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Cattaneo Andrea - - 2012
Asbestos may be naturally present in rocks and soils. In some cases, there is the possibility of releasing asbestos fibres into the atmosphere from the rock or soil, subsequently exposing workers and the general population, which can lead to an increased risk of developing asbestos-related diseases. In the present study, ...
Nomura Yoko - - 2012
OBJECTIVE: To examine the independent and synergistic effects of gestational diabetes mellitus (GDM) and low socioeconomic status (SES) on neurodevelopment and attention-deficit/hyperactivity disorder (ADHD) outcomes. DESIGN: Cohort study. SETTING: Flushing, New York. PARTICIPANTS: A total of 212 preschool children as a part of the ongoing cohort study. Main Exposures  Gestational ...
Shavel Alexey - - 2012
A procedure for the continuous production of Cu2ZnSnS4 (CZTS) nanoparticles with controlled composition is presented. CZTS nanoparticles were prepared through the reaction of the metals amino-complexes with elemental sulfur in a continuous flow reactor at moderate temperatures (300ºC-330ºC). HRTEM and XRD analysis showed the nanocrystals to have a crystallographic structure ...
Bollhöner Benjamin - - 2012
Evolutionary, as well as genetic, evidence suggests that vascular development evolved originally as a cell death programme that allowed enhanced movement of water in the extinct protracheophytes, and that secondary wall formation in the water-conducting cells evolved afterwards, providing mechanical support for effective long-distance transport of water. The extant vascular ...
Blakeney Michael - - 2012
This article considers the relationship between patenting and plant variety rights protection, through a detailed analysis of the recent determination by the Extended Board of Appeal of the European Patent Office that methods for breeding broccoli and tomatoes were not patentable. It concludes that the right to patent agricultural innovations ...
Broncel Malgorzata - - 2012
Tagging protein AMPylation: A new chemical reporter for AMPylation, recently identified as a key post-translational modification during bacterial infection, is a robust tool for detecting and identifying AMPylated proteins in vitro.
Curtin Caroline M - - 2012
The ability of nano-hydroxyapatite (nHA) particles developed in-house to act as non-viral delivery vectors is assessed. These nHA particles are combined with collagen to yield bioactive, biodegradable collagen nano-hydroxyapatite (coll-nHA) scaffolds. Their ability to act as gene-activated matrices for BMP2 delivery is demonstrated with successful transfection of mesenchymal stem cells ...
Gallardo Vanessa A - - 2012
The 2,4,6-tridehydropyridine radical cation, a analog of the elusive 1,2,3,5-tetradehydrobenzene, was generated in the gas phase and its reactivity examined. Surprisingly, the tetraradical was found not to undergo radical reactions. This behavior is rationalized by resonance structures hindering fast radical reactions. This makes the cation highly electrophilic and it rapidly ...
Saint Pierre Carolina - - 2012
Realistic experimental protocols to screen for drought adaptation in controlled conditions are crucial if high throughput phenotyping is to be used for the identification of high performance lines, and is especially important in the evaluation of transgenes where stringent biosecurity measures restrict the frequency of open field trials. Transgenic DREB1A-wheat ...
Kumar A - - 2012
SUMMARY: Our aim was (i) to investigate the hypothalamo-hypophyseal-gonadal axis in hyperthyroid Indian males, (ii) to rule out the modulatory role of adrenal steroids on it and (iii) to determine if the simultaneous rise in oestradiol and luteinising hormone (LH) in hyperthyroid males is due to a positive feedback action ...
Bates Joshua I - - 2012
The activation of the PC bond of phosphaalkenes with electrophiles is investigated as a means to prepare and characterize unusual organophosphorus compounds. Treatment of RPCHtBu (1 a: R=tBu; 1 b: R=1-adamantyl) with HOTf (0.5 equiv) affords diphosphiranium salts [RPCHtBuPR (CH(2) tBu)]OTf ([2 a]OTf and [2 b]OTf), each containing a three-membered P(2) C ring. In contrast, ...
Liu Chao - - 2012
Four new [6,6]-phenyl-C61 and C71 butylsaure n-dibutyl amides (PCBDBA) with mono- and bis- adduction on C60 and C70 cages respectively have been synthesized as models to study the effect of the mono- and bis- adduction on fullerene cages on device performance when used as electron acceptors with the donor of ...
Uy Visith - - 2012
Background  A growing body of literature documents the value of decision support interventions (DESIs) in facilitating patient participation in preference sensitive decision making, but little is known about their implementation in routine care. Objective  This study explored barriers and facilitators to prescribing DESIs in primary care. Setting and participants  Four ...
Agesen Trude H - - 2012
Background and aimsSeveral clinical factors have an impact on prognosis in stage II colorectal cancer (CRC), but as yet they are inadequate for risk assessment. The present study aimed to develop a gene expression classifier for improved risk stratification of patients with stage II CRC.Methods315 CRC samples were included in ...
Makarov Mikhail V - - 2012
The synthesis and the antitumor activity and fluorescent properties screening of novel bisphosphonate conjugates with cytotoxic 3,5-bis((hetero)arylidene)-4-piperidone residues were performed. The facile and rapid synthetic route was based on the aza-Michael addition of NH-3,5-bis((hetero)arylidene)-4-piperidones to tetraethyl ethylidenebisphosphonate. The synthesized compounds displayed high inhibitory properties towards Caov3, A549, PC3, and KB ...
Wang Mingkui - - 2012
The use of mixed self-assembled monolayers, combining hydrophobic co-adsorbents with the sensitizer, has been demonstrated to enhance the efficiency of dye-sensitized solar cells (DSCs). Herein, the influence of the anchoring groups of the co-adsorbents on the performance of the DSCs is carefully examined by selecting two model molecules: neohexyl phosphonic ...
Lan Wen-Jie - - 2012
The influence of diffusional motion on the capture and release of individual nanoparticles as they are driven through a conical-shaped glass nanopore membrane (GNM) by pressure-induced flow is reported. In these experiments, one to several hundred particles are driven through the orifice of the nanopore. Following the initial translocation, the ...
Salazar M - - 2012
Junin virus (JUNV) is the aetiological agent of Argentine haemorrhagic fever. The pathogenesis of the infection is not well understood, no licensed vaccines exist and no specific antiviral therapy is available. Previous studies have demonstrated the ability of ribavirin to delay and reduce JUNV disease and virus burden in guinea ...
Freimuth Vicki S - - 2012
Many theories of risk perception and health behavior examine cognitive dimensions of risk (i.e., perceived susceptibility or severity) but not emotional dimensions. To address this gap, the authors examined the emotional component of risk perception (as worry) and its relation to cognitive assessments of risk, self-efficacy and response efficacy, and ...
Croise Christine - - 2012
Colorimetric solid phase with spatially separated extraction and detection zones as a rapid, effective and economic method for the optical detection of cyanide in complex samples is described. The system is seven times more sensitive for the optical detection of cyanide than the same class of chemical sensors used under ...
Hoyweghen Laura Van - - 2012
INTRODUCTION: Despite the growing interest in the use of bamboo for both food and health-related applications because it provides a rich source of anti-oxidants, there is still a lack of information on the responsible secondary metabolites of the great variety of bamboo species. OBJECTIVE: To extend the knowledge on secondary ...
Walcott Brian P - - 2012
ObjectiveDural arteriovenous fistulae (dAVF) are rare vascular lesions of the CNS with potentially significant morbidity and mortality. Our experience in the treatment of children with dAVF is reported.DesignOur neurosurgical and neurointerventional pediatric database was retrospectively reviewed for patients with dAVF. Brain arteriovenous malformations, pial fistulae, vein of Galen malformations and ...
Kim Jeonghun - - 2012
Ironing it out: A FeSBA-15 catalyst with a high iron content as well as a large pore diameter has been synthesized and used for the production of soluble poly(methylene anthracene) (PMAn, see scheme). The catalyst is stable, active, reusable, and affords a high yield of high molecular weight PMAn. The ...
Tottori Soichiro - - 2012
A simple and general fabrication method for helical swimming micromachines by direct laser writing and e-beam evaporation is demonstrated. The magnetic helical devices exhibit varying magnetic shape anisotropy, yet always generate corkscrew motion using a rotating magnetic field. They also exhibit good swimming performance and are capable of pick-and-place micromanipulation ...
Murakami Ryo - - 2012
Drops of a particle-stabilised oil-in-water emulsion are encapsulated in air by using hydrophobic silica particles. Such systems, termed oil-in-water-in-air powdered emulsions, show free-flowing behavior. Successful preparation of the material is achieved by preventing oil droplets from creaming and coalescing.
Kukla Piotr - - 2012
We report a case of 59-year-old man with subarachnoid haemorrhage (SAH) complicated by ventricular fibrillation (VF). Continuous electrocardiogram monitoring revealed that J-waves appeared immediately before the VF. The present report is the first to describe a J-wave-associated VF as another possible mechanism of sudden cardiac death in patients with SAH.
Skoff Tami H - - 2012
OBJECTIVE: To evaluate the impact of the adolescent Tdap vaccination (tetanus toxoid, reduced diphtheria toxoid, and acellular pertussis vaccine) program on pertussis trends in the United States. DESIGN: Retrospective analysis of nationally reported pertussis cases, January 1, 1990, through December 31, 2009. SETTING: United States. PARTICIPANTS: Confirmed and probable pertussis ...
Cha Eun Shil - - 2012
ObjectivesParaquat is commonly used worldwide as major herbicide. The objective of this study was to investigate the association among farmers between occupational paraquat exposure and respiratory health effects.MethodsA cross-sectional survey of health effects related to an oil spill was conducted in South Korea from 2008 to 2009. For this analysis, ...
Pan H - - 2012
A genome-wide association study (GWAS) of leprosy reported four specific genetic polymorphisms of NOD2 that were associated with susceptibility to Mycobacterium leprae in China. Considering the role of NOD2 in innate immune defence, we performed a study in a Chinese population to determine whether the same SNPs of NOD2 that ...
Kovalchuk Nataliya - - 2012
The TaPR61 gene from bread wheat encodes a lipid transfer protein (LTP) with a hydrophobic signal peptide, predicted to direct the TaPR61 protein to the apoplast. Modelling of TaPR61 revealed the presence of an internal cavity which can accommodate at least two lipid molecules. The full-length gene, including the promoter ...
Wu Hsin-Hui - - 2012
Mammalian MDC1 interacts with CHK2 in the regulation of DNA damage-induced S-phase checkpoint and apoptosis, which is directed by the association of MDC1-FHA and CHK2-pThr68. However, different ligand specificities of MDC1-FHA have been reported, and no structure is available. Here we report the crystal structures of MDC1-FHA and its complex ...
Kuiken Hendrik J - - 2012
The Nuclear factor κB (NF-κB) signaling pathway controls important cellular events such as cell proliferation, differentiation, apoptosis and immune responses. Pathway activation occurs rapidly upon TNFα stimulation and is highly dependent on ubiquitination events. Using cytoplasmic to nuclear translocation of the NF-κB transcription factor family member p65 as a read-out, ...
Catalano S A - - 2012
All methods proposed to date for mapping landmark configurations on a phylogenetic tree start from an alignment generated by methods that make no use of phylogenetic information, usually by superimposing all configurations against a consensus configuration. In order to properly interpret differences between landmark configurations along the tree as changes ...
Martins Gabriel G - - 2012
BACKGROUND INFORMATION: Most cells reside in vivo in a 3D environment surrounded by extracellular-matrix and other neighboring cells, conditions that are different from those found by cells cultured in vitro on 2D substrata. Cell morphology and behavior are very different under these two different conditions, but the structural basis for ...
Zhao Mei-Xia - - 2012
The use of active components from important medical herbs has proved effective in treating various cancers. Glycyrrhizic acid (GA) is one of the many interesting triterpenoic acids with anticancerogenic potential, and is known to trigger apoptosis in hepatocarcinoma cells. In this study we combined quantum dots (QDs) with GA in ...
Pulvirenti Mariastella - - 2012
Background  Patient or person centred care is widely accepted as the philosophy and practice that underpins quality care. An examination of the Australian National Chronic Disease Strategy and literature in the field highlights assumptions about the self-manager as patient and a focus on clinical settings. Objective and Conclusion  This paper ...
Martinsen Elin Håkonsen - - 2012
This paper seeks to find different ways of addressing illness as an experience essential to the understanding of being a human being. As a conceptual point of departure, we suggest the notion of 'pathic existence' as developed by the German physician and philosopher Viktor von Weizsäcker (1886-1957). Through an analysis ...
Kegeles Lawrence S - - 2012
CONTEXT: Postmortem studies have found evidence of γ-aminobutyric acid (GABA) deficits in fast-spiking, parvalbumin-positive interneurons in the prefrontal cortex in schizophrenia. Magnetic resonance spectroscopy studies in unmedicated patients have reported glutamine or glutamate-glutamine (Glx) elevations in this region. Abnormalities in these transmitters are thought to play a role in cognitive ...
Inchaisri C - - 2012
The conception rate in dairy cows is dependent on a number of cow factors such as days in milk and insemination number. Unfortunately, some of these factors were not accounted for in optimal insemination and replacement decision models. By using wrong estimates of the conception rate, the calculated optimal insemination ...
Macgillivray Leonard R - - 2012
Caged: Taking its origin in recent work by Ward and co-workers, an overview is given over the synthesis of Archimedean and Platonic bodies by different approaches such as hydrogen-bonded self-assembly and coordination chemistry.
Fulmer Preston A - - 2012
Endospores are formed by various bacterial families, including Bacillus and Clostridium, in response to environmental stresses as a means to survive conditions inhospitable to vegetative growth. Although metabolically inert, the endospore must interact with its environment to determine an optimal time to return to a vegetative state, a process known ...
Kabat Geoffrey C - - 2012
Incidence rates of non-Hodgkin's lymphoma (NHL) increased substantially in the United States and worldwide during the latter part of the 20(th) century, but little is known about the etiology of this condition. Antioxidant nutrients may reduce the risk of NHL by quenching free radicals, which may contribute to carcinogenesis by ...
Goldstein Benjamin I - - 2012
Bipolar disorder is one of the most severe psychiatric illnesses, particularly when onset occurs during childhood or adolescence. With recent empirical evidence, questions regarding the existence of bipolar disorder among children and adolescents have given way to questions regarding prevalence. There are substantial risks inherent in misapplying diagnoses and treatments ...
Lomonosov Alexey M - - 2012
Revealing defects and inhomogeneities of physical and chemical properties beneath a surface or an interface with in-depth nanometric resolution plays a pivotal role for a high degree of reliability in nanomanufacturing processes and in materials science more generally. Nanoscale non-contact depth-profiling of mechanical and optical properties of transparent sub-micrometric low-k ...
Bloom Arnold J - - 2012
This study measured total osmolarity and concentrations of NH(4)(+), NO(3)(-), K(+), soluble carbohydrates, and organic acids in maize seminal roots as a function of distance from the apex, and NH(4)(+) and NO(3)(-) in xylem sap for plants receiving NH(4)(+) or NO(3)(-) as a sole N-source, NH(4)(+) plus NO(3)(-), or no ...
McCreaddie May - - 2012
Background  Humour is a complex, dynamic phenomenon that mainly occurs in social situations between two or more people. Most humour research reviews rehearsed as opposed to spontaneous humour and rarely review the patients' perspective. Aim  We explore patients' perspectives on the use of humour in health care. We discuss the ...
Weijs Joost H - - 2012
Using molecular dynamics, we study the nucleation and stability of bulk nanobubble clusters. We study the formation, growth, and final size of bulk nanobubbles. We find that, as long as the bubble-bubble interspacing is small enough, bulk nanobubbles are stable against dissolution. Simple diffusion calculations provide an excellent match with ...
Larsen Steen - - 2012
AIM: Mitochondrial function has previously been studied in ageing, but never in humans matched for maximal oxygen uptake (V·O2max). Furthermore, the influence of ageing on mitochondrial substrate sensitivity is not known. METHODS: Skeletal muscle mitochondrial respiratory capacity and mitochondrial substrate sensitivity was measured by respirometry in young (23±3 years) and ...
Brosché Mikael - - 2012
Production of reactive oxygen species (ROS) is linked to signalling in both developmental and stress responses. The level of ROS is controlled by both production and removal through various scavengers including ascorbic acid and glutathione. Here, the role of low ascorbic acid or glutathione concentrations was investigated on ozone-induced cell ...
Potoyan Davit A - - 2012
During allosteric motions proteins navigate rugged energy landscapes. Hence, mapping of these multidimensional landscapes into lower dimensional manifolds is important for gaining deeper insights into allosteric dynamics. Using a recently developed computational technique, we calculated the free energy difference between the open and closed states of adenylate kinase, an allosteric ...
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