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Yang Yongping - - 2012
To evaluate the efficacy and safety of ultrasound (US)-guided percutaneous argon-helium cryoablation for hepatocellular carcinoma (HCC) and determine appropriate indications. We reviewed outcomes of 300 HCC patients who underwent US-guided percutaneous cryoablation. Overall, 223 tumors (mean diameter 7.2 ± 2.8 cm) in 165 patients were incompletely ablated, while 185 tumors (mean diameter 5.6 ± 0.8 cm, ...
Chang Chung-Chou H CC Department of Medicine, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA. - - 2012
If smoking is a risk factor for Alzheimer disease (AD) but a smoker dies of another cause before developing or manifesting AD, smoking-related mortality may mask the relationship between smoking and AD. This phenomenon, referred to as competing risk, complicates efforts to model the effect of smoking on AD. Typical ...
Khoo Hui Ming HM Department of Neurosurgery, Osaka University Medical School, Suita, Osaka, - - 2012
The key to successful microvascular decompression of the neurovascular compression syndrome is maintaining the separation between the nerve and the offending vessel. We describe a transposition technique in which a local pedicled dural flap, fashioned from the petrous posterior surface, is used to retract the offending vessel away from the ...
Dovis Sebastiaan - - 2012
Visual-spatial Working Memory (WM) is the most impaired executive function in children with Attention-Deficit/Hyperactivity Disorder (ADHD). Some suggest that deficits in executive functioning are caused by motivational deficits. However, there are no studies that investigate the effects of motivation on the visual-spatial WM of children with- and without ADHD. Studies ...
Sadeh Naomi - - 2012
A long-standing debate is the extent to which psychopathy is characterized by fundamental deficits in attention or emotion. We tested the hypothesis that the interplay of emotional and attentional systems is critical for understanding processing deficits in psychopathy. A group of 63 offenders were assessed using the Psychopathy Checklist: Screening ...
Starke Robert M RM Department of Neurosurgery, University of Virginia School of Medicine, Charlottesville, Virginia 22908, USA. - - 2012
Central fever is common after aneurysmal subarachnoid hemorrhage (aSAH) and may delay ventriculoperitoneal shunt (VPS) placement. We hypothesize that drain-dependent aSAH patients with central fever or persistent fever after treatment of an identifiable cause are not at an increased risk of infectious VPS failure. Patient demographics, radiographic characteristics, temperature, incidence ...
Brown Russell A - - 2012
The N-localizer, which facilitates computed tomography-guided stereotactic surgery, was invented in the late 1970s by a medical student who built a prototype stereotactic frame to test the concept. Initial experiments using the prototype frame were soon followed by surgery in humans using the Brown-Roberts-Wells stereotactic frame.
Moran A A North West Cancer Intelligence Service, The Christie NHS Foundation Trust, Manchester, M20 3LJ, - - 2012
The risks of cancers other than breast and ovarian amongst BRCA1 and BRCA2 mutation carriers are based on relatively few family based studies with the risk of specific cancers tested in population based samples of cancers from founder populations. We assessed risks of "other cancers" in 268 BRCA1 families and ...
Aoki Tomohiro - - 2012
Despite a high mortality and morbidity of subarachnoid hemorrhage due to an intracranial aneurysm (IA), there is no effective medical treatment to prevent the rupture of IAs. Recent studies have revealed the involvement of the transactivation of proinflammatory genes by nuclear factor-κB (NF-κB) and Ets-1 in the pathogenesis of IA ...
Seo Byung-Sun - - 2012
An aplastic or twiglike middle cerebral artery (Ap/T-MCA) is an extremely rare congenital anomaly related to interference in the normal embryonic development of the MCA. To evaluate the clinical and radiological features of patients with an Ap/T-MCA. A total of 1749 conventional cerebral angiography procedures were performed in 1282 patients ...
Li Yi-Chen YC Department of Orthopaedic Surgery, E-DA Hospital, I-Shou University, Kaohsiung, - - 2012
Steel's triple innominate osteotomy was created for correcting dysplastic acetabulum in adolescents and young adults. We modified Steel's triple innominate osteotomy with two anterior incisions and ramus cuts close to the acetabulum to improve the mobility of the fragment for better coverage of the hip. The purpose of this study ...
Dhawale Arjun A - - 2012
Hip dislocation is a serious but rarely reported complication of femoral lengthening in congenital short femora. We report a retrospective series of three hip dislocations that occurred during lengthening, analyze the factors contributing to the dislocation, and discuss the treatment of this difficult problem. The average lengthening achieved was 9 ...
Saggurti Niranjan N Population Council, New Delhi, India. - - 2012
This paper examines the relationship between indicators of mobility, socio-economic vulnerabilities, and HIV risk behaviours among 5,498 mobile female sex workers (FSWs) living in the four high HIV prevalence states in India. Female sex workers with greater degree of mobility reported significantly more often than the FSWs with lesser degree ...
Froberg Lonnie - - 2012
The purpose was to compare radiographic parameters with a sex-matched and age-matched control group at the onset of disease and at skeletal maturity. The study comprised 143 patients with Legg-Calvé-Perthes disease, treated using a Thomas splint. Wiberg's centre-edge angle and the acetabular index angle were applied. The age at diagnosis ...
Schmilovitz-Weiss Hemda - - 2012
Clinical diagnosis of acute diverticulitis is currently confirmed by an abdominal computerized tomography (CT). Common practice has been to perform a colonoscopy after the event to exclude other diagnoses, mainly colon cancer. Our aim was to evaluate the yield of an early colonoscopy. Medical records of 220 patients hospitalized for ...
Opyrchal Mateusz - - 2012
Engineered measles virus (MV) strains deriving from the vaccine lineage represent a promising oncolytic platform and are currently being tested in phase I trials. In this study, we have demonstrated that MV strains genetically engineered to express the human sodium iodide symporter (NIS) have significant antitumor activity against glioma lines ...
Demaster Amanda A Division of Medical Genetics, Duke University Medical Center, Durham, NC 27710, - - 2012
Glycogen storage disease type Ia (GSD-Ia) is the inherited deficiency of glucose-6-phosphatase (G6Pase), primarily found in liver and kidney, which causes life-threatening hypoglycemia. Dogs with GSD-Ia were treated with double-stranded adeno-associated virus (AAV) vectors encoding human G6Pase. Administration of an AAV9 pseudotyped (AAV2/9) vector to seven consecutive GSD-Ia neonates prevented ...
Olfson Mark M Department of Psychiatry, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA. - - 2012
Although treatment of depression has increased in recent years, long delays commonly separate disorder onset from first treatment contact. This study evaluates the effects of psychiatric comorbidities and sociodemographic characteristics on lifetime treatment seeking and speed to first treatment contact for major depressive disorder (MDD). A cross-sectional epidemiological survey including ...
Bensinger William I - - 2012
Peripheral blood stem cells (PBSCs) have been widely adopted as a source of stem cells for allogeneic transplantation, although controversy remains regarding their role compared to the use of bone marrow. Ten-year follow-up has been reported from several large randomized trials and a recently completed trial using unrelated donor stem ...
Goldman L Elizabeth LE Department of Medicine, University of California San Francisco, San Francisco, CA 94110, USA. - - 2012
Facilities serving vulnerable women have higher false-positive rates for diagnostic mammography than facilities serving nonvulnerable women. False positives lead to anxiety, unnecessary biopsies, and higher costs. Examine whether availability of on-site breast ultrasound or biopsy services, academic medical center affiliation, or profit status explains differences in false-positive rates. We examined ...
Finger Paul T - - 2012
To test the safety, tolerability, and efficacy of subconjunctival ranibizumab (Lucentis [Genentech, Inc.]) for squamous cell carcinoma of the conjunctiva and cornea. Five patients with recurrent squamous cell carcinoma of the conjunctiva and cornea enrolled in this nonrandomized, single center, phase I pilot study as an alternative to radiation or ...
Jankowska-Gan Ewa E Division of Transplantation, Department of Surgery, University of Wisconsin School of Medicine and Public Health, Madison, WI, - - 2012
Tolerance to noninherited maternal antigens has provided clinical advantage when kidney transplants are exchanged between siblings but not when mother herself is the donor. This paradox prompted us to revisit the "two-way" hypothesis of transplant tolerance--that the immune status of both the organ recipient and the organ donor critically influences ...
Oh Jin Soo JS Department of Neurosurgery, Spine and Spinal Cord , College of Medicine, Yonsei University, Seoul, - - 2012
We established three stable neural stem cell (NSC) lines to explore the possibility of using hypoxia-specific vascular endothelial growth factor (VEGF) expressing NSC lines (EpoSV-VEGF NSCs) to treat spinal cord injury. The application of EpoSV-VEGF NSCs into the injured spinal cord after clip compression injury not only showed therapeutic effects ...
Giraudet Fabrice - - 2012
For lack of therapy targeting sensorineural hearing loss, hearing-impaired patients must be fitted with sound-amplifying hearing aids or cochlear implants, successfully in a majority of cases. Yet failures are often found among auditory neuropathies. Auditory neuropathies are a class of conditions characterized by disrupted spike synchrony in auditory pathways despite ...
Aggarwal Srijan - - 2012
Ultrafine particulate matter (UFP; diameter <0.1 μm) concentrations are relatively high on the freeway, and time spent on freeways can contribute a significant fraction of total daily UFP exposure. We model real-time size-resolved UFP concentrations in summer time on-freeway air. Particle concentrations (32 bins, 5.5 to 600 nm) were measured ...
Dagnelie Gislin G Lions Vision Research and Rehabilitation Center, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205-2020, USA. - - 2012
This review summarizes the current status of retinal prostheses, recent accomplishments, and major remaining research, engineering, and rehabilitation challenges. Retinal research, materials and biocompatibility studies, and clinical trials in patients blind from retinitis pigmentosa are representative of an emerging field with considerable promise and sobering challenges. A summary of progress ...
Abadja Farida F Comprehensive Transplant Center, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, - - 2012
The aim of this review is to provide an overview of significance of T helper 17 (Th17) immunity in acute, chronic and antibody-mediated allograft rejection. The role of Th17 immunity in development of de-novo autoimmunity following transplantation is outlined. It will also consider the impact of Th17 immunity on transplantation ...
Holmes Michael - - 2012
The National Institute for Health and Clinical Excellence (NICE) invited Boehringer Ingelheim GmbH, the manufacturer of dabigatran etexilate (DBG), to submit evidence on the clinical and cost effectiveness of this drug for the primary prevention of venous thromboembolism (VTE) in adult patients who have undergone total hip replacement (THR) or ...
Bonnet Crystel - - 2012
Usher syndrome (USH) is the most prevalent cause of hereditary deafness-blindness in humans. In this review, we pinpoint new insights regarding the molecular mechanisms defective in this syndrome, its molecular diagnosis and prospective therapies. Animal models wherein USH proteins were targeted at different maturation stages of the auditory hair cells ...
Cravedi Paolo P Renal Division, Department of Medicine, Mount Sinai School of Medicine, New York, NY 10029, - - 2012
Tailoring immunosuppressive drugs to an individual's needs is crucial to improve long-term outcomes of organ transplant patients. The purpose of this review is to summarize the data on promising biomarkers able to detect the risk of acute or chronic rejection and to discuss the potential issues for their implementation in ...
Valujskikh Anna A Department of Immunology, Lerner Research Institute, The Cleveland Clinic Foundation, Cleveland, - - 2012
Memory T cells have emerged as a major threat to transplant survival; they are well equipped and well positioned to respond to antigens in an accelerated fashion. They participate in transplant rejection and resist interventions that usually contain naïve T cells. Thus, the means to prevent memory T cells from ...
Dichter Gabriel S GS Carolina Institute for Developmental Disabilities, University of North Carolina at Chapel Hill School of Medicine, 101 Manning Drive, Chapel Hill, NC 27599-3366, USA. - - 2012
The aim of this study was to investigate reward circuitry responses in autism during reward anticipation and outcomes for monetary and social rewards. During monetary anticipation, participants with autism spectrum disorders (ASDs) showed hypoactivation in right nucleus accumbens and hyperactivation in right hippocampus, whereas during monetary outcomes, participants with ASDs ...
Hough Catherine L CL Pulmonary and Critical Care Medicine, Department of Medicine, Harborview Medical Center, University of Washington, Seattle, Washington, - - 2012
As incidence of acute lung injury (ALI) increases and case fatality decreases, long-term care of survivors is of public health importance. Previous studies demonstrate that these survivors are at risk for impairment in physical, cognitive and mental health. In this review, we will discuss recent studies that add to our ...
Gillespie-Lynch Kristen - - 2012
Longitudinal research into adult outcomes in autism remains limited. Unlike previous longitudinal examinations of adult outcome in autism, the twenty participants in this study were evaluated across multiple assessments between early childhood (M = 3.9 years) and adulthood (M = 26.6 years). In early childhood, responsiveness to joint attention (RJA), language, and intelligence were assessed. In ...
Lawton Kathy K Center for Autism Research and Treatment, University of California, 68-268 Semel Institute, Los Angeles, CA 90024, USA. - - 2012
Children with autism exhibit deficits in their quantity and quality of joint attention. Early autism intervention studies rarely document improvement in joint attention quality. The purpose of this study was to determine whether there was a change in joint attention quality for preschoolers with autism who were randomized to a ...
Consigli C C Neonatal Intensive Care Unit, “S. Pietro Fatebenefratelli” Hospital, Rome, - - 2012
Congenital chylothorax (CC) is a rare and potentially life-threatening condition. Over 50% occurs at birth and is considered as the most common cause of neonatal thoracic fluid collection. To analyse the main clinical and respiratory features of a contemporary group of CC infants. Databases for CC diagnosed between 2004 and ...
Hua Danny K - - 2012
BK virus nephropathy (BKVAN) causes about 10% of late kidney graft loss. Cidofovir is widely used to treat BKVAN, but the magnitude of the health benefits and costs are largely unknown. We aimed to evaluate the incremental health benefits and costs of cidofovir and immunosuppression reduction compared with immunosuppression reduction ...
Adhikari Arjun S - - 2012
Proteolytic degradation of fibrin, the major structural component in blood clots, is critical both during normal wound healing and in the treatment of ischemic stroke and myocardial infarction. Fibrin-containing clots experience substantial strain due to platelet contraction, fluid shear, and mechanical stress at the wound site. However, little is understood ...
Tran Duc T - - 2012
Described here is a mass spectrometry-based protocol to study the thermodynamic stability of proteins and protein-ligand complexes using the chemical denaturant dependence of the slow H/D exchange reaction of the imidazole C(2) proton in histidine side chains. The protocol is developed using several model protein systems including: ribonuclease (Rnase) A, ...
Stahlman Jodi J Abbott, Abbott Park, IL 60064, - - 2012
The impact of washing on the pharmacokinetics, systemic absorption and residual testosterone on the skin after application of a 1.62% testosterone gel was investigated in an open-label, randomized, three-way crossover study in hypogonadal men. Twenty-four hypogonadal men (total testosterone <300 ng/dL) applied 5 g of 1.62% gel (81 mg testosterone) once daily to ...
Abu Thaher Bassam - - 2012
In the course of searching for new p38α MAP kinase inhibitors, we found that the regioisomeric switch from 3-(4-fluorophenyl)-4-(pyridin-4-yl)-1-(aryl)-1H-pyrazol-5-amine to 4-(4-fluorophenyl)-3-(pyridin-4-yl)-1-(aryl)-1H-pyrazol-5-amine led to an almost complete loss of p38α inhibition, but they showed activity against important cancer kinases. Among the tested derivatives, 4-(4-fluorophenyl)-3-(pyridin-4-yl)-1-(2,4,6-trichlorophenyl)-1H-pyrazol-5-amine (6a) exhibited the best activity, with IC(50) ...
Popow Irene - - 2012
Antithymocyte globulins (ATGs) are used to prevent and treat allograft rejection and graft versus host disease. They are purified IgG fractions derived from rabbits immunized with the Jurkat T-cell line (ATG-Fresenius) or thymus cells (Thymoglobulin). Differences not only in the amounts of leukocyte reactive antibodies but also in the antigens ...
Wang Guangshun G Department of Pathology and Microbiology, College of Medicine, University of Nebraska Medical Center, 986495 Nebraska Medical Center, Omaha, Nebraska 68198-6495, United States. - - 2012
LL-23 is a natural peptide corresponding to the 23 N-terminal amino acid residues of human host defense cathelicidin LL-37. LL-23 demonstrated, compared to LL-37, a conserved ability to induce the chemokine MCP-1 in human peripheral blood mononuclear cells, a lack of ability to suppress induction of the pro-inflammatory cytokine TNF-α ...
Chavanon Olivier - - 2012
We report the case of a cardiac papillary fibroelastoma of the aortic valve resected by simple shaving the pedicle. The macroscopic view showed a jelly-like aspect, with the classical appearance of a sea anemone under water, with multiple slender fronds and numerous little submillimetric thrombi disseminated among the branches of ...
Shayan Hossein - - 2012
Up to 66% of giant pulmonary artery aneurysms are associated with severe pulmonary hypertension. For these patients, lung or heart-lung en bloc transplantation is the only definitive therapy available. To date, there have been only two reports of concomitant double lung transplant and resection of a giant pulmonary artery aneurysm. ...
Mohsin Sabeeh - - 2012
Gelucire 50/13 (G50/13) was assessed to develop controlled release formulation of salbutamol sulphate (SBL) a highly water soluble drug by semisolid matrix filling capsule technique. Drug release profiles of SBL release by using G50/13 and its blends with other hydrophilic or hydrophobic materials were investigated. Lipid matrix formulations prepared with ...
Saint-Cyr Michel M Department of Plastic Surgery, University of Texas Southwestern Medical Center, Lyon, Dallas, Texas 75390, USA. - - 2012
The transverse myocutaneous gracilis flap has traditionally been used to reconstruct smaller breasts. The authors have been performing autologous breast reconstruction utilizing the flap with two types of modifications to increase flap volume: an extended and a vertical extended flap. In this article, they discuss the different operative techniques and ...
Kawecki Damian - - 2012
Coronary artery bypass grafting (CABG) is the optimal treatment option for left main coronary artery disease (LMCAD). However, LMCAD remains a constant topic of discussion between cardiac surgeons and interventional cardiologists. The aim of this study was to assess the efficacy of LMCAD treatments by comparing the mid-term outcomes of ...
Jung Jae Hung - - 2012
A 62-year-old male patient with prostate cancer and bilateral renal cell carcinoma underwent a simultaneous robot-assisted bilateral partial nephrectomy and radical prostatectomy. We describe our initial experience of combined operation with a port strategy allowing reuse of ports and surgical considerations because of prolonged pneumoperitoneum.
Selzman Craig H - - 2012
This case describes issues related to left ventricular assist device placement in an adult with ischemic heart disease with well-compensated Ebstein's anomaly who subsequently developed severe right heart dysfunction. We discuss strategies for dealing with this rare but structurally important congenital heart defect.
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