Search Results
Results 601 - 650 of 2092
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Köstner Kim - - 2012
Vitamin D receptor (VDR) polymorphisms have important implications for vitamin D signalling and are associated with various malignancies. In a German population, the frequency of several VDR polymorphisms (Apa1, Taq1, Bgl1) in basal cell carcinomas (BCCs, n=90) and cutaneous squamous cell carcinomas (SCCs, n=100) as compared to healthy controls (n=51) ...
Krishnamoorthy Naveen - - 2012
Cutaneous angiosarcoma or lymphangiosarcoma represents an uncommon aggressive tumor known to arise on a background of chronic lymphedema secondary to various etiologies, principally following surgery or irradiation. There have been rarely reported cases of angiosarcoma following infective conditions that eventuate with lymphatic stasis. We report a case of angiosarcoma arising ...
Lin G J - - 2012
Syringe-like ZnO nanorod arrays (NRAs) synthesized by a hydrothermal method were applied as the light-harvesting layer on InGaN-based multiple quantum well (MQW) solar cells. Theoretical calculations show that the NRAs with an abrupt shrinkage of tip diameter can further suppress surface reflectance in comparison with the flat NRAs. InGaN-based MQW ...
Andrade José Paulo - - 2012
Dietary antioxidant compounds, due to their pivotal role in the modulation of cellular redox mechanisms, are gaining attention of researchers in the field of brain aging and related degenerative diseases. In this perspective, green tea (GT) can be an excellent resource, as it contains large amounts of brain-accessible polyphenols. Many ...
Linkous Amanda G - - 2012
Current attempts to disrupt the complex process of tumor blood vessel formation are predominantly focused on targeting the vascular endothelial growth factor (VEGF)-VEGFR signaling pathway. Although clinically proven to inhibit VEGF and its receptors, these pharmacologic agents are selective, but not specific. Consequently, many of the approved inhibitors also impair ...
Arango Celso - - 2012
Progressive loss of brain gray matter (GM) has been reported in childhood-onset schizophrenia; however, it is uncertain whether these changes are shared by pediatric patients with different psychoses. To examine the progression of brain changes in first-episode early-onset psychosis and their relationship to diagnosis and prognosis at 2-year follow-up. Prospective, ...
Hughes Steven - - 2012
TRPM1 is a spontaneously active non-selective cation channel that has recently been shown to play an important role in the depolarizing light responses of ON bipolar cells. Consistent with this role, mutations in the TRPM1 gene have been identified as a principal cause of congenital stationary night blindness. However, previous ...
Kempf Werner - - 2012
Cutaneous B-cell lymphomas (CBCL) are the second most common form of primary cutaneous lymphomas. The cutaneous follicle center lymphoma and the cutaneous marginal zone lymphoma (extranodal MALT type lymphoma) account for the vast majority of CBCL and manifest with nodules. These two lymphoma entities have an indolent, slowly progressive course ...
Schmidt O A - - 2012
Micrometer-sized particles are trapped in front of an air-filled hollow-core photonic crystal fiber using a novel dual-beam trap. A backward guided mode produces a divergent beam that diffracts out of the core, and simultaneously a focused laser beam launches a forward-propagating mode into the core. By changing the backward/forward power ...
Su Chen-Hsien - - 2012
Primary neuroendocrine carcinomas of the breast (PNCB) are very rare and tumor markers for this indication are not well defined. We aim at reporting a case and providing a marker useful for prognosis and prediction of tumor recurrence for patients with PNCB. A 75-year-old woman presented with a slight painful ...
Kim Hee Sun - - 2012
Heterotopic gastric mucosa has been described in all levels of the gastrointestinal tract. However, gastric heterotopia of the rectum is a rare finding. It is usually reported along with polyp located in the rectum between 5 and 8 cm from the anal verge. The most common symptom is painless rectal bleeding, ...
Epstein Jonathan I - - 2012
Epstein J I (2012) Histopathology60, 28-40Diagnosis of limited adenocarcinoma of the prostate This article provides an overview of the diagnosis of limited prostate cancer on needle biopsy. A few of the more common mimickers of prostate cancer, such as adenosis, partial atrophy, and high-grade prostatic intraepithelial neoplasia, are also covered. ...
Carter Stephen F - - 2012
Astrocytes colocalize with fibrillar amyloid-β (Aβ) plaques in postmortem Alzheimer disease (AD) brain tissue. It is therefore of great interest to develop a PET tracer for visualizing astrocytes in vivo, enabling the study of the regional distribution of both astrocytes and fibrillar Aβ. A multitracer PET investigation was conducted for ...
Kang Ji Hye - - 2012
The effect of triangular air prism (TAP) arrays with different distance-to-width (d/w) ratios on the enhancement of light extraction efficiency (LEE) of InGaN light-emitting diodes (LEDs) is investigated. The TAP arrays embedded at the sapphire/GaN interface act as light reflectors and refractors, and thereby improve the light output power due ...
Murphy P G - - 2012
Implementation of the recommendations from the Organ Donation Taskforce has introduced for the first time into the UK a nationwide framework for deceased donation. This framework is based, in principle, upon a conviction that donation should be viewed as part of end-of-life care and that the actions often necessary to ...
Kubodera Noboru - - 2012
Eldecalcitol [1α,25-dihydroxy-2β-(3-hydroxypropoxy)vitamin D(3)], an analog of calcitriol (1α,25-dihydroxyvitamin D(3)), possesses a hydroxypropoxy substituent at the 2β-position of calcitriol. Eldecalcitol has potent biological effects on bone disease such as osteoporosis. The marketing of eldecalcitol has very recently started in Japan. In consideration of this, we have been investigating practical synthesis of ...
Poinsot Véréna - - 2012
This paper describes the most important articles that have been published on amino acid analysis using CE during the period from June 2009 to May 2011 and follows the format of the previous articles of Smith (Electrophoresis 1999, 20, 3078-3083), Prata et al. (Electrophoresis 2001, 22, 4129-4138) and Poinsot et ...
Lin Chih-Kung - - 2012
Lin C-K, Tsai W-C, Lin Y-C & Hueng D-Y (2012) Histopathology 60, 320-325 Osteopontin predicts the behaviour of atypical meningioma Aim:  Although the World Health Organization (WHO) histological criteria distinguishing benign from atypical and malignant meningioma are clear, discerning benign from atypical meningioma is still somewhat difficult, leading to interobserver diagnostic ...
Albero Jorge - - 2012
We report a method to maximize the broadband modulation diffraction efficiency of liquid-crystal spatial light modulators for polychromatic applications requiring a wide range of wavelengths. An optimized encoding pattern based on the minimum Euclidean projection principle is applied in order to increase the diffraction efficiency at large wavelengths that exhibit ...
Pfaller Michael A - - 2012
Antifungal resistance continues to grow and evolve and complicate patient management, despite the introduction of new antifungal agents. In vitro susceptibility testing is often used to select agents with likely activity for a given infection, but perhaps its most important use is in identifying agents that will not work, i.e., ...
Pacini Stefania - - 2012
Searching for additional therapeutic tools to fight breast cancer, we investigated the effects of vitamin D-binding protein-derived macrophage activating factor (DBP-MAF, also known as GcMAF) on a human breast cancer cell line (MCF-7). The effects of DBP-MAF on proliferation, morphology, vimentin expression and angiogenesis were studied by cell proliferation assay, ...
Sun Bing - - 2012
We propose a double-pumped ring cavity multiwavelength fiber optical parametric oscillator (MW-FOPO) using a highly nonlinear dispersion-shifted fiber (HNL-DSF) as the gain medium and a polarization maintained fiber based Sagnac loop filter as the comblike filter. 22-wavelength lasing of the double-pumped MW-FOPO with a ripple less than ±2.5  dB and a ...
Knoop Jesper - - 2012
To determine whether muscle strength, proprioceptive accuracy, and laxity are associated with self-reported knee instability in a large cohort of knee osteoarthritis (OA) patients, and to investigate whether muscle strength may compensate for impairment in proprioceptive accuracy or laxity, in order to maintain knee stability. Data from 283 knee OA ...
Paner Gladell P - - 2012
Paner G P, Aron M, Hansel D E & Amin M B (2012) Histopathology 60, 166-186 Non-epithelial neoplasms of the prostate Non-epithelial prostatic neoplasms are infrequent and cover a broad array of entities that include both benign and highly aggressive tumours. Because they are very infrequent, there is often limited understanding ...
Shin Donghak - - 2012
The performance of multiview three-dimensional imaging systems depends on several factors, including the number of sensors, sensor pixel size, relative sensor configuration, imaging optics, and computational reconstruction algorithm. Therefore, it is important to compare the performance of such systems under equally constrained resources. In this Letter, we develop a unifying ...
Kothari Vishal - - 2012
Overexpression of cyclin D1 is associated with resistance to chemotherapy and radiotherapy in several types of cancer including head and neck squamous cell carcinoma (HNSCC). Cyclin D1 was silenced in an HNSCC cell line and its effect tested in sensitizing the cells to cisplatin, in vitro as well as in ...
Mandell David S - - 2012
To examine whether increased provision of community-based services is associated with decreased psychiatric hospitalizations among children with autism spectrum disorders (ASDs). Retrospective cohort study using discrete-time logistic regression to examine the association of service use in the preceding 60 days with the risk of hospitalization. The Medicaid-reimbursed health care system ...
Endo Hirohito - - 2012
A nucleosome is composed of intrinsically disordered histone tails and a structured nucleosome core surrounded by DNA. A variety of modifiable residues on the intrinsically disordered histone tails have been identified in the last decade. Mapping of the functional residues on the structured nucleosome core surface was recently initiated by ...
Rosik Christopher H - - 2012
In the present study we surveyed 131 adults seeking psychotherapy and pastoral care in an intensive outpatient psychotherapy program for full-time religious workers. We sought to determine whether dissociation and alexithymia are associated with spiritual well-being. We utilized the Dissociative Experiences Scale-II (DES-II), the Toronto Alexithymia Scale (TAS-20), the Spiritual ...
McKeown D W - - 2012
The main factor limiting organ donation is the availability of suitable donors and organs. Currently, most transplants follow multiple organ retrieval from heartbeating brain-dead organ donors. However, brain death is often associated with marked physiological instability, which, if not managed, can lead to deterioration in organ function before retrieval. In ...
Thill Marc - - 2012
Cyclooxygenase-2 (COX-2) is a potential molecular prognostic factor for breast cancer, and calcitriol [1,25(OH)(2)D(3)], the biologically active form of vitamin D, is a promising target in breast cancer therapy. The influence of calcitriol on the proliferation and the effects of calcitriol on the expression of prostaglandin- and vitamin D-metabolising enzymes ...
Chen Yijiang - - 2012
Infrared (IR) Earth thermal tracking is a viable option for optical communications to distant planet and outer-planetary missions. However, blurring due to finite receiver aperture size distorts IR Earth images in the presence of Earth's nonuniform thermal emission and limits its applicability. We demonstrate a deconvolution algorithm that can overcome ...
Schuster André - - 2012
The ascomycete fungus, Trichoderma reesei (anamorph of Hypocrea jecorina), represents a biotechnological workhorse and is currently one of the most proficient cellulase producers. While strain improvement was traditionally accomplished by random mutagenesis, a detailed understanding of cellulase regulation can only be gained using recombinant technologies. Aiming at high efficiency and ...
Kumagai Go - - 2012
The Δ(16) structure as a vitamin D analog enhanced vitamin D receptor (VDR) binding affinity and induced significant cell differentiation, whereas its relative calcemic activity was reduced compared to 1α,25-dihydroxyvitamin D(3) (1α,25(OH)(2)D(3)). Methodologies available to introduce a double bond at C16-C17 of the D-ring on the seco-steroidal skeleton were limited; ...
Pascali Jennifer Paola - - 2012
The present article reviews and comments the applications of capillary electrophoresis in the different areas of forensic sciences covering the time from the second half of 2009 until the first part of 2011, being the latest update of previous reviews covering the years from 2001 to 2009. Numerous articles reporting ...
Bal Amanjit - - 2012
Bal A, Suri V, Mishra B, Bhalla A, Agarwal R, Abrol A, Ratho R K & Joshi K (2012) Histopathology 60, 326-335 Pathology and virology findings in cases of fatal influenza A H1N1 virus infection in 2009-2010 Aims:  To describe the pathological findings, immunohistochemical localization of viral antigen and tissue reverse ...
McCalmont Timothy H - - 2012
Editor's note: This manuscript represents a reprise of the preceding manuscript (J Cutan Pathol 2012; 39: 21-24). It has different conclusions. The wording of the case report section is very similar in both papers but has been included in both for the convenience of the reader. The illustrations are duplicated ...
Rouf Alvi Muhammad - - 2012
Monosilicon analogs of phenolates and phenylthiolates are studied by quantum chemical calculations. Three different silaphenolates and three different silaphenylthiolates are possible; the ortho-, meta-, and para-isomers. For the silaphenolates, the meta-isomer is the thermodynamically most stable, regardless if the substituent R at Si is H, t-Bu or SiMe(3). However, with ...
Alam M Z - - 2012
Hybrid plasmonic waveguides consisting of a metal plane separated from a high-index medium by a low-index spacer have recently attracted much interest. Here we show that, by suitably choosing the dimensions and material properties of the hybrid waveguide, a very compact and broadband TE-pass polarizer can be implemented. Finite-difference time-domain ...
Deqnah Narjes - - 2012
We report the synthesis and in vitro activity of trans-bis-(2-hydroxypyridine)dichloroplatinum(II) (coded as DH3) in humour ovarian tumour models. The compound is less active than cisplatin against the parent cell line A2780 but more so against the cisplatin-resistant A2780(cisR) cell line, thus indicating that it is better able to overcome mechanisms ...
Tuohimaa P - - 2012
It has been demonstrated in several studies that serum calcidiol (25 OH vitamin D(3)) concentration is in a reversed and linear relationship with cancer risk. However, there are also studies showing no such association and some even suggest the opposite. The risk of pancreatic and oesophageal cancer seems to increase, ...
Rampino M - - 2012
To determine the potential activity and tolerability of sequential treatment in head and neck cancer, we conducted a phase II trial based on induction chemotherapy of two cycles of taxotere, cisplatin and 5-fluorouracil followed by radiotherapy plus weekly cetuximab. Thirty-six patients with stage III or IV squamous cell carcinoma of ...
Li Fei - - 2012
The polyphenolic compound resveratrol (3,4',5-trihydroxystilbene) is a naturally occurring phytochemical which has been found in more than 70 plant species, including herbs and human food products such as grapes, berries, and peanuts. Resveratrol was first isolated in 1940; however, little attention was paid to it until its benefits in coronary ...
Lin Wen-Hsing - - 2012
A high-throughput 32D(L858R/T790M) cell-based assay to identify inhibitors of the L858R/T790M mutant epidermal growth factor receptor (EGFR) pathway was established. After screening, ten hits from among 60,000 compounds in our in-house compound library were initially identified. In the secondary assays, one hit, 1-[2-(decyloxy)-2-oxoethyl]-3-methyl-2-[(4-methylphenoxy) methyl]-1H-benzimidazol-3-ium, was confirmed to directly inhibit the ...
Nessa Meher U - - 2012
In this study, combinations of resveratrol with platinum drugs cisplatin and oxaliplatin were administered to human ovarian A2780, A2780(cisR) and A2780(ZD0473R) cell lines with the aim of offering a means of overcoming drug resistance. Cell viability was quantified using the 3-(4,5-Dimethyl-2-thiazolyl)-2,5-diphenyl-2H-tetrazolium bromide (MTT) reduction assay. Combination indices and dose response ...
Vetvicka Vaclav - - 2012
β-Glucans are naturally occurring carbohydrates found in plants, fungi and some bacterial species, and currently are well-established and powerful immunomodulators with beneficial properties in cancer therapy. Recent studies suggested that some additional bioactive molecules have synergistic effects when combined with glucan. In the current study, we evaluated the anticancer properties ...
Nordahl Christine Wu - - 2012
Precocious amygdala enlargement is commonly observed in young children with autism. However, the age at which abnormal amygdala enlargement begins and the relative growth trajectories of the amygdala and total brain remain unclear. To determine whether the rate of amygdala growth is abnormal and disproportionate to total brain growth in ...
Sledjeski Eve M - - 2012
To better understand the psychophysiological correlates of peritraumatic dissociation (PD), the present study examined the relationship between reports of prior PD and sympathetic and parasympathetic functioning in response to a laboratory stress paradigm in 39 traumatized female undergraduates. Participants were asked to talk about their most distressing traumatizing experience while ...
Parry Peter I - - 2012
Pediatric bipolar disorder (PBD) reflects shifts in conceptualizing bipolar disorder among children and adolescents since the mid-1990s. Since then, PBD diagnoses, predominantly in the United States, have increased dramatically, and the diagnosis has attracted significant controversy. During the same period, psychiatric theory and practice has become increasingly biological. The aim ...
Kamen Charles - - 2012
This study examined the relationships among dissociation, childhood trauma and sexual abuse, and posttraumatic stress disorder (PTSD) symptoms in HIV-positive men. Data were collected from 167 men enrolled in a randomized clinical trial that examined a group therapy intervention to decrease HIV-related risk behavior and trauma-related stress symptoms. Participants completed ...
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