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Kar Parimal - - 2012
Acquired immune deficiency syndrome (AIDS) is caused by the human immunodeficiency virus (HIV) type 1 and 2 (HIV-1 and HIV-2). HIV-1 is observed worldwide while HIV-2 though prevalent in West Africa is persistently spreading to other parts of the world. An important target for AIDS treatment is the use of ...
Shirvanyants David D Department of Biochemistry and Biophysics, School of Medicine, University of North Carolina, Chapel Hill, North Carolina 27599, United - - 2012
Until now it has been impractical to observe protein folding in silico for proteins larger than 50 residues. Limitations of both force field accuracy and computational efficiency make the folding problem very challenging. Here we employ discrete molecular dynamics (DMD) simulations with an all-atom force field to fold fast-folding proteins. ...
Bargatin I I Kavli Nanoscience Institute and Department of Physics, Caltech, Pasadena, CA, - - 2012
We have developed arrays of nanomechanical systems (NEMS) by large-scale integration, comprising thousands of individual nanoresonators with densities of up to 6 million NEMS per square centimeter. The individual NEMS devices are electrically coupled using a combined series-parallel configuration that is extremely robust with respect to lithographical defects and mechanical ...
Sagi Vasudeva Naidu - - 2012
In the context of a "glyoxylate scenario" of primordial metabolism, the reactions of dihydroxyfumarate (DHF) with reactive small molecule aldehydes (e.g., glyoxylate, formaldehyde, glycolaldehyde, and glyceraldehyde) in water were investigated and shown to form dihydroxyacetone, tetrulose, and the two pentuloses, with almost quantitative conversion. The practically clean and selective formation ...
Creese Andrew J - - 2012
The analysis of intact glycopeptides by mass spectrometry is challenging due to the numerous possibilities for isomerization, both within the attached glycan and the location of the modification on the peptide backbone. Here, we demonstrate that high field asymmetric wave ion mobility spectrometry (FAIMS), also known as differential ion mobility, ...
Caboni Laura - - 2012
Prostate cancer (PCa) therapy typically involves administration of "classical" antiandrogens, competitive inhibitors of androgen receptor (AR) ligands, dihydrotestosterone (DHT) and testosterone (tes), for the ligand-binding pocket (LBP) in the ligand-binding domain (LBD) of AR. Prolonged LBP-targeting leads to resistance, and alternative therapies are urgently required. We report the identification and ...
Carreras Anna - - 2012
Plant polyphenols may be free radical scavengers or generators, depending on their nature and concentration. This dual effect, mediated by electron transfer reactions, may contribute to their influence on cell viability. This study used two stable radicals (tris(2,3,5,6-tetrachloro-4-nitrophenyl)methyl (TNPTM) and tris(2,4,6-trichloro-3,5-dinitrophenyl)methyl (HNTTM)) sensitive only to electron transfer reduction reactions to ...
Lonsdale Richard - - 2012
Soluble epoxide hydrolase (sEH) is an enzyme involved in drug metabolism that catalyzes the hydrolysis of epoxides to form their corresponding diols. sEH has a broad substrate range and shows high regio- and enantioselectivity for nucleophilic ring opening by Asp333. Epoxide hydrolases therefore have potential synthetic applications. We have used ...
Wang Yu-Hsiu - - 2012
Polyphosphoinositides (PPIs) and in particular phosphatidylinositol-(4,5)-bisphosphate (PI4,5P2), control many cellular events and bind with variable levels of specificity to hundreds of intracellular proteins in vitro. The much more restricted targeting of proteins to PPIs in cell membranes is thought to result in part from the formation of spatially distinct PIP2 ...
Rösgen Jörg - - 2012
Trimethylamine-N-oxide (TMAO) and urea represent the extremes among the naturally occurring organic osmolytes in terms of their ability to stabilize/destabilize proteins. Their mixtures are found in nature and have generated interest in terms of both their physiological role and their potential use as additives in various applications (crystallography, drug formulation, ...
Baud Matthias G J MG Department of Chemistry, Imperial College London, London SW7 2AZ, United - - 2012
Psammaplin A (11c) is a marine metabolite previously reported to be a potent inhibitor of two classes of epigenetic enzymes: histone deacetylases and DNA methyltransferases. The design and synthesis of a focused library based on the psammaplin A core has been carried out to probe the molecular features of this ...
Aussedat Baptiste B Laboratory for Bioorganic Chemistry, Sloan-Kettering Institute for Cancer Research, 1275 York Avenue, New York, New York 10065, - - 2012
Described herein is the first total chemical synthesis of the unique α-subunit of the human glycoprotein hormone (α-hGPH). Unlike the biologically derived glycoprotein hormones, which are isolated as highly complex mixtures of glycoforms, α-hGPH obtained by chemical synthesis contains discrete homogeneous glycoforms. Two such systems have been prepared. One contains ...
Palomaki Glenn E GE Division of Medical Screening and Special Testing, Department of Pathology and Laboratory Medicine, Women & Infants Hospital, Alpert Medical School of Brown University, Providence, Rhode Island, - - 2012
To determine whether maternal plasma cell-free DNA sequencing can effectively identify trisomy 18 and 13. Sixty-two pregnancies with trisomy 18 and 12 with trisomy 13 were selected from a cohort of 4,664 pregnancies along with matched euploid controls (including 212 additional Down syndrome and matched controls already reported), and their ...
Zhang G G Laboratory of Molecular Pharmacology, School of Pharmacy, Yantai University, Yantai, Shandong Province 264005, China. - - 2012
The purpose of this study was to test the hypothesis that administration of epigallocatechin-3-gallate (EGCG), a polyphenol present in abundance in widely consumed tea, inhibits cell proliferation, invasion, and angiogenesis in breast cancer patients. EGCG in 400 mg capsules was orally administered three times daily to breast cancer patients undergoing ...
Soberon F - - 2012
The preweaning management of dairy calves over the last 30 yr has focused on mortality, early weaning, and rumen development. Recent studies suggest that nutrient intake from milk or milk replacer during the preweaning period alters the phenotypic expression for milk yield. The objective of this study was to investigate ...
Pacheco D - - 2012
The objective of this analysis was to compare the rumen submodel predictions of 4 commonly used dairy ration programs to observed values of duodenal flows of crude protein (CP), protein fractions, and essential AA (EAA). The literature was searched and 40 studies, including 154 diets, were used to compare observed ...
Ito Osamu - - 2012
Here we report a case of spinal dural arteriovenous fistula that was diagnosed on MRA and CTA, and then treated by endovascular embolization. A 56-year-old male presented with slowly progressive intermittent claudication and numbness of the lower extremities. T2-weighted MR imaging showed the swelling of the spinal cord with an ...
De Rycke Lieve M - - 2012
Objective-To describe the anatomic features of dentition and surrounding structures of the head in rabbits assessed by use of a newly developed micro-computed tomography (CT) device. Sample-Cadavers of 7 clinically normal adult Dendermonde White domestic rabbits raised for human consumption. Procedures-The rabbits were slaughtered in a slaughterhouse, flayed, and decapitated; ...
Macrì Francesco - - 2012
Objective-To validate the use of radiography to determine the length of sagittal otoliths in intact bogue (Boops boops; a sparid fish [commonly called sea bream]). Sample-52 bogue cadavers. Procedures-Weight and standard lengths (from the tip of the snout to the caudal end of the last vertebra) of fish were measured. ...
Garrick D J - - 2012
Physiology deals with the functions of living organisms and their systems, and its scientific endeavors can be viewed as having temporally occurred in 3 phases. The first phase of physiology studies focused on determining the functions of particular organs and tissues and their functional differences according to physiological status. The ...
Scaletti R W - - 2012
The effect of organic or inorganic dietary Cu on Escherichia coli mastitis was investigated in first-lactation heifers. Twenty-eight primigravid Holstein heifers were assigned to 3 treatments in a completely randomized block design with 10 blocks of 3 animals grouped by expected calving date. Treatments were as follows: basal diet [7.1mg ...
Shaya Fadia T - - 2012
Evaluation of: Chen J, Schooling CM, Johnston JM, Hedley AJ, McGhee SM. How does socioeconomic development affect COPD mortality? An age-period-cohort analysis from a recently transitioned population in China. PLoS ONE 6(9), e24348 (2011). Chronic obstructive pulmonary disease (COPD) is a leading cause of death worldwide. The rising trend in ...
Greenwood S L - - 2012
The inclusion of the grape marc into livestock rations provides an opportunity not only to use a waste byproduct resourcefully, but also to induce beneficial metabolic changes in animals. Grape marc contains condensed tannins that could alter N metabolism, which would be beneficial from an environmental perspective. The objective was ...
Wan Cai Feng - - 2012
Purpose: To investigate the correlation between enhancement patterns and parameters of contrast material-enhanced ultrasonography (US) with prognostic factors in breast cancers. Materials and Methods: The study was approved by the institutional ethics committee, and written informed consent was obtained. Surgical resection specimens of 74 malignant breast lesions in 74 women ...
Ogawa Akiko - - 2012
Dural and perimedullary arteriovenous fistula (AVF) at the craniocervical junction tend to cause subarachnoid hemorrhage (SAH). However, their natural history and clinical manifestations still remain to be elucidated. From 2003 to 2009, we encountered 5 cases of dural and perimedullary AVF presented with SAH. They were all male, ranging in ...
Wang Xin - - 2012
Coordinated partitioning of intracellular cargoes between nuclear and cytoplasmic compartments is critical for cell survival and differentiation. The karyopherin α/β heterodimer functions to import cytoplasmic proteins that possess classical nuclear localisation signals into the nucleus. Seven karyopherinαsubtypes have been identified in mammals. The aim of this study was to determine ...
Negrón María E - - 2012
Objective-To assess the transmission of bovine viral diarrhea virus (BVDV) from experimentally infected white-tailed deer fawns to colostrum-deprived calves by use of a BVDV strain isolated from hunter-harvested white-tailed deer. Animals-5 white-tailed deer (Odocoileus virginianus) fawns and 6 colostrum-deprived calves. Procedures-Fawns were inoculated intranasally with a noncytopathic BVDV-1a isolate (2 ...
Fish J A - - 2012
The objective of this study was to determine if feed sorting can be reduced and if nutrient consumption can be limited in late-lactation cows through water addition to a nutrient-dense total mixed ration (TMR) with a dry matter (DM) content greater than 60%. Twelve lactating Holstein cows (214.8±28.5 d in ...
Heins B J - - 2012
Pure Holstein (HO) cows (n=416) were compared with Normande (NO) × HO (n=251), Montbéliarde (MO) × HO (n=503), and Scandinavian Red (SR) × HO (n=321) crossbred cows for survival, lifetime production, and profitability in 6 commercial herds in California. The SR crossbred cows were sired by both Swedish Red and ...
Duan Baozhong - - 2012
Bulbus of Fritillaria delavayi Franch. is the most commonly used antitussive and apophlegmatic in China and commonly prepared by water decoction. In this study, a novel and reliable method of high-performance liquid chromatography (HPLC) was developed both for quantitative analysis of 10 bioactive compounds (uracil, cytidine, inosine, uridine, guanosine, thymidine, ...
Dixon Suzanne - - 2012
To review the prevalence of nutrition-related complementary and alternative medicine (CAM) used by patients with cancer, to discuss nutrition issues commonly raised by cancer survivors, and to describe how the oncology health care practitioner can best address these issues. Journal articles, texts, and personal oncology nutrition clinical experience. The interest ...
Toral P G - - 2012
Supplementation of ruminant diets with plant oils and marine lipids is an effective strategy for lowering saturated fatty acid (FA) content and increasing the concentration of cis-9,trans-11 conjugated linoleic acid and long-chain n-3 FA in ruminant milk. However, changes in populations of ruminal microorganisms associated with altered biohydrogenation of dietary ...
Arriola K G - - 2012
This study determined effects of maturity, stay-green (SG) ranking, and hybrid source on dry matter (DM) yield, nutritive value, fermentation, and aerobic stability of corn hybrids. One high stay-green (HSG) hybrid and one average stay-green (ASG) hybrid with similar relative maturity (117 d) from each of 2 seed companies (Croplan ...
Bauer-Wu Susan - - 2012
To provide an overview of key issues and resources related to complementary and alternative medical (CAM) and integrative approaches in cancer care. Peer-reviewed publications and web sites of professional, federal, and academic institutions and organizations. The field of integrative oncology is growing and research evidence in this area is burgeoning. ...
- - 2012
Cover: A poster of the Ivory-billed Woodpecker (Campephilus principalis) decorates the wall of a restaurant in Brinkley, Arkansas (U.S.A.). The town is located near where the bird was reportedly sighted in 2004, 60 years after its presumed extinction. Th ree papers in this issue present new methods to estimate whether ...
Mazri C - - 2012
Lactoferrin and lactoperoxidase are whey proteins with biological properties that may provide health benefits to consumers. These properties are vulnerable to potentially denaturing conditions during processing. High-pressure treatment is an appealing alternative to the traditional heat processing of foods because it exerts an antimicrobial effect without changing the sensory and ...
Mehdinia Ali - - 2012
Nano-structured self-doped polythiophene (SPT) electrodeposited in the presence of fluorinated organic acid was applied as a thermally stable conductive polymer-based solid-phase microextraction (SPME) fiber candidate. Quantitative determination of trace levels of phthalate esters including dimethyl phthalate (DMP), diethyl phthalate (DEP), dibutyl phthalate (DBP), and diethylhexyl phthalate (DEHP) was carried out ...
Konrade Kricket A - - 2012
Objective-To determine the refractive states of eyes in domestic cats and to evaluate correlations between refractive error and age, breed, and axial globe measurements. Animals-98 healthy ophthalmologically normal domestic cats. Procedures-The refractive state of 196 eyes (2 eyes/cat) was determined by use of streak retinoscopy. Cats were considered ametropic when ...
Cao Xueli - - 2012
Counter-current chromatography (CCC) was investigated as a new sample pretreatment method for the determination of trace polycyclic aromatic hydrocarbons (PAHs) in water environmental samples. The experiment was performed with a non-aqueous binary two-phase solvent system composed of n-heptane and acetonitrile. The CCC column was first filled with the upper stationary ...
Scheetz Danielle - - 2012
The reason ovarian function and fertility are diminished in women with a low antral follicle count (AFC), despite significant numbers of follicles remaining in ovaries, is unknown. The bovine model is unique to address this question because cattle and women with a low AFC exhibit similar phenotypic characteristics including a ...
Main Elliott K - - 2012
Maternal mortality is a current and important issue for obstetrics. The challenge is to structure case reviews so that they develop real data that can inform and direct quality improvement activities. In this article, we describe a series of decisions we have made in California to organize and run our ...
Martin Tara G - - 2012
  Expert knowledge is used widely in the science and practice of conservation because of the complexity of problems, relative lack of data, and the imminent nature of many conservation decisions. Expert knowledge is substantive information on a particular topic that is not widely known by others. An expert is ...
Escobar André - - 2012
Objective-To determine the minimum anesthetic concentration (MAC) for sevoflurane and measure the dose and temporal effects of butorphanol on the MAC for sevoflurane in guineafowl. Animals-10 healthy adult guineafowl (Numida meleagris). Procedures-Each bird was anesthetized with sevoflurane, and a standard bracketing method was used to measure the MAC in response ...
Hu W-F - - 2012
The small heat shock protein, α-crystallin, exists in two isoforms, αA and αB, and displays strong ability against stress-induced apoptosis. Regarding their functional mechanisms, we and others have demonstrated that they are able to regulate members in both caspase and Bcl-2 families. In addition, we have also shown that αA ...
Fogsgaard K K - - 2012
The consequences of mastitis in terms of dairy cow behavior are relatively unknown. Future assessment of dairy cow welfare during mastitis will be facilitated by knowledge about the potential of mastitis to induce sickness behavior. Our aim was to examine behavior of dairy cows in the period from 2 d ...
Jiang Haiqiang - - 2012
This study describes the metabonomic characters of the spontaneously hypertensive rats (SHR) and intervention effects of Ping Gan prescription. Ultra performance LC coupled with Q-TOF MS (UPLC/MS-Q-TOF) was employed to develop a metabonomic method of the plasma of SHR. There was a significant difference in metabolic profiling observed between predose ...
Heins B J - - 2012
Normande (NO)×Holstein (HO) crossbred cows (n=251), Montbéliarde (MO)×HO crossbred cows (n=503), and Scandinavian Red (SR)×HO crossbred cows (n=321) were compared with pure HO cows (n=416) for fertility, somatic cell score (SCS), and 305-d projected milk, fat, and protein production during their first 5 lactations. The SR was a combination of ...
Bennie Marion M Strathclyde Institute for Pharmacy & Biomedical Sciences, University of Strathclyde, Glasgow, - - 2012
Multiple and intensive demand measures in Scotland have appreciably enhanced prescribing efficiency for proton pump inhibitors (PPIs) and statins in 2007 versus 2001. Statin utilization enhanced by measures to increase doses prescribed, including the Quality and Outcome Framework (QoF). Ascertain whether the plethora of measures continue to enhance prescribing efficiency ...
Katz Vern L - - 2012
Since Roman times, physicians have been instructed to perform postmortem cesarean deliveries to aid in funeral rites, baptism, and in the very slim chance that a live fetus might still be within the deceased mother's womb. This procedure was disliked by physicians being called to a dying mother's bedside. As ...
Tavornpanich Saraya - - 2012
Objective-To develop a better system for classification of herd infection status for paratuberculosis (Johne's disease [JD]) in US cattle herds on the basis of the risk of potential transmission of Mycobacterium avium subsp paratubeculosis. Sample-Simulated data for herd size and within-herd prevalence; sensitivity and specificity for test methods obtained from ...
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