-based effective pharmacologic options are available for treating the core deficits of autism spectrum disorders (ASDs), which are best addressed by behavioral and educational interventions. However, such evidence exists for several of the frequently associated/comorbid symptoms such as aggression and severe irritability, hyperactivity, and repetitive behaviors, which ...
Seitchik Jason L - - 2012
Bioorthogonal ligation methods with improved reaction rates and less obtrusive components are needed for site-specifically labeling proteins without catalysts. Currently no general method exists for in vivo site-specific labeling of proteins that combines fast reaction rate with stable, nontoxic, and chemoselective reagents. To overcome these limitations, we have developed a ...
Tsai I-Ming - - 2012
A 19-year-old woman with skeletal Class III malocclusion, paranasal depression, and a low mandibular plane angle was treated with orthodontics and orthognathic surgery. Dental decompensation and protraction of maxillary right third molar to replace maxillary right second molar were performed before surgery. Clockwise rotation of maxillo-mandibular complex was applied by ...
Richardson Frank - - 2012
E-Cadherin and vimentin protein expression was assessed in late stage non-small cell lung cancer tumors from the placebo controlled clinical trial, NCIC-CTG BR.21, to determine if these markers had the potential to predict outcome of erlotinib therapy. E-Cadherin and vimentin protein expression levels were assessed in tumors from 95 patients, ...
Bohluli Behnam - - 2012
The nasal base is an important aspect of the nose with a complex anatomic architecture comprising a combination of cartilages, skin, connective tissues, and ligaments. Recent studies show that all nasal base deformities cannot be corrected by simple excision and suturing techniques. Alar release and medialization would be effective in ...
Khechoyan David D The Craniofacial Center, Seattle Children's Hospital, Seattle, Wash. 98105, - - 2012
There is controversy regarding whether the frontal bossing associated with sagittal synostosis requires direct surgical correction or spontaneously remodels after isolated posterior cranial expansion. The authors retrospectively measured changes in frontal bone morphology in patients with isolated sagittal synostosis 2 years after open posterior and midvault cranial expansion and compared ...
Spitale Naomi - - 2012
The ability to assess the inflammatory status of a patient's airway using a noninvasive method is the ideal situation for clinicians. Owing in part to the relationship between the levels of exhaled nitric oxide to inflammation and the ease of the technique, the measurement of the fraction of exhaled nitric ...
Schult Catrin - - 2012
Inhibition of signal transduction pathways has been successfully introduced into cancer treatment. The dual phosphatidylinositol 3-kinase (PI3K) and mammalian target of rapamycin (mTOR) inhibitor NVP-BEZ235 has antitumor activity in vitro against solid tumors. Here, we examined the activity of NVP-BEZ235 in acute lymphoblastic leukemia (ALL) cells and the best modalities ...
Nerguizian Vahé - - 2012
In a microbiological device, cell or particle manipulation and characterization require the use of electric field on different electrodes in several configurations and shapes. To efficiently design microelectrodes within a microfluidic channel for dielectrophoresis focusing, manipulation and characterization of cells, the designer will seek the exact distribution of the electric ...
Trejo-Valdivia Belem - - 2012
Determine Vaccination Coverage (VC) among adults 60 years of age and older (EP), for influenza, pneumococcal and tetanus vaccines, association with socio-demographic characteristics and heterogeneity at state level. Cross-sectional analysis based on information from 18 015 households visited in a national survey. General and vaccine information (self-report) for a randomly ...
Fekete Mirela - - 2012
Pharmacological inhibition of the phosphoinositide 3-kinase (PI3K)/Akt pathway prevents G(1) cell cycle progression into S, resulting in G(1) accumulation. The hypothesis that this arrest might negatively impact on chemotherapeutic agents primarily effective in S, G(2) or M-phase was investigated. Inhibition of PI3K/Akt pathway signaling via LY294002 and Akti-1/2 was demonstrated ...
Rubin Rebecca Lash - - 2012
In this prospective longitudinal study, we compared the prevalence of mandibular second molar eruption difficulties in patients treated with appliances to maintain mandibular arch perimeter. Other independent variables (age, molar angulation, space-width ratio, treatment time, and sex) were tested for their value as predictors of eruption difficulty. Three hundred one ...
Fourie Eleanor - - 2012
Gold(I) and platinum(II) d(10) and d(8) electronic complexes such as (Au(PPh(2)CH(2)CH(2)PPh(2))(2))Cl and cisplatin, ((H(3)N)(2)PtCl(2)), possess strong antineoplastic activities. Almost no information is available regarding the anticancer activity of isoelectronic silver(I) d(10) complexes. This study examined the cytotoxicity of stable water-soluble silver(I) carboxylates. The results were related to the cytotoxicity of ...
Bagheri Shahrokh C - - 2012
The last 2 decades have witnessed significant changes in both technical and philosophic aspects of rhinoplasty surgery. Many of these changes are designed to provide more predictable, lasting, and enhanced cosmetic results of surgery without compromise of function. Although the aim of this procedure remains unchanged, the techniques and methodology ...
Schall Carol - - 2012
Individuals and their parents frequently turn to pediatricians, adolescent medicine specialists, and psychologists to answer questions about the course and outcomes of their disorder. This article provides a description of the characteristics of autism spectrum disorders (ASD) in adolescence and early adulthood. It also describes essential elements of high school ...
Raghavan Shyam S SS Division of Plastic and Reconstructive Surgery, Stanford University Medical Center, Palo Alto, Calif., - - 2012
Tissue-engineered flexor tendon grafts may allow reconstruction of severe tendon losses. One critical factor is the optimization of cell proliferation and reseeding. Use of growth factors--basic fibroblast growth factor (bFGF), insulin-like growth factor (IGF)-1, and platelet-derived growth factor (PDGF)-BB--may improve culture conditions for human fibroblasts, tenocytes, and adipose-derived stem cells ...
Pott Júnior Henrique - - 2012
Serositis is commonly seen in systemic lupus erythematosus (SLE). Approximately 16% of patients with SLE have pleural or pericardial involvement. However, peritoneal involvement is extremely rare, and clinically seen in a small group of patients. This is the case report of a 47-year old female with discoid lupus who evolved ...
McGorray Susan P - - 2012
Moving teeth rapidly and avoiding posttreatment relapse are fundamental goals of orthodontic treatment. In-vitro and animal studies suggest that the human hormone relaxin might increase the rate of movement and the stability through its effect on the periodontal ligament. The purpose of this study was to compare relaxin and a ...
Gebbia Vittorio - - 2012
Oral metronomic chemotherapy is a therapeutic option which is particularly attractive due to its ease of administration and low toxic burden. Its mechanism of action probably involves antiangiogenetic effect rather than a classical antiproliferative effect like standard maximally tolerated dose-based regimens. A retrospective analysis of 61 patients with advanced breast ...
Bohluli Behnam - - 2012
Lateral osteotomy is a controversial step in rhinoplasty, which is usually performed to narrow a wide nose, widen a narrow bony pyramid, straighten a deviated nose, or close an open roof deformity. The osteotomy is performed using several methods, although the internal continuous and external perforator are the main ways ...
Wolfram Dolores D Department of Plastic and Reconstructive Surgery, Innsbruck Medical University, Innsbruck, Austria. - - 2012
The authors investigated the immunological mechanisms underlying extensive peri-silicone implant capsule formation, one of the most frequent postoperative complications in patients receiving silicone mammary implants. The authors studied immune response activation by phenotypic and functional characterization of lymphocytes accumulated within this tissue. Intracapsular lymphoid cells and autologous peripheral blood mononuclear ...
Sakamoto Bryan - - 2012
A 45 year old man with metastatic colon cancer presented with uncontrollable abdominal wall pain. Transversus abdominis plane (TAP) block with ropivacaine and methylprednisolone was performed with excellent pain relief, which allowed a significant weaning of the patient's opioid requirements. A second TAP block was performed with a 33% ethanol ...
Burlingame Byron - - 2012
Patients wearing personal clothing into the OR Key words: patient attire, underwear. Tracking and documenting implants Key words: implant, implant documentation, infection prevention. Returning explants to patients Key words: implant, returning explanted devices.
Liu Yu - - 2012
This study reports the development of a novel liposomal formulation containing boanmycin (BAM) by the pH-gradient, spherical symmetric experimental design. DSC was used to elucidate the thermotropic transition of the soybean egg phosphatidylcholine (EPCS) bilayers. The DSC analysis showed that the incorporation of cholesterol into the EPCS bilayers caused a ...
Brenol Claiton Viegas - - 2012
Human leukocyte antigen G (HLA-G) is a non-classic class I major histocompatibility complex (MHC) molecule characterized by low polymorphism in its coding region, a limited tissue distribution pattern in physiologic conditions, and expression through soluble isoforms and isoforms bound to surface membranes through alternative splicing. HLA-G is fairly known since ...
Mertlíková-Kaiserová Helena - - 2012
9-[2-(phosphonomethoxy)ethyl] guanine (PMEG) is a nucleotide analogue with anticancer activity. Here we investigate the role of ERK, p38, JNK and AKT kinases in PMEG-induced apoptosis. CCRF-CEM and HL-60 leukemia cells were used to assess MAPK mRNA and protein expression in PMEG-treated cells. MAPK activation was measured using phospho-specific antibodies. Apoptosis ...
Venton Geoffroy - - 2012
Despite great improvements in the management of metastatic clear cell renal carcinoma, complete responses with antiangiogenic therapies are infrequent and complete pathological responses remain anecdotal. We report the complete pathological response of a solitary bone metastasis from a clear cell renal carcinoma after sequential treatment with sunitinib and radiotherapy. In ...
Vernooij Meike W - - 2012
The role of structural neuroimaging in the diagnosis of Alzheimer's disease (AD) is becoming increasingly important. As a consequence, a basic understanding of what are normal brain changes in aging is key to be able to recognize what is abnormal. The first part of this article discusses normal versus pathologic ...
Waters James M - - 2012
Single primer amplification is shown to yield a DNA profile that is reproducible when based on the sequence content of the amplicons rather than on the pattern of length polymorphism. The sequence-based profile increases in reliability with increasing numbers of cycles of amplification. This process uses an arbitrarily chosen primer ...
Pepper Jon-Paul JP Department of Otolaryngology-Head and Neck Surgery, Division of Facial Plastic and Reconstructive Surgery, University of Michigan Medical Center, Livonia, Mich. 48152, USA. - - 2012
Postoperative psychosocial distress is a critical aspect of surgery, particularly in aesthetically sensitive areas. In this study, the authors assess the level of psychosocial distress associated with nasal reconstruction. The authors also compare postoperative distress levels associated with different reconstructive techniques throughout the healing process. The authors conducted a prospective ...
Seth Akhil K AK Division of Plastic Surgery, Feinberg School of Medicine, Northwestern University, Chicago, Ill., - - 2012
Bacterial biofilm is recognized as a major detriment to wound healing. The efficacy of traditional wound care against biofilm has never been studied. The authors evaluated the effect of clinical strategies against biofilm-infected wounds in a quantitative, in vivo model. Using a rabbit ear biofilm model, wounds were inoculated with ...
Müntener C R - - 2012
In 2010, we observed again an increase in the number of declarations reported to the vigilance system for veterinary medicinal products up to a total of 160. The species and drug classes reported remained the same as in previous years: the majority of adverse drug reactions (ADRs) concerned either dogs ...
Aras Banu - - 2012
The force application period is a modifiable factor in root resorption. There is still ambiguity if the continuity of force application is advantageous in terms of root resorption and tooth movement. In this prospective randomized clinical trial, we compared the effects of 2 reactivation periods of controlled-intermittent and continuous forces ...
Choi Jongsoon - - 2012
We investigated the expression of melanoma-associated antigen gene (MAGE), human synovial sarcoma on X chromosome (SSX) and their clinical implications in sporadic colon cancer. Fresh tissue samples from 37 patients with colorectal adenocarcinomas were analyzed for MAGE and SSX mRNA by reverse transcription-polymerase chain reaction (RT-PCR) and their paraffin-embedded tissues ...
Bunyan Reem F - - 2012
Central nervous system (CNS) inflammatory demyelinating diseases are a group of disorders that include multiple sclerosis, acute disseminated encephalomyelitis, and neuromyelitis optica. These conditions may result in emergencies because of severe inflammatory destruction of CNS tissues or complications thereof. Most of these conditions are responsive to appropriate therapy and early ...
Qaqish Clement - - 2012
We partition this discussion of revisional surgery based on perceived problems with the primary rhinoplasty. This will focus on either underresection or overresection of tissues and the ensuing clinical result. We also discuss some select problems associated with manipulation of tissues via suturing or grafting and briefly discuss functional considerations ...
Cordeiro Peter G PG Memorial Sloan-Kettering Cancer Center, New York, NY 10021, USA. - - 2012
The objective of this study was to analyze early complications and long-term outcomes in patients undergoing salvage mastectomy and immediate tissue expander/implant reconstruction for cancer recurrence following breast conservation therapy (lumpectomy/irradiation). A review of all tissue expander/implant reconstructions performed by a single surgeon over an 11-year period from 1997 to ...
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