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Results 401 - 450 of 2154
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Wirth Samantha E - - 2012
The ESX-1 secretion system is required for pathogenicity of Mycobacterium tuberculosis (Mtb). Despite considerable research, little is known about the structural components of ESX-1, or how these proteins are assembled into the active secretion apparatus. Here, we exploit the functionally related ESX-1 apparatus of Mycobacterium smegmatis (Ms) to show that ...
Hossmann Konstantin-Alexander - - 2012
Brain injury after focal ischemia evolves along two basically different pathophysiologies, depending on the severity of the primary flow reduction and the dynamics of postischemic recirculation. In permanent and gradually reversed focal ischemia as after thromboembolic occlusion, primary core injury is irreversible but the expansion of the core into the ...
Plantinga Theo S - - 2012
The ability of humans to digest the milk component lactose after weaning requires persistent production of the lactose-converting enzyme lactase. Genetic variation in the promoter of the lactase gene (LCT) is known to be associated with lactase production and is therefore a genetic determinant for either lactase deficiency or lactase ...
Krause Matthias - - 2012
The use of inappropriate cementation techniques has been suggested as an adverse factor for the long-term survival of hip-resurfacing arthroplasty. Inadequate initial fixation, thermal osteonecrosis and interface biological reactions are possible causes of failure. We analysed morphological changes associated with the cementation technique in a large collection of retrieved femoral ...
Breen Karen A - - 2012
The antiphospholipid syndrome (APS) is the association of thrombosis and recurrent pregnancy loss and/or pregnancy morbidity with persistent antiphospholipid antibodies (aPL). Increased complement activation has been implicated in the pathogenesis of APS in animal models. It was our objective to evaluate complement activation in patients with aPL or primary antiphospholipid ...
Hayward C P M - - 2012
Platelet aggregometry and dense granule adenosine triphosphate (ATP) release assays are helpful to diagnose platelet disorders. Some laboratories simultaneously measure aggregation and ATP release using Chronolume® a commercial reagent containing D-luciferin, firefly luciferase and magnesium. Chronolume® can potentiate sub-maximal aggregation responses, normalising canine platelet disorder findings. We investigated if Chronolume® ...
Lichtenstein Bruce R - - 2012
As a prelude to engineering artificial energy conversion proteins emulating biology, we examine the inclusion of a synthetic naphthoquinone amino acid in a characterized host-guest protein and determine the effects of its quinone and hydroquinone forms on the helix-coil distribution.
Chacko Ari George - - 2012
To document the neurological outcome, spinal alignment and segmental range of movement after oblique cervical corpectomy (OCC) for cervical compressive myelopathy. This retrospective study included 109 patients--93 with cervical spondylotic myelopathy and 16 with ossified posterior longitudinal ligament in whom spinal curvature and range of segmental movements were assessed on ...
Blandini Fabio - - 2012
Parkinson's disease (PD) therapy is still centered on the use of L-3,4-dihydroxyphenylalanine (L-DOPA), which is hampered by numerous side effects, including abnormal involuntary movements known as L-DOPA-induced dyskinesias (LIDs). LIDs are the result of pre- and postsynaptic changes at the corticostriatal level, induced by chronic and pulsatile stimulation of striatal ...
Panel Pierre - - 2012
To assess face and construct validity of a new virtual reality (VR) training simulator for hysteroscopic placement of tubal sterilization implants. Nonrandomized, controlled trial comparing responses and performance of novices and experts on the simulator. Canadian task force II-1. Forty-six gynecologists were personally invited or recruited at the 33rd Conference ...
Sheldon Wendy R - - 2012
Uterotonic drugs are recommended for the prevention and treatment of postpartum hemorrhage (PPH), and oxytocin is considered the gold standard for both indications due to its established efficacy and safety. Unfortunately, access to oxytocin is still limited in many low-resource settings due to the need for cool storage, sterile equipment ...
van Dokkum Liesjet L Movement to Health Laboratory, Montpellier-1 University, EuroMov, 700 Avenue du Pic Saint Loup, 34090 Montpellier, - - 2012
We investigated the visual perception of biological movement by people post-stroke, using minimal kinematic displays. A group of twenty patients and a group of twelve age-matched healthy controls were asked to judge movement fluency. The movements to judge were either displayed as an end-point dot or as a stick-figure of ...
Tsutsumi Ryosuke R Division of Neuroscience, Department of Neurology, Graduate School of Medicine, University of Tokyo, 7-3-1, Hongo, Bunkyo-ku, Tokyo 113-8655, Japan. - - 2012
In mild cognitive impairment (MCI), the corpus callosum is known to be affected structurally. We evaluated callosal function by interhemispheric inhibition (IHI) using transcranial magnetic stimulation (TMS) in MCI patients. We investigated 12 amnestic MCI patients and 16 healthy age-matched control subjects. The IHI was studied with a paired-pulse TMS ...
Cheng Beibei B Department of Electrical and Computer Engineering, Missouri University of Science and Technology, Rolla, MO 65409, - - 2013
Basal cell carcinoma (BCC) is the most common cancer in the US. Dermatoscopes are devices used by physicians to facilitate the early detection of these cancers based on the identification of skin lesion structures often specific to BCCs. One new lesion structure, referred to as dirt trails, has the appearance ...
Gartland Alison A Mellanby Centre for Bone Research, Academic Unit of Bone Biology, Department of Human Metabolism, University of Sheffield, Sheffield, UK. - - 2012
The P2X7 receptor gene (P2RX7) is highly polymorphic with five previously described loss-of-function (LOF) single-nucleotide polymorphisms (SNP; c.151+1G>T, c.946G>A, c.1096C>G, c.1513A>C and c.1729T>A) and one gain-of-function SNP (c.489C>T). The purpose of this study was to determine whether the functional P2RX7 SNPs are associated with lumbar spine (LS) bone mineral density ...
Cottrell Elizabeth E Arthritis Research UK Primary Care Centre, Primary Care Sciences, Keele University, Keele, Staffordshire ST5 5BG, UK. - - 2012
Inflammatory arthritis (IA) has significant physical, psychosocial and economic consequences. Delays in diagnosis and initiation of treatment significantly impact on prognosis. The infrequent, variable, non-specific and, sometimes, indolent presentation make recognition of IA by primary care physicians (PCPs) challenging. To undertake an in-depth case review assessing the diagnostic trajectory of ...
Messerli-Bürgy N N Department of Epidemiology and Public Health, University College London, UK. - - 2012
Depressed mood following an acute coronary syndrome (ACS) is a risk factor for future cardiac morbidity. Hypothalamic-pituitary-adrenal (HPA) axis dysregulation is associated with depression, and may be a process through which depressive symptoms influence later cardiac health. Additionally, a history of depression predicts depressive symptoms in the weeks following ACS. ...
Smithers L G LG Discipline of Public Health, School of Population Health and Clinical Practice, University of Adelaide, Adelaide, South Australia, Australia. - - 2012
Data from the Avon Longitudinal Study of Parents and Children (ALSPAC) have previously shown that dietary patterns are observable by 3 years. However, it is not clear when dietary patterns emerge. We aimed to describe dietary patterns in early life and their associations with maternal and infant sociodemographic characteristics. Principal ...
Zeng Yiming Y Department of Orthopaedic Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, - - 2012
The purpose of the present study was to determine the side and sex differences in acetabular dimension and orientation in normal Chinese adults, which are not known well but are important in hip joint replacement surgery. The acetabular parameters, including anteversion angle (AV.A), abduction angle (AB.A), center edge angle (CE.A), ...
Jakovljevic Djordje G DG MoveLab-Physical Activity and Exercise Research, MRC Centre for Brain Ageing and Vitality, Newcastle University, Newcastle upon Tyne, UK. - - 2012
Bioreactance is a novel non-invasive method for cardiac output measurement that involves the analysis of blood flow-dependent changes in the phase shifts of electrical currents applied across the chest. The present study (1) compared resting and exercise cardiac outputs determined by bioreactance and bioimpedance methods and those estimated from measured ...
Portal-Núñez Sergio S Bone and Mineral Metabolism Laboratory, Instituto de Investigación Sanitaria (IIS)-Fundación Jiménez Díaz, Avda. Reyes Católicos, 2, 28040, Madrid, Spain. - - 2013
An age-related bone loss occurs, apparently associated with the concomitant increase in an oxidative stress situation. However, the underlying mechanisms of age-related osteopenia are ill defined since these studies are time consuming and require the use of many animals (mainly rodents). Here, we aimed to characterize for the first time ...
Dornan Tim T Department of Educational Development and Research, Maastricht University, The Netherlands. - - 2012
The drive to quality-manage medical education has created a need for valid measurement instruments. Validity evidence includes the theoretical and contextual origin of items, choice of response processes, internal structure, and interrelationship of a measure's variables. This research set out to explore the validity and potential utility of an 11-item ...
Briggs David B DB Department of Chemistry and Biochemistry, University of Arizona, MRB Diabetes Research, Tucson, AZ 85724, - - 2012
Adiponectin, a hormone secreted from adipocytes, has been shown to protect against development of insulin resistance, ischemia-reperfusion injury, and inflammation. Adiponectin assembles into multiple oligomeric isoforms: trimers, hexamers and several higher molecular weight (HMW) species. Of these, the HMW species are selectively decreased during the onset of type 2 diabetes. ...
Cooper Ziva D ZD College of Physicians and Surgeons of Columbia University, New York State Psychiatric Institute and Department of Psychiatry, Division on Substance Abuse, 1051 Riverside Drive, New York, NY 10032, - - 2012
Commonly abused drugs including opioids, stimulants and alcohol activate glia cells, an effect that has been identified across species. Glia, specifically astrocytes and microglia, have been shown to contribute directly to behaviors predictive of the abuse liability of these drugs. Although still in its infancy, research investigating the effects of ...
Meng Lingzhong L Department of Anesthesiology & Perioperative Care, University of California Irvine Medical Center, 101 The City Drive South, Bldg. 53, Rm. 227, Orange, CA 92868, USA. - - 2012
During anesthesia, maneuvers which cause the least disturbance of cerebral oxygenation with the greatest decrease in intracranial pressure would be most beneficial to patients with intracranial hypertension. Both head-up tilt (HUT) and hyperventilation are used to decrease brain bulk, and both may be associated with decreases in cerebral oxygenation. In ...
Price Kimber L KL Department of Psychiatry and Behavioral Sciences, Division of Clinical Neuroscience, Medical University of South Carolina, 67 President Street MSC 861, Charleston, SC 29425, USA. - - 2013
D-Cycloserine (DCS), a partial glutamate N-methyl-D-aspartate (NMDA) receptor agonist, enhances extinction of conditioned fear responding; preliminary data suggest that it may facilitate extinction of drug cue reactivity. This study investigates DCS effects on cocaine cue craving and drug use in cocaine-dependent subjects. Thirty-two subjects were randomly assigned to receive (1) ...
Goyal Abhinav A Department of Medicine, Emory School of Medicine, Atlanta, GA 30322, USA. - - 2012
Clinical practice guidelines recommend maintaining serum potassium levels between 4.0 and 5.0 mEq/L in patients with acute myocardial infarction (AMI). These guidelines are based on small studies that associated low potassium levels with ventricular arrhythmias in the pre-β-blocker and prereperfusion era. Current studies examining the relationship between potassium levels and ...
Yourman Lindsey C LC Division of Geriatrics, Department of Medicine, University of California, San Francisco, San Francisco, CA 94121, - - 2012
To better target services to those who may benefit, many guidelines recommend incorporating life expectancy into clinical decisions. To assess the quality and limitations of prognostic indices for mortality in older adults through systematic review. We searched MEDLINE, EMBASE, Cochrane, and Google Scholar from their inception through November 2011. We ...
Phelan Elizabeth A EA Division of Gerontology and Geriatric Medicine, Department of Medicine, School of Public Health and Community Medicine, University of Washington, Seattle, WA 98104-2499, USA. - - 2012
Dementia is associated with increased rates and often poorer outcomes of hospitalization, including worsening cognitive status. New evidence is needed to determine whether some admissions of persons with dementia might be potentially preventable. To determine whether dementia onset is associated with higher rates of or different reasons for hospitalization, particularly ...
Pletcher Mark J MJ Department of Epidemiology and Biostatistics, University of California, San Francisco, 185 Berry St, Ste 5700, San Francisco, CA 94107, USA. - - 2012
Marijuana smoke contains many of the same constituents as tobacco smoke, but whether it has similar adverse effects on pulmonary function is unclear. To analyze associations between marijuana (both current and lifetime exposure) and pulmonary function. The Coronary Artery Risk Development in Young Adults (CARDIA) study, a longitudinal study collecting ...
MacDonald Cristin C School of Biomedical Engineering, Drexel University, Philadelphia, Pennsylvania 19104, - - 2012
To investigate the kinetics, mechanism and extent of MNP loading into endothelial cells and the effect of this loading on cell function. MNP uptake was examined under field on/off conditions, utilizing varying magnetite concentration MNPs. MNP-loaded cell viability and functional integrity was assessed using metabolic respiration, cell proliferation and migration ...
Fowles Eileen R ER The University of Texas at Austin, School of Nursing, 1700 Red River Street, Austin, TX 78701-1499, USA. - - 2012
Pre-eclampsia is a multi-system disorder caused by inadequate placentation in early pregnancy; however, little is known about the influence of nutrient intake on placental development during the crucial 1st trimester. The objective of this study was to examine the relationships between nutrient intake and the raw values and ratios of ...
Aguirre J I JI Department of Physiological Sciences, University of Florida, Gainesville, FL 32610, USA. - - 2012
The rice rat (Oryzomys palustris) develops periodontitis-like lesions when fed a diet rich in sucrose and casein (H-SC). We aimed to establish whether this model can accurately mimic the development of human periodontitis. For this purpose, 28-day-old rice rats (15/group) were assigned to standard (STD) or H-SC diets and sacrificed ...
Domenech Maribella M Department of Biomedical Engineering and Wisconsin Institute for Medical Research, University of Wisconsin-Madison, Madison, Wisconsin 53705, - - 2012
Despite strong evidence for the involvement of the stroma in Hedgehog signaling, little is known about the identity of the stromal cells and the signaling mechanisms that mediate the growth promoting effect of Hh signaling. We developed an in vitro co-culture model using microchannel technology to examine the effect of ...
Ferguson Shawn M SM Department of Cell Biology, Yale University School of Medicine, New Haven, Connecticut 06510, USA. - - 2012
Dynamin, the founding member of a family of dynamin-like proteins (DLPs) implicated in membrane remodelling, has a critical role in endocytic membrane fission events. The use of complementary approaches, including live-cell imaging, cell-free studies, X-ray crystallography and genetic studies in mice, has greatly advanced our understanding of the mechanisms by ...
Soontornniyomkij Virawudh V Department of Psychiatry, University of California, San Diego, La Jolla, CA, USA. - - 2012
FK506 binding protein (FKBP)-51 and FKBP52 act as molecular chaperones to control glucocorticoid receptor (GR) sensitivity. Dysregulation of proteins involved in GR-mediated signaling can lead to maladaptive stress response and aging-related cognitive decline. As HIV infection is related to chronic stress, we hypothesized that altered cortical expression of these proteins ...
Iwamoto Jun - - 2012
Background and Objective: Chronic kidney disease is associated with an increased risk of fragility fractures. A retrospective study was conducted to compare outcomes after 3 years of alendronate treatment in postmenopausal osteoporotic Japanese women with or without renal dysfunction (RD). Methods: One hundred and thirty-five postmenopausal osteoporotic Japanese women (mean ...
Wopereis Suzan - - 2012
The prevalence of diabetes mellitus type 2 could be significantly reduced by early identification of subjects at risk allowing better prevention and earlier treatment. Glucose intolerance (GI) is a hallmark of the pre-diabetic stage. This study aims at identifying a) prognostic biomarkers predicting the risk of developing GI later in ...
Kornyshev Alexei A - - 2012
We present model calculations for the reflection spectrum of an ordered two dimensional array of metallic nanoparticles located near an electrochemical interface. We consider three cases, nanoparticles at: (i) a metal electrode, (ii) a transparent semiconductor electrode, and (iii) an electrified liquid/liquid interface. In the case of a metal electrode, ...
Rogers James V - - 2012
Abstract Within the past decade, human infections with the highly pathogenic avian influenza H5N1 have resulted in approximately 60% mortality and increased the need for vaccines and therapeutics. Understanding the molecular events associated with pathology can aid this effort; therefore, this study was conducted to assess microRNA (miRNA) expression in ...
Simpson Courtney M - - 2012
Growth differentiation factor 9 (GDF9) controls granulosa cell growth and differentiation during early ovarian folliculogenesis and regulates cumulus cell function and ovulation rate in the later stages of this process. Similar to other TGF-β superfamily ligands, GDF9 is secreted from the oocyte in a noncovalent complex with its prodomain. In ...
Torras Juan - - 2012
The conformational properties of the optically active regioregular poly[(R)-3-(4-(4-ethyl-2-oxazolin-2-yl) phenyl) thiophene] (PEOPT) were explored by molecular dynamics on a single chain using several solvents of increasing polarity. Furthermore, their aggregate formation was studied over a wide range of temperatures using a replica exchange molecular dynamics simulation providing simulation data representative ...
Gelsomino Sandro - - 2012
Despite its proven efficacy, the Cox-Maze III procedure did not gain widespread acceptance for the treatment of lone atrial fibrillation (LAF) because of its complexity and technical difficulty. Surgical ablation for LAF can now be successfully performed utilizing minimally invasive techniques. This article provides an overview of the current state ...
Chen Lena M - - 2012
BACKGROUND: =0.02). However, choosing a hospital in thetop quartile (or decile) of performance in prior years did not decrease a patient's chance of dying (P=0.29, or P=0.27). Performanceranking was not associated with a change in market share for hospitals or for physicians, or with leaving practice (all P>0.05).ConclusionsPublic reporting on ...
Nienhaus G Ulrich - - 2012
Like the battery bunny: The novel photoswitchable fluorescent protein rsEGFP can be cycled between its fluorescent and nonfluorescent states more than a thousand times and is, therefore, a superb marker for high-resolution RESOLFT imaging (RESOLFT=reversible saturable optical fluorescence transition) and data storage applications.
Dunworth Moira - - 2012
This study explored the different values of staff from two care homes for older people in which the managers had different qualifications (social worker vs. nursing). Their views were examined to explore whether the values of the staff might reflect any value difference originating in the professional backgrounds of the ...
Clegg William - - 2012
Subtle differences: By using a combination of advanced crystallographic techniques and complementary computational approaches to assess the relative energies and conformational preferences, Me(2) Zn has been shown to form two different crystal structures. At temperatures above 180 K the methyl groups are staggered, whereas below 180 K the methyl groups ...
Hutchison James A - - 2012
Electromagnetic vacuum fields are omnipresent in our universe, inducing many events such as spontaneous emission, Lamb shift, and Van der Waals forces. As demonstrated here, a chemical reaction can be influenced by strongly coupling the energy landscape governing the reaction pathway to vacuum fields in an optical cavity (see picture; ...
Prummer Michael - - 2012
Following the success of small-molecule high-throughput screening (HTS) in drug discovery, other large-scale screening techniques are currently revolutionizing the biological sciences. Powerful new statistical tools have been developed to analyze the vast amounts of data in DNA chip studies, but have not yet found their way into compound screening. In ...
Wang Dong - - 2012
Based on the assumption that only a few genes are differentially expressed in a disease and have balanced upward and downward expression level changes, researchers usually normalise microarray data by forcing all of the arrays to have the same probe intensity distributions to remove technical variations in the data. However, ...
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