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Miyoshi Jun - - 2011
BACKGROUND: Host-intestinal microbial interaction plays an important role in the pathogenesis of inflammatory bowel diseases (IBDs). The surface molecules of the intestinal epithelium act as receptors for bacterial adhesion and regulate the intestinal bacteria. Some known receptors are the mucosal blood type antigens, which are regulated by the fucosyltransferase2 (FUT2) ...
Takahashi Yoko - - 2011
Although soy foods are recommended to prevent hyperlipidemia and related diseases, it is unclear how their active ingredients exert their effects. Here, the effects of tofu (soybean curd) and its putative active components, protein and isoflavone, on lipid metabolism in male rats were compared. Tofu and soy protein significantly lowered ...
Tanase Stefania - - 2011
Two new d-f cyanido-bridged 1D assemblies [RE(pzam)(3)(H(2)O)Mo(CN)(8)]·H(2)O (RE = Sm(iii), Er(iii)) were synthesized and their magneto-structural properties have been studied by field-dependent magnetization and specific heat measurements at low temperatures (≥0.3 K). Below ≈ 10 K the ground state of both the Sm(iii) and Er(iii) ions is found to be ...
Kezunovic Nebojsa - - 2011
The pedunculopontine nucleus (PPN), part of the reticular activating system, modulates waking and paradoxical sleep. During waking and paradoxical sleep, EEG responses are characterized by low-amplitude, high-frequency oscillatory activity in the beta-gamma band range (~20-80 Hz). We have previously reported that gamma band activity may be intrinsically generated by the ...
Hajek Tomas - - 2012
Converging evidence suggests that the brain-derived neurotrophic factor (BDNF) gene Val66Met polymorphism affects brain structure. Yet the majority of studies have shown no effect of this polymorphism on hippocampal volumes, perhaps due to small effect size. We performed a meta-analysis of studies investigating the association between Val66Met BDNF polymorphism and ...
Langford Katherine H - - 2011
A robust multi-residue method was developed for the analysis of a selection of pharmaceutical compounds, illicit drugs and personal care product bactericides in sediments and sludges. Human pharmaceuticals were selected for analysis in Scottish sewage sludge and freshwater sediments based on prescription, physico-chemical and occurrence data. The method was suitable ...
Li Y Y Department of Biochemistry and Molecular Biology, The George Washington University Medical School, Washington, DC 20037, - - 2012
Histone acetyltransferases (HATs) have a central role in the modification of chromatin as well as in the pathogenesis of a broad set of diseases including cancers. Gcn5 is the first identified transcription-related HAT that has been implicated in the regulation of diverse cellular functions. However, how Gcn5 proteins are regulated ...
Mahmud Hasan - - 2011
The (pro)renin-renin receptor, (P)RR, was discovered as an important novel component of the renin angiotensin system (RAS). The functional significance of (P)RR is widely studied in renal and vascular pathologies and has sparked interest for a potential role in cardiovascular disease. To investigate the role of (P)RR in cardiac pathophysiology, ...
Hämmerle Christoph H F - - 2011
Objectives: To test whether or not transmucosal healing at two-piece implants is as successful as submerged placement regarding crestal bone levels and patient satisfaction. Material and methods: Adults requiring implants in the anterior maxilla or mandible in regions 21-25, 11-15, 31-35 or 41-45 (WHO) were recruited for this randomized, controlled ...
Stoker Geert - - 2011
Purpose: The aim of the study was to compare the differences in the long-term clinical and radiologic effects for three different treatment strategies with implant-supported overdentures in the edentulous mandible, with a special emphasis on smoking. Materials and methods: In a randomized- controlled clinical trial, 110 edentulous patients participated. Thirty-six ...
Takaya Jun - - 2011
Reactions of bis(o-(diphenylphosphino)phenyl)methylsilane with M(PPh(3))(4) (M = Ni, Pd, Pt) were investigated. When M = Ni or Pd, synthesis and isolation of η(2)-(Si-H) complexes of mononuclear Ni(0) and Pd(0) were achieved for the first time as frozen intermediates for oxidative addition of the Si-H bond. Structural analysis by X-ray and ...
Bonifaz Alexandro - - 2011
Endemic deep or systemic mycoses are common in specific geographical areas of the world. Coccidioidomycosis is present in semi-desert areas, histoplasmosis and paracoccidioidomycosis in tropical regions and blastomycosis belongs to temperate climates. The two former are widely distributed in the American continent and some tropical regions of the world; the ...
Getz Angela - - 2011
Depression is a debilitating mental disorder, and selective serotonin reuptake inhibitors (SSRIs) constitute the first-line antidepressant treatment choice for the clinical management of this illness; however, the mechanisms underlying their therapeutic actions and side effects remain poorly understood. Here, we compared the effects of two SSRIs, fluoxetine and citalopram, on ...
Kong Rong-Mei - - 2011
Aptamers represent a class of single-stranded DNA or RNA oligonucleotides that play important roles in biosensing and biomedical applications. However, aptamers can gain more flexibility as molecular recognition tools by taking advantage of the unique chemical and physical properties provided by nanomaterials. Such aptamer-nanomaterial conjugates are having an increasing impact ...
Luo Y - - 2011
Tumor cell migration is a well-orchestrated multistep process that drives cancer development and metastasis. Previous data indicated that CD146 expression correlates with malignant progression and metastatic potential of human melanoma cells. However, the exact molecular mechanism of how CD146 promotes melanoma cell migration still remains poorly understood. Here, we report ...
Shilon Y - - 2011
Background  Accidental injuries are a leading cause of paediatric morbidity and mortality. We hypothesized that attention deficit hyperactivity disorder (ADHD), a common childhood disorder characterized by behaviours such as hyperactivity and impulsivity, is a risk factor for accidental injuries. Previous retrospective studies suggested that children with ADHD have an increased ...
Mohamed Mohamed Taha - - 2011
This paper reports two experiments using sentences with a temporary ambiguity between a direct object and a sentence complement analysis that is resolved toward the normally preferred direct object analysis. Postverbal noun phrases in these sentences could be ambiguously attached as either a direct object or the subject of a ...
Benini Stefano - - 2011
The crystal structure of Helicobacter pylori holo-NikR, a Ni(2+)-dependent transcription factor, determined at pH 7.3, shows four square-planar nickel-binding sites, involving one cysteinate and three histidine ligands. This observation reconciles previous inconsistencies among calorimetric data, structural information at non-physiological pH, and computational studies.
Mehl Christian - - 2011
Objectives: The main goals of this in vitro study were to evaluate the influence of thermocycling, ultrasonic stress and the removal force preload on the retrievability of cemented implant crowns using a clinical removal device (Coronaflex) and evaluating the tensile strength using a universal testing machine (UTM). Methods: Thirty-six crowns ...
Milburn J A - - 2011
Introduction:  Most studies of haemodialysis (HD) patients compare venous blood samples from controls with samples from the vascular access (VA) of HD patients. We hypothesised that VA samples may be more prothrombotic compared with venous samples. Methods:  Samples were taken simultaneously from the VA and the contralateral antecubital vein, from ...
Nakayashiki Hitoshi - - 2011
In mythology, the Trickster is an archetype who typically behaves selfishly and delights in playing tricks and breaking ordinary rules. In many myths and folktales, however, the Trickster also brings new knowledge and, ultimately, has positive effects on the community. Transposable elements (TEs) might have played such a role in ...
Gaston A M - - 2011
Background  Adolescence is a period associated with poor glycaemic control. The key developmental concerns of young people are in conflict with the requirements of diabetes self-management. This study explores the relative influence of adolescents' and caregivers' illness representations and how any difference/similarity in their representations may be related to adolescents' ...
Urrechaga E - - 2011
Introduction:  Low hemoglobin density (LHD%) is a new parameter provided by Beckman-Coulter derived from the mean cell hemoglobin concentration, using the mathematical sigmoid transformation [Formula: see text] This study investigated the reliability of LHD% for the assessment of iron status in the presence of inflammation. Methods:  Healthy subjects (n = 90) and ...
Schizas A M P - - 2011
Background  Vector volume manometry (VVM) can be used to assess patients with fecal incontinence. The VVM may be performed using a station pull through, or an automated technique. Currently no standard technique or equipment exists to assess anal canal VVM. This study aimed to assess the different techniques to produce ...
Raatz Bodo - - 2011
Areal plant architecture is largely based on the activity of axillary meristems (AM), initiated in the axils of leaves. The Arabidopsis gene LATERAL SUPPRESSOR (LAS), which is expressed in well defined domains at the adaxial boundary of leaf primordia, is a key regulator of AM formation. Precise definition of organ ...
Delic Sabit - - 2011
Aims: The molecular mechanisms underlying the infiltrative growth of glioblastomas, the most common primary tumours of the central nervous system in adults, are still poorly understood. We aimed to identify and functionally validate novel glioma invasion-associated candidate genes. Methods: Microarray-based expression analysis was applied to identify differentially expressed genes in ...
Shanahan Denise J - - 2011
shanahan d.j. (2011) Bedrails and vulnerable older adults: how should nurses make 'safe and sound' decisions surrounding their use? International Journal of Older People Nursing doi: 10.1111/j.1748-3743.2011.00285.x Aim and objectives.  This paper examines the available evidence and uses ethical principles to answer how nurses should make safe and sound decisions surrounding ...
Barlow J L JL MRC Laboratory of Molecular Biology, Cambridge, UK. - - 2011
Interleukin (IL)-25 (IL-17E) is a potent inducer of the type-2 immune effector response. Previously we have demonstrated that a neutralizing anti-IL-25 antibody, given during the establishment of ovalbumin-specific lung allergy, abrogates airways hyperreactivity. Blocking IL-25 results in the suppression of IL-13, a cytokine known to exacerbate pulmonary inflammation, and an ...
Braamse A M J - - 2011
Identifying factors that predict health-related quality of life (QOL) following hematopoietic SCT, is important in estimating patients' abilities to adjust to the consequences of their disease and treatment. As the studies that have been published on this subject are scattered, the present study aimed to systematically review prognostic factors for ...
Hocking Matthew C - - 2011
Many childhood brain tumor survivors experience significant neurocognitive late effects across multiple domains that negatively affect quality of life. A theoretical model of survivorship suggests that family functioning and survivor neurocognitive functioning interact to affect survivor and family outcomes. This paper reviews the types of neurocognitive late effects experienced by ...
Li Jing-Min - - 2011
Stomatal transpiration, which is an efficient way to carry water from the roots up to the leaves, can be described by "diameter-law". According to the law, the flow rate induced by micropore transpiration far exceeded that induced by macroscale evaporation, and it can be controlled by opening (or closing) some ...
González-Sánchez L - - 2011
A complete quantum study for the state-to-state Li + HF(v,j,m) → LiF(v',j',Ω') + H reactive collisions has been performed using a wave packet method, for different initial rotational states and helicity states of the reactants. The state-to-state differential cross section has been simulated, and the polarization of products extracted. It ...
Damiano L - - 2011
We have recently shown that the adaptor protein p140Cap regulates tumor properties in terms of cell motility and growth. Here, by using the highly metastatic rat adenocarcinoma cell line MTLn3-epidermal growth factor receptor (EGFR), we assess the role of p140Cap in metastasis formation. Orthotopic transplantation of MTLn3-EGFR cells over-expressing p140Cap ...
Johansson Carina B - - 2011
Aim: To investigate bone-to-implant bonding for some novel surface modifications with a hierarchic structure and to correlate the in vivo results with surface roughness parameters. Materials and methods: Newly developed implants surfaces were tested in rabbits and compared with the commercially available OsseoSpeed(™) (OS) implant. The blasted test samples were ...
Chafetz Michael - - 2011
The Symptom Validity Scale (SVS) for low-functioning individuals (Chafetz, Abrahams, & Kohlmaier, 2007) employs embedded indicators within the Social Security Psychological Consultative Examination (PCE) to derive a score validated for malingering against two criterion tests: Test of Memory Malingering (TOMM) and Medical Symptom Validity Test (MSVT). When any symptom validity ...
Arumuganathan T - - 2011
The synthesis and characterization of a series of molybdenum ([MoO(2)Cl(L(n))]; L(1) (1), L(2) (3)) and tungsten ([WO(2)Cl(L(n))]; L(1) (2), L(2) (4)) dioxo complexes (L(1) = 1-methyl-4-(2-hydroxybenzyl)-1,4-diazepane and L(2) = 1-methyl-4-(2-hydroxy-3,5-di-tert-butylbenzyl)-1,4-diazepane) of tridentate aminomonophenolate ligands HL(1) and HL(2) are reported. The ligands were obtained by reductive amination of 1-methyl-1,4-diazepane with the ...
Spiegel S S Department of Biochemistry and Molecular Biology, Virginia Commonwealth University School of Medicine Richmond, Richmond, VA 23298, USA. - - 2012
The class-I histone deacetylases (HDACs) HDAC1 and HDAC2 belong to a family of 11 zinc-dependent human HDACs and are overexpressed in many cancers. Inhibitors of these HDACs now in clinical trials show activity against several types of cancers. This review is focused on recent advances in both clinical and preclinical ...
Doyle Karen M - - 2011
The stimuli for neuronal cell death in neurodegenerative disorders are multi-factorial and may include genetic predisposition, environmental factors, cellular stressors such as oxidative stress and free radical production, bioenergy failure, glutamate-induced excitotoxicity, neuroinflammation, disruption of Ca(2+) -regulating systems, mitochondrial dysfunction and misfolded protein accumulation. Cellular stress disrupts functioning of the ...
Bell James R - - 2011
1. Important sex differences exist in ischemic heart disease. Estrogen has been conventionally regarded as providing a cardioprotective benefit and testosterone frequently perceived to exert a deleterious effect. However, there is accumulating evidence which argues against this simple dichotomy, suggesting that the influence of estrogen and testosterone conferring benefit or ...
Wang Ren - - 2011
The one-pot synthesis of benzo[f]quinolin-3-ones and benzo[a]phenanthridein-5-ones was achieved by the inter- and intramolecular photoannulation of 6-chloropyridin-2-ones and 3-chloroisoquinolin-1-ones with phenylacetylene or tethered phenylacetylene. The reactions were proceeded by photoaddition of 6-chloropyridin-2-ones and 3-chloroisoquinolin-1-ones to phenylacetylene to give the chlorine-substituted stilbenoids, and then 6π electrocyclization of the stilbenoids and oxidation ...
Simon-Loriere Etienne E Center for Infectious Disease Dynamics, Department of Biology, Mueller Laboratory, The Pennsylvania State University, University Park, USA. - - 2011
Recombination occurs in many RNA viruses and can be of major evolutionary significance. However, rates of recombination vary dramatically among RNA viruses, which can range from clonal to highly recombinogenic. Here, we review the factors that might explain this variation in recombination frequency and show that there is little evidence ...
Scott K D - - 2011
Background  This study investigates the association between inhalant use and information processing (IP) in adjudicated polysubstance users. Polysubstance users who used inhalants (n= 158) were compared with polysubstance users who did not use inhalants (n= 303). Hispanic Americans comprised 72% of the participants; European Americans, African Americans and Asian Americans ...
Spronk S - - 2011
BACKGROUND: The aim of this study was to determine the cost-effectiveness of ultrasound screening for abdominal aortic aneurysm (AAA) in men aged 65 years, for both the Netherlands and Norway. METHODS: A Markov model was developed to simulate life expectancy, quality-adjusted life-years, net health benefits, lifetime costs and incremental cost-effectiveness ...
Kataoka Mayumi - - 2011
The synthesis of the 3'-deoxyapionucleoside 3''-triphosphates (apioNTPs) having the four natural nucleobases and their enzymatic incorporation into a DNA-DNA primer-template have been tried. Therminator DNA polymerase was shown to incorporate these apioNTPs effectively giving 43mer DNA-apioNA chimera.
Isfan F - - 2011
The literature contains a substantial amount of information about factors that adversely influence the linear growth in up to 85% of patients undergoing haematopoietic SCT (HSCT) with TBI and/or cranial irradiation (CI) for acute leukaemia (AL). By contrast, only a few studies have evaluated the impact of growth hormone (GH) ...
Barsukova Anna G AG Vollum Institute, Oregon Health & Science University, 3181 SW Sam Jackson Park Road, Portland, OR 97239, - - 2011
A proposed mechanism of neuronal death associated with a variety of neurodegenerative diseases is the response of neurons to oxidative stress and consequent cytosolic Ca(2+) overload. One hypothesis is that cytosolic Ca(2+) overload leads to mitochondrial Ca(2+) overload and prolonged opening of the permeability transition pore (PTP), resulting in mitochondrial ...
Daneshyar M - - 2011
Sixty male broiler chickens fed a diet supplemented with 130 mg/kg stevioside (S group) or an unsupplemented diet (C group) from day 1 of age onwards. On day 21 of age, ten birds from either the S (SH) or C (CH) group were injected subcutaneously with 100 μg human serum albumin (HSA) ...
Luo Sijie - - 2011
In this work the ISOL24 database of isomerization energies of large organic molecules presented by Huenerbein et al. [Phys. Chem. Chem. Phys., 2010, 12, 6940] is updated, resulting in the new benchmark database called ISOL24/11, and this database is used to test 50 electronic model chemistries. To accomplish the update, ...
Arias A A Department of Molecular Biosciences, University of California, Davis School of Veterinary Medicine, Davis, CA 95616, - - 2012
Glioblastomas are among the most incurable cancers. Our past findings indicated that glioblastoma cells, but not neurons or glia, require the transcription factor ATF5 (activating transcription factor 5) for survival. However, it was unknown whether interference with ATF5 function can prevent or promote regression/eradication of malignant gliomas in vivo. To ...
Castrejón I - - 2011
The coexistence of systemic lupus erythematosus (SLE) and myasthaenia gravis (MG) has been reported previously. Because of their shared clinical characteristics and autoantibody-mediated pathogenesis, an SLE expert panel decided to include MG as one of the 19 neuropsychiatric SLE syndromes. This study reports a cluster of three cases of SLE/MG ...
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