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Rösgen Jörg - - 2012
Trimethylamine-N-oxide (TMAO) and urea represent the extremes among the naturally occurring organic osmolytes in terms of their ability to stabilize/destabilize proteins. Their mixtures are found in nature and have generated interest in terms of both their physiological role and their potential use as additives in various applications (crystallography, drug formulation, ...
Wang Yu-Hsiu - - 2012
Polyphosphoinositides (PPIs) and in particular phosphatidylinositol-(4,5)-bisphosphate (PI4,5P2), control many cellular events and bind with variable levels of specificity to hundreds of intracellular proteins in vitro. The much more restricted targeting of proteins to PPIs in cell membranes is thought to result in part from the formation of spatially distinct PIP2 ...
Sagi Vasudeva Naidu - - 2012
In the context of a "glyoxylate scenario" of primordial metabolism, the reactions of dihydroxyfumarate (DHF) with reactive small molecule aldehydes (e.g., glyoxylate, formaldehyde, glycolaldehyde, and glyceraldehyde) in water were investigated and shown to form dihydroxyacetone, tetrulose, and the two pentuloses, with almost quantitative conversion. The practically clean and selective formation ...
Creese Andrew J - - 2012
The analysis of intact glycopeptides by mass spectrometry is challenging due to the numerous possibilities for isomerization, both within the attached glycan and the location of the modification on the peptide backbone. Here, we demonstrate that high field asymmetric wave ion mobility spectrometry (FAIMS), also known as differential ion mobility, ...
Shirvanyants David - - 2012
Until now it has been impractical to observe protein folding in silico for proteins larger than 50 residues. Limitations of both force field accuracy and computational efficiency make the folding problem very challenging. Here we employ discrete molecular dynamics (DMD) simulations with an all-atom force field to fold fast-folding proteins. ...
Bargatin I I Kavli Nanoscience Institute and Department of Physics, Caltech, Pasadena, CA, - - 2012
We have developed arrays of nanomechanical systems (NEMS) by large-scale integration, comprising thousands of individual nanoresonators with densities of up to 6 million NEMS per square centimeter. The individual NEMS devices are electrically coupled using a combined series-parallel configuration that is extremely robust with respect to lithographical defects and mechanical ...
Baud Matthias G J MG Department of Chemistry, Imperial College London, London SW7 2AZ, United - - 2012
Psammaplin A (11c) is a marine metabolite previously reported to be a potent inhibitor of two classes of epigenetic enzymes: histone deacetylases and DNA methyltransferases. The design and synthesis of a focused library based on the psammaplin A core has been carried out to probe the molecular features of this ...
Aussedat Baptiste - - 2012
Described herein is the first total chemical synthesis of the unique α-subunit of the human glycoprotein hormone (α-hGPH). Unlike the biologically derived glycoprotein hormones, which are isolated as highly complex mixtures of glycoforms, α-hGPH obtained by chemical synthesis contains discrete homogeneous glycoforms. Two such systems have been prepared. One contains ...
Palomaki Glenn E GE Division of Medical Screening and Special Testing, Department of Pathology and Laboratory Medicine, Women & Infants Hospital, Alpert Medical School of Brown University, Providence, Rhode Island, - - 2012
To determine whether maternal plasma cell-free DNA sequencing can effectively identify trisomy 18 and 13. Sixty-two pregnancies with trisomy 18 and 12 with trisomy 13 were selected from a cohort of 4,664 pregnancies along with matched euploid controls (including 212 additional Down syndrome and matched controls already reported), and their ...
Vallejo J A - - 2012
The first step in cheesemaking is the milk clotting process, in which κ-caseinolytic enzymes contribute to micelle precipitation. The best enzyme for this purpose is chymosin because of its high degree of specificity toward κ-casein. Although recombinant bovine chymosin is the most frequently used chymosin in the industry, new sources ...
Van Dole Kristen B - - 2012
Despite being used in multiple studies, the Menopause-Specific Quality of Life Questionnaire (MENQOL) has not been assessed with factor analysis, a common method of item reduction in quality of life tools. The Menopause Epidemiology Study is a cross-sectional population-based study of women 40 to 65 years old in the United ...
Touho Hajime - - 2012
Preparation of a scalp artery as a donor is the first step in the procedure of direct anastomosis for the treatment of ischemic type moyamoya disease. In some cases, the scalp artery is not visualized well on cerebral angiograms. Another scalp artery must be used as a donor or it ...
Singh R P - - 2012
The adult male Japanese quail has a well developed cloacal gland that produces meringue-like white foam. The physiological significance of the cloacal gland and its foam is still unclear. Therefore, we conducted two experiments to establish the functional role of the cloacal gland and its foam in natural mating and ...
Negrón María E - - 2012
Objective-To assess the transmission of bovine viral diarrhea virus (BVDV) from experimentally infected white-tailed deer fawns to colostrum-deprived calves by use of a BVDV strain isolated from hunter-harvested white-tailed deer. Animals-5 white-tailed deer (Odocoileus virginianus) fawns and 6 colostrum-deprived calves. Procedures-Fawns were inoculated intranasally with a noncytopathic BVDV-1a isolate (2 ...
Fish J A - - 2012
The objective of this study was to determine if feed sorting can be reduced and if nutrient consumption can be limited in late-lactation cows through water addition to a nutrient-dense total mixed ration (TMR) with a dry matter (DM) content greater than 60%. Twelve lactating Holstein cows (214.8±28.5 d in ...
Heins B J - - 2012
Pure Holstein (HO) cows (n=416) were compared with Normande (NO) × HO (n=251), Montbéliarde (MO) × HO (n=503), and Scandinavian Red (SR) × HO (n=321) crossbred cows for survival, lifetime production, and profitability in 6 commercial herds in California. The SR crossbred cows were sired by both Swedish Red and ...
Duan Baozhong - - 2012
Bulbus of Fritillaria delavayi Franch. is the most commonly used antitussive and apophlegmatic in China and commonly prepared by water decoction. In this study, a novel and reliable method of high-performance liquid chromatography (HPLC) was developed both for quantitative analysis of 10 bioactive compounds (uracil, cytidine, inosine, uridine, guanosine, thymidine, ...
Dixon Suzanne - - 2012
To review the prevalence of nutrition-related complementary and alternative medicine (CAM) used by patients with cancer, to discuss nutrition issues commonly raised by cancer survivors, and to describe how the oncology health care practitioner can best address these issues. Journal articles, texts, and personal oncology nutrition clinical experience. The interest ...
Konrade Kricket A - - 2012
Objective-To determine the refractive states of eyes in domestic cats and to evaluate correlations between refractive error and age, breed, and axial globe measurements. Animals-98 healthy ophthalmologically normal domestic cats. Procedures-The refractive state of 196 eyes (2 eyes/cat) was determined by use of streak retinoscopy. Cats were considered ametropic when ...
Alonso-Hearn M - - 2012
The objective of this study was to evaluate the efficacy of a new heat-killed Mycobacterium avium ssp. paratuberculosis (MAP) vaccine for control of premature culling in tuberculosis-free dairy cattle. Feces and gastrointestinal tissues were collected from 50 vaccinated cows and 38 nonvaccinated cows at slaughter and analyzed by bacteriological culture ...
Katsuta Toshiro - - 2012
A 30 year-old, 28 weeks-pregnant woman (gravida 2, para 2) suffered from a sudden onset of aphasia when she was having a chat in the upright position. Although the initial symptom soon disappeared, transient attacks of aphasia combined with weakness in the right arm occurred intermittently, particularly when she uprose. ...
de Souza Silveira Cristine D - - 2012
This paper proposes a new analytical procedure based on the headspace solid-phase microextraction (HS-SPME) technique and gas chromatography-selected ion monitoring-mass spectrometry (GC-SIM-MS) for the determination of 16 phenols extracted from leather samples. The optimized conditions for the HS-SPME were obtained through two experimental designs - a two-level fractional factorial design ...
Zhu D - - 2012
The yellow color of Cheddar cheese whey arises from a residual amount of annatto that partitions into the whey during Cheddar cheese manufacture. Bleaching of the color using hydrogen peroxide or benzoyl peroxide is often a prerequisite to produce an acceptable neutral-colored whey protein concentrate and isolate. However, the use ...
Izumo Tsuyoshi - - 2012
A 67-year-old man presented a three-month history of double vision and slight numbness at his right forehead. Neurological examination on admission demonstrated diplopia at lower gaze and mild hypesthesia at right frontal. MRI disclosed an extraconal cystic mass, centered over the superior rectus muscle, in the superior part of the ...
Wong Jennifer - - 2012
Recently, growing attention has been devoted to developing patient decision aids and decisional support interventions to aid patients in their decision-making when making treatment choices in oncology. Treatment discussions are challenging, both for physicians to transfer medical information to patients, and for patients to conceptualize these risks and benefits and ...
English Christopher - - 2012
Cutaneous malignancies are the most common primary malignancies of the hand. The hand surgeon may be the first physician to see these patients or may have the patients referred to them because of expertise in this anatomical region. This article reviews diagnosis and treatment, including margin of resection and need ...
Qu Ning - - 2012
Spermatogonial stem cells (SSCs) are the foundation of spermatogenesis, and are characterised by their ability to self-renew and to produce differentiated progeny that form spermatozoa. It has been demonstrated that rat spermatogenesis can occur in the seminiferous tubules of congenitally immunodeficient recipient mice after transplantation of rat SSCs. However, the ...
Clark Steven L - - 2012
The maternal death rate in the United States has shown no improvement in several decades and may be increasing. On the other hand, hospital systems that have instituted comprehensive programs directed at the prevention of maternal mortality have demonstrated rates that are half of the national average. These programs have ...
Bissonnette N - - 2012
The aim of this study was to characterize the osteopontin (OPN) secreted in bovine milk and to determine whether the different forms are the product of spliced variants. Spliced variants of the human gene and secreted osteopontin isoforms have been reported in human tumor tissue. In bovine milk, we identified ...
Alsaaod M - - 2012
The objective was to investigate infrared thermography (IRT) as a noninvasive diagnostic tool for early detection of foot pathologies in dairy cows. This was achieved by measuring changes in coronary band temperature before and after claw trimming in response to visual detection of abnormalities of the hooves. We hypothesized that ...
Wijga S - - 2012
This genome-wide association study aimed to identify loci associated with lactation-average somatic cell score (LASCS) and the standard deviation of test-day somatic cell score (SCS-SD). It is one of the first studies to combine detailed phenotypic and genotypic cow data from research dairy herds located in different countries. The combined ...
Abzug Joshua M - - 2012
Numerous dermatologic conditions may be visualized by the hand surgeon during office hours, including when examining patients for an alternative chief problem. Although the primary focus of the visit may be unrelated to a skin lesion, it is important for the hand surgeon to be familiar with these lesions to ...
Garcia-Herreros M - - 2012
Previous studies have shown that developmental kinetic rates following IVF are lower in female than in male blastocysts and that this may be related to differences in glucose metabolism. In addition, an inhibition of phosphatidylinositol 3-kinase (PI3-K) inhibits glucose uptake in murine blastocysts. Therefore, the aim of this study was ...
Haeri Sina - - 2012
Hemorrhage remains as one of the top 3 obstetrics related causes of maternal mortality, with most deaths occurring within 24-48 hours of delivery. Although hemorrhage related maternal mortality has declined globally, it continues to be a vexing problem. More specifically, the developing world continue to shoulder a disproportionate share of ...
Miles James E - - 2012
Objective-To compare 5 patellar position indices at various stifle joint angles in cadavers of red foxes, determine measurement reliability, and assess the suitability of these indices for clinical use. Sample-Pelvic limbs from cadavers of 12 red foxes (Vulpes vulpes). Procedures-Patellar position in each limb at 7 stifle joint angles (30° ...
Schoenberg K M - - 2012
Nonlactating Holstein cows (n=12) in late pregnancy were used to determine effects of plane of nutrition followed by feed deprivation on metabolic responses to insulin. Beginning 48 d before expected parturition, cows were fed to either a high plane (HP) or a low plane (LP) of nutrition (162 and 90% ...
Linardi Renata L - - 2012
Objective-To characterize the bioavailability and pharmacokinetics of oral and injectable formulations of methadone after IV, oral, and intragastric administration in horses. Animals-6 healthy adult horses. Procedures-Horses received single doses (each 0.15 mg/kg) of an oral formulation of methadone hydrochloride orally or intragastrically or an injectable formulation of the drug orally, ...
Harzia H - - 2012
We hypothesize that, through milk composition and different milk metabolites, it is possible to characterize the technological properties (e.g., coagulation) of milk. In this research, liquid chromatography mass spectrometry was used to obtain profiles of low molecular weight organic compounds in 143 milk samples. The metabolic profiles of milk from ...
Trasande Leonardo - - 2012
The obesity epidemic has transformed children's healthcare, such that diabetes, hypertension and the metabolic syndrome are phrases more commonly used by child health providers than ever before. This article reviews the economic consequences of this epidemic for healthcare delivery systems, both in the short term when obesity has been associated ...
Berg Wendie A - - 2012
Purpose: To determine whether adding shear-wave (SW) elastographic features could improve accuracy of ultrasonographic (US) assessment of breast masses. Materials and Methods: From September 2008 to September 2010, 958 women consented to repeat standard breast US supplemented by quantitative SW elastographic examination in this prospective multicenter institutional review board-approved, HIPAA-compliant ...
Filazi A - - 2012
A simple, precise, accurate, and validated reverse-phase HPLC method was developed for the determination of melamine in milk (pasteurized and UHT milk) and dairy products (powdered infant formula, fruit yogurt, soft cheese, and milk powder). Following extraction with acetonitrile:water (50:50, vol/vol), samples were purified by filter (0.45μm), separated on a ...
Kamoshima Yuuta - - 2012
Glioblastoma multiforme (GBM) is the most common and aggressive primary brain tumor with an extremely poor prognosis in spite of multimodal treatment approaches. The median survival time of patients with GBM is 15 months, and only 3-5% of patients survive longer than 36 months. Those patients who survive over 36 ...
Elliott John P - - 2012
Sudden unexpected changes in the life of a family create many different emotions in various family members. The death of a young woman during or after her pregnancy is especially difficult because of the strain it places on family dynamics. One of the consequences is that there is, commonly, a ...
Zanna Giordana - - 2012
Objective-To determine whether high-frequency diagnostic ultrasonography is useful for assessment of skin thickness in Shar-Peis. Animals-10 healthy Shar-Peis and 10 healthy Beagles used as controls. Procedures-Ultrasonographic examination of the skin was performed on 4 cutaneous sites by use of a 13-MHz linear-array transducer, and the mean of 3 measurements was ...
Chibisa G E - - 2012
A study was conducted to determine the effects of replacing canola meal (CM) as the major protein source with wheat-based dried distillers grains with solubles (W-DDGS) on ruminal fermentation, microbial protein production, omasal nutrient flow and animal performance. Eight lactating dairy cows were fed in a replicated 4 × 4 ...
London M L - - 2012
Three studies were conducted to determine the relationship between dairy heifer growth and placing in the show ring. In the first study, 1,744 commercial dairy heifers (all breeds and crossbred animals) were evaluated to determine effects of growth on placing within Georgia Commercial Dairy Heifer Shows from 2007 to 2010. ...
Kumar Praveen - - 2012
The effect of mobile-phase constituents (pH and ionic strength) and chromatographic behaviour of ten aminoglycosides (streptomycin, dihydrostreptomycin, spectinomycin, apramycin, paramomycin, kanamycin A, gentamycin C1, gentamycin C2/C2a, gentamycin C1a and neomycin) in the bare silica, amino, amide and zwitterionic phases of hydrophilic interaction chromatography (HILIC) were studied systematically. Among the stationary ...
Collinge William - - 2012
To review recent findings on the utilization of massage by cancer patients, including evidence of effects in supportive and palliative cancer care, current understanding of safety considerations and adaptations needed, education of professional and family caregivers to provide this form of support, and guidelines for oncology nurses in referring patients. ...
Ganyaglo Gabriel Y K - - 2012
A 6-year (2004-2009) review of maternal deaths is presented to establish particular trends at the eastern regional hospital (1 of 10 regional hospitals in Ghana). There were a total of 191 maternal deaths over the period, with a total of 19,965 live births, giving a maternal mortality ratio of 957 ...
Greenwood S L - - 2012
The inclusion of the grape marc into livestock rations provides an opportunity not only to use a waste byproduct resourcefully, but also to induce beneficial metabolic changes in animals. Grape marc contains condensed tannins that could alter N metabolism, which would be beneficial from an environmental perspective. The objective was ...
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