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Alavez Silvestre S Buck Institute for Research on Aging, Novato, CA 94945, USA. - - 2012
Over the last 10 years, various screens of small molecules have been conducted to find long sought interventions in aging. Most of these studies were performed in invertebrates but the demonstration of pharmacological lifespan extension in the mouse has created considerable excitement. Since aging is a common risk factor for several ...
Kwon Jeongho - - 2012
Sqstm1/p62 functions in the non-canonical activation of nuclear factor (erythroid-derived 2)-like 2 (Nrf2). However, its physiological relevance is not certain. Here, we show that p62(-/-) mice exhibited an accelerated presentation of ageing phenotypes, and tissues from these mice created a pro-oxidative environment owing to compromised mitochondrial electron transport. Accordingly, mitochondrial ...
Subesinghe Manil - - 2012
A 52-year-old female smoker presenting with unexplained weight loss underwent CT and FDG PET/CT imaging, which demonstrated an extremely hypermetabolic mediastinal mass with calcification, necrosis, and features of local invasiveness. Mediastinoscopy and biopsy were followed by successful surgical resection of an encapsulated mass showing the typical histologic features of follicular ...
Onyon Clare - - 2012
Background:  Problem-based learning (PBL) is a teaching method where the use of clinical problems is the starting point for learning, and it is through the process of working through these problems that students acquire the knowledge and skills required to be a doctor. Context  Many advantages of PBL over traditional ...
Arrowsmith Fiona E - - 2012
Aim  The aim of this study was to measure resting energy expenditure (REE) and energy intake in children with quadriplegic cerebral palsy (CP), to relate these to anthropometric measurements, and to determine the influence of nutritional rehabilitation on REE. Methods  Fifty-six children (20 females, 36 males; age range 3y 11mo-18y; ...
Nguyen Vien X - - 2012
Unilateral hypermetabolic lesion of parotid gland demonstrated on PET/CT imaging may originate from a large spectrum of benign or malignant processes, such as adenoma, Warthin's tumor, oncocytic neoplasm, lymphoma, and primary or secondary malignancy of the gland. Bilateral and multifocal parotid gland disease is less common but possible because of ...
Chun Linda J - - 2012
: The aim of this study was to determine the morbidity of a defunctioning loop ileostomy and the subsequent closure rate, and to identify the predictors of complications and nonclosure of stoma. : This study is a retrospective review of a single-institution experience. : All patients who underwent a planned ...
Schumacher Silvia - - 2012
To develop a theoretical model for riboflavin ultraviolet-A cross-linking treatment that can predict the increase in stiffness of the corneal tissue as a function of the ultraviolet intensity and riboflavin concentration distribution, as well as the treatment time. A theoretical model for calculating the increase in corneal cross-linking (polymerization rate) ...
Miller Lisa - - 2012
Background:  Over the last few years the London Deanery has offered workshops in supervision skills for clinical teachers. In response to the concern that supervision conversations are time consuming, we devised an exercise to promote the ability to carry out a small piece of supervision that can nudge forwards an ...
McEvoy Michelle - - 2012
Objectives:  Virtual patients are used across a variety of clinical disciplines for both teaching and assessment, but are they an appropriate environment in which to develop professional skills? This study aimed to evaluate students' perceived effectiveness of an online interactive virtual patient developed to augment a personal professional development curriculum, ...
Rakheja Rajan - - 2012
A 29-year-old male presented with a 6-month history of left hip pain. Radiography and CT demonstrated a 6-cm lytic lesion of the left acetabulum. F-18 FDG PET for staging of the biopsy-proven malignant PEComa demonstrated intense hypermetabolism corresponding to the lytic left acetabulum. The patient underwent left hemipelvectomy with reconstructive ...
Agrawal Archi - - 2012
We report the imaging findings in extra-articular chondrocalcinosis in a 53-year-old man with swelling and pain in right scapular area for 1 year. Plain radiography showed a right scapular area calcific mass. The clinical suspicion was of a soft tissue sarcoma. As a part of diagnostic workup, a bone scan ...
Smith Samantha E - - 2012
Background:  The General Medical Council mandates that UK medical graduates must be able to 'prescribe drugs safely, effectively and economically'. However, data from three UK medical schools show that graduates are poorly prepared for prescribing, and a recent study detected a prescribing error rate of 8.4 per cent amongst foundation year 1 ...
Courville Xan F - - 2012
Objective. To perform a cost-effectiveness analysis to evaluate preoperative use of mupirocin in patients with total joint arthroplasty (TJA). Design. Simple decision tree model. Setting. Outpatient TJA clinical setting. Participants. Hypothetical cohort of patients with TJA. Interventions. A simple decision tree model compared 3 strategies in a hypothetical cohort of patients with TJA: (1) obtaining ...
Auchus Mary Louise - - 2012
In 2005, results from the Arimidex, Tamoxifen Alone or in Combination (ATAC) trial ushered in a new era of endocrine therapy for hormone-responsive malignancies. This study demonstrated that, compared with tamoxifen (a selective estrogen receptor modulator), anastrozole (aromatase inhibitor [AI]) prolonged time to recurrence and disease-free survival for postmenopausal women ...
Hassan Fahim Ul - - 2012
A 46-year-old man, with a history of bilateral amputations, presented with a long-standing chronic nonhealing wound at the left below-knee amputation, which was sustained after a crush injury. The patient was referred for a bone scan to exclude osteomyelitis of the left stump. The bone scan showed increased uptake in ...
Kaiser Andreas M - - 2012
: Continent ileostomy is an alternative for patients who are either not candidates for an ileo-anal pullthrough or in whom an ileo-anal pullthrough failed. We previously described a new type of continent ileostomy (T-pouch) with a nonintussuscepting valve. : This study performed an outcomes analysis of the first 10 years ...
Piciu Doina - - 2012
Papillary thyroid microcarcinoma is defined as a papillary thyroid cancer measuring <10 mm in its largest diameter. We present the scan images of a 36-year-old white woman, with the diagnosis of an incidental papillary thyroid microcarcinoma of 2 mm developed from lymphatic thyroiditis, associated with an invasive papillary thyroid carcinoma ...
Lucchinetti Eliana - - 2012
Two preconditioning stimuli should induce a more consistent overall cell protection. We hypothesized that remote ischemic preconditioning (RIPC, second preconditioning stimulus) applied during isoflurane inhalation (first preconditioning stimulus) would provide more protection to the myocardium of patients undergoing on-pump coronary artery bypass grafting. In this placebo-controlled randomized controlled study, patients ...
Im Hyung-Jun - - 2012
PURPOSE:: To assure the surgical completeness of the bilateral axillo-breast approach (BABA) endoscopic thyroidectomy (ET), we compared ET and open thyroidectomy (OT) by means of the radioactive iodine (RAI) uptake of remnant thyroid. MATERIALS AND METHODS:: From January 2003 to May 2007, 46 patients who had received RAI ablation after ...
Manohar Kuruva - - 2012
Metastases are the most common intraocular malignancy. Determination of the primary site and entire burden of disease as a part of initial staging is important in choosing the most appropriate management strategy. F-18 FDG PET/CT can demonstrate primary neoplasms and the whole-body total burden of disease. We present 2 cases ...
Park In Ja - - 2012
The robotic system offers potential technical advantages over laparoscopy for total mesorectal excision with radical lymphadenectomy for rectal cancer. However, the requirement for fixed docking limits its utility when the working volume is large or patient repositioning is required. The purpose of this study was to evaluate short-term outcomes associated ...
Wuang Yee-Pay - - 2012
Aim  To examine the internal consistency, test-retest reliability, and responsiveness of the Movement Assessment Battery for Children-Second Edition (MABC-2) Test for children with developmental coordination disorder (DCD). Method  One hundred and forty-four Taiwanese children with DCD aged 6 to 12 years (87 males, 57 females) were tested on three separate occasions: ...
McFarlane Michelle M Ophthalmology and Vision Sciences and, The Hospital for Sick Children, Toronto, Ontario, - - 2012
To investigate the relationship between long-term glycemic control and photopic negative response (PhNR) changes in the blue flash ERG in adolescents with type 1 diabetes (T1D) without diabetic retinopathy (DR). After light adaptation, ERG responses to 1.60 cd·s/m(2) blue (420 nm) flashes (blue flash ERG) and 3.0 cd·s/m(2) white flashes ...
Ambrosini Valentina - - 2012
A case of Erdheim-Chester disorder, a rare non-Langerhans' cell histiocytosis, was referred for restaging by F-18 FDG PET/CT more than 10 years after initial diagnosis. The patient presented diabetes insipidus, hypergondotropic hypogonadism, and osteosclerotic lesions. Previous bone scintigraphy documented pathognomonic long bones' involvement. Chronic steroid and hormone replacement therapy was ...
Gadoud Amy - - 2012
Background:  All newly qualified doctors will look after patients in the last stages of life. Context:  This article is a review of the literature regarding medical students learning from hospice patients, focusing on practical concerns of relevance to those involved in organising or conducting medical student teaching. Innovation:  Medical students ...
Waters Joshua A - - 2012
: Single-port laparoscopy remains a novel technique in the field of colorectal surgery. Several small series have examined its safety for colon resection. : Our aim was to analyze our entire experience and short-term outcomes with single-port laparoscopic right hemicolectomy since its introduction at our institution. We assert that this ...
Mertens Jeroen - - 2012
Many reports in the literature have focused on FDG PET imaging at conventional (60 minutes after injection) or delayed (several hours after injection) intervals, which exploits increased glycolysis in tumors for diagnosis. However, in rapidly growing tumors, accelerated glycolysis is, among other factors, mediated by hypoxia and poor perfusion. Interestingly, ...
Rijcken Emile - - 2012
: Single-incision laparoscopic surgery is a development in the field of minimally invasive surgery that is being increasingly used for colorectal procedures. : We report on the short-term results of single-port laparoscopic ileocolic resection in patients with ileocecal Crohn's disease. : This investigation is a retrospective matched-pair control study. Data ...
Gupta Pushpender - - 2012
Because bone-seeking radiopharmaceuticals are excreted into the urine by the kidneys, normal kidneys and bladder are well visualized on skeletal scintigrams leading to incidental detection of urinary tract abnormalities in up to 15% of bone scans. Although the findings pertaining to the urinary tract on skeletal scintigraphy are seldom suggestive ...
Tita Alan T N - - 2012
Higher-dose oxytocin is more effective than lower-dose regimens to prevent postpartum hemorrhage after cesarean delivery. We compared two higher-dose regimens (80 units and 40 units) to our routine regimen (10 units) among women who delivered vaginally. In a double-masked randomized trial, oxytocin (80 units, 40 units, or 10 units) was ...
Mestre-Fusco Antoni - - 2012
A 28-year-old man with headache, nausea, and decreased vision had a left parieto-occipital tumor demonstrated by MRI. Postradical resection and histology showed a solid mass containing rhabdoid cells, 10% positive for Ki-67. After completing chemotherapy and radiotherapy treatment, follow-up MRI revealed possible tumoral recurrence. Cerebral F-18 FDG PET revealed no ...
Zevit Noam - - 2012
Background:  Helicobacter pylori-associated disease has led to aggressive diagnostic and eradication protocols that are partially responsible for the decrease in prevalence of H. pylori carriage. Recent evidence indicates that in low-prevalence populations, H. pylori may have protective effects on allergic diseases. The aim of this study was to explore the relationship between ...
Billionnet Cécile - - 2012
Air pollution constitutes a major public health concern because of its ubiquity and of its potential health impact. Because individuals are exposed to many air pollutants at once that are highly correlated with each other, there is a need to consider the multi-pollutant exposure phenomenon. The characteristics of multiple pollutants ...
Messaris Evangelos - - 2012
: Early readmission after discharge from the hospital is an undesirable outcome. Ileostomies are commonly used to prevent symptomatic anastomotic complications in colorectal resections. : The aim of this study was to identify factors predictive of readmission after colectomy/proctectomy and diverting loop ileostomy. : This study is a retrospective review. ...
Stefanelli Antonella - - 2012
We report a case of a patient with relapse of POEMS syndrome (peripheral neuropathy, organomegaly, endocrinopathy, monoclonal plasma proliferative disorder, skin changes) that occurred 6 years after an autologous peripheral blood stem cell transplantation. F-18 FDG PET/CT showed several hypermetabolic as well as nonhypermetabolic bone lesions. Based on these findings, ...
Ku┼║bicki Lukasz - - 2012
Early cutaneous melanomas may present a substantial diagnostic challenge. We have already reported that expression of cyclooxygenase-2 (COX-2) may be useful for differentiating between cutaneous melanomas and naevi. The purpose of this study was to examine the value of COX-2 in a challenging task of differential diagnosis of early melanomas ...
Price Matthew A MA Department of Medical Affairs, International AIDS Vaccine Initiative, New York, NY, USA. - - 2012
To identify and describe populations at risk for HIV in 3 clinical research centers in Kenya and South Africa. Prospective cohort study. Volunteers reporting recent sexual activity, multiple partners, transactional sex, sex with an HIV-positive partner, or, if male, sex with men (MSM; in Kenya only) were enrolled. Sexually active ...
He Wenting - - 2012
Poly(adenosine diphosphate [ADP]-ribose) polymerase 1 (PARP1), a protein involved in the DNA repair mechanism, plays an important role in carcinogenesis. In this study, we investigated whether single nucleotide polymorphisms of PARP1 contribute to gastric cancer (GC) and its precursor lesions (gastric precancerous lesions; GPL) in a case-control study conducted in ...
Seet Li-Fong - - 2012
To investigate the expression of SPARC and matrix metalloproteinases (MMPs) in normal conjunctiva and pterygium tissues. This study involved paired control or uninvolved conjunctiva and pterygium tissue from 21 patients. Quantitative real-time PCR was performed to assess SPARC and MMP mRNA expression, whereas Western blot analysis was performed to assess ...
Handa Victoria L VL Department Gynecology and Obstetrics, Johns Hopkins School of Medicine, Baltimore, Maryland, USA. - - 2012
To investigate whether episiotomy, perineal laceration, and operative delivery are associated with pelvic floor disorders after vaginal childbirth. This is a planned analysis of data for a cohort study of pelvic floor disorders. Participants who had experienced at least one vaginal birth were recruited 5-10 years after delivery of their ...
Smith Simon D - - 2012
Background:  Medical error continues to significantly harm patients, notwithstanding the continued efforts to improve the situation over the past decade. We report a pilot project using high-fidelity simulation to integrate the World Health Organisation (WHO) patient safety curriculum into undergraduate medical education. Methods:  From the literature on avoidable medical error ...
Zaccagnino Maria - - 2012
Bridgette is a 6-year-old girl, who presented with sudden onset of refusal to eat or drink. The only precipitating event was a nightmare the previous night. She described a dream in which her mother and maternal aunt, dressed as witches, and father and maternal uncle, appearing as bats, wanted to ...
Schootman Mario M Departments of Medicine and Pediatrics, Division of Health Behavior Research, Washington University School of Medicine, Saint Louis, MO 63108, USA. - - 2012
To estimate the effect of hypothetical changes in modifiable predictors on the incidence of fair-to-poor self-rated health (SRH) in breast cancer survivors. In 2007-2008, we interviewed 832 breast cancer survivors 1 year after diagnosis (baseline) and 1 year later. First, multivariable logistic regression models estimated the association between the predictors ...
Kaemmerer Daniel - - 2012
: Previous studies of the intraoperative use of a hand-held gamma probe to localize metastases and primary tumors have shown improved assessment of tumor spread and changes in surgical management based on additional information gained by radioguided surgery (RGS). : The aim was to test the feasibility and advantages of ...
Hirose Yasumitsu - - 2012
: The aim of this study was to compare endoscopic macroscopic classification with fluorine-18 fluorodeoxyglucose (F-18 FDG) uptake in gastric mucosa-associated lymphoid tissue (MALT) lymphoma and to investigate the usefulness of F-18 FDG positron emission tomography (PET) for diagnosing gastric MALT lymphoma. : Sixteen patients with gastric MALT lymphoma who ...
Hentschel Michael - - 2012
: To define the appropriate scan time for fluorine-18-labeled dihydroxyphenylalanine (F-18 DOPA) PET in oncological imaging of pheochromocytomas and paragangliomas. : F-18 DOPA PET examinations were performed in 9 patients with 7 pheochromocytomas and 4 head and neck paragangliomas using a dedicated PET scanner. The acquisition started with a dynamic ...
Pak Kyoungjune - - 2012
: There are various etiologies, which can result in nonosseous, nonurologic uptake in bone scintigraphy. This study aimed to evaluate the influence of the interval between gadolinium (Gd)-containing contrast of MRI and Tc-99m DPD (Tc-99m 3,3-diphosphono-1,2-propanedicarboxylic acid) on bone scintigraphy. : We retrospectively analyzed 1028 patients with bone scintigraphy performed ...
Chen Joan - - 2012
There have been recent concerns about the safety of proton pump inhibitors (PPIs). We focus here on 3 specific concerns-the possible interaction between PPIs and clopidogrel, the postulated link between PPI use and fractures, and the possibility that long-term PPI use might lead to hypomagnesemia. There is evidence for an ...
Kahler Christopher W - - 2012
High levels of trait hostility are associated with wide-ranging interpersonal deficits and heightened physiological response to social stressors. These deficits may be attributable in part to individual differences in the perception of social cues. The present study evaluated the ability to recognize facial emotion among 48 high hostile (HH) and ...
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