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Kindrachuk Jason - - 2012
Monkeypox virus (MPXV) is comprised of two clades: Congo Basin MPXV, with an associated case fatality rate of 10%, and Western African MPXV, which is associated with less severe infection and minimal lethality. We thus postulated that Congo Basin and West African MPXV would differentially modulate host cell responses and, ...
Hampson D R - - 2011
Autism spectrum disorders (ASDs) are neurodevelopmental disorders whose prevalence has risen over the past two decades. Current drug treatments for ASDs and the related disorders-fragile X syndrome (FXS) and Rett syndrome-target specific symptoms but do not address the basic underlying etiologies. However, based partly on an improved understanding of the ...
Grasby Stephen E - - 2011
Abstract Gypsum filled "pipe" features were discovered in the proglacial area of the Borup Fiord Pass supraglacial sulfur spring. Stable isotope data suggest that gypsum is formed through oxidation of sulfides and are consistent with models of sulfuric acid speleogenesis. These results suggest that gypsum pipes are paleo-spring discharge channels ...
Sano S - - 2012
Glucocorticoid (GC) excess promotes adipose tissue accumulation, and 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) plays an important role in the local amplification of GC. Therefore, in this study, we investigated the effects of carbenoxolone (CBX), an 11β-HSD1 inhibitor, on morphological changes in visceral fat, and the expression of genes involved in ...
Almeida Rodrigo P P - - 2011
In Xylella fastidiosa the fatty acid signal molecule DSF is produced and sensed by components of the regulation of pathogenicity factors (rpf) cluster; lack of DSF production in RpfF mutants results in a non-vector transmissible phenotype yet cells are hypervirulent to grape. rpfB has not been characterized in X. fastidiosa, ...
Patronas Yianna - - 2012
Carney complex (CNC) is a multiple endocrine neoplasia syndrome due to inactivating mutations in the PRKAR1A gene that codes for type Iα regulatory (RIα) subunit of protein kinase A. Most PRKAR1A mutations are subject to nonsense mRNA decay (NMD) and, thus, lead to haploinsufficiency. Patient phenotyping for CNC features and ...
Hughes Stella - - 2011
BackgroundThe Expanded Disability Status Scale (EDSS) is widely used to rate multiple sclerosis (MS) disability, but lack of disease duration information limits utility in assessing severity. EDSS ranking at specific disease durations was used to devise the MS Severity Score, which is gaining popularity for predicting outcomes. As this requires ...
Trott J F - - 2011
At face value there are clear and established roles for prolactin (PRL) in the regulation of mammary gland growth, lactogenesis, and galactopoiesis. However, these actions of PRL do not occur in isolation, but rather are finely attuned to, and coordinated with, many local, reproductive, and metabolic events in the female. ...
Kiely Kim M - - 2011
OBJECTIVE: To evaluate a harmonized binary measure of self-reported hearing loss against gold standard audiometry in an older adult population. METHOD: Seven nationally representative population-based studies were harmonized and pooled (n = 23,001). Self-report items were recoded into a dichotomous format. Audiometric hearing loss was defined by averaged pure-tone thresholds ...
Tofuku Katsuhiro - - 2011
An 84-year-old man experienced right buttock pain that radiated gradually to his right lower extremity over a few months before admission. MRI revealed a space occupying intraspinal lesion that was close to the right-sided L4-L5 facet joint and an extraspinal lesion posterior to the right-sided L5 lamina. The lesions appeared ...
Woo Patrick C Y - - 2012
Dicistroviridae and Picornaviridae are two phylogenetically related families of positive-sense single-stranded RNA viruses in the picornavirus-like superfamily with similar gene contents but different genome organizations and hosts. In a surveillance study involving 1,472 samples from 368 dogs over a 22-month period, we identified a novel picornavirus-like virus from 47 fecal ...
Lo Chao-Sheng - - 2012
We investigated the effects of dual renin-angiotensin system (RAS) blockade on angiotensin-converting enzyme-2 (Ace2) expression, hypertension, and renal proximal tubular cell (RPTC) apoptosis in type 1 diabetic Akita angiotensinogen (Agt)-transgenic (Tg) mice that specifically overexpress Agt in their RPTCs. Adult (11 wk old) male Akita and Akita Agt-Tg mice were ...
Goodman Laura B - - 2012
Equine herpesvirus 1 (EHV-1) induces a variety of disease manifestations, including respiratory disease, abortions, and myeloencephalopathy. Several vaccines are commercially available but could not previously be distinguished by serologic testing from infection with EHV-1 (or the closely related EHV-4). Currently available vaccines are not reliably protective against the severe manifestations ...
Silva N R F A - - 2012
The present investigation hypothesized that the reliability of reduced-thickness monolithic lithium disilicate crowns is high relative to that of veneered zirconia (Y-TZP) and comparable with that of metal ceramic (MCR) systems. CAD/CAM first mandibular molar full-crown preparations were produced with uniform thicknesses of either 1.0-mm or 2.0-mm occlusal and axial ...
John Bijo K - - 2011
BACKGROUND: Equivocal data demonstrate the efficacy of ethanol lock therapy (ELT) in preventing catheter-related bloodstream infections (CRBSIs) in home parenteral nutrition (HPN) patients, but it is not currently a standard of practice. The objective of this study is to investigate the efficacy of ELT in reducing the incidence of CRBSIs ...
Anand R - - 2011
Alzheimer's disease (AD), the most common cause of dementia, results from the interplay of various deregulated mechanisms triggering a complex pathophysiology. The neurons suffer from and slowly succumb to multiple irreversible damages, resulting in cell death and thus memory deficits that characterize AD. In spite of our vast knowledge, it ...
Adhikari Tika - - 2011
Bacterial leaf streak (BLS), caused by Xanthomonas translucens pv. undulosa, has become more prevalent recently in North Dakota and neighboring states. From five locations in North Dakota, 226 strains of X. translucens pv. undulosa were collected and evaluated for pathogenicity and then selected strains were inoculated on a set of ...
Fourcade Julien J Department of Medicine, Division of Hematology/Oncology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, - - 2012
Cytotoxic T cells that are present in tumors and capable of recognizing tumor epitopes are nevertheless generally impotent in eliciting tumor rejection. Thus, identifying the immune escape mechanisms responsible for inducing tumor-specific CD8(+) T-cell dysfunction may reveal effective strategies for immune therapy. The inhibitory receptors PD-1 and Tim-3 are known ...
Qiu Chen C Laboratory of Structural Biology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709, - - 2012
mRNA control networks depend on recognition of specific RNA sequences. Pumilio-fem-3 mRNA binding factor (PUF) RNA-binding proteins achieve that specificity through variations on a conserved scaffold. Saccharomyces cerevisiae Puf3p achieves specificity through an additional binding pocket for a cytosine base upstream of the core RNA recognition site. Here we demonstrate ...
Baéza E - - 2011
Because of the increasing demand for raw cuts and processed products, there is a trend to producing very heavy broilers. Breeds that are used for such kinds of production have been intensively selected for growth rate and breast meat yield, and birds are reared for a longer period than standard ...
Zhang Ying E - - 2011
ABSTRACT: The TGF-beta family of cytokines encompasses a large number of versatile poly-peptide growth factors regulating a multitude of cellular processes in almost every aspect of cellular function, including proliferation, differentiation, apoptosis, migration, and adhesion. Inappropriate signaling by these factors is closely linked to cancer and other diseases. Although much ...
Erdmann J - - 2012
Hyperinsulinemia of nondiabetic overweight and obese subjects is associated with weight-dependent increased insulin secretion and decreased insulin clearance. The present analysis examines whether similar effects can be observed in overweight and obese patients with type 2 diabetes mellitus (DM2). Additionally basal and postprandial insulin secretion and clearance were analyzed in ...
Panesar Nirmal S - - 2011
BackgroundMost cultures believe in ghosts and for the Chinese, the seventh lunar month-the ghost month-causes particular concern. 'The gates of hell' are open for the first 14 days of the month which allows the restless ghosts of people who were hungry when they died to haunt the living. In this ...
Tangney Christy C - - 2011
A growing body of evidence is supportive of the influence of nutritional factors on cognitive health. There is evidence relating nutrition to cognitive measures to assess cognitive change over time, but such functional changes may not reflect the neuroanatomic or pathologic alterations that have occurred. Brain imaging may complement clinical ...
García-Bailo Bibiana - - 2011
BACKGROUND: High-abundance plasma proteins are involved in disease-associated pathways and are useful in the diagnosis of nutritional and disease states. However, little is known about how concentrations of many plasma proteins vary between individuals from different ethnocultural groups with different dietary habits. OBJECTIVE: We explored the association between plasma proteomic ...
Zhang Qinghua - - 2012
Multiple signaling pathways are involved in the tight regulation of Toll-like receptor (TLR) signaling, which is important for the tailoring of inflammatory response to pathogens in macrophages. It is widely accepted that TLR signaling can activate Notch pathway; however, whether full activation of Notch signaling can feedback modulate TLR signaling ...
Lorenson Mary Y - - 2012
Prolactin (PRL) in milk influences maturation of gastrointestinal epithelium and development of both the hypothalamo-pituitary and immune systems of offspring. Here, we demonstrate that most PRL in human milk is part of a novel, high-affinity, multicomponent binding complex found on the milk fat globule membrane and not in whey. To ...
Gaffo Angelo L - - 2011
Data supporting an association between high levels of serum urate and cardiovascular disease have continued to emerge. Basic science data, small clinical trials, and epidemiologic studies have provided support for the idea of a true causal effect. In this paper, we present evidence about the association between hyperuricemia and selected ...
Trcka Jiri - - 2011
Background: Although rice (Oryza sativa) is one of the most common cereals produced and consumed around the world, there have been only a few reports on immediate hypersensitivity reactions after ingestion of rice. Few clinical studies on rice allergy in Asia have been reported concerning rhinitis, asthma and atopic dermatitis. ...
Baumgard L H - - 2011
Heat stress compromises efficient animal production by marginalizing nutrition, management, and genetic selection efforts to maximize performance endpoints. Modifying farm infrastructure has yielded modest success in mitigating heat stress-related losses yet poor production during the summer remains arguably the costliest issue facing livestock producers. Reduced output (i.e., milk yield, muscle ...
Raksin Jonathan N - - 2012
Motor-related forebrain areas in higher vertebrates also show responses to passively presented sensory stimuli. However, sensory tuning properties in these areas, especially during wakefulness, and their relation to perception, are poorly understood. In the avian song system, HVC (proper name) is a vocal-motor structure with auditory responses well defined under ...
Ramirez-Gomez Francisco - - 2011
The gene encoding IgH δ has been found in all species of teleosts studied to date. However, catfish (Ictalurus punctatus) is the only species of fish in which a secretory form of IgD has been characterized, and it occurs through the use of a dedicated δ-secretory exon, which is absent ...
Tao Jianmin - - 2012
The van der Waals interaction is a weak, long-range correlation, arising from quantum electronic charge fluctuations. This interaction affects many properties of materials. A simple and yet accurate estimate of this effect will facilitate computer simulation of complex molecular materials and drug design. Here we develop a fast approach for ...
McWilliam Leitch E C EC Centre for Infectious Diseases, University of Edinburgh, Summerhall, Edinburgh, United - - 2012
Enterovirus 71 (EV71) is responsible for frequent large-scale outbreaks of hand, foot, and mouth disease worldwide and represent a major etiological agent of severe, sometimes fatal neurological disease. EV71 variants have been classified into three genogroups (GgA, GgB, and GgC), and the latter two are further subdivided into subgenogroups B1 ...
Holder Beth S - - 2011
Normal pregnancy is associated with the presence of circulating placental microvesicles (MV). Increased MV shedding and altered immune activation are seen in patients with preeclampsia, suggesting that placental MV may play a role in the pathophysiology of this disease. Therefore, the aim of this study was to investigate the activation ...
Zhao Zan - - 2011
We fabricated a layer-by-layer (LbL) film of temperature-responsive homopolymers at neutral pH and studied its temperature-dependent solubility. We firstly measured the cloud point of mixed solutions of temperature-responsive polymers. The significant decrease of cloud point suggested that the intermolecular interaction between two polymer chains of different kinds was stronger than ...
Clark Ian P - - 2011
The photochemistry of (η<sup>6</sup>-anisole)Cr(CO)<sub>3</sub> and (η<sup>6</sup>-thioanisole)Cr(CO)<sub>3</sub> was investigated by pico second time-resolved infrared spectroscopy in <i>n</i>-heptane solution at 298 K. Two independent excited states are populated following 400 nm excitation of each of these complexes. An excited state with some metal-to-CO charge-transfer character is responsible for the CO-loss process which ...
Hauner Hans - - 2011
BACKGROUND: The composition of long-chain PUFAs (LCPUFAs) in the maternal diet may affect obesity risk in the mother's offspring. OBJECTIVE: We hypothesized that a reduction in the n-6 (omega-6):n-3 (omega-3) LCPUFA ratio in the diet of pregnant women and breastfeeding mothers may prevent expansive adipose tissue growth in their infants ...
Mäkinen Ville-Petteri - - 2011
Type 1 diabetic patients with varying severity of kidney disease were investigated to create multi-metabolite models of the disease process. Urinary albumin excretion rate was measured for 3 358 patients with type 1 diabetes. Prospective records were available for 1 051 patients, of whom 162 showed progression of albuminuria (8.3-year follow-up), and ...
Adam Heather J - - 2011
Changes in the epidemiology of Streptococcus pneumoniae were reported worldwide after the introduction of the 7-valent pneumococcal vaccine, particularly an increase in multi-drug resistant (MDR) 19A strains. Subsequently, a 13-valent pneumococcal vaccine (PCV-13) has been introduced. This study assessed the incidence of S. pneumoniae serotypes in all age groups prior ...
Stefanova Valentina T - - 2011
Human embryonic stem cells (hESCs) have the potential to revolutionize many biomedical fields ranging from basic research to disease modeling, regenerative medicine, drug discovery and toxicity testing. A multitude of hESC lines have been derived worldwide since the first five lines by Thomson and colleagues 13 years ago, but many ...
Davis Herbert T - - 2011
Abstract The purpose of this study was to use retrospective data, including citations for driving while intoxicated (DWI), to assess the long-term effectiveness of a program consisting of Screening and Brief Intervention (SBI) for at-risk alcohol users and its impact on traffic safety. A second objective was to study ethnic ...
Bull Rowena A - - 2012
Norovirus (NoV) is an emerging RNA virus that has been associated with global epidemics of gastroenteritis. Each global epidemic arises with the emergence of novel antigenic variants. While the majority of NoV infections are mild and self-limiting, in the young, elderly, and immunocompromised, severe and prolonged illness can result. As ...
White David - - 2012
The repair of DNA damage in highly compact, transcriptionally silent heterochromatin requires that repair and chromatin packaging machineries be tightly coupled and regulated. KAP1 is a heterochromatin protein and co-repressor that binds to HP1 during gene silencing but is also robustly phosphorylated by Ataxia telangiectasia mutated (ATM) at serine 824 ...
Berruezo Antonio - - 2012
Ventricular tachycardia (VT) ablation in patients with arrhythmogenic right ventricular dysplasia/cardiomyopathy (ARVD/C) has a low success rate. A more extensive epicardial (Epi) arrhythmogenic substrate could explain the low efficacy. We report the results of combined endocardial (Endo) and Epi VT ablation and conducting channel (CC) elimination. Eleven consecutive patients with ...
Xu Xiongfei - - 2011
Stromal microenvironments of bone marrow, lymph nodes, and spleen have been shown to be able to regulate immune cell differentiation and function. Our previous studies demonstrate that splenic stroma could drive mature dendritic cells (DC) to further proliferate and differentiate into regulatory DC subset that could inhibit T cell response ...
Hultquist Judd F JF Department of Biochemistry, Molecular Biology and Biophysics, Institute for Molecular Virology, Center for Genome Engineering, University of Minnesota, Minneapolis, Minnesota, - - 2012
HIV-1 requires the cellular transcription factor CBFβ to stabilize its accessory protein Vif and promote APOBEC3G degradation. Here, we demonstrate that both isoforms of CBFβ allow for increased steady-state levels of Vif, enhanced APOBEC3G degradation, and increased viral infectivity. This conserved functional interaction enhances the steady-state levels of Vif proteins ...
Ratchford Stephen M SM Department of Human Physiology, University of Oregon, Eugene, Oregon 97403-1240, - - 2012
Total knee arthroplasty (TKA) utilizes a tourniquet to reduce blood loss, maintain a clear surgical "bloodless" field, and to ensure proper bone-implant cementing. In 2007, over 600,000 TKAs were performed in the United States, and this number is projected to increase to 3.48 million procedures performed annually by 2030. The ...
Salazar D E - - 2012
Modeling and simulation were used extensively in the development of an indication for the use of olmesartan medoxomil in pediatric patients with hypertension. Simulations based on models developed in adult patients indicated that two dose groups were sufficient to estimate a dose-response relationship, thereby reducing by one-third the number of ...
Westerveld Marleen F - - 2011
This study investigated if the story retelling and comprehension task Ana Gets Lost, that is frequently used with school-aged children, has clinical utility with a preschool population. The study also assessed the task's concurrent and predictive validity with norm-referenced tests of language performance. A total of 92 typically-developing 4-year-old children ...
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