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Grammes F - - 2012
Heart and skeletal muscle inflammation (HSMI) is a disease causing considerable mortality in farmed Atlantic salmon. We have previously reported that pre-feeding of tetradecylthioacetic acid (TTA) reduces the mortality during a natural outbreak of HSMI. In the present paper we show that in the cardiac ventricle, during HSMI infection, pre-feeding ...
Xia Ruiping - - 2012
Parkinson's disease (PD) is a chronic progressive neurodegenerative disease that is clinically manifested by a triad of cardinal motor symptoms - rigidity, bradykinesia and tremor - due to loss of dopaminergic neurons. The motor symptoms of PD become progressively worse as the disease advances. PD is also a heterogeneous disease ...
Macpherson H L - - 2012
Vibrio splendidus is a pathogen that can cause major losses during the early stages of larval turbot rearing when live feed (rotifers or Artemia) is used. As haemolytic bacteria have often been associated with larval rearing losses, we studied the role of the V. splendidus haemolysin in infection of larvae. From ...
Yan Jing-Zhi - - 2012
Objective Postsynaptic density protein 95 (PSD-95) plays important roles in the regulation of glutamate signaling, such as that of N-methyl-D-aspartate receptors (NMDARs). In this study, the functional roles of PSD-95 in tyrosine phosphorylation of NMDAR subunit 2A (NR2A) and in apoptosis-like cell death induced by oxygen-glucose deprivation (OGD) in cultured ...
Zeng Wei-Zheng - - 2012
The recent demonstration of proton signaling in C. elegans muscle contraction suggests a novel mechanism for proton-based intercellular communication and has stimulated enthusiasm for exploring proton signaling in higher organ-isms. Emerging evidence indicates that protons are produced and regulated in localized space and time. Furthermore, identification of proton regulators and ...
Shi Wen-Zhen - - 2012
Objective To determine whether aquaporin-4 (AQP4) regulates acute lesions, delayed lesions, and the associated microglial activation after cryoinjury to the brain. Methods Brain cryoinjury was applied to AQP4 knockout (KO) and wild-type mice. At 24 h and on days 7 and 14 after cryoinjury, lesion volume, neuronal loss, and densities ...
Badakali Meenakshi - - 2012
Neu-Laxova syndrome is a rare lethal congenital disorder involving multiple systems. Intrauterine growth retardation, ichthyosis, microcephaly, abnormal facial findings and limb contractures are its key features. We present a stillborn female baby of 1.5 kg with characteristic features including growth retardation, microcephaly, severe ectropion, micrognathia, flattened nose, eclabion, large ears, ...
Cao Hong - - 2012
Objective The rostral anterior cingulate cortex (rACC) is implicated in processing the emotional component of pain. N-methyl-D-aspartate receptors (NMDARs) are highly expressed in the rACC and mediate pain-related affect by activating a signaling pathway that involves cyclic adenosine monophosphate (cAMP)/protein kinase A (PKA) and/or extracellular regulated kinase (ERK)/cAMP-response element-binding protein ...
Oliva-Teles A - - 2012
Under intensive culture conditions, fish are subject to increased stress owing to environmental (water quality and hypoxia) and health conditions (parasites and infectious diseases). All these factors have negative impacts on fish well-being and overall performance, with consequent economic losses. Though good management practices contribute to reduce stressor effects, stress ...
Chu Yu-Xia - - 2012
Objective The present study aimed to investigate the potential roles of spinal microglia and downstream molecules in the induction of spinal long-term potentiation (LTP) and mechanical allodynia by tetanic stimulation of the sciatic nerve (TSS). Methods Spinal LTP was induced in adult male Sprague-Dawley rats by tetanic stimulation of the ...
McCormack Paul L - - 2012
Dasatinib (Sprycel®) is an orally administered small molecule inhibitor of multiple tyrosine kinases, including BCR-ABL and SRC family kinases, which is indicated for the treatment of adults with newly diagnosed chronic-phase chronic myeloid leukemia (CML), CML (chronic-, accelerated- or blast-phase) with resistance or intolerance to prior therapy, including imatinib, or ...
Saksida S M - - 2012
Juvenile pink salmon, Oncorhynchus gorbuscha (Walbaum), in the Broughton Archipelago region of western Canada were surveyed over 2 years for sea lice (Lepeophtheirus salmonis and Caligus clemensi), gross and microscopic lesions and evidence of infections with viruses and bacteria. The 1071 fish examined had an approximate ocean residence time no longer ...
Soldevilla H F - - 2012
The link between autoimmunity and infectious agents has been strongly suggested by reports of lupus or lupus-like syndromes following immunization. This report describes three patients with either newly diagnosed systemic lupus erythematosus (SLE) or SLE flare, following vaccination for human papilloma virus (HPV). CASE 1: A 17-year-old female completed two ...
Soheilian Masoud - - 2012
The purpose of this study was to report the 24-month findings of a randomized clinical trial comparing intravitreal bevacizumab (IVB) injection alone or in combination with intravitreal triamcinolone acetonide (IVT) versus macular laser photocoagulation (MPC) as a primary treatment for diabetic macular edema. The eyes were randomly assigned to 1 ...
Faigenbaum Avery D - - 2012
Although the power clean test is routinely used to assess strength and power performance in adult athletes, the reliability of this measure in younger populations has not been examined. Therefore, the purpose of this study was to determine the reliability of the 1-repetition maximum (1RM) power clean in adolescent athletes. ...
Gherardi R K - - 2012
Aluminium oxyhydroxide (alum), a nanocrystalline compound forming agglomerates, has been used in vaccines for its immunological adjuvant effect since 1927. Alum is the most commonly used adjuvant in human and veterinary vaccines, but the mechanisms by which it stimulates immune responses remain incompletely understood. Although generally well tolerated, alum may ...
Snigdha Shikha S Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, Irvine, California 92697-4540, USA. - - 2012
Death-mediating proteases such as caspases and caspase-3 in particular, have been implicated in neurodegenerative processes, aging and Alzheimer's disease. However, emerging evidence suggests that in addition to their classical role in cell death, caspases play a key role in modulating synaptic function. It is remarkable that active caspases-3, which can ...
Côté Sebastien S Department of Pathology and Cell Biology and Groupe de recherche sur le système nerveux central, University of Montreal, Montreal, QC H3C 3J7, - - 2012
Glycine and γ-aminobutyric acid (GABA) are depolarizing during early development but the purpose is unclear. We tested the effect of altering glycine signaling in zebrafish embryos by overexpressing the potassium-chloride co-transporter type 2 (KCC2) to reverse the chloride gradient or by blocking glycine receptors with strychnine or by selectively knocking ...
Kemppi Carita C Department of Physical and Rehabilitation Medicine, Turku University Hospital, Turku, Finland. - - 2012
The aim of this study was to evaluate the relationship between the functional status of patients with low back pain and the perceived importance of pain-related everyday functions assessed in the Oswestry Disability Index. The sample was based on 219 successive adult patients with low back pain referred to a ...
Petzold Anita A Faculty of Medicine, School of Physical and Occupational Therapy, McGill University, Montreal, Quebec, Canada. - - 2012
The aim of this study was to investigate: (i) the feasibility of delivering a multi-modal knowledge translation intervention specific to the management of acute post-stroke unilateral spatial neglect; and (ii) the impact of the knowledge translation intervention on occupational therapists' knowledge of evidence-based unilateral spatial neglect problem identification, assessment and ...
Stenberg Gunilla G Department of Community Medicine and Rehabilitation, Physiotherapy, Umeå University, Umeå, Sweden. - - 2012
The aim of this study was to explore, from a gender perspective, patients' expectations prior to seeking healthcare for neck or back pain, and their subsequent experiences of the care and rehabilitation they received. Thematized interviews with 12 patients, 7 women and 5 men, using open-ended questions, were analysed according ...
Hostettler Stefanie S Institute of Human Movement Sciences, Exercise Physiology, ETH Zurich, Zurich, - - 2012
To determine and compare haemodynamic responses at maximal arm-crank (ACE) and wheelchair exercise (WCE) in individuals with cervical spinal cord injury and pair-matched able-bodied individuals. Nine male, motor-complete cervical spinal cord injured and 9 able-bodied individuals performed graded, maximal ACE and WCE. Cardiac output, heart rate, and stroke volume were ...
Kesikburun Serdar S Department of Physical Medicine and Rehabilitation, Turkish Armed Forces Rehabilitation Center, Gülhane Military Medical Academy, Ankara, Turkey. - - 2012
We report here a case of neoplastic brachial plexopathy detected by musculoskeletal ultrasonography in a patient with chronic cervicobrachialgia. A 71-year-old man presented at Gülhane Military Medical Academy, Turkish Armed Forces Rehabilitation Center, Ankara, Turkey with a one-year history of cervicobrachial pain radiating to the left arm and numbness in ...
Gantschnig Brigitte E BE Zurich University of Applied Sciences, School of Health Professions, Institute of Occupational Therapy, Zurich, Switzerland. - - 2012
To evaluate cross-regional validity of the Assessment of Motor and Process Skills (AMPS) with a specific focus on valid use with Middle Europeans. Descriptive cross-regional validation study. A total of 1346 participants from Middle Europe and 144,143 participants from North America, UK/Ireland, the Nordic Countries, other Europe, Australia/New Zealand and ...
Bernuz Benjamin B Neurorehabilitation Unit, Leon Berard Hospital, Hyeres, France. - - 2012
A 43-year-old woman with cerebral palsy and disabling spasticity underwent a series of 4 implantations of intrathecal baclofen pumps, performed by two teams. A history of 3 aseptic local skin reactions over the site of insertion started 4 months after the first insertion, once with partial pump exposure. There were ...
Vista E S ES Oklahoma Medical Research Foundation, Oklahoma City, OK 73104, - - 2012
Antiphospholipid syndrome is characterized by autoantibodies against cardiolipins (aCL), lupus anticoagulant, and independent β2-glycoprotein (β2GPI). Controversy exists as to whether vaccination triggers the development of antiphospholipid antibodies (aPL) in patients with systemic lupus erythematosus (SLE). Patients with SLE (101) and matched controls (101) were enrolled from 2005-2009 and received seasonal ...
Selander Nicklas N The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, - - 2012
Diazo sulfonylamidines readily undergo enantioselective oxygen transfer from sulfur to carbon atom in the presence of chiral rhodium(II) carboxylates resulting in chiral sulfinylamidines. This unusual asymmetric atom transfer "reduction" occurs rapidly under mild conditions, and sulfinylamidines are obtained in excellent yield.
Mercadante Sebastiano - - 2012
Breakthrough pain (BTP) is a transient exacerbation of pain that occurs either spontaneously, or in relation to a specific predictable or unpredictable trigger, despite relatively stable and adequately controlled background pain. The principal pharmacological treatment of BTP is represented by the administration of opioids as needed. Oral opioids have traditionally ...
Taguchi Taketo - - 2012
Oxomanganese(V) species have been implicated in a variety of biological and synthetic processes, including their role as a key reactive center within the oxygen-evolving complex in photosynthesis. Nearly all mononuclear Mn(V)-oxo complexes have tetragonal symmetry, producing low-spin species. A new high-spin Mn(V)-oxo complex that was prepared from a well-characterized oxomanganese(III) ...
So Christopher R CR Genetically Engineered Materials Science and Engineering Center, Department of Materials Science and Engineering, University of Washington, Seattle, Washington 98195, United - - 2012
Self-assembly of proteins on surfaces is utilized in many fields to integrate intricate biological structures and diverse functions with engineered materials. Controlling proteins at bio-solid interfaces relies on establishing key correlations between their primary sequences and resulting spatial organizations on substrates. Protein self-assembly, however, remains an engineering challenge. As a ...
Czapla Monika - - 2012
Homodimeric structure of cytochrome bc₁, a common component of biological energy conversion systems, builds in four catalytic quinone oxidation/reduction sites and four chains of cofactors (branches) that, connected by a centrally located bridge, form a symmetric H-shaped electron transfer system. The mechanism of operation of this complex system is under ...
Garcia-Rodriguez R - - 2012
INTRODUCTION. Carotid stenosis accounts for about 25% of all ischaemic cerebrovascular events. Carotid angioplasty and stenting (CAS) is a minimally invasive procedure used as an alternative to carotid endarterectomy, especially in high surgical risk patients. AIM. To analyse the effectiveness and safety of the endovascular treatment of carotid stenosis in ...
Molinuevo J L - - 2012
INTRODUCTION AND AIM. The potential benefits of the therapy for patients with chronic diseases such as Alzheimer's disease depends largely on adherence to the treatment. The main objective of this study was to assess which of the strategies used by physicians in clinical practice were effective in improving adherence in ...
Toribio-Diaz M E - - 2012
INTRODUCTION. The medical report is a legal, written document issued by the physician, exposing the clinical history and the diagnostic and therapeutic protocols applied to the patient. AIM. To evaluate the patient knowledge about the medical report and its usefulness. PATIENTS AND METHODS. We included consecutive first-visit patients attended in ...
Clua-Espuny J L - - 2012
INTRODUCTION. The prevalence and cardiovascular risk factors control (CVRF) are determining to suffer a stroke and its relapse which arise the mortality and disability. AIM. To estimate the incidence of the first episode of ictus and describe the results in primary and secondary cardiovascular prevention. PATIENTS AND METHODS. Observational and ...
Gomez-Ibanez A - - 2012
Non-convulsive status epilepticus is a significant issue for a neurologist because, despite its low prevalence, it mimics other pathologies, with therapeutics and prognostic outcomes. Diagnosis is based on clinical features, mainly mental status or impaired consciousness and electroencephalographic changes, so electroencephalogram is the first exploration we must perform with clinical ...
Moreno B - - 2012
INTRODUCTION. The advance in the achievement of effective therapies for multiple sclerosis (MS), the definition of appropriate therapeutic windows and to establish better diagnostic and prognostic biomarkers have become a challenging task for both researchers and clinicians. Some pitfalls in clinical trials might be related to lack of adequacy of ...
Pardal-Fernández José Manuel - - 2012
Hypereosinophilic syndrome is produced by what is usually a multiple infiltration of eosinophils into tissues, and may be secondary or idiopathic, depending on whether it is related to a specific aetiology or not. It is not uncommon for it to include nerve disease, but it is unusual for it to ...
Hysolli Eriona - - 2012
X-chromosome inactivation (XCI) is an important mechanism employed by mammalian XX female cells to level X-linked gene expression with that of male XY cells. XCI occurs early in development as the pluripotent cells of the inner cell mass (ICM) in blastocysts successively differentiate into cells of all three germ layers. ...
Ertel Adam - - 2012
Aging drives large systemic reductions in oxidative mitochondrial function, shifting the entire body metabolically towards aerobic glycolysis, a.k.a, the Warburg effect. Aging is also one of the most significant risk factors for the development of human cancers, including breast tumors. How are these two findings connected? One simplistic idea is ...
Lasater Kathie - - 2012
Calls for multisite studies are increasing in nursing education. However, the challenge of implementing consistent protocols and maintaining rigorous standards across sites can be daunting. One purpose of a recent multisite, collaborative, simulation study was to evaluate a digital toolkit's effectiveness for managing a multisite study. We describe the digital ...
Breckenridge Diane M - - 2012
The ultimate outcomes for succeeding in a collegiate prelicensure nursing program are earning a Bachelor of Science in Nursing degree and passing the NCLEX-RN(®). The Risk Assessment Profile, Strategies for Success (RAPSS) is a criterion-based instrument that incorporates demographic and academic risk indicators. A convenience sample (N = 255) obtained ...
Benson Gerry - - 2012
This study describes the development of emotional intelligence (EI), leadership, and caring in undergraduate nursing students throughout their educational program. A correlational, repeated measures study design was used. Fifty-two nursing students completed four self-report questionnaires on three occasions (T1, T2, T3): BarOn Emotional Quotient Inventory: Short (EQ-i:S), Self-Assessment Leadership Instrument ...
Fazekas T - - 2012
Allogeneic hematopoietic stem cell transplantation (HSCT) in childhood is associated with severe pulmonary complications, but the pathophysiologic mechanisms remain unclear. Our aim was to evaluate the association of total and specific IgE, eosinophil cationic protein (ECP) and eosinophilia in HSCT recipients with pulmonary complications. We prospectively measured total and specific ...
Lagares Alfonso - - 2012
BACKGROUND: Perfusion computed tomography (CT) is a rapid technique that allows the measurement of acute disturbances in local and global cerebral blood flow in patients suffering stroke and spontaneous subarachnoid haemorrhage (SAH). The purpose of this study was to establish the relationship between different measures of brain perfusion made on ...
Masaki Tadahiko - - 2012
BACKGROUND: No appropriate management of chronic intestinal pseudo-obstruction (CIP) has been established. PATIENTS AND METHODS: The clinicopathological parameters of 103 cases collected by a nationwide questionnaire study were reviewed. RESULTS: The CIP cases were primary in 86 (83%) cases and secondary in 15 (15%) cases. The age of onset of ...
Alsamak S - - 2012
AIM: The purpose of this study was to investigate the geometric characteristics, composition, microstructure, and pullout strength of commercially available orthodontic mini-implants. MATERIAL AND METHODS: The mini-implants used were AbsoAnchor®, Dual-Top™ JA, Spider Screws® K1, and Vector-TAS™. The geometric features were measured by optical microscopy. Surface texture and elemental composition ...
Schroeter E - - 2012
BACKGROUND: Droperidol had been used as an effective antiemetic since the 1970s but was withdrawn from the market in 2001 because of a black box warning about QT prolongation and possible cardiac arrhythmia after high doses. In the meantime the black box warning has seriously been questioned and parenteral droperidol ...
Jörgren Fredrik - - 2012
PURPOSE: Improved outcome after rectal cancer surgery requires identification of novel risk factors of tumour recurrence in order to personalise therapy, that is, enhanced selection of high-risk patients to additional radiochemotherapy or intensified follow-up. In several tumour types, including colorectal cancer, high expression of the membrane-cytoskeleton linker ezrin has been ...
Kocsis A - - 2012
OBJECTIVE: The impaction of maxillary canines is a frequently encountered clinical problem in orthodontic practice. Patients' refusal to participate in long-term treatment or ankylosis of the impacted tooth result in various treatment difficulties. The aim of this study was to evaluate the possible role of mini-screws in the management of ...
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