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Results 451 - 500 of 2093
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Lynch Shannon M - - 2012
Recent guidelines for incarcerated women's programming have called for interventions that address offenders' traumatic experiences, posttraumatic stress disorder (PTSD), and substance use in an integrated manner. Seeking Safety (SS) is an empirically supported cognitive behavioral manualized treatment for individuals with PTSD and substance use disorders. This study examined the effectiveness ...
Crandall Ella Phillips - - 2012
There were a number of issues confronting public health nurses in 1919, including the differentiation of practice between visiting nurses and public health nurses, use of community partnerships when developing a new nursing service in a community, and standards of nursing work. Other issues included the focus of nursing work ...
Nawa Masahito - - 2012
To investigate the relation between neutrophil elastase (NE) and proliferation of breast cancer cells and whether the NE inhibitor sivelestat could both contribute and be applied to therapy for anti-epithelial growth factor receptor 2 (HER2)-positive breast cancers. The proliferation or inhibition of breast cancer cell line SKBR-3 by each agent ...
Wang Hanzheng - - 2012
A porous-wall hollow glass microsphere (PW-HGM) was investigated as an optical resonator for chemical vapor sensing. A single mode optical fiber taper was used to interrogate the microresonator. Adsorption of chemical molecules into the nanosized pores induced a refractive index change of the thin wall and thus a shift in ...
Ostrosky-Zeichner Luis - - 2012
Despite the availability of newer antifungal drugs, outcomes for patients with invasive fungal infections (IFIs) continue to be poor, in large part due to delayed diagnosis and initiation of appropriate antifungal therapy. Standard histopathologic diagnostic techniques are often untenable in at-risk patients, and culture-based diagnostics typically are too insensitive or ...
Suetsugu Atsushi - - 2012
The tumor microenvironment (TME) has an important influence on tumor progression. For example, we have discovered that passenger stromal cells are necessary for metastasis. In this report, we describe six different cyan fluorescent protein (CFP) multicolor TME nude mouse models. The six different implantation models were used to image the ...
Lundström Sebastian - - 2012
Autism spectrum disorders (ASDs) have been suggested to represent the extreme end of a normal distribution of autisticlike traits (ALTs). However, the evidence of this notion is inconclusive. To study whether there are similar genetic and/or environmental etiologies behind ASDs and ALTs. A nationwide twin study. Consenting parents of all ...
Rehammar R - - 2012
A square planar photonic crystal composed of carbon nanofibers was fabricated using e-beam lithography and chemical vapor deposition. The diffraction properties of the system were characterized experimentally and compared with theory and numerical simulations. The intensities of the (-1,0) and (-1,-1) diffraction beams were measured as functions of the angles ...
Randhawa G - - 2012
Deceased donation in the UK relies upon family consent. Approaching a family at the tragic time of a loved one's death requires significant emotional resilience from staff. The UK is comprised of individuals who have a number of life and death values which are, to some extent, based upon their ...
Bremmer F - - 2012
Testicular germ cell tumours (TGCTs) are the most common malignancy in young men aged 18-35 years. They are clinically and histologically subdivided into seminomas and non-seminomas. 1,25-Dihydroxyvitamin D (1,25(OH)(2)D(3)) is the active form of vitamin D and exerts its actions via a specific intracellular vitamin D receptor (VDR). Several investigations ...
- - 2012
COVER IMAGE: The cover shows a histological analysis of an ear section from a C57BL/6 mouse that was first sensitised with 2,4-dinitrofluorobenzene on the belly and then challenged 4 days later with 2,4-dinitrofluorobenzene on the ear. Haematoxylin and eosin staining shows massive skin infiltration by mononuclear cells and granulocytes 24 ...
Wo Jianghai - - 2012
A simple and robust refractive index (RI) sensor based on a Mach-Zehnder interferometer has been demonstrated. A section of optical microfiber drawn from silica fiber is employed as the sensing arm. Because of the evanescent field, a slight change of the ambient RI will lead to the variation of the ...
Kosmidis Paris A - - 2012
Aim: The purpose of this study was to compare two single agents paclitaxel (intravenous) versus vinorelbine (oral) in non-small cell lung cancer (NSCLC) patients with performance status (PS):2. The patients were randomized to receive either oral vinorelbine 60 mg/m(2) on days 1, 8, 15 every 4 weeks for 4 cycles ...
Egevad Lars - - 2012
Egevad L (2012) Histopathology 60, 118-124 Handling of radical prostatectomy specimens Accurate reporting of radical prostatectomy specimens is becoming more important as we gain insights into how cancer therapy should be tailored according to risk categories. Adjuvant therapy after radical prostatectomy is now given more commonly to patients with pathological findings ...
Pan Shilong - - 2012
A photonic approach to the simultaneous measurement of the frequency, pulse amplitude (PA), pulse width (PW), and time of arrival (TOA) of an unknown pulsed microwave signal is proposed and demonstrated. The measurement is performed based on optical carrier-suppressed modulation, complementary optical filtering, low-speed photodetection, and electrical signal processing. A ...
Kontoyiannis Dimitrios P - - 2012
Effective management of invasive fungal infections (IFIs) depends on early individualized therapy that optimizes efficacy and safety. Considering the negative consequences of IFI, for some high-risk patients the potential benefits of prophylactic therapy may outweigh the risks. When using a prophylactic, empiric, or preemptive therapeutic approach, clinicians must take into ...
Yamauchi Kensuke - - 2012
Stromal cells are essential for tumor growth. Stromal cells interact with cancer cells during tumor growth and progression. We report here the development of a tri-color imageable mouse model to visualize the interaction between host cells and cancer cells. To observe subcellular cancer cell dynamics in vivo, HT-1080 human fibrosarcoma ...
Ozaktas Haldun M - - 2012
Fresnel integrals corresponding to different distances can be interpreted as scaled fractional Fourier transformations observed on spherical reference surfaces. Transverse samples can be taken on these surfaces with separation that increases with propagation distance. Here, we are concerned with the separation of the spherical reference surfaces along the longitudinal direction. ...
Morales La Madrid Andres - - 2012
MYCN-amplification is strongly associated with other high-risk prognostic factors and poor outcome in neuroblastoma. Infrequently, amplification of MYCN has been identified in localized tumors with favorable biologic features. Outcome for these children is difficult to predict and optimal treatment strategies remain unclear. We report a 5-month-old who presented with an ...
Price D P T - - 2012
Laws and policies governing the use of organs for transplantation are evolving rapidly in response to sensitivity to ethical concerns and increasing shortages of transplantable organs. They are necessarily becoming increasingly detailed and complex. Professional practice will be enhanced by clear statements of current provisions, and the debates accompanying their ...
Sawada Daisuke - - 2012
The synthesis of 14-epi-1α,25(OH)(2)previtamin D(3), 14-epi-19-nor-1α,25(OH)(2)previtamin D(3), and their 2-substituted analogs is described. The vitamin D receptor (VDR) binding affinity was further evaluated and 2α-methyl substituted 14-epi-1α,25(OH)(2)previtamin D(3) had 17-fold more potent affinity than 14-epi-1α,25(OH)(2)previtamin D(3).In the comparison of these compounds, the effects of thermal equilibrium, with or without 19-carbon ...
Martin Vittoria - - 2012
Martin V, Banfi S, Bordoni A, Leoni-Parvex S & Mazzucchelli L (2012) Histopathology 60, 336-346 Presence of cytogenetic abnormalities in Spitz naevi: a diagnostic challenge for fluorescence in-situ hybridization analysis Aims:  Spitz naevi are difficult to diagnose, because of significant overlap with melanomas. It has been recently demonstrated that the LSI ...
Beer Trevor W - - 2012
The histopathological features of atypical fibroxanthoma (AFX) overlap with those of poorly differentiated carcinoma, melanoma and leiomyosarcoma in the skin. As there are no specific stains to identify AFX, the diagnosis is essentially one of exclusion and requires completion of a panel of immunostains. Recently, it has been suggested that ...
Lee Jonathan Y - - 2012
We demonstrate a novel periodically patterned ring resonator evanescently coupled with a coupler waveguide (CWG) on a silicon-on-insulator platform. In order to optimize the coupling, we phase match the ring resonator and the CWG by tuning the width of the CWG. In the transmission spectra, we measure a high extinction ...
Ferreira Adilson Kleber - - 2012
Antineoplastic phospholipids (ALPs) represent a promising class of drugs with a novel mode of action undergoes rapid turnover in the cell membrane of tumors, interfering with lipid signal transduction, inducing cell death. The aim of this study was to investigate the synthetic phosphoethanolamine (Pho-s) as a new anticancer agent. Cell ...
Singh Amika - - 2012
To describe the prospective relationship between physical activity and academic performance. Prospective studies were identified from searches in PubMed, PsycINFO, Cochrane Central, and Sportdiscus from 1990 through 2010. We screened the titles and abstracts for eligibility, rated the methodological quality of the studies, and extracted data. Studies had to report ...
Ghai Rajesh - - 2012
Isothermal titration calorimetry (ITC) is a biophysical technique for measuring the formation and dissociation of molecular complexes and has become an invaluable tool in many branches of science from cell biology to food chemistry. By measuring the heat absorbed or released during bond formation, ITC provides accurate, rapid, and label-free ...
Brand Bethany L - - 2012
This article provides an overview of the process of developing the 5th edition of the Diagnostic and Statistical Manual of Mental Disorders (DSM-5) of the American Psychiatric Association with a focus on issues related to the trauma-related disorders, particularly the dissociative disorders (DD). We also discuss the highlights of research ...
Grant William B - - 2012
Background/Aim: This paper reviews ecological studies of the ultraviolet-B (UVB)-vitamin D-cancer hypothesis based on geographical variation of cancer incidence and/or mortality rates. The review is based largely on three ecological studies of cancer rates from the United States; one each from Australia, China, France, Japan, and Spain; and eight multicountry, ...
Macdonald Jamie H - - 2012
To determine the effect of 6 years of routine management on body composition, physical functioning, and quality of life, and their interrelationships, in men with idiopathic vertebral fracture. Twenty men with idiopathic vertebral fracture (patients: mean ± SD age 58 ± 6 years) were age and height matched to 28 ...
Scheller Maik - - 2012
Wide wavelength tunability of single- and two-color operating vertical-external-cavity-surface-emitting lasers (VECSELs) is demonstrated. Employing an external feedback based on a diffractive grating outside the cavity of a narrow-line single-color VECSEL allows for a continuous tuning of the emission wavelength over 10 nm. Employing a dual-feedback-configuration for tunable two-color emission, a ...
Bilic Josipa - - 2012
The state of a cell is defined by the genes it transcribes and the epigenetic landscape that regulates their expression. Pluripotent cells have markedly different epigenetic signatures when compared with differentiated cells. Permissive chromatin, high occurrence of bivalent domains, and low levels of heterochromatin allow pluripotent cells to react to ...
Romiti Adriana - - 2012
A possible anticancer role for somatostatin has been suggested. This study assessed the presence of somatostatin receptor subtype 2A (SSTR2A) in gastric cancer, correlating its expression with histological type, grade, human epidermal growth factor receptor 2 (HER2) expression, and disease outcome. Gastric cancer tissues of 51 consecutive patients were collected ...
Farrell Michael H - - 2012
To demonstrate a quantitative abstraction method for Communication Quality Assurance projects to assess physicians' communication about hidden emotions after newborn genetic screening. Communication quality indicator analysis. Standardized parent encounters performed in practicing physicians' clinics or during educational workshops for residents. Fifty-nine pediatrics residents, 53 pediatricians, and 31 family physicians. Intervention  ...
Zhen-Qiang Fang - - 2012
Ischemia and subsequent reperfusion (I/R) damage kidney tubular cells and consequently impair renal function. Rabbit bone marrow mesenchymal stem cells (BM-MSCs) expressing human bone morphogenic protein-7 (hBMP-7) regenerated tubular cells and improved renal function in a kidney I/R model. Rabbits were injected immediately after I/R with one of the following: ...
Gunzburg Menachem J - - 2012
Src-homology (SH2) domains are an attractive target for the inhibition of specific signalling pathways but pose the challenge of developing a truly specific inhibitor. The G7-18NATE cyclic peptide is reported to specifically inhibit the growth factor receptor bound protein 7 (Grb7) adapter protein, implicated in the progression of several cancer ...
Tian Fei - - 2012
Aim: Cisplatin resistance is an important issue in lung cancer. We aimed at investigating if the Hedgehog pathway inhibitor GDC-0449 is effective in cisplatin-resistant cells and if it alters intracellular Ca(2+)-homeostasis. The cytoplasmatic ([Ca(2+)](cyto)) and endoplasmatic ([Ca(2+)])(ER) Ca(2+) concentration of HCC (adeno carcinoma of the lung) and H1339 (small cell ...
Schneider Sebastian - - 2012
The prediction of the structure of the protein-protein complex is of great importance to better understand molecular recognition processes. During systematic protein-protein docking, the surface of a protein molecule is scanned for putative binding sites of a partner protein. The possibility to include external data based on either experiments or ...
Ito Komei - - 2012
Cow's milk allergy is one of the most common food allergies among younger children. We investigated IgE antibodies to milk, and IgE and IgG4 antibodies to casein, α-lactalbumin and β-lactoglobulin in cow's milk allergic (CMA) and non-allergic (non-CMA) children in order to study their clinical usefulness. Eighty-three children with suspected ...
Ko Wen-Chin - - 2012
Aim:To investigate the signaling pathways involved in thrombin-induced connective tissue growth factor (CTGF) expression in rat vascular smooth muscle cells (VSMCs).Methods:Experiments were preformed on primary rat aortic smooth muscle cells (RASMCs) and a rat VSMC line (A10). CTGF protein levels were measured using Western blotting. Luciferase reporter genes and dominant ...
Fine Samson W - - 2012
Fine S W & Reuter V E (2012) Histopathology 60, 142-152 Anatomy of the prostate revisited: implications for prostate biopsy and zonal origins of prostate cancer Over the past 25 years, our understanding of prostatic disease has evolved secondary to the increased detection, treatment and study of both benign and neoplastic prostatic ...
Sun Haishan - - 2012
Because of stronger optical confinement density, silicon slot waveguides tend to have higher scattering loss than normal ridge waveguides with same sidewall roughness. A wet chemical process is found to be highly effective in reducing the surface roughness and scattering loss. A reduction in scattering loss by 10.2 dB/cm for ...
Kim Hyo Geun - - 2012
Alzheimer's disease (AD) is a chronic neurodegenerative disorder and is the most common cause of progressive dementia in aging. Research on AD therapy has been partly successful in terms of developing symptomatic treatments, but there have been a number of failures with regard to developing disease-modifying therapies. The pathogenesis of ...
Xie Hui - - 2012
Obstructive sleep apnea (OSA) is well known for its metabolic as well as neurobehavioral consequences. Chronic intermittent hypoxia (IH) is a major component of OSA. In recent years, substantial advances have been made in elucidating the cellular and molecular mechanisms underlying the effect of chronic IH on neurocognitive functions, many ...
Nieder Carsten - - 2012
Non-small cell lung cancer (NSCLC) is a major cause of cancer-related death and utilization of health care resources worldwide. Significant costs are generated in the months before death, with hospitalization being a major cost driver. Moreover, hospital death causes physical and emotional distress. We analyzed factors predicting the likelihood of ...
Kristiansen Glen - - 2012
Kristiansen G (2012) Histopathology 60, 125-141 Diagnostic and prognostic molecular biomarkers for prostate cancer Prostate cancer is the most common malignant tumour in men and is a major research focus of pathologists, urologists and uro-oncologists alike. The pathologist is confronted with an increasing number of biospsies, necessitating ancillary tests in morphologically ...
Zang Di - - 2012
Visual correspondence has been a major research topic in the fields of image registration, 3D reconstruction, and object tracking for some decades. However, due to the radiometric variations of images, conventional approaches fail to produce robust matching results. The traditional method of intensity-based mutual information performs very good for global ...
Krause Rolfdieter - - 2012
Aim: The goal was to analyze the link between blood levels of calcidiol and all-cause, cardiac and infectious diseases, and mortality due to cancer in hemodialysis patients. This study retrospectively evaluated a representative sub-cohort (n=6,518) of German hemodialysis patients from the incidence cohorts 1997-2006. Most (58.8%) were found to be ...
Rouzaire Paul - - 2012
The cover shows a histological analysis of an ear section from a C57BL/6 mouse that was first sensitised with 2,4-dinitrofluorobenzene on the belly and then challenged 4 days later with 2,4-dinitrofluorobenzene on the ear. Haematoxylin and eosin staining shows massive skin infiltration by mononuclear cells and granulocytes 24 h after ...
Le Moal Eric - - 2012
Two-photon excitation provides efficient optical sectioning in three-dimensional fluorescence microscopy, independently of a confocal detection. In two-photon laser-scanning microscopy, the image resolution is governed by the volume of the excitation light spot, which is obtained by focusing the incident laser beam through the objective lens of the microscope. The light ...
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