Search Results
Results 1 - 50 of 2994
1 2 3 4 5 6 7 8 9 10 >
Szewka Aimee J AJ Department of Ophthalmology, Emory University School of Medicine, Atlanta, GA, - - 2013
Increased body mass index (BMI) has been associated with increased risk of idiopathic intracranial hypertension (IIH), but the relationship of BMI to visual outcomes in IIH is unclear. A retrospective chart review of all adult cases of IIH satisfying the modified Dandy criteria seen at our institution between 1989 and ...
F Mearin - - 2012
Dyspepsia and functional dyspepsia represent a highly significant public health issue. A good definition of dyspepsia is key for helping us to better approach symptoms, decision making, and therapy indications.During the last few years many attempts were made at establishing a definition of dyspepsia. Results were little successful on most ...
J Rodríguez-Sánchez - - 2012
Among the many complications of celiac disease, mesenteric lymph node syndrome cavitated is considered one of the rarest, there is few case series published in the literature. The etiology and pathophysiology are unknown but because of its high mortality rate, estimated to be around 50%, it should recognize at an ...
C Jimeno-Ayllón - - 2012
Aim: to study the possible differences in the final diagnosis of chronic pancreatitis by using standard classification described by Wiersema et al. and the new classification proposed recently by Rosemont.Material and methods: forty-seven patients with the diagnosis of chronic pancreatitis were included in this study. The parenchymal and ductal criteria ...
Vaidya Rahul - - 2012
Stabilization after a pelvic fracture can be accomplished with an anterior external fixator. These devices are uncomfortable for patients and are at risk for infection and loosening, especially in obese patients. As an alternative, we recently developed an anterior subcutaneous pelvic internal fixation technique (ASPIF). We asked if the ASPIF ...
Lohi Olli - - 2012
Congenital fibrosarcomas are malignant tumors that arise in soft tissues. In infants this unique tumor does not commonly metastasize, even though there may be local recurrences. We report here a boy who had congenital fibrosarcoma in his right foot, which was completely excised at the age of 3 days. Four ...
Mitchell Jonathan A - - 2012
The study's purpose was to determine whether time spent in screen-based sedentary behavior is associated with change in cardiorespiratory fitness (CRF) levels in children from age 11 to 13, adjusting for vigorous physical activity (VPA). Participants were children (n = 2097) enrolled in the control arm of the HEALTHY Study, ...
Farr Joshua Nicholas JN Department of Physiological Sciences, The University of Arizona, Tucson, AZ 85721-0093, USA. - - 2012
Fat contained within skeletal muscle is strongly associated with obesity, type 2 diabetes mellitus, and metabolic syndrome. Physical inactivity may be a risk factor for greater fat infiltration within skeletal muscle during growth. We sought to examine the relationship between physical activity and skeletal muscle fat content of the calf ...
Papageorgiou Peter C - - 2012
By inducing BK (bradykinin)-stimulated adrenomedullary catecholamine release, bolus injection of the β-fragment of activated plasma coagulation Factor XII (β-FXIIa) transiently elevates BP (blood pressure) and HR (heart rate) of anaesthetized, vagotomized, ganglion-blocked, captopril-treated bioassay rats. We hypothesized that intravenous infusion of β-FXIIa into intact untreated rats would elicit a qualitatively ...
van Steenbergen Henk - - 2012
Negative affect in healthy populations regulates the appraisal of demanding situations, which tunes subsequent effort mobilization and adjustments in cognitive control. In the present study, we hypothesized that dysphoria in depressed individuals similarly modulates this adaptation, possibly through a neural mechanism involving serotonergic regulation. We tested the effect of dysphoria ...
Chen Min-Hsuan - - 2012
As part of the visual cycle, the retinal chromophore in both rod and cone visual pigments undergoes reversible Schiff base hydrolysis and dissociation following photobleaching. We characterized light-activated release of retinal from a short-wavelength-sensitive cone pigment (VCOP) in 0.1% dodecyl maltoside using fluorescence spectroscopy. The half-time (t(1/2)) of release of ...
Nastrucci Candida - - 2012
Discovery, isolation, biochemical/pharmacological characterization, pre-clinical and clinical trials of drugs derived from the marine environment are continuously developing and increasing. One of the most promising area is cancer therapy. Currently, there are two drugs approved by the Food and Drug Administration (FDA) and European Agency for the Evaluation of Medicinal ...
Olsen Marianne - - 2012
Several large biobanks comprising umbilical cord blood samples have been established allowing efforts to characterize the prevalence and risk factors for preleukemic cell clones in healthy newborns. This study explores the feasibility of demonstrating translocation ETV6-RUNX1 transcripts by reverse transcription polymerase chain reaction in newborns enrolled in a large Danish ...
Liu Yaoyang - - 2012
Systemic lupus erythematosus (SLE) is a chronic disabling autoimmune disease that significantly impacts the quality of life of patients, and can associate with several complications including end-stage renal disease and shortened lifespan. A central component in the pathogenesis of SLE is the B-cell production of autoantibodies to multiple self-antigens. Since, ...
Li Min - - 2012
Type 1 diabetes mellitus is caused by the autoimmune destruction of β cells within the islets. In recent years, innate immunity has been proposed to play a key role in this process. High-mobility group box 1 (HMGB1), an inflammatory trigger in a number of autoimmune diseases, activates proinflammatory responses following ...
Uhm Tae Gi - - 2012
DNA methylation may regulate gene expression by restricting the access of transcription factors. We have previously demonstrated that GATA-1 regulates the transcription of the CCR3 gene by dynamically interacting with both positively and negatively acting GATA elements of high affinity binding in the proximal promoter region including exon 1. Exon ...
Hooper Lisa M - - 2012
Primary care physicians play a significant role in depression care, suicide assessment, and suicide prevention. However, little is known about what factors relate to and predict quality of depression care (assessment, diagnosis, and treatment), including suicide assessment. The authors explored the extent to which select patient and physician factors increase ...
Talisuna-Alamo Stella S Medical Department, Reach Out Mbuya HIV/AIDS Initiative, Kampala, Uganda. - - 2012
We evaluated the benefit of socioeconomic support (S-E support), comprising various financial and nonfinancial services that are available based on assessment of need, in reducing mortality and lost to follow-up (LTFU) at Reach Out Mbuya, a community-based, antiretroviral therapy program in Uganda. Retrospective observational cohort data from adult patients enrolled ...
Culshaw Abigail A Medical Research Council Human Immunology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Oxford, United - - 2012
The sequence diversity that exists between HIV-1 strains presents a major obstacle to the design of a vaccine that will be effective on a global scale. Focusing on highly conserved cytotoxic T-lymphocyte epitopes as vaccine targets has been called into question by evidence that variation within epitope flanking regions can ...
Best Brookie M BM Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, CA 92093-0719, USA. - - 2012
Tenofovir is a nucleotide HIV reverse transcriptase inhibitor whose chemical properties suggest that it may not penetrate into the central nervous system in therapeutic concentrations. The study's objective was to determine tenofovir's penetration into cerebrospinal fluid (CSF). CNS HIV Antiretroviral Therapy Effects Research is a multicenter observational study to determine ...
Wilson Kristy J KJ Purdue University College of Pharmacy and Purdue University Center for Cancer Research, West Lafayette, IN 47907-2064, - - 2012
The ErbB4 receptor tyrosine kinase possesses both tumour suppressor and oncogenic activities. Thus pharmacological agents are needed to help elucidate ErbB4 functions. However, limitations of existing ErbB4 agonists and antagonists have led us to seek novel ErbB4 antagonists. The Q43L mutant of the ErbB4 agonist NRG2β (neuregulin 2β) stimulates ErbB4 ...
Jasti Susmita S Department of Anatomy and Cell Biology, University of Kansas Medical Center, Kansas City, Kansas 66160, - - 2012
Loss-of-function mutations in the autoimmune regulator (AIRE) gene are responsible for autoimmune polyglandular syndrome type 1 (APS-1), which commonly manifests as infertility in women. AIRE is a transcriptional regulator that promotes expression of tissue-restricted antigens in the thymus, including antigens specific to the ovary. Thymic expression of ovarian genes under ...
Schneider Michael F MF Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, - - 2012
Plasma HIV-1 RNA was measured in 306 samples, collected from 273 highly active antiretroviral therapy-experienced men, using both the Roche COBAS TaqMan (limit of detection = 20 copies per milliliter) and Roche Amplicor (limit of detection = 50 copies per milliliter) assays. Mixtures of Gaussian distributions incorporating left-censored data were ...
May Lauren T LT Department of Pediatrics, University of Colorado School of Medicine, Aurora, CO, - - 2012
Undifferentiated (embryonal) sarcoma of the liver is a rare malignant tumor, most commonly seen in children aged 6 to 10 years. Previously believed to carry a poor prognosis, more recent reports indicate that treatment regimens combining surgical resection and adjuvant chemotherapy can yield long-term, disease-free survival. In this study, we ...
Pyr Dit Ruys Sébastien - - 2012
eEF2K [eEF2 (eukaryotic elongation factor 2) kinase] phosphorylates and inactivates the translation elongation factor eEF2. eEF2K is not a member of the main eukaryotic protein kinase superfamily, but instead belongs to a small group of so-called α-kinases. The activity of eEF2K is normally dependent upon Ca(2+) and calmodulin. eEF2K has ...
Turner Robert - - 2012
Dancers frequently present with hip pain. The etiology of this pathology has not been clearly identified from an anatomical perspective. Structural variations including hip dysplasia and dynamic variables from the foot to the pelvis will be discussed. Understanding the etiology as a structural entity, neuromuscular entity or a combination of ...
Gosiengfiao Yasmin - - 2012
It remains unclear how to optimally incorporate gemcitabine and docetaxel into the management of patients with recurrent osteosarcoma. We describe 4 pediatric patients with recurrent osteosarcoma who were treated with gemcitabine ± docetaxel and resection. One patient had a partial response and 2 had stable disease. Two patients subsequently underwent ...
Razansky Daniel D Institute for Biological and Medical Imaging (IBMI), Technische Universität München and Helmholtz Zentrum München, Ingolstädter Landstraβe 1, 85764 Neuherberg, Germany. - - 2012
For centuries, biological discoveries were based on optical imaging, in particular microscopy but also several chromophoric assays and photographic approaches. With the recent emergence of methods appropriate for bio-marker in vivo staining, such as bioluminescence, fluorescent molecular probes and proteins, as well as nanoparticle-based targeted agents, significant attention has been ...
Solivio Morwena J - - 2012
Oxidative DNA-protein cross-links have received less attention than other types of DNA damage and remain as one of the least understood types of oxidative lesion. A model system using ribonuclease A and a 27-nucleotide DNA was used to determine the propensity of oxidative cross-linking to occur in the presence of ...
May John F JF Department of Biochemistry, University of Wisconsin-Madison, Madison, Wisconsin 53706-1544, United - - 2012
Even in the absence of a template, glycosyltransferases can catalyze the synthesis of carbohydrate polymers of specific sequence. The paradigm has been that one enzyme catalyzes the formation of one type of glycosidic linkage, yet certain glycosyltransferases generate polysaccharide sequences composed of two distinct linkage types. In principle, bifunctional glycosyltransferases ...
Joseph Wout - - 2012
ABSTRACT-: In situ electromagnetic (EM) radio frequency (RF) exposure to base stations of emerging wireless technologies is assessed at 311 locations, 68 indoor and 243 outdoor, spread over 35 areas in three European countries (Belgium, The Netherlands, and Sweden) by performing narrowband spectrum analyzer measurements. The locations are selected to ...
Shizuma Kiyoshi - - 2012
Radiological investigations of fallout from the atomic bomb detonated over Hiroshima city on 6 August 1945 are important to estimate doses for inhabitants. The authors have analyzed the concentrations of (137)Cs, (235)U, and (238)U in streaks of black rain caused by the atomic bomb using gamma-ray spectroscopy and the ICP-QMS ...
Sasaki Masato - - 2012
To prevent recurrence of cerebrovascular disease (CVD), adequate control of blood pressure (BP) is extremely important for the treatment of hypertensive CVD patients. As absence of the nocturnal fall of BP by the expected 10-20% from daytime levels is reported to exaggerate target organ injury, 24-h ambulatory blood pressure monitoring ...
Komoto Shintaro - - 2012
Most living organisms exhibit circadian rhythms that are generated by endogenous circadian clocks, the master one being present in the suprachiasmatic nuclei (SCN). Output signals from the SCN are believed to transmit standard circadian time to peripheral tissue through sympathetic nervous system and humoral routes. Therefore, the authors examined the ...
Solmaz Fevzi - - 2012
Abstract Conclusion: Sensorineural hearing loss (SNHL) is a neurological situation and celiac disease (CD) may be seen coincidentally. Children with clinical signs of hearing deficiency of unknown etiology should be assessed for CD. Objective: CD is a chronic inflammatory gluten-dependent intestinal disease and has extraintestinal findings. The aim of this ...
Seggio Joseph A - - 2012
Alcohol consumption causes disruptions in a variety of daily rhythms, including the sleep-wake cycle. Few studies have explored the effect of alcohol exposure only during developmental stages preceding maturation of the adult circadian clock, and none have examined the effects of alcohol on clock function in Drosophila. This study investigates ...
Gray Joel E - - 2012
A handheld portable dental intraoral x-ray system is available in the United States and elsewhere. The system is designed to minimize the user's radiation dose. It includes specially designed shielding of the x-ray tube housing and an integral radiation shield to minimize backscatter. Personnel radiation dose records were obtained from ...
Utpala-Kumar Ranjani - - 2012
The present study tests the perceived norms hypothesis in relation to different levels of heavy episodic drinking (HED) among university students. In 2007, 303 students from residence halls and the School of Psychology at the University of Wollongong, Australia, completed a questionnaire about their alcohol consumption and associated attitudes and ...
Flegal F N - - 2012
Currently, the dicentric chromosome assay (DCA) is used to estimate radiation doses to individuals following accidental radiological and nuclear overexposures when traditional dosimetry methods are not available. While being an exceptionally sensitive method for estimating doses by radiation, conventional DCA is time-intensive and requires highly trained expertise for analysis. For ...
Koski-Jännes Anja - - 2012
This study, funded by the Academy of Finland, explores how different stakeholder groups in Finland attribute responsibility for various addictions. A random general population survey and surveys with addiction treatment professionals and clients (n = 1,338) were conducted in 2007-2008. The data were analyzed with analyses of variance and logistic ...
Skuterud Lavrans - - 2012
ABSTRACT-: The Chernobyl fallout is an enduring challenge to reindeer husbandry in Norway, and South Sámi reindeer herders in central and southern Norway are as contaminated by Cs as inhabitants close to Chernobyl. Therefore, Norwegian authorities continuously recommend to these reindeer herders the use of countermeasures to reduce their intake ...
Hegenbart Lars - - 2012
ABSTRACT-: Voxel2MCNP is a program that sets up radiation protection scenarios with voxel models and generates corresponding input files for the Monte Carlo code MCNPX. Its technology is based on object-oriented programming, and the development is platform-independent. It has a user-friendly graphical interface including a two- and three-dimensional viewer. A ...
Polednak Anthony P - - 2012
Apparent per-capita alcohol consumption in 2001 in four US regions (West, Northeast, South, and Midwest), and in 50 states was examined in relation to mortality rates (1999-2004) from liver cirrhosis and for the subcategory alcoholic liver disease. Alcohol consumption and mortality rates were highest in the west. The alcoholic liver ...
Bastianini Stefano - - 2012
A daily rhythm of blood pressure (BP), with maximum values in the activity period, carries important prognostic information. The extent to which this rhythm depends on behavioral factors remains debated. Mice are the species of choice for functional genomics. In mice, episodes of wakefulness and sleep are not restricted to ...
Farah Christopher - - 2012
ABSTRACT-: Prolonged radon exposure has been linked to lung cancer. Cancer registry data indicates excess risk for age-adjusted lung cancer in Maine. Maine's mean residential radon activity exceeds the EPA maximum contaminant level (MCL). This paper describes the application of spatial autocorrelation methods to retrospective data as a means of ...
Hackett Tillie-Louise - - 2012
We currently understand little about the mechanisms that lead to airway remodeling in asthma. The origin of the mesenchymal cells that contribute to fibrosis of the airway is poorly understood. However, emerging evidence suggests that the airway epithelium could contribute to airway remodeling through the process of epithelial-mesenchymal transition (EMT) ...
Emond Christy A - - 2012
ABSTRACT-: The terrorist use of a radiological dispersal device (RDD) has been described as "not if, but when" (). Exposures from such an event could occur by a number of routes including inhalation, wound contamination, or embedded fragments. Several of the radionuclides thought to be potential RDD components are metals ...
Sarin Enisha - - 2012
The study was conducted from August to December 2007 , in two urban, poor neighborhoods in Delhi. A respondent-driven sampling was used to recruit 343 injection drug users who were interviewed with a survey questionnaire that included items of human rights abuses, health service utilization, and sociodemographic characteristics. Multivariate logistic ...
Jiang Xinwei - - 2012
Context: Heart failure (HF) is a progressive deterioration in heart function associated with overactivity of the sympathetic nervous system. Elevated sympathetic nervous system activity down regulates the β-adrenergic signal system, suppressing β-adrenoceptors (β-ARs)-mediated contractile support in the failing heart. Objective: We investigated the effects of β(2)-AR gene transfer on shortening ...
Conroy Deirdre A - - 2012
Sleep disturbances in alcohol-dependent (AD) individuals may persist despite abstinence from alcohol and can influence the course of the disorder. Although the mechanisms of sleep disturbances of AD are not well understood and some evidence suggests dysregulation of circadian rhythms, dim light melatonin onset (DLMO) has not previously been assessed ...
1 2 3 4 5 6 7 8 9 10 >