Search Results
Results 451 - 500 of 2154
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Sangiorgi Giuseppe - - 2012
Background: The concomitant use of femoral and popliteal accesses has been recommended for challenging superficial femoral artery (SFA) occlusions, but no comprehensive comparison of this approach to a strategy of femoral access only is available. We thus aimed to appraise the risk-benefit balance of retrograde popliteal access as bail-out strategy ...
Edahiro Ayako - - 2012
Aim:  In elderly patients with dementia, disturbed eating behavior is understood to be a core symptom or a behavioral and psychological symptom of dementia (BPSD). The purpose of the present study was to investigate the factors affecting self-feeding in elderly patients with Alzheimer's disease (AD). Methods:  A total of 150 ...
Lacasce Ann S - - 2012
Few randomized trials have compared therapies in mantle cell lymphoma (MCL), and the role of aggressive induction has not been clearly defined. The NCCN Non-Hodgkin's Lymphoma Outcomes Database, a prospective cohort study collecting clinical, treatment, and outcome data at 7 NCCN centers, provides a unique opportunity to compare the effectiveness ...
Indraswari Fransisca - - 2012
Traumatic brain injury (TBI) and intracerebral hemorrhage (ICH) are leading causes of neurological mortality and disability in the US. However, therapeutic options are limited and clinical management remains largely supportive. HMG CoA reductase inhibitors (statins) have pleiotropic mechanisms of action in the setting of acute brain injury, and have been ...
Li Fang - - 2012
The fifth element: An efficient new synthetic method for accessing 3,6-dihydro-2H-thiopyrans (1) in one pot has been developed. This method employs an anionic cascade, which is triggered by the addition of a vinyl nucleophile to a carbonyl group followed by S to O thiophosphate migration and an intramolecular thiolate displacement. ...
Fini Adamo - - 2012
Eight cyclic aliphatic amines, pyrrolidine (Py), piperidine (Pp), morpholine (M), piperazine (Pz), and the N-hydroxyethyl (HE) analogues, were employed to prepare a salt with acidic diclofenac (D). These salts were examined by thermal [differential scanning calorimetry (DSC), thermogravimetric analysis, and hot-stage microscopy (HSM)] and spectroscopic [Fourier transform infrared (FTIR), Raman, ...
Lee Seung-Whan - - 2012
Background: To date, drug-eluting stent (DES) implantation has not been compared with coronary artery bypass grafting (CABG) for ostial left main coronary artery (LMCA) lesions. Methods: Of the 263 patients in the MAIN-COMPARE registry with ostial LMCA stenosis, 123 were treated with percutaneous coronary intervention (PCI) with DES and 140 ...
Zhu Junming - - 2012
Background We evaluated an open stented elephant trunk (sET) technique combined with cardiac operations for a one-stage treatment of patients with complicated Stanford type B aortic dissection (AoD) and cardiac diseases.Methods Between April 2007 and March 2010, 16 patients with Stanford B AoD and cardiac diseases (mean age 49.75 ± 13.42 years) ...
Jenh Chung-Her - - 2012
ABSTRACT: BACKGROUND: The CXCR3 receptor and its three interferon-inducible ligands (CXCL9, CXCL10 and CXCL11) have been implicated as playing a central role in directing a Th1 inflammatory response. Recent studies strongly support that the CXCR3 receptor is a very attractive therapeutic target for treating autoimmune diseases, such as rheumatoid arthritis, ...
Pantos I - - 2012
Radiation exposure of the operator during cardiac catheter ablation procedures was assessed for an experienced cardiologist adopting various measures of radiation protection and utilised electroanatomic navigation. Chip thermoluminescent dosemeters were placed at the eyes, chest, wrists and legs of the operator. The ranges of fluoroscopy time and air kerma area ...
Cordell Geoffrey A - - 2012
Paradigm shifts in the strategies and the sciences that would enhance the quality, safety, and efficacy of traditional medicines and dietary supplements in global health care are discussed. Some of the challenges facing traditional medicine in health care are described, and the importance of defining clear goals and directions for ...
Sharma Alok - - 2012
OBJECTIVE:To review the literature describing the efficacy and safety of deep brain stimulation (DBS) as an adjunct to pharmacotherapy and to determine the best treatment option for patients with Parkinson disease (PD).DATA SOURCES:Literature was obtained through MEDLINE/PubMed (1948-September, week 2, 2011) and a bibliographic review of relevant articles. Key words ...
Narwal Mohit - - 2012
Tankyrases are poly(ADP-ribose) polymerases that have many cellular functions. They play pharmaceutically important roles, at least in telomere homeostasis and Wnt signaling, by covalently ADP-ribosylating target proteins and consequently regulating their functions. These features make tankyrases potential targets for treatment of cancer. We report here crystal structures of human tankyrase ...
Kwak Eun-Young - - 2012
The phenomenon known as multiple-drug resistance, whereby anti-cancer agents are expelled from cancer cells, makes it necessary to develop methods that will reliably increase the accumulation of anti-cancer agents within cancer cells. To accomplish this goal, a new model compound, Val-SN-38, was synthesized by introducing valine to SN-38, an active ...
Wang Peng-Jun - - 2012
Gliomas are the most common type of primary brain tumor in the central nervous system of adults. Maternally Expressed Gene 3 (MEG3) is an imprinted gene located at 14q32 that encodes a non-coding RNA associated with tumorigenesis. However, little is known about whether and how MEG3 regulates glioma development. In ...
Fiehler J - - 2012
The detection rate of intracranial aneurysms has increased with the improved availability of non-invasive imaging methods. Moreover, persons who have relatives with intracranial aneurysms increasingly demand imaging to rule out aneurysms. To deal with these problems, radiologists require basic knowledge regarding the detection and treatment of unruptured intracranial aneurysms. The ...
Kanda Junya - - 2012
Allogeneic hematopoietic cell transplantation (HCT) is an effective treatment for adult T-cell leukemia (ATL), raising the question about the role of graft-versus-leukemia effect against ATL. In this study, we retrospectively analyzed the effects of acute and chronic graft-versus-host disease (GVHD) on overall survival, disease-associated mortality, and treatment-related mortality among 294 ...
Abdelmalek M F - - 2012
A large prospective, open-label, randomized trial evaluated conversion from calcineurin inhibitor (CNI)- to sirolimus (SRL)-based immunosuppression for preservation of renal function in liver transplantation patients. Eligible patients received liver allografts 6-144 months previously and maintenance immunosuppression with CNI (cyclosporine or tacrolimus) since early posttransplantation. In total, 607 patients were randomized ...
Fayed Nicolás - - 2012
Alzheimer's disease (AD) is the most common cause of dementia in elderly people in western countries. However important goals are unmet in the issue of early diagnosis and the development of new drugs for treatment. Magnetic resonance imaging (MRI) and volumetry of the medial temporal lobe structures are useful tools ...
Schurr Karl - - 2012
Objective: To determine the reliability of the minimum sit-to-stand height test, its responsiveness and its relationship to leg muscle strength among rehabilitation unit inpatients and outpatients.Design: Reliability study using two measurers and two test occasions. Secondary analysis of data from two clinical trials.Setting: Inpatient and outpatient rehabilitation services in three ...
Bazemore R A - - 2012
Volatile chemical profiles collected from the headspace of Aspergillus fumigatus (a pathogenic fungus that causes invasive pulmonary aspergillosis, allergic bronchopulmonary aspergillosis and chronic fungal sinusitis) grown on media with the connective tissue protein elastin, found in lung tissue, contained a large abundance of the sesquiterpene farnesene (3,7,11-trimethyl-1,3,6,10-dodecatetraene) and, depending on ...
Friedman A L - - 2012
Hemorrhagic deaths of living kidney donors from failure of vascular clips used on the renal artery, first documented in 2006, have continued due to postoperative Hem-o-lok clip failure with sudden, massive bleeding. While the FDA issued a Class II recall of the Hem-o-lok clip for laparoscopic donor nephrectomies in 2006, ...
Thibeaux Roman - - 2012
The extracellular matrix (ECM) and its role in the outcome of infectious diseases have been poorly investigated. In this study, we determined the impact of the collagen fibers architecture on the invasive process of the enteric parasite Entamoeba histolytica. The behavior of E. histolytica wild type and silenced for the ...
Rodríguez-Herva José J - - 2012
The bacterial pathogen Pseudomonas syringae pv tomato DC3000 suppresses plant innate immunity with effector proteins injected by a type III secretion system (T3SS). The cysteine protease effector HopN1, which reduces the ability of DC3000 to elicit programmed cell death in nonhost tobacco, was found to also suppress the production of ...
Carracedo-Martínez Eduardo - - 2012
BACKGROUND: The aim of this study was to assess the quantitative changes in systemic use of piroxicam after the issue of a health safety warning about its risks and the subsequent implementation of prior authorisation. METHODS: We determined the number of monthly daily defined doses/1000 inhabitants/day (DHDs) of piroxicam in ...
Kalliomäki Jarkko - - 2012
1. The aim was to investigate effects of nabilone on capsaicin-induced pain and hyperalgesia, and on biomarkers of cannabinoid CNS effects. 2. A randomized, double-blind, placebo-controlled, crossover study was conducted in 30 healthy male volunteers receiving single doses of nabilone 1, 2 or 3 mg. Pain intensity after intradermal capsaicin injections in ...
Cranley Lisa A - - 2012
Background: There has been little research to date exploring nurses' uncertainty in their practice. Understanding nurses' uncertainty is important because it has potential implications for how care is delivered. Purpose: The purpose of this study is to develop a substantive theory to explain how staff nurses experience and respond to ...
Andrus Bruce W - - 2012
BackgroundServices provided by cardiologists represent a major portion of Medicare expenditures for specialist physicians. The absolute growth and distribution of these services over the past decade have not been well described.Methods and ResultsWe analyzed fee-for-service Medicare Part B claims for each year from 1999-2008 and selected claims from physicians whose ...
Gaffney Kathleen F - - 2012
Background: The World Health Organization has identified childhood obesity as a major threat to global health. Accumulating evidence indicates that excess weight early in life is predictive of later childhood and adolescent obesity. Clinical practice guidelines for infant feeding behaviors have been developed by national and international health organizations. The ...
Burgess Stewart Tg - - 2012
ABSTRACT: BACKGROUND: Sheep scab is a highly contagious disease of sheep caused by the ectoparasitic mite Psoroptes ovis. The disease is endemic in the UK and has significant economic impact through its effects on performance and welfare. Diagnosis of sheep scab is achieved through observation of clinical signs e.g. itching, ...
Tatum Ernest Cheryl - - 2012
Absolute room temperature (294K ± 2K) absorption cross sections for the Ã<sup>1</sup>A<sub>2</sub> - X̃<sup>1</sup>A<sub>1</sub> electronic transition of formaldehyde have been measured over the spectral range 30285 - 32890 cm<sup>-1</sup> (304 - 330 nm) using ultraviolet (UV) laser absorption spectroscopy. Accurate high-resolution absorption cross sections are essential for atmospheric monitoring and ...
Tsubata Yukari - - 2012
Aim:  The number of elderly patients with non-small-cell lung cancer (NSCLC) is increasing in Japan. We retrospectively analyzed and compared the safety and efficacy of chemotherapy in elderly and non-elderly NSCLC patients who received chemotherapy at Shimane University Hospital. Methods:  We carried out a retrospective analysis of survival in a ...
Lee Min-Jeong - - 2012
The in-line monitoring of pharmaceutical processes with high risk, such as crystallization, has been one of the most popular research topics in recent years. Sulfamerazine (SMZ), a well-known sulfonamide antibacterial agent was investigated to examine the mechanism of polymorphic conversion by solvent-mediated polymorphic transformation (SMPT). The primary purpose of this ...
Roy L - - 2012
Fundamentals of biological dosimetry are described in the International Atomic Energy Agency manual, but all over the world each laboratory is using its own protocol. To test the influence of protocol variations, some blood samples were exposed to 0.5 Gy of gamma radiation and mitotic index and dicentric rates were ...
Eisele Sylvia - - 2012
The elaboration of novel pathogenic aspects of multiple sclerosis (MS) requires the analysis of well defined stages of lesion development. However, specimens of certain stages and lesion types are either present in small brain biopsies, insufficient in size for further molecular studies or available as formalin fixed and paraffin embedded (FFPE) ...
Kiotseridis Hampus - - 2012
BACKGROUND: Several instruments have been developed for measuring asthma control, but there is still a need to provide a structure for primary care asthma reviews. AIMS: The Active Life with Asthma (ALMA) tool was developed with the aim of structuring patient visits and assessing asthma treatment in primary care. The ...
Esquilin Jose M - - 2012
X chromosome inactivation is normally a random event that is regulated by the X chromosome itself. Rarely, females are affected by X-linked disorders from extremely skewed X-chromosome inactivation. Here we report a family with Hemophilia B with female expression through inherited X skewing that appears to be independent of either ...
Jastorff Jan - - 2012
Using functional magnetic resonance imaging, we investigated the effect of motor preparation/execution on the activation of visual cortical areas by action observation. We presented videos of human actors performing several fine manipulative actions (e.g., grasping) with the hand or foot, together with appropriate control stimuli. Subjects either responded in a ...
Bąbolewska Edyta - - 2012
The aim of study was to compare the potency of different bacterial antigens to induce rat mature mast cell to cysteinyl leukotriene (cysLT) generation. We examined Toll-like receptor (TLR)2 agonists, i.e. lipoteichoic acid (LTA) Staphylococcus faecalis, Streptococcus pyogenes, Bacillus subtilis and Staphylococcus aureus, lipoarabinomannan (LAM) Mycobacterium smegmatis, peptydoglican (PGN) Staphylococcus ...
Deguzman Pamela B - - 2012
Guidelines recommend aggressive goals for lipid and blood pressure reduction for high risk patients with diabetes mellitus and atherosclerotic coronary disease. However, it remains unclear how many patients achieve treatment goals versus the number of people merely placed on treatment. We conducted an observational study in an academic cardiology clinic. ...
Timms Chris - - 2012
Gastro-oesophageal reflux disease (GORD) has been implicated in the worsening of several respiratory disorders. Current methods of diagnosis lack accuracy, are invasive and can be costly. Recently, novel methods of analysing lung pathophysiology have been developed including the use of an electronic nose and analysis of components of exhaled breath ...
Senyuk Bohdan - - 2012
We demonstrate scaffolding of plasmonic nanoparticles by topological defects induced by colloidal microspheres to match their surface boundary conditions with a uniform far-field alignment in a liquid crystal host. Displacing energetically costly liquid crystal regions of reduced order, anisotropic nanoparticles with concave or convex shapes not only stably localize in ...
Husu Hannu - - 2012
We demonstrate that the second-order nonlinear optical response of noncentrosymmetric metal nanoparticles (metamolecules) can be efficiently controlled by their mutual ordering in an array. Two samples with minor change in ordering have nonlinear responses differing by a factor of up to 50. The results arise from polarization-dependent plasmonic resonances modified ...
Perina The Ems Examination Task Force American Board Of Emergency Medicine Debra G - - 2012
Abstract On September 23, 2010, the American Board of Medical Specialties (ABMS) approved emergency medical services (EMS) as a subspecialty of emergency medicine. As a result, the American Board of Emergency Medicine (ABEM) is planning to award the first certificates in EMS medicine in the fall of 2013. The purpose ...
Arazpour Mokhtar - - 2012
Background and Aim: This article describes the development and testing of a new powered gait orthosis to potentially assist spinal cord injury patients to walk by producing synchronized hip and knee joint movements. Technique: The first evaluation of the orthosis was performed without users, and was followed by evaluation of ...
Bouton Marie-Christine - - 2012
Serine protease inhibitors, termed serpins, are key regulators in many biological events. Protease nexin-1 (PN-1) is a serpin which is barely detectable in plasma but found in many organs and produced by most cell types, including monocytes, platelets and vascular cells. It has a large inhibition spectrum since it is ...
Qi W - - 2012
Amputation or degloving injuries of the thumb or index finger are highly disabling. We describe the use of twin dorsal middle finger flaps harvested from the dorsal aspects of the middle and ring fingers, and based on one palmar proper digital artery, its venae comitantes, and the dorsal branches of ...
White Christopher R H - - 2012
Abstract Objective: Hypoxic-ischaemic encephalopathy (HIE) is a major acute neurologic manifestation of perinatal asphyxia associated with significant mortality and morbidity. The study aimed to develop a simple, accurate method of predicting HIE at delivery. Methods: Between January 2003 and December 2009, all HIE cases were identified from the 38,404 deliveries ...
Nguyen Hai T - - 2012
Background and Purpose  Escitalopram, the S(+)-enantiomer of citalopram is the most selective serotonin (5-HT) reuptake inhibitor approved. Although all serotonin selective reuptake inhibitors (SSRIs) increase extracellular levels of serotonin ([5-HT](ext) ), some of them also enhance, to a lower extent, extracellular levels of norepinephrine ([NE](ext) ). However, the mechanisms by ...
da S Maia Pedro I - - 2012
Na[AuCl(4)]·2H(2)O reacts with tridentate thiosemicarbazide ligands, H(2)L1, derived from N-[N',N'-dialkylamino(thiocarbonyl)]benzimidoyl chloride and thiosemicarbazides under formation of air-stable, green [AuCl(L1)] complexes. The organic ligands coordinate in a planar SNS coordination mode. Small amounts of gold(I) complexes of the composition [AuCl(L3)] are formed as side-products, where L3 is an S-bonded 5-diethylamino-3-phenyl-1-thiocarbamoyl-1,2,4-triazole. The ...
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