Search Results
Results 201 - 250 of 3980
< 1 2 3 4 5 6 7 8 9 10 >
Chen Peng - - 2011
Carbon tetrachloride (CCl(4) ) is a well-established model for screening hepato-protective drugs. The aim of the present study was to evaluate the potential protective effects of a novel soluble β-glucan salecan on acute liver injury induced by CCl(4) in mice and to further explore the underlying mechanisms. Mice were given ...
Bourquin Yannyk - - 2011
The diagnosis of infectious diseases in the Developing World is technologically challenging requiring complex biological assays with a high analytical performance, at minimal cost. By using an opto-acoustic immunoassay technology, integrating components commonly used in mobile phone technologies, including surface acoustic wave (SAW) transducers to provide pressure driven flow and ...
Hayashi I I Department of Neuropathology and Neuroscience, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo, - - 2012
Several lines of evidence suggest that aberrant Notch signaling contributes to the development of several types of cancer. Activation of Notch receptor is executed through intramembrane proteolysis by γ-secretase, which is a multimeric membrane-embedded protease comprised of presenilin, nicastrin (NCT), anterior pharynx defective 1 and PEN-2. In this study, we ...
Lee Moo-Seung MS Department of Microbial and Molecular Pathogenesis, Texas A&M Health Science Center, Bryan, TX 77807, - - 2011
The bacterial virulence factors Shiga toxins (Stxs) are expressed by Shigella dysenteriae serotype 1 and certain Escherichia coli strains. Stxs are protein synthesis inhibitors and induce apoptosis in many cell types. Stxs induce apoptosis via prolonged endoplasmic reticulum stress signalling to activate both extrinsic and intrinsic pathways in human myeloid ...
Ahn Sang-Hoon - - 2011
Objectives: Minimally invasive sinus elevation and augmentation using a transalveolar approach can reduce perioperative complications and patient discomfort. A specially designed reamer accomplishes this without the use of an osteotome or a mallet. The objective of this study is to present this technique with relevant clinical cases and patient outcomes. ...
Ahn Andrew C AC Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, USA. - - 2011
As the intermediate layer between the muscle and skin, the subcutaneous tissue frequently experiences shear and lateral stresses whenever the body is in motion. However, quantifying such stresses in vivo is difficult. The lack of such measures is partly responsible for our poor understanding of the biomechanical behaviors of subcutaneous ...
Zufferey A - - 2011
In healthy subjects, platelet hyperreactivity is a global phenomenon - as opposed to agonist-specific - and epinephrine-induced platelet aggregation (EPA) is a reliable marker of this phenotype. Few data are available on platelet reactivity and the relationship between EPA and aggregation induced by other agonists in cardiovascular patients. It was ...
Fynne L L Neurogastroenterology Unit, Department of Hepatology and Gastroenterology V, Aarhus University Hospital, Aarhus, Denmark. - - 2011
Faecal incontinence affects 40% of patients with systemic sclerosis (SSc). Several factors, including impaired anal sphincter function, reduced rectoanal sensation, abnormal rectoanal wall properties, and fast gastrointestinal transit, can cause faecal incontinence. Internal anal sphincter function is reduced in some patients with SSc, but other factors causing faecal incontinence remain ...
Scarborough Timothy D - - 2011
We report on the photoionization and photofragmentation of benzene (C(6)H(6)) and of the monohalobenzenes C(6)H(5)-X (X = F, Cl, Br, I) under intense-field, single-molecule conditions. We focus 50-fs, 804-nm pulses from a Ti:sapphire laser source, and record ion mass spectra as a function of intensity in the range ∼10(13) W/cm(2) ...
Benes C H - - 2012
Multiple SRC-family kinases (SFKs) are commonly activated in carcinoma and appear to have a role in metastasis through incompletely understood mechanisms. Recent studies have shown that CDCP1 (CUB (complement C1r/C1s, Uegf, Bmp1) Domain-Containing Protein-1) is a transmembrane protein and an SRC substrate potentially involved in metastasis. Here we show that ...
Choi In Ho - - 2011
The second to fourth digit ratio (2D:4D) has been proposed as a putative biomarker for prenatal testosterone and covaries with the sensitivity of the androgen receptor (AR). Both prenatal testosterone and the AR play a central role in penile growth. In this study, we investigated the relationship between digit ratio ...
Gomes de Oliveira Rubelisa Cândido - - 2011
Objective: To identify the characteristics of bone tissue microarchitecture by microCT at dental implant bone sites, describing them in terms of clinical parameters. Material and methods: Forty-six bone implant sites of the maxilla and mandible from 32 volunteers were evaluated by conventional radiographs and CT scans. During the installation of ...
Siegel Jason T - - 2011
Living organ donation offers a means of overcoming the shortage of viable organs available for transplant: a shortage particularly problematic among Hispanics. One barrier standing between those in need of a kidney and a successful transplant operation is an inability, and often lack of desire, to talk to loved ones ...
Lei N - - 2011
We introduce a method to electrically stimulate individual neurons at single-cell resolution in arbitrary spatiotemporal patterns with precise control over stimulation thresholds. By exploiting a custom microelectronic chip, up to 65 000 non-Faradaic electrodes can be uniquely addressed with electrode density exceeding 6500 electrodes mm(-2). We demonstrate extracellular stimulation of dispersed ...
Bellanger Xavier - - 2011
Genomic islands, flanked by attachment sites, devoid of conjugation and recombination modules and related to the integrative and conjugative element (ICE) ICESt3, were previously found in Streptococcus thermophilus. Here, we show that ICESt3 transfers to a recipient harbouring a similar engineered genomic island, CIMEL(3) catR(3) , and integrates by site-specific ...
Defrance C - - 2011
To cite this article: Defrance C, Bousquet P-J, Demoly P. Evaluating the negative predictive value of provocation tests with nonsteroidal anti-inflammatory drugs. Allergy 2011; DOI: 10.1111/j.1398-9995.2011.02671.x. ABSTRACT: Background:  The nonsteroidal anti-inflammatory drugs (NSAIDs) hypersensitivity work-up is based on clinical history, skin tests, and drug provocation tests. The negative predictive value ...
Dhalla Shayesta - - 2011
Abstract HIV vaccine preparedness studies (VPS) are important precursors to HIV vaccine trials. As well, they contribute to an understanding of motivators and barriers for participation in hypothetical HIV vaccine trials. Motivators can take the form of altruism and a desire for social benefits. Perceived personal benefits, including psychological, personal, ...
Salmond Robert J - - 2011
The mammalian target of rapamycin (mTOR) integrates signalling responses to growth factors and nutrients. The macrolide rapamycin inhibits mTOR function and has been used extensively to demonstrate a critical role for mTOR in immune responses. This mini-review summarizes recent evidence demonstrating an integral role for mTOR in the differentiation of ...
Williams Thomas L - - 2011
Alzheimer's disease is the most common form of dementia and pathological hallmarks include the loss of neurons through cell death, the accumulation of amyloid fibres in the form of extracellular neuritic plaques. Amyloid fibrils are composed of the Amyloid-β peptide, which is known to assemble to form "toxic" oligomers that ...
Kim Nam-Kyung - - 2011
The N-methyl-d-aspartate receptor (NMDAR) exhibits strong voltage-dependent block by extracellular Mg(2+) , which is relieved by sustained depolarization and glutamate binding, and which is central to the function of the NMDAR in synaptic plasticity. Rapid membrane depolarization during agonist application reveals a slow unblock of NMDARs, which has important functional ...
Spector Aimee - - 2011
Objectives: Cognitive Stimulation Therapy (CST) can lead to significant improvements in cognitive function and quality of life for people with dementia. This study sought to investigate whether improvements found in clinical trials were also noted by people with dementia, their carers and group facilitators in everyday life. Method: Qualitative interviews ...
Kessler C M - - 2011
The pharmacokinetic (PK) profiles of von Willebrand factor (VWF) /factor VIII (FVIII) concentrates are important for treatment efficacy and safety of von Willebrand disease (VWD) patients. This prospective, head-to-head, randomised crossover study compared the PK profile of a new, high purity, human plasma-derived (pd)VWF/FVIII concentrate, Wilate®, with the PK profile ...
Boulsourani Z - - 2011
The linear trinuclear Cu(ii) complexes [Cu(3)(L(1))(4)(H(2)tea)(2)] (1), [Cu(3)(L(2))(4)(H(2)tea)(2)]·2CH(3)CN (2), [Cu(3)(L(2))(4)(H(2)tea)(2)] (3), [Cu(3)(L(1))(2)(H(2)tea)(2)(NO(3))(2)] (4) and the dinuclear complex [Cu(2)(L(1))(2)(H(2)tea)(2)] (5), where L(1) = 2-thiophene carboxylate, L(2) = 2-(thiophen-2-yl)-acetate and H(2)tea = the single deprotonated form of triethanolamine have been prepared and characterised while the crystal structures of 1-4 have been determined. ...
Barbieri Antonio - - 2011
Accumulating evidence suggest that chronic stress can be a cofactor for the initiation and progression of cancer. Here we evaluated the role of endothelial nitric oxide synthase (eNOS) in stress-promoted tumor growth of murine B16F10 melanoma cell line in C57BL/6 mice. Animals subjected to restraint stress showed increased levels ACTH, ...
Singh Sarita - - 2011
A new protopine alkaloid, protomexicine and a new isoflavonoid, mexitin, together with 8-methoxydihydrosanguinarine, 13-oxoprotopine, rutin and quercetrin have been isolated from the aerial part of the methanolic extract of Argemone mexicana. The structures of these compounds have been established by various spectral data. The structure of protomexicine was further confirmed ...
Bastian Daniel - - 2011
Abstract Background. Danger patterns and pattern recognition receptors have been targets in the investigation and treatment of systemic inflammatory response syndrome and sepsis. Lipopolysaccharide (LPS)-binding protein (LBP) presents LPS and gram-positive bacterial cell wall products to the receptors TLR4/MD-2 and TLR2, respectively. Low concentrations of LBP stimulate responses to LPS ...
Crewe H K - - 2011
The 'relative activity factor' (RAF) compares the activity per unit of microsomal protein in recombinantly expressed cytochrome P450 enzymes (rhCYP) and human liver without separating the potential sources of variation (i.e. abundance of enzyme per mg of protein or variation of activity per unit enzyme). The dimensionless 'inter-system extrapolation factor' ...
Del Castillo Trevor J - - 2011
This report describes the synthesis and characterization of 1,5-bis-triphenylphosphinegold(i) 1,2,3-triazolate (3((1,5))). The synthesis of the dinuclear complex 3((1,5)) is achieved via an unprecedented inorganic click (iClick) reaction between the metal-azide PPh(3)AuN(3) (1) and the metal-acetylide PPh(3)Au-C[triple bond, length as m-dash]CPh (2). Characterization of 3((1,5)) includes multinuclear NMR spectroscopy, combustion analysis, ...
Niu X - - 2012
In clear-cell renal cell carcinoma (ccRCC), inactivation of the tumor suppressor von Hippel-Lindau (VHL) occurs in the majority of the tumors and is causal for the pathogenesis of ccRCC. Recently, a large-scale genomic sequencing study of ccRCC tumors revealed that enzymes that regulate histone H3 lysine 4 trimethylation (H3K4Me3), such ...
Nelis Sharon M - - 2011
Objectives: This study explores the extent to which awareness of social and emotional function is reduced in early-stage dementia and whether this relates to the quality of life of the person with dementia (PwD), the quality of the relationship between the PwD and carer and carer stress. Method: Ninety-seven participants ...
Turowski C - - 2011
BACKGROUND: The aetiology of choledochal malformation is not known. Babbitt's hypothesis remains a popular concept, and assumes that activated pancreatic juice refluxes through the common pancreatobiliary channel causing mural damage and subsequent biliary dilatation. This hypothesis was tested clinically by evaluating the relationship between epithelial histology, choledochal pressure and degree ...
Sperança Adriane - - 2011
A series of 4-Se-(Te,-S-)-isochromenones and 3-substituted isochromenones were synthesized in good yields via FeCl3-mediated cyclization of alkynylaryl esters with different diorganyl dichalcogenides. This methodology was carried out at room temperature, using inexpensive and environmentally friendly iron salts as metallic source and under air atmosphere. The reaction showed to be tolerant ...
Zhu Baocun - - 2011
A highly selective ratiometric fluorescent chemodosimeter derived from 4-hydroxynaphthalimide was designed and synthesized to image palladium species in living cells by virtue of a palladium-catalyzed depropargylation reaction, and it could monitor three typical palladium species (0, + 2 and + 4) without additional reagents.
Morelli Catia - - 2011
Mesoporous silica nanoparticles (MSNs) have been proposed as DNA and drug delivery carriers, as well as efficient tools for fluorescent cell tracking. The major limitation is that MSNs enter cells regardless of a target-specific functionalization. Here we show that non functionalized MSNs, synthesized using a PEG surfactant-based interfacial synthesis procedure, ...
Roe Allyson D AD Department of Neurosciences, University of California, San Diego School of Medicine, La Jolla, CA, - - 2011
Clinical studies suggest that exposure to stress can increase risk for Alzheimer's disease (AD). Although the precise links between stress and vulnerability to develop AD remain uncertain, recent animal work suggests that stress may promote susceptibility to AD pathology by activating tau kinases and inducing tau phosphorylation (tau-P). Our previous ...
Han Xuelin - - 2011
Internalization of Listeria monocytogenes into non-phagocytic cells is tightly controlled by host cell actin dynamics and cell membrane alterations. However, knowledge about the impact of phosphatidylcholine cleavage driven by host cell phospholipase D (PLD) on Listeria internalization into epithelial cells is limited. Here, we report that L. monocytogenes activates PLD ...
Nelson Nathaniel W - - 2011
MMPI-2 RF profiles of 128 U.S. soldiers and veterans with history of concussion were examined. Participants evaluated in forensic (n = 42) and clinical (n = 43) settings showed significantly higher validity and clinical elevations relative to a research group (n = 43). In the full sample, a multivariate GLM identified main effects for disability claim ...
Smirnova T T Department of Anatomy and Structural Biology, Albert Einstein College of Medicine, Bronx, NY 10801, - - 2012
Many malignancies show increased expression of the epidermal growth factor (EGF) receptor family member ErbB3 (HER3). ErbB3 binds heregulin β-1 (HRGβ1) and forms a heterodimer with other ErbB family members, such as ErbB2 (HER2) or EGF receptor (EGFR; HER1), enhancing phosphorylation of specific C-terminal tyrosine residues and activation of downstream ...
Zhang Zhi-Yun - - 2011
1. High-fat and high-energy diet during pregnancy leads to a risk for long-term consequences on fetal development as well as postnatal health of offspring. To investigate the effects of such diet on fetal programming, we established a high-energy intake pregnant rat model using chocolate and fructose beverage as supplement to ...
Fabian Elisabeth - - 2011
Eur J Clin Invest 2011 ABSTRACT: Background  Since oxidative stress might cause and promote cardiovascular risk factors such as oxidized low-density lipoproteins (oxLDL), apolipoprotein(a) [apo(a)], asymmetric dimethylarginine (ADMA) and fetuin A, we investigated antioxidant enzyme activities in relation to the vascular redox balance and these risk factors in elderly people. ...
Liao Z - - 2011
Objectives: To analyse the clinical features of Chinese undifferentiated spondyloarthritis (USpA) patients with predominantly axial involvement, and in particular the influence of human leucocyte antigen (HLA)-B27 and magnetic resonance imaging (MRI) of the sacroiliac joint (SIJ) on the classification of axial USpA. Methods: Patients with low back pain for ≥ ...
Balas Robert - - 2011
Recent research has shown that coherence judgements of semantically related word triads are facilitated by a subtle positive response triggered by their increased fluency of processing. Such positive affective response serves as a cue indicating semantic coherence. However, we argue that the fluency of processing is not the only source ...
Lin Tzu Yu - - 2011
The present study was to investigate the effect and the possible mechanism of luteolin, a food-derived flavonoid, on endogenous glutamate release in nerve terminals of rat cerebral cortex (synaptosomes). Luteolin inhibited the release of glutamate evoked by the K+ channel blocker 4-aminopyridine (4-AP), and this phenomenon was concentration-dependent. The effect ...
Garnett S P - - 2011
The epidemic of obesity as measured by body mass index (BMI) maybe plateauing. However, studies using skin-fold and waist circumference measurements suggest that BMI may underestimate changes in fatness in children. In this study we examine changes in waist circumference and waist-to-height ratio (WHtR) in Australian children between 1985 and ...
Hahn Sabine - - 2011
Aims.  To investigate the feasibility of a survey measuring patient and visitor violence after translation and modification, namely the Survey of Violence Experienced by Staff (German version revised) and to validate the shortened Perception of Aggression Scale (POAS-S) and the Perception of Importance of Intervention Skills Scale (POIS) after adaptation ...
Boonen H - - 2011
Background  A considerable number of children are confronted with a chronic or long-term illness in their lives. For these children, absenteeism is problematic, because education plays a major role in stimulating their cognitive development and in promoting a sense of normalcy and psychosocial well-being. In the literature, a great deal ...
Cirulli Elizabeth T - - 2011
Clinicians routinely query factors known to impact cognitive test scores, including age and education. However, without data delineating the impact of less-frequently tracked variables, clinicians are limited to educated inferences about their effect. We explored the relationship of demographics, pastimes, and strategies with cognitive scores in a sample of 499 ...
Maassen Anna - - 2011
Besides the previously described nitric oxide-detoxification activity we identified new features of class-1 non-symbiotic hemoglobin from Medicago sativa (Mhb1). Under in vitro conditions, using peroxidase in-gel activity assay, theMhb1 protein was shown to possess also peroxidase-like activity. Due to this activity, in the presence of nitrite and hydrogen peroxide, the ...
Gamble L D - - 2012
MYCN amplification is a major biomarker of poor prognosis, occurring in 25-30% of neuroblastomas. MYCN has contradictory roles in promoting cell growth and sensitizing cells to apoptosis. We have recently shown that p53 is a direct transcriptional target of MYCN in neuroblastoma and that p53-mediated apoptosis may be an important ...
Bashara Haitham - - 2011
Objectives: The aim of the present study was to evaluate the effects of a novel bone substitute system (Natix(®) ), consisting of porous titanium granules (PTG) and a bovine-derived xenograft (Bio-Oss(®) ), on hard tissue remodelling following their placement into fresh extraction sockets in dogs. Material and methods: Six modalities ...
< 1 2 3 4 5 6 7 8 9 10 >