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Results 451 - 500 of 2092
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Linkous Amanda G - - 2012
Current attempts to disrupt the complex process of tumor blood vessel formation are predominantly focused on targeting the vascular endothelial growth factor (VEGF)-VEGFR signaling pathway. Although clinically proven to inhibit VEGF and its receptors, these pharmacologic agents are selective, but not specific. Consequently, many of the approved inhibitors also impair ...
Arango Celso - - 2012
Progressive loss of brain gray matter (GM) has been reported in childhood-onset schizophrenia; however, it is uncertain whether these changes are shared by pediatric patients with different psychoses. To examine the progression of brain changes in first-episode early-onset psychosis and their relationship to diagnosis and prognosis at 2-year follow-up. Prospective, ...
Hughes Steven - - 2012
TRPM1 is a spontaneously active non-selective cation channel that has recently been shown to play an important role in the depolarizing light responses of ON bipolar cells. Consistent with this role, mutations in the TRPM1 gene have been identified as a principal cause of congenital stationary night blindness. However, previous ...
Kempf Werner - - 2012
Cutaneous B-cell lymphomas (CBCL) are the second most common form of primary cutaneous lymphomas. The cutaneous follicle center lymphoma and the cutaneous marginal zone lymphoma (extranodal MALT type lymphoma) account for the vast majority of CBCL and manifest with nodules. These two lymphoma entities have an indolent, slowly progressive course ...
Schmidt O A - - 2012
Micrometer-sized particles are trapped in front of an air-filled hollow-core photonic crystal fiber using a novel dual-beam trap. A backward guided mode produces a divergent beam that diffracts out of the core, and simultaneously a focused laser beam launches a forward-propagating mode into the core. By changing the backward/forward power ...
Su Chen-Hsien - - 2012
Primary neuroendocrine carcinomas of the breast (PNCB) are very rare and tumor markers for this indication are not well defined. We aim at reporting a case and providing a marker useful for prognosis and prediction of tumor recurrence for patients with PNCB. A 75-year-old woman presented with a slight painful ...
Lin Wen-Hsing - - 2012
A high-throughput 32D(L858R/T790M) cell-based assay to identify inhibitors of the L858R/T790M mutant epidermal growth factor receptor (EGFR) pathway was established. After screening, ten hits from among 60,000 compounds in our in-house compound library were initially identified. In the secondary assays, one hit, 1-[2-(decyloxy)-2-oxoethyl]-3-methyl-2-[(4-methylphenoxy) methyl]-1H-benzimidazol-3-ium, was confirmed to directly inhibit the ...
Kim Hee Sun - - 2012
Heterotopic gastric mucosa has been described in all levels of the gastrointestinal tract. However, gastric heterotopia of the rectum is a rare finding. It is usually reported along with polyp located in the rectum between 5 and 8 cm from the anal verge. The most common symptom is painless rectal bleeding, ...
Epstein Jonathan I - - 2012
Epstein J I (2012) Histopathology60, 28-40Diagnosis of limited adenocarcinoma of the prostate This article provides an overview of the diagnosis of limited prostate cancer on needle biopsy. A few of the more common mimickers of prostate cancer, such as adenosis, partial atrophy, and high-grade prostatic intraepithelial neoplasia, are also covered. ...
Carter Stephen F - - 2012
Astrocytes colocalize with fibrillar amyloid-β (Aβ) plaques in postmortem Alzheimer disease (AD) brain tissue. It is therefore of great interest to develop a PET tracer for visualizing astrocytes in vivo, enabling the study of the regional distribution of both astrocytes and fibrillar Aβ. A multitracer PET investigation was conducted for ...
Kosmidis Paris A - - 2012
Aim: The purpose of this study was to compare two single agents paclitaxel (intravenous) versus vinorelbine (oral) in non-small cell lung cancer (NSCLC) patients with performance status (PS):2. The patients were randomized to receive either oral vinorelbine 60 mg/m(2) on days 1, 8, 15 every 4 weeks for 4 cycles ...
Egevad Lars - - 2012
Egevad L (2012) Histopathology 60, 118-124 Handling of radical prostatectomy specimens Accurate reporting of radical prostatectomy specimens is becoming more important as we gain insights into how cancer therapy should be tailored according to risk categories. Adjuvant therapy after radical prostatectomy is now given more commonly to patients with pathological findings ...
Shire Abdirashid M AM Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN 55905, - - 2012
To study the frequencies of chronic hepatitis B virus (HBV) and hepatitis C virus (HCV) infection, and their associations with hepatocellular carcinoma (HCC) in immigrant Somalis seen at Mayo Clinic in Rochester, Minnesota. We determined the frequencies of HBV and HCV infection and HCC in immigrant Somalis seen at Mayo ...
Pan Shilong - - 2012
A photonic approach to the simultaneous measurement of the frequency, pulse amplitude (PA), pulse width (PW), and time of arrival (TOA) of an unknown pulsed microwave signal is proposed and demonstrated. The measurement is performed based on optical carrier-suppressed modulation, complementary optical filtering, low-speed photodetection, and electrical signal processing. A ...
Ko Wen-chin WC Graduate Institute of Clinical Medicine, College of Medicine, Taipei Medical University, Taiwan, - - 2012
To investigate the signaling pathways involved in thrombin-induced connective tissue growth factor (CTGF) expression in rat vascular smooth muscle cells (VSMCs). Experiments were preformed on primary rat aortic smooth muscle cells (RASMCs) and a rat VSMC line (A10). CTGF protein levels were measured using Western blotting. Luciferase reporter genes and ...
Rampino M - - 2012
To determine the potential activity and tolerability of sequential treatment in head and neck cancer, we conducted a phase II trial based on induction chemotherapy of two cycles of taxotere, cisplatin and 5-fluorouracil followed by radiotherapy plus weekly cetuximab. Thirty-six patients with stage III or IV squamous cell carcinoma of ...
Fine Samson W - - 2012
Fine S W & Reuter V E (2012) Histopathology 60, 142-152 Anatomy of the prostate revisited: implications for prostate biopsy and zonal origins of prostate cancer Over the past 25 years, our understanding of prostatic disease has evolved secondary to the increased detection, treatment and study of both benign and neoplastic prostatic ...
Jacobsen Steven J SJ Department of Research and Evaluation, Southern California Permanente Medical Group, Pasadena, CA, - - 2012
To determine the distribution of longitudinal changes in serum prostate-specific antigen (PSA) levels from a population-based sample of men. In this prospective cohort study, a random sample of Olmsted County, Minnesota, men aged 40 to 79 years in 1990 were followed up biennially from January 1, 1990, through August 29, ...
Sun Haishan - - 2012
Because of stronger optical confinement density, silicon slot waveguides tend to have higher scattering loss than normal ridge waveguides with same sidewall roughness. A wet chemical process is found to be highly effective in reducing the surface roughness and scattering loss. A reduction in scattering loss by 10.2 dB/cm for ...
Catalán Pilar - - 2012
Brachypodium distachyon is being widely investigated across the world as a model plant for temperate cereals. This annual plant has three cytotypes (2n = 10, 20, 30) that are still regarded as part of a single species. Here, a multidisciplinary study has been conducted on a representative sampling of the ...
Kim Hyo Geun - - 2012
Alzheimer's disease (AD) is a chronic neurodegenerative disorder and is the most common cause of progressive dementia in aging. Research on AD therapy has been partly successful in terms of developing symptomatic treatments, but there have been a number of failures with regard to developing disease-modifying therapies. The pathogenesis of ...
Deqnah Narjes - - 2012
We report the synthesis and in vitro activity of trans-bis-(2-hydroxypyridine)dichloroplatinum(II) (coded as DH3) in humour ovarian tumour models. The compound is less active than cisplatin against the parent cell line A2780 but more so against the cisplatin-resistant A2780(cisR) cell line, thus indicating that it is better able to overcome mechanisms ...
Mullins Tanya L Kowalczyk TL Division of Adolescent Medicine, Department of Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA. - - 2012
To (1) examine perceptions of risk of human papillomavirus (HPV) and other sexually transmitted infections (STIs), (2) examine perceived need for safer sexual behaviors, and (3) determine factors associated with less perceived need for safer sexual behaviors, all in the context of receiving the first HPV vaccination. Cross-sectional baseline analysis ...
Berney Dan - - 2012
Berney D & Cheng L (2012) Histopathology 60, 1-3 Prostate cancer: towards the standardization and synthesis of morphology, genetics, and prognosis Prostate cancer research and diagnosis is undergoing a revolution in our understanding of the disease process and standardization of diagnostic criteria. Although great progress has been made, there remain many ...
Hatt Mathieu - - 2012
The objective of this study was to investigate the clinical impact of partial-volume effect (PVE) correction on the predictive and prognostic value of metabolically active tumor volume (MATV) measurements on (18)F-FDG PET baseline scans for therapy response and overall survival in esophageal cancer patients. Fifty patients with esophageal cancer treated ...
Kamen Charles - - 2012
This study examined the relationships among dissociation, childhood trauma and sexual abuse, and posttraumatic stress disorder (PTSD) symptoms in HIV-positive men. Data were collected from 167 men enrolled in a randomized clinical trial that examined a group therapy intervention to decrease HIV-related risk behavior and trauma-related stress symptoms. Participants completed ...
Mythri R B - - 2012
Parkinson's disease (PD) is an age-associated neurodegenerative disease clinically characterized as a movement disorder. The motor symptoms in PD arise due to selective degeneration of dopaminergic neurons in the substantia nigra of the ventral midbrain thereby depleting the dopamine levels in the striatum. Most of the current pharmacotherapeutic approaches in ...
Ostrosky-Zeichner Luis - - 2012
Despite the availability of newer antifungal drugs, outcomes for patients with invasive fungal infections (IFIs) continue to be poor, in large part due to delayed diagnosis and initiation of appropriate antifungal therapy. Standard histopathologic diagnostic techniques are often untenable in at-risk patients, and culture-based diagnostics typically are too insensitive or ...
Suetsugu Atsushi - - 2012
The tumor microenvironment (TME) has an important influence on tumor progression. For example, we have discovered that passenger stromal cells are necessary for metastasis. In this report, we describe six different cyan fluorescent protein (CFP) multicolor TME nude mouse models. The six different implantation models were used to image the ...
Lundström Sebastian - - 2012
Autism spectrum disorders (ASDs) have been suggested to represent the extreme end of a normal distribution of autisticlike traits (ALTs). However, the evidence of this notion is inconclusive. To study whether there are similar genetic and/or environmental etiologies behind ASDs and ALTs. A nationwide twin study. Consenting parents of all ...
Rehammar R - - 2012
A square planar photonic crystal composed of carbon nanofibers was fabricated using e-beam lithography and chemical vapor deposition. The diffraction properties of the system were characterized experimentally and compared with theory and numerical simulations. The intensities of the (-1,0) and (-1,-1) diffraction beams were measured as functions of the angles ...
Tuohimaa P - - 2012
It has been demonstrated in several studies that serum calcidiol (25 OH vitamin D(3)) concentration is in a reversed and linear relationship with cancer risk. However, there are also studies showing no such association and some even suggest the opposite. The risk of pancreatic and oesophageal cancer seems to increase, ...
Holmdahl Rikard - - 2012
The dramatic increase in the amount of research data being produced necessarily leads to higher demands on statistical thresholds and on experimental planning. This is to avoid positive selection of multiple tested data. Here we would like to highlight the need for including littermate controls in animal experiments, in particular ...
Ito Taisuke - - 2012
Spontaneous remission occurs in up to 80% of patients with limited patchy alopecia areata (AA) within 1 year. Therefore, not all patients of AA simplex/multiplex need extensive treatments, and "wait and see" is one of the choices for some patients. However, once the hair loss show progressive course, it is really ...
Henson John - - 2012
Diffractive arrays of silver nanocylinders are used to increase the radiative efficiency of InGaN/GaN quantum wells emitting at near-green wavelengths. Large enhancements in luminescence intensity (up to a factor of nearly 5) are measured when the array period exceeds the emission wavelength in the semiconductor material. The experimental results and ...
Durrenberger Pascal F PF Department of Medicine, Section of Infectious Diseases and Immunity, Commonwealth Building, Hammersmith Campus, Imperial College London, - - 2012
Pathogenic or regulatory effects of natural killer (NK) cells are implicated in many autoimmune diseases, but evidence in multiple sclerosis (MS) and its murine models remains equivocal. In an effort to illuminate this, we have here analysed expression of the prototypic NK cell marker, NCR1 (natural cytotoxicity triggering receptor; NKp46; ...
Murphy P G - - 2012
Implementation of the recommendations from the Organ Donation Taskforce has introduced for the first time into the UK a nationwide framework for deceased donation. This framework is based, in principle, upon a conviction that donation should be viewed as part of end-of-life care and that the actions often necessary to ...
Kubodera Noboru - - 2012
Eldecalcitol [1α,25-dihydroxy-2β-(3-hydroxypropoxy)vitamin D(3)], an analog of calcitriol (1α,25-dihydroxyvitamin D(3)), possesses a hydroxypropoxy substituent at the 2β-position of calcitriol. Eldecalcitol has potent biological effects on bone disease such as osteoporosis. The marketing of eldecalcitol has very recently started in Japan. In consideration of this, we have been investigating practical synthesis of ...
Poinsot Véréna - - 2012
This paper describes the most important articles that have been published on amino acid analysis using CE during the period from June 2009 to May 2011 and follows the format of the previous articles of Smith (Electrophoresis 1999, 20, 3078-3083), Prata et al. (Electrophoresis 2001, 22, 4129-4138) and Poinsot et ...
Lin Chih-Kung - - 2012
Lin C-K, Tsai W-C, Lin Y-C & Hueng D-Y (2012) Histopathology 60, 320-325 Osteopontin predicts the behaviour of atypical meningioma Aim:  Although the World Health Organization (WHO) histological criteria distinguishing benign from atypical and malignant meningioma are clear, discerning benign from atypical meningioma is still somewhat difficult, leading to interobserver diagnostic ...
Abraham Ronnie M RM Department of Pathology, University of Pennsylvania, Philadelphia, PA, - - 2012
A subset of difficult melanocytic lesions exists with histopathologic features that evade diagnostic consensus from even expert dermatopathologists. Comparative genomic hybridization (CGH) has emerged as a useful diagnostic tool to categorize these lesions, by identifying known chromosomal aberrations in malignant melanoma or the lack thereof in melanocytic nevi. However, determining ...
Albero Jorge - - 2012
We report a method to maximize the broadband modulation diffraction efficiency of liquid-crystal spatial light modulators for polychromatic applications requiring a wide range of wavelengths. An optimized encoding pattern based on the minimum Euclidean projection principle is applied in order to increase the diffraction efficiency at large wavelengths that exhibit ...
Divella Rosa - - 2012
The aim of our study was to improve the detection of HCC by measuring alpha-fetoprotein (AFP) in addition to other molecular markers by estimating the plasma concentration of transforming growth factor beta (TGF-β) and epidermal growth factor receptor (EGFR). In particular, the role of hepatitis C and B viruses (HCV ...
Morisaki Tomohito - - 2012
The patient was a 74-year-old woman. She visited a dermatology clinic with a complaint of discomfort in the anal region. Erosion was observed in the anal region, and biopsies were performed. She was diagnosed with Bowen's disease and was referred to the dermatology department of our hospital for treatment. At ...
Bostwick David G - - 2012
Bostwick D G & Cheng L (2012) Histopathology 60, 4-27 Precursors of prostate cancer High-grade prostatic intraepithelial neoplasia (PIN) is the only accepted precursor of prostatic adenocarcinoma, according to numerous studies of animal models and man; other proposed precursors include atrophy and malignancy-associated changes (with no morphologic changes). PIN is ...
Chang Kai-Ping - - 2012
The plasma concentration of Epstein-Barr virus (EBV) DNA is associated with tumor burden and prognosis in patients with nasopharyngeal carcinoma (NPC), but data on the relationship between viral load and (18)F-FDG PET functional parameters are lacking. We examined the association of (18)F-FDG PET functional parameters and EBV DNA load with ...
Najavits Lisa M - - 2012
Few studies have examined the relationship between posttraumatic stress disorder (PTSD), substance use disorder, and dissociation. We studied 77 women with current PTSD and substance dependence, classified into high- versus low-dissociation groups per the Dissociative Experiences Scale. They were compared on trauma- and substance-related symptoms, cognitions, coping skills, social adjustment, ...
Hamilton Kristen R - - 2012
Delay discounting is a reduction in the subjective value of a delayed outcome. Elevated delay discounting is a type of impulsivity that is associated with harmful behaviors, including substance abuse and financial mismanagement. Elevated delay discounting as related to addiction and financial mismanagement was reviewed from psychological, neurobiological, and behavioral ...
Hita-Yañez E - - 2012
Sleep disturbances are prevalent in patients with Alzheimer's disease (AD), being one of the most troubling symptoms during the progression of disease. However, little effort has been devoted to determine if impaired sleep patterns appear years before AD diagnosis is made. This study tries to shed light on this issue ...
Watson C J E - - 2012
Over the course of the last century, organ transplantation has overcome major technical limitations to become the success it is today. The breakthroughs include developing techniques for vascular anastomoses, managing the immune response (initially by avoiding it with the use of identical twins and subsequently controlling it with chemical immunosuppressants), ...
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