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Results 601 - 650 of 2092
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Vanderhoek Matt M Department of Medical Physics, University of Wisconsin, Madison, Wisconsin 53705-2275, - - 2012
PET-based treatment response assessment typically measures the change in maximum standardized uptake value (SUV(max)), which is adversely affected by noise. Peak SUV (SUV(peak)) has been recommended as a more robust alternative, but its associated region of interest (ROI(peak)) is not uniquely defined. We investigated the impact of different ROI(peak) definitions ...
Lynch Shannon M - - 2012
Recent guidelines for incarcerated women's programming have called for interventions that address offenders' traumatic experiences, posttraumatic stress disorder (PTSD), and substance use in an integrated manner. Seeking Safety (SS) is an empirically supported cognitive behavioral manualized treatment for individuals with PTSD and substance use disorders. This study examined the effectiveness ...
Crandall Ella Phillips - - 2012
There were a number of issues confronting public health nurses in 1919, including the differentiation of practice between visiting nurses and public health nurses, use of community partnerships when developing a new nursing service in a community, and standards of nursing work. Other issues included the focus of nursing work ...
Thill Marc M Department of Obstetrics and Gynecology, University Hospital Schleswig-Holstein, Campus Lübeck, Ratzeburger Allee 160, 23538 Lübeck, Germany. - - 2012
Cyclooxygenase-2 (COX-2) plays a crucial role in prognosis of malignancy and has been associated with carcinogenesis, particularly neoangiogenesis and tumor progression. 15-Hydroxyprostaglandin dehydrogenase (15-PGDH) is described as a tumour suppressor in cancer. The antiproliferative effects of calcitriol [1,25(OH)(2)D(3)] mediated via the vitamin D receptor (VDR) render vitamin D a promising ...
Lutz Manfred B - - 2012
The hematopoietic growth factor GM-CSF has long been known for its colony-formation properties in the generation of neutrophils, macrophages and DCs. However, a study by Miah et al. in this issue of the European Journal of Immunology [Eur. J. Immunol. 2012. 42: 58-68] reports that GM-CSF also terminates its own ...
Gao Changxin - - 2012
We present an instance-based attention model to predict where humans could look first when searching for an object instance, and we show its application in image synthesis. The proposed model learns configurational rules from vast scene images described by global scene representations. The rules are then used to predict the ...
Manara A R - - 2012
Donation after circulatory death (DCD) describes the retrieval of organs for the purposes of transplantation that follows death confirmed using circulatory criteria. The persisting shortfall in the availability of organs for transplantation has prompted many countries to re-introduce DCD schemes not only for kidney retrieval but increasingly for other organs ...
Meinzer Marcus - - 2012
Approaches for treating poststroke language impairments (aphasia) based on constraint-induced (CI) principles were first introduced in 2001. CI principles as previously applied to upper extremity and locomotor retraining in stroke survivors were derived from basic neuroscience. They comprise forced-use of the affected modality, a gradual rebuilding of targeted functions using ...
Wagner Dennis - - 2012
A novel method to measure 1,25-dihydroxyvitamin D (1,25(OH)(2)D) in human tissue was developed and validated. The objectives of this study were to determine whether 1,25(OH)(2)D is present in human colon tissue and to characterize the relationship between human colon tissue and serum 1,25(OH)(2)D concentrations. Normal colon tissue specimens and matched ...
- - 2012
Cover image:  Schematic diagram of the renal medullary endothelin system. See Nakano and Pollock, pp 104-110. •  Ca(2+) - sensing receptors in rat myometrium •  Age-induced changes in sensory neurons •  Gelatinases and obesity •  Timing of fructose intake affects body fat •  Tanshinone IIA attenuates ET-1 expression •  Frontiers ...
Hughes Caitlin Elizabeth - - 2012
In this Harm Reduction Digest two observers and scholars of the 2001 Portuguese drug policy reform consider divergent accounts of the reform which viewed it as a 'resounding success' or a 'disastrous failure'. Acknowledging from their own experience the inherent difficulties in studying drug law reform, Caitlin Hughes and Alex ...
Deng Huan - - 2012
Deng H, Gao Y-B, Wang H-F, Jin X-L & Xiao J-C (2012) Histopathology 60, 249-260 Expression of deleted in malignant brain tumours 1 (DMBT1) relates to the proliferation and malignant transformation of hepatic progenitor cells in hepatitis B virus-related liver diseases Aims:  The molecular mechanisms underlying proliferation and malignant transformation of ...
Dong Lin - - 2012
We report the lasing performance and photobleaching of gain material containing a water solution of Rhodamine 6G dye and gold nanoparticles (NPs). In comparison to a pure dye solution, the investigated material demonstrated both enhancement and quenching of the lasing output, depending on the relative concentration of the gold NPs. ...
Woo Hae Dong - - 2012
The effects of soy products and isoflavone on breast cancer recurrence were compared according to receptor status including epidermal growth factor receptor-2 (HER2) with 339 Korean women. Dietary intake of soy foods was assessed using a validated food frequency questionnaire with 103 food items. Twenty-five patients experienced breast cancer recurrence, ...
Yang Zhiming - - 2012
Uniform nanospheres with tunable size down to 30 nm were prepared simply by heating amphiphilic block copolymers in polar solvents. Unlike reverse micelles prepared in nonpolar, oily solvents, these nanospheres have a hydrophilic surface, rendering them good dispersibility in water. Furthermore, they are present as individual, separated, rigid particles upon ...
Gardiner D - - 2012
There is growing medical consensus in a unifying concept of human death. All human death involves the irreversible loss of the capacity for consciousness, combined with the irreversible loss of the capacity to breathe. Death then is a result of the irreversible loss of these functions in the brain. This ...
Smits Marion - - 2012
Smits M, Visch-Brink EG, van de Sandt-Koenderman ME, van der Lugt A. Advanced magnetic resonance neuroimaging of language function recovery after aphasic stroke: a technical review. Arch Phys Med Rehabil 2012;93(1 Suppl 1):S4-14. Two advanced magnetic resonance neuroimaging techniques, functional magnetic resonance imaging (fMRI) and diffusion tensor imaging (DTI), have ...
Salehin Darius - - 2012
The anticarcinogenic potential of vitamin D 25(OH)D has been attributed to the inhibition of proliferation of cells from different carcinomas. Reduced serum levels of 25(OH)D are associated with an increased incidence of various types of cancer. The influence of serum 25(OH)D on the incidence and outcome of patients with vulvar ...
Ren Xiaojiao - - 2012
A novel three-dimension micro-device was formulated to control delivery of 5-fluorouracil (5-FU) for the treatment of solid tumors. The poly-(lactic-co-glycolic) acid (PLGA), which is both biocompatible and biodegradable, was used as carrier material. The characteristics of drug release in vitro and in vivo and the performance of the micro-device after ...
Zen Yoh Y Institute of Liver Studies, King's College Hospital, London, UK. - - 2012
Biliary and pancreatic ductal systems can be involved in several lymphoplasmacytic inflammatory conditions, including primary sclerosing cholangitis, immunoglobulin G (IgG) 4-related cholangitis and autoimmune pancreatitis. Here in we describe an unusual pancreatocholangitis whose features suggest a distinct disease entity. The study group consists of five adult patients, three with predominantly ...
Scott M - - 2012
This, the third of our series of articles on statistics in veterinary medicine, moves onto the more complex concepts of hypothesis testing and confidence intervals. As these two areas are widely discussed in many clinical research publications, an awareness of the underlying methodology behind their use is essential to appreciate ...
Wentsch Katrin Sarah - - 2012
We present in this Letter experimental results of a Yb:Sc<sub>2</sub>SiO<sub>5</sub> (Yb:SSO) thin-disk laser. To our knowledge, this is the first lasing demonstration of this crystal in thin-disk configuration reported on to date. Preliminary tests regarding the characterization and the laser operation are presented. Two different resonator configurations, a simple linear ...
Ramamurthy Bhagavathi B Department of Molecular, Cellular and Developmental Biology, Yale University, New Haven, Connecticut 06520-8103, - - 2012
Myosin VI (Myo6) is unique among myosins in that it moves toward the minus (pointed) end of the actin filament. Thus to exert tension on, or move cargo along an actin filament, Myo6 is working against potentially multiple plus (barbed)-end myosins. To test the effect of plus-end motors on Myo6, ...
Marzulli G - - 2012
The onset of neurodegenerative diseases has become more frequent than in the past also in relation to inappropriate dietary habits adopted in the western world. Nutraceuticals are currently investigated in order to prevent or retard the outcome of the so-called diet-related diseases, even including neurodegenerative pathologies. Here, we have in ...
Yamade Mihoko - - 2012
We investigated the effects of trastuzumab, an anti-HER2 humanized monoclonal antibody, on DNA breaks induced by SN-38, a topoisomerase-1 inhibitor, in gastric cancer cell lines positive or negative for HER2 expression. NCI-N87 (HER2+) and MKN74 (HER2-) cells were exposed to SN-38 in the presence or absence of trastuzumab. Trastuzumab was ...
Labayen Idoia - - 2012
To examine the association of exclusive breastfeeding (BF) duration on serum fibrinogen levels of children and adolescents from Estonia and Sweden, controlling for other potential confounding factors that could mediate in this relationship. Cross-sectional study. Estonia and Sweden. A total of 704 children (mean [SD] age, 9.5 [0.4] years) and ...
Celik Emrah - - 2012
Sample-probe contact duration (dwell time) and loading force are two important parameters for the atomic force microscopy (AFM) force spectroscopy measurements of ligand-receptor interaction. A prolonged contact time may be required to initiate ligand-receptor binding as a result of slow on-rate kinetics or low reactant density. In general, increasing contact ...
Sledjeski Eve M - - 2012
To better understand the psychophysiological correlates of peritraumatic dissociation (PD), the present study examined the relationship between reports of prior PD and sympathetic and parasympathetic functioning in response to a laboratory stress paradigm in 39 traumatized female undergraduates. Participants were asked to talk about their most distressing traumatizing experience while ...
Naeser Margaret A - - 2012
Repetitive transcranial magnetic stimulation (rTMS) has been reported to improve naming in chronic stroke patients with nonfluent aphasia since 2005. In part 1, we review the rationale for applying slow, 1-Hz, rTMS to the undamaged right hemisphere in chronic nonfluent aphasia patients after a left hemisphere stroke; and we present ...
Lopes Nair - - 2012
The triple-negative subgroup of breast cancer includes a cluster of tumors exhibiting low E-cadherin expression (metaplastic carcinomas). In several cancer models, 1 alpha,25-dihydroxyvitamin D(3) (1α,25(OH)(2)D(3)) induces differentiation by increasing E-cadherin expression. The Vitamin D receptor (VDR) was evaluated as a possible therapeutic target for metaplastic carcinomas and 1α,25(OH)(2)D(3) effects as ...
Rodd Celia - - 2012
To determine the frequency of incident vertebral fractures (IVF) 12 months after glucocorticoid (GC) initiation in children with rheumatic diseases and to identify children at higher risk. Children with rheumatic diseases initiating GC were enrolled in a prospective observational study. Annual spine radiographs were evaluated using the Genant semiquantitative method. ...
Stewart Michael W MW Department of Ophthalmology, Mayo Clinic, Jacksonville, FL 32224, USA. - - 2012
Vascular endothelial growth factor (VEGF) plays an important role in both physiologic and pathologic angiogenesis and contributes to increased permeability across both the blood-retinal and blood-brain barriers. After 2 decades of extensive research into the VEGF families and receptors, specific molecules have been targeted for drug development, and several medications ...
Zou Wenhai - - 2012
Taking the chromaticity inconstancy of LCDs and the inverse efficiency into account, a novel local colorimetric characterization model was developed in this Letter. Rather than dividing the device color space into many subspaces to refine the chromaticity description as existent local models, the proposed model tailored the transformation relationship uniquely ...
Pfaller Michael A - - 2012
Antifungal resistance continues to grow and evolve and complicate patient management, despite the introduction of new antifungal agents. In vitro susceptibility testing is often used to select agents with likely activity for a given infection, but perhaps its most important use is in identifying agents that will not work, i.e., ...
Pacini Stefania - - 2012
Searching for additional therapeutic tools to fight breast cancer, we investigated the effects of vitamin D-binding protein-derived macrophage activating factor (DBP-MAF, also known as GcMAF) on a human breast cancer cell line (MCF-7). The effects of DBP-MAF on proliferation, morphology, vimentin expression and angiogenesis were studied by cell proliferation assay, ...
Bevilacqua Laura - - 2012
Childhood trauma may predispose individuals to aggressive behavior, and both childhood trauma and aggressive behavior are associated with hypothalamic-pituitary-adrenal axis dysregulation. To determine whether there would be an interaction between genetic variation in FKBP5 and childhood trauma in predicting aggressive behavior. Cross-sectional study. Four FKBP5 single-nucleotide polymorphisms used in previous ...
Bachovchin Daniel A DA The Skaggs Institute for Chemical Biology and Department of Chemical Physiology, The Scripps Research Institute, 10550 N. Torrey Pines Road, La Jolla, California 92037, - - 2012
Serine hydrolases perform crucial roles in many biological processes, and several of these enzymes are targets of approved drugs for indications such as type 2 diabetes, Alzheimer's disease and infectious diseases. Despite this, most of the human serine hydrolases (of which there are more than 200) remain poorly characterized with ...
Sun Bing - - 2012
We propose a double-pumped ring cavity multiwavelength fiber optical parametric oscillator (MW-FOPO) using a highly nonlinear dispersion-shifted fiber (HNL-DSF) as the gain medium and a polarization maintained fiber based Sagnac loop filter as the comblike filter. 22-wavelength lasing of the double-pumped MW-FOPO with a ripple less than ±2.5  dB and a ...
Rudge C - - 2012
Organ donation and transplant rates vary widely across the globe, but there remains an almost universal shortage of deceased donors. The unmet need for transplants has resulted in many systematic approaches to increase donor rates, but there have also been practices that have crossed the boundaries of legal and ethical ...
Wilkinson Ray - - 2012
Wilkinson R, Wielaert S. Rehabilitation targeted at everyday communication: can we change the talk of people with aphasia and their significant others within conversation? To investigate whether aphasia therapy can change the talk of speakers with aphasia and/or their significant others within conversation. Small number of intervention studies targeting conversations ...
Sergeev Igor N - - 2012
The hormone 1,25-dihydroxyvitamin D(3) (1,25(OH)(2)D(3)) regulates a variety of signaling pathways via intracellular Ca(2+). Modulation of apoptosis is emerging as a promising strategy for treatment and prevention of cancer. Cellular Ca(2+) has been implicated in triggering of apoptosis, however, the vitamin D/Ca(2+)-dependent targets involved in apoptotic signaling have not been ...
Go Heounjeong - - 2012
Go H, Kim J E, Kim Y A, Chung H K, Khwarg S I, Kim C-W & Jeon Y K (2012) Histopathology 60, 296-312 Ocular adnexal IgG4-related disease: comparative analysis with mucosa-associated lymphoid tissue lymphoma and other chronic inflammatory conditions Aims:  Making a differential diagnosis of IgG4-related disease from mucosa-associated lymphoid ...
Glusac Earl J - - 2012
The rise in malignant melanoma incidence has been termed "epidemic". Closer scrutiny of epidemiologic data suggests overdiagnosis as the true cause of the dramatic rise in melanoma incidence. In epidemiologic terms, "overdiagnosis" describes lesions that are histologically malignant but biologically benign. Overdiagnosis is not unique to melanoma screening but is ...
Forbes Andrew - - 2012
Laser beam shaping by phase-only transformations, often referred to as field mapping, has for a long time been considered wavelength dependent. In this Letter we outline a simple mathematical argument that shows how the problem may be formulated in a wavelength tunable manner, requiring only a minor adjustment in the ...
Li Fei - - 2012
The polyphenolic compound resveratrol (3,4',5-trihydroxystilbene) is a naturally occurring phytochemical which has been found in more than 70 plant species, including herbs and human food products such as grapes, berries, and peanuts. Resveratrol was first isolated in 1940; however, little attention was paid to it until its benefits in coronary ...
Nawa Masahito - - 2012
To investigate the relation between neutrophil elastase (NE) and proliferation of breast cancer cells and whether the NE inhibitor sivelestat could both contribute and be applied to therapy for anti-epithelial growth factor receptor 2 (HER2)-positive breast cancers. The proliferation or inhibition of breast cancer cell line SKBR-3 by each agent ...
Bhattacharyya Sagnik S Department of Psychosis Studies, Institute of Psychiatry, King's College London, De Crespigny Park, London, England. - - 2012
The aberrant processing of salience is thought to be a fundamental factor underlying psychosis. Cannabis can induce acute psychotic symptoms, and its chronic use may increase the risk of schizophrenia. We investigated whether its psychotic effects are mediated through an influence on attentional salience processing. To examine the effects of ...
Wang Hanzheng - - 2012
A porous-wall hollow glass microsphere (PW-HGM) was investigated as an optical resonator for chemical vapor sensing. A single mode optical fiber taper was used to interrogate the microresonator. Adsorption of chemical molecules into the nanosized pores induced a refractive index change of the thin wall and thus a shift in ...
Tian Fei - - 2012
Aim: Cisplatin resistance is an important issue in lung cancer. We aimed at investigating if the Hedgehog pathway inhibitor GDC-0449 is effective in cisplatin-resistant cells and if it alters intracellular Ca(2+)-homeostasis. The cytoplasmatic ([Ca(2+)](cyto)) and endoplasmatic ([Ca(2+)])(ER) Ca(2+) concentration of HCC (adeno carcinoma of the lung) and H1339 (small cell ...
Lee Joyce M JM Division of Pediatric Endocrinology, Child Health Evaluation and Research Unit, University of Michigan, 300 North Ingalls Building, Room 6E18, Campus Box 5456, Ann Arbor, MI 48109-5456, USA. - - 2012
To evaluate the relation between excess body mass index (BMI)-years, a measure of the degree to which an individual's BMI (calculated as weight in kilograms divided by height in meters squared) exceeds the reference BMI and the duration for which he or she carries excess BMI, and incident diabetes. Longitudinal ...
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