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Results 451 - 500 of 2454
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Brohawn Stephen G - - 2012
TRAAK channels, members of the two-pore domain K(+) (potassium ion) channel family K2P, are expressed almost exclusively in the nervous system and control the resting membrane potential. Their gating is sensitive to polyunsaturated fatty acids, mechanical deformation of the membrane, and temperature changes. Physiologically, these channels appear to control the ...
Prakash G - - 2012
To analyze whether an association exists between keratometric and pachymetric changes in the cornea, and whether it can be used to create pachymetric cutoff criteria secondary to keratometric criteria. In this cross-sectional study, 1000 candidates presenting to the refractive surgery services of a tertiary care hospital underwent bilateral Orbscan IIz ...
Sorbi Reza - - 2012
Fragility fractures represent a major health problem, as they cause deformity, disability and increased mortality rates. Orthopaedic surgeons should identify patients with fragility fractures and manage their osteoporosis in order to reduce the risk of future fracture; therefore, orthopaedic surgeons' knowledge about managing fragile fracture should be evaluated. A questionnaire ...
Ke F - - 2012
BOK/MTD was discovered as a protein that binds to the anti-apoptotic Bcl-2 family member MCL-1 and shares extensive amino-acid sequence similarity to BAX and BAK, which are essential for the effector phase of apoptosis. Therefore, and on the basis of its reported expression pattern, BOK is thought to function in ...
Hertle E - - 2012
C3 is the central component of the complement system and activation of C3 via any of the three major activation pathways-the classical, the lectin and the alternative pathways-results in initiation of the terminal complement pathway and release of the anaphylatoxin C3a. Both terminal pathway activation and signalling of C3a and ...
Cochrane T F - - 2012
To determine the incidence of acute retinal necrosis (ARN) in the United Kingdom and to describe the demographics, management, and visual outcome in these patients. This was a prospective study carried out by the British Ophthalmological Surveillance Unit (BOSU) between September 2007 and October 2008. Initial and 6-month questionnaires were ...
Potse Mark - - 2012
Next to clinical and experimental research, mathematical modeling plays a crucial role in medicine. Biomedical research takes place on many different levels, from molecules to the whole organism. Due to the complexity of biological systems, the interactions between components are often difficult or impossible to understand without the help of ...
Chen Wen - - 2012
Protein splicing is a self-catalyzed and spontaneous post-translational process in which inteins excise themselves out of precursor proteins while the exteins are ligated together. We report the first discovery of an intramolecular disulfide bond between the two active-site cysteines, Cys1 and Cys+1, in an intein precursor composed of the hyperthermophilic ...
Moc Jerzy - - 2012
A comprehensive ab initio investigation using coupled cluster theory with the aug-cc-pVnZ, n = D,T basis sets is carried out to identify distinct structures of the Al(4)H(14)(-) cluster anion and to evaluate its fragmentation stability. Both thermodynamic and mechanistic aspects of the fragmentation reactions are studied. The observation of this ...
Satoskar Anjali A - - 2012
The application of molecular techniques to characterize clinical kidney biopsies has the potential to provide insights into glomerular diseases that cannot be revealed by traditional renal pathology. The present work is a proof-of-concept approach to test whether proteomic analysis of glomeruli isolated from clinical biopsies by laser capture microdissection can ...
Sak Jarosław - - 2012
Population biobanks offer new opportunities for public health, are rudimentary for the development of its new branch called Public Health Genomics, and are important for translational research. This article presents organizational models of population biobanks in selected European countries. Review of bibliography and websites of European population biobanks (UK, Spain, ...
Muhleman Mitchel - - 2012
The proatlas is derived from the fourth occipital sclerotome in human embryos. It usually fuses with the three upper occipital sclerotomes to form the occipital bone. However, this does not always occur. Manifestations of a partial proatlas structure may persist due to failure of fusion. These embryological remnants can induce ...
Mitreva Makedonka - - 2012
The sequencing of the genome and transcriptome of Schistosoma haematobium, a highly prevalent blood fluke and human parasite with a proven link to malignant bladder cancer, marks the 160(th) anniversary of its discovery as the first schistosome known to infect humans. Comparative genomic analyses of S. haematobium and the more ...
Ordaz Sarah - - 2012
Females begin to demonstrate greater negative affective responses to stress than males in adolescence. This may reflect the concurrent emergence of underlying differences in physiological response systems, including corticolimbic circuitries, the hypothalamic-pituitary-adrenal axis (HPAA), and the autonomic nervous system (ANS). This review examines when sex differences in physiological reactivity to ...
Gardener Hannah - - 2012
Diet and regular soft drinks have been associated with diabetes and the metabolic syndrome, and regular soft drinks with coronary heart disease. To determine the association between soft drinks and combined vascular events, including stroke. A population-based cohort study of stroke incidence and risk factors. PARTICANTS: Participants (N= 2564, 36% men, ...
Meeker Rick B - - 2012
Although lentiviruses such as human, feline and simian immunodeficiency viruses (HIV, FIV, SIV) rapidly gain access to cerebrospinal fluid (CSF), the mechanisms that control this entry are not well understood. One possibility is that the virus may be carried into the brain by immune cells that traffic across the blood-CSF ...
Zaratiegui Mikel - - 2012
One of the most striking properties of RNA interference (RNAi) in Caenorhabditis elegans is its persistence in offspring after the triggering double-stranded RNA (dsRNA) has disappeared. A new study reveals that a heterochromatic silencing mark is deposited around the targets of RNAi and is transmitted through generations. These results show ...
Fragasso Gabriele - - 2012
Treatment of arterial hypertension can be a difficult exercise. Anti-hypertensive treatments need to be administered, keeping in mind the pathophysiological mechanisms and correlates at the base of arterial hypertension in the specific patient. The common pathophysiological mechanisms at the base of hypertension and their undisputed mechanistic relationship with clinical events. ...
Salvadó Laia - - 2012
The nuclear receptors Peroxisome Proliferator-Activated Receptors (PPAR)α and PPARγ are therapeutic targets for hypertriglyceridemia and insulin resistance, respectively. Evidence is now emerging that the PPARβ/δ isotype is a potential pharmacological target for the treatment of insulin resistance and type 2 diabetes mellitus. In this review, the capacity of PPARβ/δ to ...
Senn Theresa E TE Center for Health and Behavior, Syracuse University, Syracuse, NY 13244, USA. - - 2012
Childhood sexual abuse (CSA) is associated with sexual risk behavior in adulthood, but little research has investigated processes that might mediate this relation. The purpose of this study was to investigate whether constructs suggested by the traumagenic dynamics (TD) model (a theory of the effects of CSA) or constructs suggested ...
Richmond Tracy K TK Division of Adolescent Medicine, Department of Medicine, Children's Hospital Boston, Boston, MA, USA. - - 2012
Our objective was to determine if sexual orientation groups differ in accuracy of BMI (kg/m(2)) calculated from self-reported height and weight and if weight status modifies possible differences. Using gender-stratified multiple linear regression to analyze Wave III of the National Longitudinal Study of Adolescent Health (n = 12,197), we examined ...
Libbey Jane E JE Department of Pathology, University of Utah School of Medicine, 30 North 1900 East, 3R330 SOM, Salt Lake City, UT 84132, - - 2012
Major histocompatibility complex class I-restricted CD8(+) cytotoxic T lymphocytes are involved in the pathogenesis of multiple sclerosis (MS) and both autoimmune, experimental autoimmune encephalomyelitis, and viral, Theiler's murine encephalomyelitis virus (TMEV) infection, animal models of MS. Following TMEV infection, certain T cell hybridomas, generated from cloned TMEV-induced CD8(+) T cells, ...
Shungu Dikoma C DC Department of Radiology, Weill Medical College of Cornell University, New York, NY 10021, USA. - - 2012
Chronic fatigue syndrome (CFS) is a complex illness, which is often misdiagnosed as a psychiatric illness. In two previous reports, using (1)H MRSI, we found significantly higher levels of ventricular cerebrospinal fluid (CSF) lactate in patients with CFS relative to those with generalized anxiety disorder and healthy volunteers (HV), but ...
Sansone Susanna-Assunta SA Oxford e-Research Centre, University of Oxford, Oxford, UK. - - 2012
To make full use of research data, the bioscience community needs to adopt technologies and reward mechanisms that support interoperability and promote the growth of an open 'data commoning' culture. Here we describe the prerequisites for data commoning and present an established and growing ecosystem of solutions using the shared ...
Ghosh Rohini R South Asia Network for Chronic Disease, Public Health Foundation of India, New Delhi, India. - - 2012
The countdown database to track the maternal and child survival rate, as set by the Millennium Development Goal, reported recently that India's progress is not satisfactory in reducing newborn and child deaths. Articles on neonatal and child mortality in India were accessed from PubMed/MEDLINE. Risk factors associated with neonatal and ...
Matsunaga Toshiyuki T Laboratory of Biochemistry, Gifu Pharmaceutical University, Gifu 501-1196, Japan. - - 2012
9,10-Phenanthrenequinone (9,10-PQ), a major quinone in diesel exhaust particles, induces apoptosis via the generation of reactive oxygen species (ROS) because of 9,10-PQ redox cycling. We have found that intratracheal infusion of 9,10-PQ facilitates the secretion of surfactant into rat alveolus. In the cultured rat lung, treatment with 9,10-PQ results in ...
Iovino S S Department of Cellular and Molecular Biology and Pathology, University of Naples Federico II, - - 2012
TGF-beta1 has been shown to induce autophagy in certain cells but whether and how this action is exerted in muscle and whether this activity relates to TGF-beta1 control of muscle cell differentiation remains unknown. Here, we show that expression of the autophagy-promoting protein phosphoprotein enriched in diabetes/phosphoprotein enriched in astrocytes ...
Aberle Judith H JH Department of Virology, Medical University of Vienna, Vienna, Austria. - - 2013
It is well established that immunologic memory generated early in life can be maintained into old age and mediate robust anamnestic antibody responses. Little is known, however, about the initiation of memory B cells in the elderly. We have conducted a prospective analysis of the quantities and functionalities of antigen-specific ...
Kulminski Alexander M AM Center for Population Health and Aging, Duke University, Box 90408, Trent Hall, Room 002, Durham, NC 27708, USA. - - 2013
Studies focusing on unraveling the genetic origin of health span in humans assume that polygenic, aging-related phenotypes are inherited through Mendelian mechanisms of inheritance of individual genes. We use the Framingham Heart Study (FHS) data to examine whether non-Mendelian mechanisms of inheritance can drive linkage of loci on non-homologous chromosomes ...
Jolley Keith A - - 2012
No single genealogical reconstruction or typing method currently encompasses all levels of bacterial diversity, from domain to strain. We propose ribosomal multilocus sequence typing (rMLST), an approach which indexes variation of the 53 genes encoding the bacterial ribosome protein subunits (rps genes), as a means of integrating microbial genealogy and ...
Shapses S A SA Department of Nutritional Sciences, Rutgers University, 96 Lipman Drive, New Brunswick, NJ 08901-8525, USA. - - 2012
The goal in this study was to examine the hormonal and dietary predictors of true fractional Ca absorption (TFCA) in adult women and to determine whether TFCA differs due to body weight. Results showed that TFCA is higher in obese individuals and dietary fat, estradiol, and 1,25-dihydroxy vitamin D are ...
Clarke John D JD University of Arizona, Department of Pharmacology and Toxicology, 1703 E. Mabel Street, Tucson, AZ 85721, - - 2012
Organic anion transporting polypeptide (OATP) uptake transporters are important for the disposition of many drugs and perturbed OATP activity can contribute to adverse drug reactions (ADRs). It is well documented that both genetic and environmental factors can alter OATP expression and activity. Genetic factors include single nucleotide polymorphisms (SNPs) that ...
Kibe R R Louisiana State University Health Sciences Center, Gene Therapy Program, New Orleans, LA 70112, - - 2012
Interleukin-7 (IL-7) is an essential T-cell survival cytokine. IL-7 receptor (IL-7Rα) deficiency severely impairs T-cell development due to substantial apoptosis. We hypothesized that IL-7Rα(null)-induced apoptosis is partially contributed by an elevated p53 activity. To investigate the genetic association of IL-7/IL-7Rα signaling with the p53 pathway, we generated IL-7Rα(null)p53(null) (DKO) mice. ...
Heiss Wolf-Dieter - - 2012
BACKGROUND AND PURPOSE: Cerebrolysin showed neuroprotective and neurotrophic properties in various preclinical models of ischemia and small clinical trials. The aim of this large double-blind, placebo-controlled randomized clinical trial was to test its efficacy and safety in patients with acute ischemic stroke. METHODS: Patients with acute ischemic hemispheric stroke were ...
Sirvent Juan Alberto - - 2012
Indium-mediated allylation of N-tert-butanesulfinyl ketimines afforded in high yields and diastereoselectivities homoallylic amine derivatives with the nitrogen atom bonded to a quaternary stereocenter.
Chen Kun - - 2012
An immunoassay based on surface enhanced Raman scattering (SERS) spectroscopy was developed to detect muramidase released protein (MRP) antibody against Streptococcus suis II (SS2) utilizing thorny gold nanoparticles (tAuNPs) as SERS substrates. Initially, tAuNPs with multi-branches were prepared by the seed-mediated growth method in the absence of templates and surfactants, ...
Kim Jong-Chan - - 2012
Abstract: BACKGROUND:The aim of this study was to evaluate the lung-protective effect of combined remote ischemic pre- and post-conditioning (RIPC(pre) plus RIPC(post)) in patients undergoing complex valvular heart surgery. METHODS:This was a randomized, placebo-controlled, and double-blind trial. Fifty-four patients were randomly allocated into the RIPC(pre) plus RIPC(post) group or Control ...
Selli Daniele - - 2012
The possibility of tuning the electronic properties of graphene by tailoring the morphology at the nanoscale or by chemical functionalization opens interesting perspectives towards the realization of devices for nanoelectronics. Indeed, the integration of the intrinsic high carrier mobilities of graphene with functionalities that are able to react to external ...
Duman Mustafa - - 2012
Background/Aims: To evaluate tumor invasion (T staging) and lymph node metastasis (N staging) of colorectal cancer preoperatively by using multi-detector computerized tomography (MDCT) and to compare with the histopathological findings. Methodology: MDCT scan was performed for 73 patients with pathological proven colorectal carcinoma. One radiologist prospectively evaluated the depth of ...
Robin Nathaniel H - - 2012
Purpose:In-service exams are a commonly used educational tool in postgraduate medical education. Although most specialties utilize such an exam, medical genetics did not. It was decided in the spring of 2009 at the inaugural Medical Genetics Residency Program Directors (PDs) Group meeting to develop and implement such a test.Methods:Using questions ...
Ruiz Elena - - 2012
Three closely related Klebsiella pneumoniae strains isolated from the same patient harboured bla(CTX-M-15), bla(OXA-1), bla(SHV-11), qnrS1, aac(6')-Ib-cr, oqxAB, aac(3)-II and aph(3')-Ia genes. Two of the isolates were recovered after treatment with meropenem and showed resistance to carbapenems. Sequencing of ompK35 and ompK36 porin genes of carbapenem resistant strains revealed the ...
Mehta Akanksha - - 2012
Introduction: Although sperm have been shown to be present in the post-ejaculate urine (PEU) of both fertile and infertile men, the number of sperm present in the post-ejaculate urine of the general population has never been well-defined. The objective of this study was to describe the semen and PEU findings ...
Segers Filip M E - - 2012
OBJECTIVE: Scavenger receptor A (SR-A) is abundantly expressed by macrophage and plays a critical role in foam cell formation and atherogenesis. In search of selective SR-AI antagonists, we have used affinity selection of a phage displayed peptide library on the synthetic extracellular domain of SR-AI. METHODS AND RESULTS: Phage selection ...
Van Way Charles W CW - - 2012
The purpose of this review is 2-fold. First, it speculates on future scientific work that will have the greatest effect on clinical practice of nutrition care. Second, it discusses the current and future state of the healthcare system, paying special attention to demographic trends and the future of healthcare reform ...
Saario Sirpa - - 2012
Throughout Western Europe, psychiatric care has been subjected to 'modernisation' by the implementation of various managerial reforms in order to achieve improved mental health services. This paper examines how practitioners resist specific managerial reforms introduced in Finnish outpatient clinics and a child psychiatry clinic. The empirical study involves documentary research ...
Lifshits Marina - - 2012
Six new metabolites, micropeptin KT1042, microguanidine KT636, aeruginosins KT608A, KT608B, and KT650, and pseudoaeruginosin KT554, were isolated along with the known micropeptins SF909 and HM978, cyanopeptolin S, anabaenopeptin F, and the two isomers of planktocyclin-S-oxide from a bloom material collected from Lake Kinneret, Israel, in March 2005. The structure elucidation ...
Sun Yan-Jun - - 2012
Four new tetrahydrofuranoid lignans, (-)-tanegool-7'-methyl ether ( 1), (+)-7'-methoxylariciresinol ( 2), sinolignan C ( 3), and epipinoresinol-4,4'-di- O- β- D-glucopyranoside ( 4), were isolated from the roots and rhizomes of SINOPODOPHYLLUM EMODI together with one known lignan ( 5). Their structures and stereochemistry were elucidated on the basis of spectroscopic ...
Lear Scott A - - 2012
South Asians have a higher risk for cardiovascular disease (CVD) that remains largely unexplained. We hypothesized that the increased CVD risk in South Asians compared to Europeans is mediated through higher levels of visceral adipose tissue (VAT) in South Asians compared to total body fat and subcutaneous abdominal adipose tissue ...
Patrone Vania - - 2012
The gut microbiota has been shown to be involved in host energy homeostasis and diet-induced metabolic disorders. To gain insight into the relationship between diet, microbiota and host, we evaluated the effects of a high-fat (HF) diet on the gut bacterial community in weaning mice. C57BL/6 mice were fed either ...
Peng Hui-Qing - - 2012
A good harvest: Two self-assembling strategies (micellization and electrostatic attraction) and covalent capture were employed to construct a robust, inexpensive, efficient artificial light-harvesting system. The synthesis was achieved by a one-pot reaction. A high density of the antenna chromophores was achieved without self-quenching and excimer formation, thus affording extremely efficient ...
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