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Results 401 - 450 of 2835
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Swaans M J - - 2012
BACKGROUND: Percutaneous left atrial appendage (LAA) closure can be an alternative to coumadin treatment in patients with atrial fibrillation (AF) at high risk for thromboembolic events and/or bleeding complications. We report the initial experience with this new technique. METHODS: Patients were eligible if they had AF with a high stroke ...
Monsé Christian - - 2012
Exposures to air contaminants, such as chemical vapors and particulate matter, pose important health hazards at workplaces. Short-term experimental exposures to chemical vapors and particles in humans are a promising attempt to investigate acute effects of such hazards. However, a significant challenge in this field is the determination of effects ...
Jones Richard A - - 2012
Tumour vasculogenesis can occur by a process referred to as vasculogenic mimicry, whereby the vascular structures are derived from the tumour itself. These tumours are highly aggressive and do not respond well to anti-angiogenic therapy. Here, we use the well characterised ECV304 cell line, now known as the bladder cancer ...
Boundy-Mills Kyria - - 2012
The importance of selecting optimal yeast strains for research or industrial applications is often underestimated. For example, utilizing a strain background that already provides the desired stress tolerance or nutrient utilization profile can eliminate costly strain optimization. Yeast culture collections can provide not only the yeast strains but also data ...
Kyriazis Iason - - 2012
The Protease-Activated Receptors ( PARs ) are G-protein-coupled receptors ( GPCRs ) characterized by a unique mechanism of activation. They carry built in their extended N-terminal structure their own activating agonist, in the form of a cryptic tethered ligand , unmasked by an irreversible proteolytic cleavage. Besides, PARs display several ...
Wong Eric C EC Department of Radiology, UCSD Center for Functional MRI, 9500 Gilman Drive, MC 0677, La Jolla, CA 92093-0677, USA. - - 2012
The goal of this work is to use vessel encoded arterial spin labeling (VEASL) methods to detect feeding arteries without prior knowledge of their positions, and map the vascular territory of each. Five healthy subjects were scanned, each with four different tagging planes. The VEASL tagging method was modified to ...
Pettersen Betty J - - 2012
Previous work studying vegetarians has often found that they have lower blood pressure (BP). Reasons may include their lower BMI and higher intake levels of fruit and vegetables. Here we seek to extend this evidence in a geographically diverse population containing vegans, lacto-ovo vegetarians and omnivores. Data are analysed from ...
Augustine Nimmy - - 2012
The aim of this study was to identify novel biofilm inhibitors from actinomycetes isolated from the Arctic against Vibrio cholerae, the causative agent of cholera. The biofilm inhibitory activity of actinomycetes was assessed using biofilm assay and was confirmed using air-liquid interphase coverslip assay. The potential isolates were identified using ...
Williams Lauren - - 2012
OBJECTIVE: Maternal nutrition knowledge has frequently been identified as an important target for nutrition promotion interventions. The aim of the present study was to investigate whether maternal nutrition knowledge is more strongly associated with the mother's own diet or that of her child. DESIGN: Cross-sectional multivariate linear regression with interactions ...
Matsubara Shigeki - - 2012
Jaundice in hyperemesis gravidarum may cause physicians to suspect several underlying diseases. Jaundice appeared in a woman with hyperemesis gravidarum and an ultrasound revealed biliary sludge. Hydration concomitantly ameliorated the symptoms, jaundice and the biliary sludge. Another woman with hyperemesis gravidarum showed elevated aminotransferases, with biliary sludge also being present. ...
Natarajan Arutselvan - - 2012
PURPOSE: This study aims to evaluate (64)Cu-DOTA-rituximab (PETRIT) in a preclinical transgenic mouse model expressing human CD20 for potential clinical translation. PROCEDURES: (64)Cu was chelated to DOTA-rituximab. Multiple radiolabeling, quality assurance, and imaging experiments were performed. The human CD20 antigen was expressed in B cells of transgenic mice (CD20TM). The ...
Uyar Belkiz - - 2012
Laser hair removal is a relatively effective method for thick hair. Despite the risk for induction of fine hair growth, application of laser for fine dark hair is sometimes inevitable. We investigate the effects of 755-nm Alexandrite laser on fine dark facial hair and evaluate the induction rates of fine ...
Tan Sioh-Yang - - 2012
Aging has profound effects on the immune system, including thymic involution, reduced diversity of the T cell receptor repertoire, reduced effector T cell and B cell function and chronic increase of proinflammatory cytokine production by innate immune cells. The precise effects of aging on conventional dendritic cells (cDC), the main ...
Sahoo Sushama - - 2012
Epidemic dropsy (ED) results from accidental ingestion of adulterated mustard oil with argemone oil. Chief organs involved in this disease are heart, subcutaneous tissue, eyes and kidneys. Nervous system involvement is very rare. Objective manifestation of neurological involvement is even rarer. The authors report two cases from the same family, ...
Liew D - - 2012
BACKGROUND: The statin authorisation form implemented in the Netherlands in January 2009 has led to significant switching of patients from atorvastatin to generic simvastatin, but often to less than equipotent doses. We sought to assess the potential consequences of this. METHODS: A modelling analysis was undertaken using data from a ...
Akaza Narifumi - - 2012
Malassezia globosa is a major pathogen of Malassezia folliculitis (MF) and the predominant species on human skin. The aim of this study was to clarify the differences between M. globosa and other cutaneous Malassezia species, M. restricta, M. dermatis, M. sympodialis and M. furfur. The optimum growth temperature, effects of compounds of sweat and free ...
Kendler K S KS Department of Psychiatry, Virginia Commonwealth University, Richmond, VA 23298, USA. - - 2012
Our tendency to see the world of psychiatric illness in dichotomous and opposing terms has three major sources: the philosophy of Descartes, the state of neuropathology in late nineteenth century Europe (when disorders were divided into those with and without demonstrable pathology and labeled, respectively, organic and functional), and the ...
Turaka Kiran - - 2012
Multiple sclerosis (MS) is a demyelinating disease of the central nervous system and is the common cause of optic neuritis. Fingolimod, an immunosuppressive agent, is used in MS to prevent acute exacerbations. We report a case of relapsing-remitting MS treated with fingolimod. The patient presented with an acute decrease in ...
Mehta Rutvik J - - 2012
Obtaining thermoelectric materials with high figure of merit ZT is an exacting challenge because it requires the independent control of electrical conductivity, thermal conductivity and Seebeck coefficient, which are often unfavourably coupled. Recent works have devised strategies based on nanostructuring and alloying to address this challenge in thin films, and ...
Xu Fengqin - - 2012
Zinc finger proteins (ZFPs) that contain multiple cysteine and/or histidine residues perform important roles in various cellular functions, including transcriptional regulation, cell proliferation, differentiation, and apoptosis. The Cys-Cys-His-His (C(2)H(2)) type of ZFPs are the well-defined members of this super family and are the largest and most complex proteins in eukaryotic ...
Banu S - - 2012
The progress of metabolic syndrome (MetS) continues with the onset of type-2 diabetes mellitus (Type-2 DM) along with linkage to other disorders such as neurodegenerative, especially Alzheimer's disease (AD), via oxidative stress and low grade systemic inflammatory process. Type-2 DM and AD are health disorders of priority research. The treatment ...
Casiraghi Antonella - - 2012
The effect of a homologue series of nonionic surfactants, namely poly(ethylene glycol) (PEG) fatty acid esters, differing in oxyethylene (PEG 8, PEG 12, and PEG 40) and fatty acid (stearate, mono and di-laurate, and mono and di-oleate) chain lengths, on in vitro skin permeability of ketoprofen (KTP) vehicled in plasters ...
Joffe Steven - - 2012
Randomized controlled trials (RCTs) are central to evidence-based clinical and health-policy decisions. However, RCTs highlight the tension between the therapeutic obligations of the physician and the scientific obligations of the investigator. Clinical equipoise, defined as honest professional disagreement among expert clinicians about the preferred treatment, is often cited as the ...
Bartelt Alexander - - 2012
Important causes for modern epidemics such as obesity, diabetes, and cardiovascular disease are over- and malnutrition. Dietary as well as endogenous lipids are transported through the bloodstream in lipoproteins, and disturbances in lipoprotein metabolism are associated with atherosclerosis, heart disease, and diabetes. Recent findings reveal biological principles-how lipoproteins, in particular ...
Kaur Gurpreet - - 2012
The focus of the present study was to explore lead (Pb)-induced metabolic alterations vis-à-vis ultrastructural changes in wheat roots to establish Pb toxicity syndrome at a structural level. Pb (50-500 μM) enhanced malondialdehyde (an indicator of lipid peroxidation) and hydrogen peroxide content, and electrolyte leakage, thereby suggesting reactive oxygen species-induced disruption ...
Madsen Henry - - 2012
From the mid-1980s, we recorded a significant increase in urinary schistosomiasis infection rate and transmission among inhabitants of lakeshore communities in the southern part of Lake MalaƔi, particularly on Nankumba peninsula in Mangochi District. We suggested that the increase was due to over-fishing, which reduced the density of snail-eating fishes, ...
Saad Abdo M - - 2012
Abstract Objective. Gastroesophageal reflux disease (GERD) is a multifactorial disorder characterized by reflux of acidic gastric contents into the esophagus leading to tissue damage and symptoms. The role of H. pylori in the pathogenesis of GERD is controversial. Therefore, we performed a meta-analysis on the effect of H. pylori treatment ...
Kása P - - 2012
The topic of this article is the compression physics of different gum bases which can be used to prepare chewing gum tablets by direct compression. Three different gum bases, Pharmagum(®) C, M and S, were tested alone and in different combinations. The preparations were compressed with a Korsch EK0 eccentric ...
Badawy Ahmed M - - 2012
Objective. To compare the efficacy of aromatase inhibitor vs. gonadotrophin releasing hormone agonists in treating premenopausal women with uterine adenomyosis. Design. A prospective randomized controlled study. Setting. A university hospital and a private practice setting. Population. Thirty-two patients with uterine adenomyosis. Methods. Patients were randomized to receive oral letrozole (2.5 ...
Forsberg Anna M - - 2012
Abstract Objective. There are few prospective studies of the prevalence of colonic neoplasia in the normal population. In order to properly evaluate screening-protocols for colorectal cancer in risk groups (e.g., older subjects or those with a family history), it is essential to know the prevalence of adenomas and cancer in ...
Simmers T A - - 2012
Remote follow-up has proven its safety and efficacy in the literature, and indeed in daily use. It saves the patient time and travel, allows earlier detection of events, and reduces inappropriate shocks. At the same time, it is not infallible and definitely not a universal substitute for in-office visits, as ...
Guven Cahit - - 2012
Previous research using US data suggests that height, as a marker for early investments in health, is associated with better cognitive functioning in later life, but this association disappears once education is controlled for. Using an English cohort of men and women older than 50 years, we find that the association ...
Dionigi Gianlorenzo - - 2012
PURPOSE: The options for haemostasis and dissection during modern thyroid surgery include the use of a bipolar vessel sealing system and ultrasonic technology. The aim of this study was to compare these energy-based devices (EBDs) with respect to their use in open thyroidectomy. METHODS: The FOCUS Shear (F) and LigaSure ...
Golbasi Zehra - - 2012
OBJECTIVES: This cross-sectional study was conducted with the aim of determining the quality of sexual life and related factors in women with gynaecological cancers. METHODS: The study was conducted in the gynaecological oncology clinic of a state hospital. Women who were diagnosed with gynaecological cancers constituted the study population. Eighty ...
Lymperopoulos Anastasios - - 2012
Despite significant advances in pharmacological and clinical treatment, heart failure (HF) remains the number one killer disease in the western world. HF is a chronic and progressive clinical syndrome mainly characterized by reduction in left ventricular ejection fraction and adverse remodeling of the myocardium. One of its hallmark molecular abnormalities ...
Tasca Giorgio - - 2012
GNE myopathy (MIM 600737) is an autosomal recessive muscle disease caused by mutations in the UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase (GNE) gene. Besides the typical phenotype, characterized by the initial involvement of the distal leg muscles that eventually spreads proximally with sparing of the quadriceps, uncommon presentations with a non-canonical clinical phenotype, ...
Rex Karsten Fleischer - - 2012
Abstract Objective. Infection with hepatitis B virus (HBV) is endemic among Arctic populations where it may have a benign course. However, the relation of HBV to migration to low endemic areas is unknown, as it is for hepatitis D and C, and details on the influence of delta virus at ...
Kowalczyk Bartlomiej - - 2012
Microcrystals of desired sizes are important in a range of processes and materials, including controlled drug release, production of pharmaceutics and food, bio- and photocatalysis, thin-film solar cells and antibacterial fabrics. The growth of microcrystals can be controlled by a variety of agents, such as multivalent ions, charged small molecules, ...
Tousoulis D - - 2012
Coronary atherosclerosis is the pathophysiologic background of coronary artery disease. Vascular calcification is an actively regulated form of calcified tissue metabolism and a common feature of coronary atherosclerotic plaques. Interestingly, systematic research has revealed that vascular mineralization, is also a strong and independent predictor of cardiovascular morbidity and mortality. Recently, ...
Al Jafari A A - - 2012
Acetylcholinesterase (AChE)-inhibition is an area of priority research as various roles have been attributed to AChE in neurodegenerative disorders and cancer as well. In the present study, a comparative multiple 4 dimensional (4D)-approach was applied to analyze human platelet AChE-inhibition by cyclophosphamide (CP). AChE activity was assessed by measuring the ...
Batu Ezgi Deniz - - 2012
The primary systemic vasculitides in childhood are quite rare except for Henoch-Schönlein purpura and Kawasaki disease. These are usually self-limited diseases. The etiopathogenesis for most of them is not clearly understood. However, it is usually thought that environmental triggers (mostly infectious) evoke an aggravated inflammatory response in susceptible individuals. The ...
Rösler Frank - - 2012
The goal of behavioral neuroscience is to map psychological concepts onto physiological and anatomical concepts and vice versa. The present paper reflects on some of the hidden obstacles that have to be overcome in order to find unique psychophysiological relationships. These are, among others: (1) the different status of concepts ...
Bloesch Emily K - - 2012
Recent research has shown that being able to interact with an object causes it to be perceived as being closer than objects that cannot be interacted with. In the present study, we examined whether that compression of perceived space would be experienced by people who simply observed such interactions by ...
Geng Hongwei - - 2012
Kernel texture is a major factor influencing the classification and end use properties of wheat (Triticum aestivum L.), and is mainly controlled by the Puroindoline a (Pina) and Puroindoline b (Pinb) genes. Recently, a new puroindoline gene, Puroindoline b-2 (Pin b-2), was identified. In this study, 388 wheat cultivars and ...
Sui Zhixian - - 2012
Background. Women who are overweight or obese during pregnancy are at increased risk of a number of adverse pregnancy outcomes. Objective. To systematically review the literature to assess the benefits and harms of an exercise intervention for pregnant women who are overweight or obese. Search strategy. A literature search of ...
Farra N - - 2012
Rett syndrome (RTT) is a neurodevelopmental autism spectrum disorder caused by mutations in the methyl-CpG-binding protein 2 (MECP2) gene. Here, we describe the first characterization and neuronal differentiation of induced pluripotent stem (iPS) cells derived from Mecp2-deficient mice. Fully reprogrammed wild-type (WT) and heterozygous female iPS cells express endogenous pluripotency ...
Rustad James R - - 2012
Reactions involving minerals and glasses in water are slow and difficult to probe spectroscopically but are fundamental to the performance of oxide materials in green technologies such as automotive thermoelectric power generation, CO(2) capture and storage and water-oxidation catalysis; these must be made from geochemically common elements and operate in ...
Cohen J - - 2012
In this paper, we examine the clinical and economic challenges that face developers of and payers for personalized drugs and companion diagnostics. We review and summarize clinical, regulatory and reimbursement issues with respect to eight, high profile personalized medicines and their companion diagnostics. Subsequently, we determine Medicare parts B and ...
Ballal Mamatha - - 2012
The authors report a rare case of diarrhea caused by Moraxella osloensis in a pediatric child with Hemolytic Uremic Syndrome/Acute Renal Failure (HUS/ARF). A 6-y-old boy was referred to the Pediatric Unit with a 3 d history of bloody diarrhea with mucus and fever and decreased urine output for 6 d. Microbiological ...
Duce Celia - - 2012
In this work, we characterized paint reconstructions using ovalbumin and casein as binders, and cinnabar (HgS) as a pigment, before and after artificial ageing. Egg and casein are common paint binders that were used historically in the technique of tempera painting. Despite extensive research on the identification of proteinaceous binders ...
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