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Layden Jennifer E - - 2012
Both donor and recipient race impact outcomes after liver transplantation (LT), especially for hepatitis C virus (HCV). The interaction and simultaneous impact of both on patient survival is not clearly defined. The purpose of this study was to examine the impact of donor and recipient race on recipient and graft ...
Moro Claire Valiente CV CNRS, UMR 5557, Ecologie Microbienne, Université de Lyon, Villeurbanne, France. - - 2012
Extensive use of herbicides in agriculture is accompanied by the risk of environmental contamination of aquatic ecosystems. The present study shows the effects of the herbicides chlortoluron and mesotrione on three microalgae species: two chlorophyceae (Pediastrum tetras, Ankistrodesmus fusiformis) and one diatom (Amphora coffeaeformis). The authors calculated the IC50 for ...
Ahmad Israr - - 2012
Malaysian tualang honey possesses strong antioxidant and anti-inflammatory properties. Here, we evaluated the effect of tualang honey on early biomarkers of photocarcinogenesis employing PAM212 mouse keratinocyte cell line. Keratinocytes were treated with tualang honey (1.0%, v/v) before a single UVB (150 mJ cm(-2) ) irradiation. We found that the treatment ...
Desotelle Joshua A JA Department of Dermatology, University of Wisconsin, Madison, WI, - - 2012
Biologically, light including ultraviolet (UV) radiation is vital for life. However, UV exposure does not come without risk, as it is a major factor in the development of skin cancer. Natural protections against UV damage may have been affected by lifestyle changes over the past century, including changes in our ...
Noble-Jamieson Gabriele - - 2012
Systemic lupus erythematosus (SLE) is a multi-system inflammatory disease characterized by the presence of auto-antibodies. Liver enzyme abnormalities are common but clinical liver dysfunction with jaundice is rare. We report a juvenile female patient with SLE who developed jaundice 9 months after her initial presentation. Further investigations including liver biopsy ...
Snyder K A M KA Penn State Heart and Vascular Institute, Pennsylvania State University College of Medicine, Hershey, PA 17033-2390, - - 2012
We tested the hypotheses that vasoconstrictor responses to limb dependency are: (i) greater in the leg than the arm, (ii) impaired with age and (iii) not sympathetically mediated. Vascular responses to limb dependency (i.e. lowering the limb from heart level to 30 cm below heart level) were determined in 17 ...
Seeley Erin H EH Vanderbilt University, - - 2012
Imaging mass spectrometry can generate three-dimensional volumes showing molecular distributions in an entire organ or animal through registration and stacking of serial tissue sections. Here, we review the current state of 3D imaging mass spectrometry as well as provide insights and perspectives on the process of generating 3D mass spectral ...
Zhu Haihong H State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, Institute of Infectious Diseases, the First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, - - 2012
ITX 5061 is a scavenger receptor B1 antagonist that has entered phase 1 clinical trials in hepatitis C virus (HCV)-infected humans. We evaluated ITX 5061 in combination with interferon-α, ribavirin, and HCV protease and polymerase inhibitors in a genotype 2a infectious virus system. ITX 5061 is a potent inhibitor of ...
Weihmann Tom - - 2012
Unlike most other arthropods, spiders have no extensor muscles in major leg joints. Therefore, hydraulic pressure generated in the prosoma provides leg extension. For decades, this mechanism was held responsible for the generation of the majority of the ground reaction forces, particularly in the hind legs. During propulsion, the front ...
Mettam Jessica J - - 2012
Trigeminally innervated, mechanically sensitive chemoreceptors (M) were previously identified in rainbow trout, Oncorhynchus mykiss, but it is not known whether these receptors are responsive only to noxious, chemical irritants or have a general chemosensory function. This study aimed to characterise the stimulus-response properties of these receptors in comparison with polymodal ...
Harraca V - - 2012
The resurgence in developed countries of the common bed bug, Cimex lectularius, has led to a search for new sustainable methods to monitor and control this human ectoparasite. Because of increased resistance to insecticides, traps baited with attractive cues are considered a promising method to be developed into efficient monitoring ...
Takei Gen L - - 2012
Salmonid fish sperm motility is known to be suppressed in millimolar concentrations of extracellular K(+), and dilution of K(+) upon spawning triggers cAMP-dependent signaling for motility initiation. In a previous study, however, we demonstrated that suspending sperm in a 10% glycerol solution and subsequent dilution into a low-osmotic solution induced ...
Chiou Tsyr-Huei - - 2012
Biological signals based on color patterns are well known, but some animals communicate by producing patterns of polarized light. Known biological polarizers are all based on physical interactions with light such as birefringence, differential reflection or scattering. We describe a novel biological polarizer in a marine crustacean based on linear ...
Christensen A K - - 2012
The alewife (Alosa pseudoharengus) is a clupeid that undergoes larval and juvenile development in freshwater preceding marine habitation. The purpose of this study was to investigate osmoregulatory mechanisms in alewives that permit homeostasis in different salinities. To this end, we measured physiological, branchial biochemical and cellular responses in juvenile alewives ...
Olsson Mats - - 2012
In diploid animals, males and females share most of the genome (except sex-specific elements, such as sex chromosome genes), yet despite sharing the underlying genes that hard-wire traits, males and females may differ in their phenotypes when traits are controlled by proximate mechanisms, such as hormones. In color polymorphic species ...
Gompels Mark M North Bristol NHS Trust, Bristol, United Kingdom. - - 2012
The CD4 count and CD4 percentage (CD4%) are both strong predictors of clinical disease progression in human immunodeficiency virus (HIV). Although individuals may show discordancy between their CD4 count and CD4%, the clinical relevance of this is unclear. Discordancy was defined where the CD4% was ≤10th percentile for a selected ...
Kankova Zuzana - - 2012
The effects of maternal androgens on fitness-related traits of offspring are generally assumed to be epigenetic adaptations to the environment that may be encountered by the next generation. Possible constraints of high yolk androgen transfer are still not understood, although a suppressed immune response in offspring is frequently considered. The ...
Maclea Kyle S - - 2012
Molt-induced claw muscle atrophy in decapod crustaceans facilitates exuviation and is coordinated by ecdysteroid hormones. There is a 4-fold reduction in mass accompanied by remodeling of the contractile apparatus, which is associated with an 11-fold increase in myofibrillar protein synthesis by the end of the premolt period. Loss of a ...
Bolek Siegfried - - 2012
When returning to the site of a successful previous forage, where does one search for the goodies? Should one rely on experience from the previous homebound journey, or should one consider the outbound journey as well, or even exclusively? Desert ants are particularly well suited for pursuing this question because ...
Anyon Matthew J - - 2012
Tarsal adhesive pads are crucial for the ability of insects to traverse their natural environment. Previous studies have demonstrated that for both hairy and smooth adhesive pads, significant reduction in adhesion can occur because of contamination of these pads by wax crystals present on plant surfaces or synthetic microspheres. In ...
Seebacher Frank - - 2012
Locomotor performance is linked to fitness and health of animals and is expected to be under strong selection. However, interindividual variation in locomotor performance is pronounced in many species. It was our aim to investigate the relative importance of energy metabolism and calcium handling in determining sprint and sustained locomotion ...
Packard Gary C - - 2012
The allometric method, which often is attributed to Julian Huxley, entails fitting a straight line to logarithmic transformations of the original bivariate data and then back-transforming the resulting equation to form a power function in the arithmetic scale. Development of the technique was strongly influenced by Huxley's own research on ...
Borazjani Iman - - 2012
In this work we study the hydrodynamics of a bluegill sunfish performing a C-start maneuver in unprecedented detail using 3-D numerical simulations guided by previous laboratory experiments with live fish. The 3-D fish body geometry and kinematics are reconstructed from the experiments using high-speed video and prescribed as input to ...
Niehaus Amanda C - - 2012
Physiological ecologists have long sought to understand the plasticity of organisms in environments that vary widely among years, seasons and even hours. This is now even more important because human-induced climate change is predicted to affect both the mean and variability of the thermal environment. Although environmental change occurs ubiquitously, ...
Stavenga Doekele G - - 2012
The wings of the swordtail butterfly Graphium sarpedon (the Common Bluebottle) have blue/green-colored patches that are covered on the underside by two types of scales: white and glass scales. Transmission and scanning electron microscopy revealed that the white scales are classically structured: the upper lamina, with prominent ridges and large ...
Roy Sumita S Oral and Maxillofacial Pathology, School of Clinical Dentistry, University of Sheffield, Sheffield, - - 2012
Tannerella forsythia is an important pathogen in periodontal disease. Previously, we showed that its sialidase activity is key to utilization of sialic acid from a range of human glycoproteins for biofilm growth and initial adhesion. Removal of terminal sialic acid residues often exposes β-linked glucosamine or galactosamine, which may also ...
Miyata Haruhiko H Department of Biology, University of California, Riverside, California, USA. - - 2012
Many motile processes are regulated such that movement occurs only upon activation of a signaling cascade. Sperm from a variety of species are initially quiescent and must be activated prior to beating. The signaling events leading to the activation and regulation of sperm motility are not well characterized. Mature seminal ...
Carta Fabrizio F Laboratorio di Chimica Bioinorganica, Polo Scientifico, Università degli Studi di Firenze, Room 188, Via della Lastruccia 3, 50019 Sesto Fiorentino, Florence, - - 2012
A series of dithiocarbamates were prepared by reaction of primary/secondary amines with carbon disulfide in the presence of bases. These compounds were tested for the inhibition of four human (h) isoforms of the zinc enzyme carbonic anhydrase, CA (EC 4.2.1.1), hCA I, II, IX, and XII, involved in pathologies such ...
Dewan Varun - - 2012
The human immunodeficiency virus type 1 (HIV-1) capsid protein (CA) plays a critical role in the viral life cycle. The C-terminal domain (CTD) of CA binds to human lysyl-tRNA synthetase (hLysRS), and this interaction facilitates packaging of host cell tRNA(Lys,3), which serves as the primer for reverse transcription. Here, we ...
Andrews Bree - - 2012
It has long been known that survival of preterm infants strongly depends upon birth weight and gestational age. This study addresses a different question - whether the gestational maturity improves neurodevelopmental outcomes for ventilated infants born at 23-28 weeks who survive to neonatal intensive care unit (NICU) discharge. We performed ...
Park Jiwoon - - 2012
This paper presents a cost-effective, rapid, and fully automated lab-on-a-disc for simultaneous detection of multiple protein biomarkers in raw samples such as whole blood or whole saliva. For the diagnosis of cardiovascular disease, here, a novel centrifugal microfluidic layout was designed to conduct the simultaneous detection of high sensitivity C-reactive ...
Chun Joong-Hyun - - 2012
Ready access to (18)F-labeled aryl synthons is required for preparing novel radiotracers for molecular imaging with positron emission tomography. Diaryliodonium salts react with cyclotron-produced no-carrier-added [(18)F]fluoride ion to produce [(18)F]aryl fluorides. We aimed to prepare functionalized diaryliodonium salts to serve as potential precursors for producing useful (18)F-labeled aryl synthons, such ...
Goduti Daniel J DJ Department of Biological Sciences, Dartmouth College, Hanover, New Hampshire 03755, - - 2012
Numerous studies have indicated that each of the seven projections associated with the central pair of microtubules plays a distinct role in regulating eukaryotic ciliary/flagellar motility. Mutants which lack specific projections have distinct motility phenotypes. For example, Chlamydomonas pf6 mutants lack the C1a projection and have twitchy, non-beating flagella. The ...
Patel Kieren K Department of Molecular and Cell Biology, University of California, Berkeley, California 94720, - - 2012
Cytoplasmic linker associated proteins (CLASPs) comprise a class of microtubule (MT) plus end-binding proteins (+TIPs) that contribute to the dynamics and organization of MTs during many cellular processes, among them mitosis. Human CLASP proteins contain multiple MT-binding domains, including tumor over-expressed gene (TOG) domains, and a Ser-x-Ile-Pro (SxIP) motif known ...
Ou Li - - 2012
p27(Kip1) (p27), a prototypical intrinsically disordered protein (IDP), regulates eukaryotic cell division through interactions with cyclin-dependent kinase (Cdk)/cyclin complexes. The activity, stability, and subcellular localization of p27 are regulated by phosphorylation. We illustrate how p27 integrates regulatory signals from several non-receptor tyrosine kinases (NRTKs) to activate Cdk4 and initiate cell ...
Haighton Lois A - - 2012
Mycotoxins, such as ochratoxin A (OTA), can occur from fungal growth on foods. OTA is considered a possible risk factor for adverse renal effects in humans based on renal tumors in male rats. For risk mitigation, Health Canada proposed maximum limits (MLs) for OTA based largely on a comparative risk ...
Mulero P - - 2012
INTRODUCTION. Hypnic headache is a rare condition, since less than 150 cases have been reported to date. The second edition of the International Headache Classification (IHC2) has set out the diagnostic criteria of this condition, although some of them can be considered excessively strict. AIMS. To present a series of ...
Scattone Anna - - 2012
Scattone A, Serio G, Marzullo A, Nazzaro P, Corsi F, Cocca M P, Mattoni M, Punzi A, Gentile M, Buonadonna A L & Pennella A (2012) Histopathology60, 472-481 High Wilms' tumour gene (WT1) expression and low mitotic count are independent predictors of survival in diffuse peritoneal mesothelioma Aims:  To evaluate ...
Potera Carol - - 2012
An earlier model of Magnet care focused on nurses' work environment, not outcomes.
Chen San-Ni - - 2012
The purpose of this study was to report the clinical characteristics and surgical outcome of familial exudative vitreoretinopathy-associated rhegmatogenous retinal detachment. Retrospective interventional case series of patients with familial exudative vitreoretinopathy-associated rhegmatogenous retinal detachment. All cases had preoperative and postoperative clinical evaluations. Eyes were divided into three groups: no, moderate, ...
Roush Karen - - 2012
It's time to lose the attitude-for our patients' sake and ours.
Pfeifer Gail M - - 2012
Hospital attorneys had disputed the claim, saying reasonable accommodations were offered.
Neumann Jens - - 2012
A test predicting distant metastases would be valuable for prognostication in colon cancer (CC). In previous studies, CC with microsatellite instability (MSI) showed a reduced risk of distant metastases. High expression of CD133 and β-catenin, both related to cancer stem cell phenotypes, might be predictive markers for metastasis. The aim ...
Secades J J - - 2012
Stroke is a leading cause of mortality and the main cause of severe and long-term disability in adults. Following treatment during the acute phase, there is a need to continue the treatment of the patients in the rehabilitation phase, in order to improve the outcome and daily life activities. This ...
Piscuoglio Salvatore - - 2012
Piscuoglio S, Zlobec I, Pallante P, Sepe R, Esposito F, Zimmermann A, Diamantis I, Terracciano L, Fusco A & Karamitopoulou E (2012) Histopathology 60, 397-404 HMGA1 and HMGA2 protein expression correlates with advanced tumour grade and lymph node metastasis in pancreatic adenocarcinoma Aims:  Pancreatic ductal adenocarcinoma follows a multistep model of ...
Wyss Susi - - 2012
An encounter with a nurse in Africa proves hard to forget.
Daraï E - - 2012
Colorectal resection for endometriosis is a major operation exposing patients to the risk of severe digestive and urological complications. The objective of this review is to evaluate surgery-related urological morbidity of which little is known to date. We searched MEDLINE for articles published on colorectal resection for endometriosis between 1998 ...
Ottonello M - - 2012
The SAT-16 is a 16-item self-administered questionnaire measuring patient satisfaction with the quality of care during stay in a rehabilitation unit. A comprehensive psychometric analysis of SAT-16 was performed using both classical test theory and Rasch analysis (RA) to examine its validity and metric properties, and provide further insights for ...
Rodrigo-Gil J - - 2012
INTRODUCTION. More than a third of the patients with acute stroke have urinary disorders that should be evaluated and treated. AIM. To evaluate the effectiveness of portable ultrasound scanner in patients with acute stroke. PATIENTS AND METHODS. Randomized clinical trial with stroke patients admitted consecutively to the stroke unit between ...
He Yufan Y Center for Photochemical Sciences, Department of Chemistry, Bowling Green State University, Bowling Green, Ohio 43403, United - - 2012
Combining atomic force microscopy and fluorescence resonance energy transfer spectroscopy (AFM-FRET), we have developed a single-molecule AFM-FRET nanoscopy approach capable of effectively pinpointing and mechanically manipulating a targeted dye-labeled single protein in a large sampling area and simultaneously monitoring the conformational changes of the targeted protein by recording single-molecule FRET ...
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