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Jamal Ahmed - - 2012
Effective hand hygiene has long been recognised as an important way to reduce the transmission of bacterial and viral pathogens in healthcare settings. However, many studies have shown that adherence to hand hygiene remains low, and improvement efforts have often not delivered sustainable results. The Children's Hospital at Westmead is ...
Sivey John D - - 2012
Cl<sub>2</sub> and Cl<sub>2</sub>O are highly reactive electrophiles capable of influencing rates of disinfection byproduct (DBP) precursor chlorination in solutions of free available chlorine (FAC). The current work examines how organic compound structure influences susceptibility toward chlorination by Cl<sub>2</sub> and Cl<sub>2</sub>O relative to the more abundant (but less reactive) electrophile HOCl. ...
Im Inhwan - - 2012
The leaf extract of guava (Psidium cattleianum Sabine) has traditionally been used for the treatment of diarrhea and diabetes in East Asia and other countries. Recently, the leaf extract has been employed in the therapy of cancer, bacterial infections, and inflammation in experimental models. However, the exact mechanisms of how ...
Lan Wen-Jie - - 2012
The influence of diffusional motion on the capture and release of individual nanoparticles as they are driven through a conical-shaped glass nanopore membrane (GNM) by pressure-induced flow is reported. In these experiments, one to several hundred particles are driven through the orifice of the nanopore. Following the initial translocation, the ...
Salazar M - - 2012
Junin virus (JUNV) is the aetiological agent of Argentine haemorrhagic fever. The pathogenesis of the infection is not well understood, no licensed vaccines exist and no specific antiviral therapy is available. Previous studies have demonstrated the ability of ribavirin to delay and reduce JUNV disease and virus burden in guinea ...
Carmosino Monica - - 2012
The central role of Na+-K+-2Cl- cotrasporter type 2 (NKCC2) in the vectorial transepithelial salt reabsorption in thick ascending limb cells from Henle's loop in the kidney is evidenced by the effects of loop diuretics, the pharmacological inhibitors of NKCC2, that are among the most powerful antihypertensive drugs available to date. ...
Szegezdi Eva - - 2012
Here we show by computer modeling that kinetics and outcome of signal transduction in case of hetero-oligomerizing receptors of a promiscuous ligand largely depend on the relative amounts of its receptors. Promiscuous ligands can trigger the formation of nonproductive receptor complexes, which slows down the formation of active receptor complexes ...
Ortega-Galisteo Ana P - - 2012
Peroxisomes, single-membrane-bounded organelles with essentially oxidative metabolism, are key in plant responses to abiotic and biotic stresses. Recently, the presence of nitric oxide (NO) described in peroxisomes opened the possibility of new cellular functions, as NO regulates diverse biological processes by directly modifying proteins. However, this mechanism has not yet ...
Zhao Haichao - - 2012
A series of methyl- or benzyl-capped oligoethylene glycol functionalized 2,5-dibromo-3-oxythiophenes are synthesized and successfully polymerized by either Grignard metathesis (GRIM) polymerization or reductive coupling polymerization to yield the corresponding polymers in reasonable yields and molecular weights with narrow molecular weight distribution. These synthesized polyoxythiophenes exhibit high electroactivity and stability in ...
Martinsen Elin Håkonsen - - 2012
This paper seeks to find different ways of addressing illness as an experience essential to the understanding of being a human being. As a conceptual point of departure, we suggest the notion of 'pathic existence' as developed by the German physician and philosopher Viktor von Weizsäcker (1886-1957). Through an analysis ...
Kegeles Lawrence S LS Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York, NY, USA. - - 2012
Postmortem studies have found evidence of γ-aminobutyric acid (GABA) deficits in fast-spiking, parvalbumin-positive interneurons in the prefrontal cortex in schizophrenia. Magnetic resonance spectroscopy studies in unmedicated patients have reported glutamine or glutamate-glutamine (Glx) elevations in this region. Abnormalities in these transmitters are thought to play a role in cognitive impairments ...
Inchaisri C - - 2012
The conception rate in dairy cows is dependent on a number of cow factors such as days in milk and insemination number. Unfortunately, some of these factors were not accounted for in optimal insemination and replacement decision models. By using wrong estimates of the conception rate, the calculated optimal insemination ...
Macgillivray Leonard R - - 2012
Caged: Taking its origin in recent work by Ward and co-workers, an overview is given over the synthesis of Archimedean and Platonic bodies by different approaches such as hydrogen-bonded self-assembly and coordination chemistry.
Fulmer Preston A - - 2012
Endospores are formed by various bacterial families, including Bacillus and Clostridium, in response to environmental stresses as a means to survive conditions inhospitable to vegetative growth. Although metabolically inert, the endospore must interact with its environment to determine an optimal time to return to a vegetative state, a process known ...
Bollhöner Benjamin - - 2012
Evolutionary, as well as genetic, evidence suggests that vascular development evolved originally as a cell death programme that allowed enhanced movement of water in the extinct protracheophytes, and that secondary wall formation in the water-conducting cells evolved afterwards, providing mechanical support for effective long-distance transport of water. The extant vascular ...
Blakeney Michael - - 2012
This article considers the relationship between patenting and plant variety rights protection, through a detailed analysis of the recent determination by the Extended Board of Appeal of the European Patent Office that methods for breeding broccoli and tomatoes were not patentable. It concludes that the right to patent agricultural innovations ...
Broncel Malgorzata - - 2012
Tagging protein AMPylation: A new chemical reporter for AMPylation, recently identified as a key post-translational modification during bacterial infection, is a robust tool for detecting and identifying AMPylated proteins in vitro.
Leuschner Florian F Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Simches Research Building, Boston, MA 02114, - - 2012
Monocytes (Mo) and macrophages (MΦ) are emerging therapeutic targets in malignant, cardiovascular, and autoimmune disorders. Targeting of Mo/MΦ and their effector functions without compromising innate immunity's critical defense mechanisms first requires addressing gaps in knowledge about the life cycle of these cells. Here we studied the source, tissue kinetics, and ...
Curtin Caroline M - - 2012
The ability of nano-hydroxyapatite (nHA) particles developed in-house to act as non-viral delivery vectors is assessed. These nHA particles are combined with collagen to yield bioactive, biodegradable collagen nano-hydroxyapatite (coll-nHA) scaffolds. Their ability to act as gene-activated matrices for BMP2 delivery is demonstrated with successful transfection of mesenchymal stem cells ...
Walcott Brian P - - 2012
ObjectivePediatric pial arteriovenous fistulae (pAVF) are rare vascular lesions of the CNS, reported to have up to a 25% association with hereditary hemorrhagic telangiectasia. The presentation, treatment and syndromes associated with pAVF in children are reported here.DesignA pediatric database for pAVF was retrospectively reviewed. Patients with carotid-cavernous fistulae, dural arteriovenous ...
Yang Chih-Min - - 2012
Lycopene is primarily metabolized by carotenoid monoxygenase II into apo-8'- and apo-12'-lycopenal in the rat liver. Although lycopene possesses antimetastatic activity in a highly invasive hepatoma SK-Hep-1 cell line, little is known whether its metabolites have a similar effect. In this study, we investigated the antimetastatic effects of apo-8'-lycopenal (1-10 ...
Tong Na - - 2012
ABSTRACT Genetic polymorphisms in the promoter regions of FAS, FASL and CASP8 involved in apoptotic signaling pathway were thought to be associated with susceptibility to cancer. We hypothesized whether the functional genetic variants were associated with risk of childhood acute lymphoblastic leukemia (ALL). A case-control study in a Chinese population ...
Tottori Soichiro - - 2012
A simple and general fabrication method for helical swimming micromachines by direct laser writing and e-beam evaporation is demonstrated. The magnetic helical devices exhibit varying magnetic shape anisotropy, yet always generate corkscrew motion using a rotating magnetic field. They also exhibit good swimming performance and are capable of pick-and-place micromanipulation ...
Murakami Ryo - - 2012
Drops of a particle-stabilised oil-in-water emulsion are encapsulated in air by using hydrophobic silica particles. Such systems, termed oil-in-water-in-air powdered emulsions, show free-flowing behavior. Successful preparation of the material is achieved by preventing oil droplets from creaming and coalescing.
Howitt Jason - - 2012
PTEN (phosphatase and tensin homologue deleted on chromosome TEN) is the major negative regulator of phosphatidylinositol 3-kinase signaling and has cell-specific functions including tumor suppression. Nuclear localization of PTEN is vital for tumor suppression; however, outside of cancer, the molecular and physiological events driving PTEN nuclear entry are unknown. In ...
Shi Liqiao L Institute of Molecular Medicine and Genetics, Georgia Health Sciences University, GA 30912-3000, - - 2012
The peripheral taste system presents an excellent model for studying the consequences of neural injury, for the damaged nerve and sensory cells and the neighboring, intact neural cells. Sectioning a primary afferent nerve, the chorda tympani (CT), rapidly recruits neutrophils to both sides of the tongue. The bilateral neutrophil response ...
Wu Hsin-Hui - - 2012
Mammalian MDC1 interacts with CHK2 in the regulation of DNA damage-induced S-phase checkpoint and apoptosis, which is directed by the association of MDC1-FHA and CHK2-pThr68. However, different ligand specificities of MDC1-FHA have been reported, and no structure is available. Here we report the crystal structures of MDC1-FHA and its complex ...
Kumar A - - 2012
SUMMARY: Our aim was (i) to investigate the hypothalamo-hypophyseal-gonadal axis in hyperthyroid Indian males, (ii) to rule out the modulatory role of adrenal steroids on it and (iii) to determine if the simultaneous rise in oestradiol and luteinising hormone (LH) in hyperthyroid males is due to a positive feedback action ...
Liu Chao - - 2012
Four new [6,6]-phenyl-C61 and C71 butylsaure n-dibutyl amides (PCBDBA) with mono- and bis- adduction on C60 and C70 cages respectively have been synthesized as models to study the effect of the mono- and bis- adduction on fullerene cages on device performance when used as electron acceptors with the donor of ...
Catalano S A - - 2012
All methods proposed to date for mapping landmark configurations on a phylogenetic tree start from an alignment generated by methods that make no use of phylogenetic information, usually by superimposing all configurations against a consensus configuration. In order to properly interpret differences between landmark configurations along the tree as changes ...
Bates Joshua I - - 2012
The activation of the PC bond of phosphaalkenes with electrophiles is investigated as a means to prepare and characterize unusual organophosphorus compounds. Treatment of RPCHtBu (1 a: R=tBu; 1 b: R=1-adamantyl) with HOTf (0.5 equiv) affords diphosphiranium salts [RPCHtBuPR (CH(2) tBu)]OTf ([2 a]OTf and [2 b]OTf), each containing a three-membered P(2) C ring. In contrast, ...
Walcott Brian P - - 2012
ObjectiveDural arteriovenous fistulae (dAVF) are rare vascular lesions of the CNS with potentially significant morbidity and mortality. Our experience in the treatment of children with dAVF is reported.DesignOur neurosurgical and neurointerventional pediatric database was retrospectively reviewed for patients with dAVF. Brain arteriovenous malformations, pial fistulae, vein of Galen malformations and ...
Lepillier Antoine - - 2012
AimsPermanent pacemaker (PM) implantation is temporarily contraindicated in patients (pts) with sepsis. In patients with symptomatic atrioventricular (AV) block and infection, prolonged VVI pacing is therefore usually ensured by a ventricular pacing lead (PL) connected to an external PM generator. In patients with normal sinus function and heart failure, the ...
Figueiredo T C - - 2012
We propose a bioinformatics pipeline in which we use an ESTs database to predict and validate single-nucleotide polymorphisms (SNPs) directly linked to gene-coding regions at the HLA class I genes (HLA-A, HLA-B and HLA-C). Annotation originated from our analysis revealed various classes of possible new variations that may indicate possible ...
Balaji Alexandra B - - 2012
OBJECTIVE: To identify the human immunodeficiency virus (HIV)-related risk behaviors associated with HIV testing among US high school students who reported ever having sexual intercourse. DESIGN: Secondary analysis of a cross-sectional study. SETTING: The 2009 national Youth Risk Behavior Survey. PARTICIPANTS: A total of 7591 US high school students who ...
Hassan Samira - - 2012
The flavonoid pathway produces a diverse array of plant compounds with functions in UV protection, as antioxidants, pigments, auxin transport regulators, defence compounds against pathogens and during signalling in symbiosis. This review highlights some of the known function of flavonoids in the rhizosphere, in particular for the interaction of roots ...
Li Dapeng D Baylor Institute for Immunology Research, Dallas, TX 75204, - - 2012
Dendritic cells (DCs) can initiate and shape host immune responses toward either immunity or tolerance by their effects on antigen-specific CD4(+) T cells. DC-asialoglycoprotein receptor (DC-ASGPR), a lectinlike receptor, is a known scavenger receptor. Here, we report that targeting antigens to human DCs via DC-ASGPR, but not lectin-like oxidized-LDL receptor, ...
Kabat Geoffrey C - - 2012
Incidence rates of non-Hodgkin's lymphoma (NHL) increased substantially in the United States and worldwide during the latter part of the 20(th) century, but little is known about the etiology of this condition. Antioxidant nutrients may reduce the risk of NHL by quenching free radicals, which may contribute to carcinogenesis by ...
Goldstein Benjamin I - - 2012
Bipolar disorder is one of the most severe psychiatric illnesses, particularly when onset occurs during childhood or adolescence. With recent empirical evidence, questions regarding the existence of bipolar disorder among children and adolescents have given way to questions regarding prevalence. There are substantial risks inherent in misapplying diagnoses and treatments ...
Lomonosov Alexey M - - 2012
Revealing defects and inhomogeneities of physical and chemical properties beneath a surface or an interface with in-depth nanometric resolution plays a pivotal role for a high degree of reliability in nanomanufacturing processes and in materials science more generally. Nanoscale non-contact depth-profiling of mechanical and optical properties of transparent sub-micrometric low-k ...
Zhao Hong H Department of Trauma Surgery, Tongji Hospital, Huazhong University of Science & Technology, Wuhan, - - 2012
Aquaporin-2 (AQP2) is a vasopressin-regulated water channel located in the collecting tubule and collecting duct cells of mammalian kidney. The aim of this study is to investigate whether PKCα plays a role in vasopressin-induced AQP2 trafficking in mouse inner medullary collecting duct 3 (mIMCD3) cells. AQP2-mIMCD3 stable cell line was ...
de Groot Eric P - - 2012
Asthma and allergic rhinitis are the two most common chronic disorders in childhood and adolescence. To date, no study has examined the impact of comorbid allergic rhinitis on asthma control in children. To examine the prevalence of allergic rhinitis in children with asthma, and the impact of the disease and ...
Premachandran Sudha - - 2012
Ethanol has been used to achieve thymic depletion in myasthenia gravis patients. Ethanol (95%) has also been used widely in the therapy of many tumors including hepatocellular carcinoma. In light of these findings, we delineated the differential immunotoxic behavior and mechanism of lower concentration of ethanol towards murine EL-4 lymphoma ...
Freimuth Vicki S - - 2012
Many theories of risk perception and health behavior examine cognitive dimensions of risk (i.e., perceived susceptibility or severity) but not emotional dimensions. To address this gap, the authors examined the emotional component of risk perception (as worry) and its relation to cognitive assessments of risk, self-efficacy and response efficacy, and ...
Kuiken Hendrik J - - 2012
The Nuclear factor κB (NF-κB) signaling pathway controls important cellular events such as cell proliferation, differentiation, apoptosis and immune responses. Pathway activation occurs rapidly upon TNFα stimulation and is highly dependent on ubiquitination events. Using cytoplasmic to nuclear translocation of the NF-κB transcription factor family member p65 as a read-out, ...
Uy Visith - - 2012
Background  A growing body of literature documents the value of decision support interventions (DESIs) in facilitating patient participation in preference sensitive decision making, but little is known about their implementation in routine care. Objective  This study explored barriers and facilitators to prescribing DESIs in primary care. Setting and participants  Four ...
Agesen Trude H - - 2012
Background and aimsSeveral clinical factors have an impact on prognosis in stage II colorectal cancer (CRC), but as yet they are inadequate for risk assessment. The present study aimed to develop a gene expression classifier for improved risk stratification of patients with stage II CRC.Methods315 CRC samples were included in ...
Makarov Mikhail V - - 2012
The synthesis and the antitumor activity and fluorescent properties screening of novel bisphosphonate conjugates with cytotoxic 3,5-bis((hetero)arylidene)-4-piperidone residues were performed. The facile and rapid synthetic route was based on the aza-Michael addition of NH-3,5-bis((hetero)arylidene)-4-piperidones to tetraethyl ethylidenebisphosphonate. The synthesized compounds displayed high inhibitory properties towards Caov3, A549, PC3, and KB ...
Wang Mingkui - - 2012
The use of mixed self-assembled monolayers, combining hydrophobic co-adsorbents with the sensitizer, has been demonstrated to enhance the efficiency of dye-sensitized solar cells (DSCs). Herein, the influence of the anchoring groups of the co-adsorbents on the performance of the DSCs is carefully examined by selecting two model molecules: neohexyl phosphonic ...
Zickafoose Joseph S JS Department of Pediatrics, University of Michigan, 300 N Ingalls, Ann Arbor, MI 48109, USA. - - 2012
To determine whether hospital discharges for intussusception in children younger than 1 year have changed since the reintroduction of rotavirus vaccine in the United States. Serial cross-sectional analysis. US hospitals. Children younger than 1 year with a discharge diagnosis of intussusception identified in the Kids' Inpatient Database, a series of ...
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