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Li Xue-Quan - - 2011
A novel amphiphilic camptothecin prodrug that spontaneously arranges into nanomicelles which preferentially release the cytotoxic drug under tumor-relevant reductive conditions is designed.
Chiappe Cinzia - - 2011
The polarity of a series of ionic liquids (ILs) arising from the quaternarization of N-methylmorpholine, N-methylpyrrolidine, N-methylpiperidine, N-methylazepane, 4-hydroxy-1-methylpiperidine, 1,2-dimethylimidazole and 1-methylimidazole with simple alkyl chains and/or hydroxyl (mono or dihydroxyl) functionalized alkyl chains and having bistriflimide, dicyanamide or nitrate as counteranions has been investigated using solvatochromic dyes and it ...
Leontyev Sergey - - 2011
OBJECTIVE: The study objective was to evaluate the outcomes of surgery for active infective endocarditis with aortic root abscess formation. METHODS: Between July 1996 and June 2009, 1161 patients underwent operation for aortic valve endocarditis, of whom 172 had aortic root abscess. The infected valve was native in 96 patients ...
Roh Hyun Cheol - - 2011
Enterotoxigenic Bacteroides fragilis (ETBF) produces a ∼20-kDa heat-labile enterotoxin (BFT) that plays an essential role in mucosal inflammation. Although a variety of inflammatory cells is found at ETBF-infected sites, little is known about leukocyte adhesion in response to BFT stimulation. We investigated whether BFT affected the expression of ICAM-1 and ...
Hobbie K R - - 2011
Small fish models have been used for decades in carcinogenicity testing. Demonstration of common morphological changes associated with specific mechanisms is a clear avenue by which data can be compared across divergent phyletic levels. Dimethylnitrosamine, used in rats to model human alcoholic cirrhosis and hepatic neoplasia, is also a potent ...
Bösenberg Adrian T - - 2011
In recent years the inclusion of regional techniques to pediatric anesthesia has transformed practice. Simple procedures such as caudal anesthesia with local anaesthetics can reduce the amounts of general anesthesia required and provide complete analgesia in the postoperative period while avoiding large amounts of opioid analgesia with potential side effects ...
Chaar Cassius Iyad Ochoa - - 2011
Endovenous laser therapy (EVLT) is an accepted form of axial vein ablation for symptomatic venous reflux but there is debate regarding its efficacy and complication rates in large veins (≥1 cm). In addition, its role in the treatment of small saphenous veins (SSVs) and anterior accessory veins (AAVs) has not ...
Krahn Gloria L - - 2011
The World Health Organization in collaboration with the World Bank developed the World Report on Disability to inform governments of countries about the importance of disability, analyze scientific information, and provide recommendations for action at the national and international levels. The report is remarkably readable, comprehensive, and concise. There are ...
Sun Cai-xing - - 2011
A modified hemilaminectomy was introduced in an attempt to explore the operative techniques and the values of the limited approach to spinal cord tumors. Forty-five consecutive patients with intradural extramedullary lesions, who underwent modified hemilaminectomy, were studied retrospectively. The intraspinal tumors were removed via the limited bone window with a ...
Nielssen Olav B - - 2011
Evidence has emerged of a higher risk of serious violence in first-episode psychosis. This study compared the characteristics of two groups of persons with psychosis found not guilty of violent offenses on the grounds of mental illness (NGMI): those who had not yet been treated and those who had previously ...
Ramakrishnan Gopakumar - - 2011
Emission of pulses of electromagnetic radiation in the terahertz range is observed when ultrathin gold films on glass are illuminated with femtosecond near-IR laser pulses. A distinct maximum is observed in the emitted terahertz amplitude from films of average thickness just above the percolation threshold. Our measurements suggest that the ...
Carro Lorena - - 2011
A Gram positive actinobacterium, strain PM267T, was isolated from a marine sediment sample in the Mediterranean Sea. The new strain produced extensively branched substrate and aerial hyphae that carried spiral spore chains. Substrate and aerial mycelia were cream-white and white, respectively. Diffusible pigments were not observed. 16S rRNA gene sequence ...
Kozubowski Lukasz L Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, NC 27710, - - 2011
Calcineurin is a calcium-calmodulin-activated serine/threonine-specific phosphatase that operates during cellular responses to stress and plays a prominent role in transcriptional control, whereas regulatory events beyond transcription are less well characterized. This study reveals a novel transcription-independent role of calcineurin during the temperature stress response in the human fungal pathogen Cryptococcus ...
Whitrow Melissa J - - 2011
Waist:height has been proposed as an indicator of cardiovascular risk. We investigated the association of waist:height with systolic BP (sBP) in 3 year old children. Body mass index was a significant predictor of sBP, whereas waist:height was not: suggesting waist:height is not a useful indicator of sBP in this age ...
Reule Claudia A - - 2011
Background There are many possible predisposing factors for Achilles tendon disorders suggested in the literature but their pathogenetic relevance is not proven in most cases. The asymmetric mechanical load distribution within the Achilles tendon during locomotion is frequently addressed as a major risk factor for Achilles tendon disorders. The spatial ...
Sonne Mette Paulii - - 2011
Aims: Physical inactivity is considered to be deleterious to vascular health, and in particular first degree relatives to patients with type 2 diabetes (FDR) and persons born with low birth weight (LBW) who may later in life develop cardiovascular disease. A period of imposed physical inactivity could unmask this risk. ...
Chen Yu-Ju - - 2011
Background The adverse effects of a failed ventilator weaning trial on the subsequent weaning attempts are not well understood. Objectives To examine physiological and psychological factors that may be predictive of risk for repeated weaning failures and prolonged mechanical ventilation. Methods A prospective predictive study of 102 subjects, age 34 ...
Yang Liquan L Departments of Biomedical Genetics, University of Rochester Medical Center, Rochester, New York 14612, - - 2011
Angiogenesis is a critical step during cancer progression. The VEGF is a major stimulator for angiogenesis and is predominantly contributed by cancer cells in tumors. Inhibition of the VEGF signaling pathway has shown promising therapeutic benefits for cancer patients, but adaptive tumor responses are often observed, indicating the need for ...
Falini Brunangelo - - 2011
Acute myeloid leukemia (AML) carrying nucleophosmin (NPM1) mutations displays distinct molecular and clinical-pathological features that led to its inclusion as provisional entity in 2008 WHO classification of myeloid neoplasms. Since NPM1 mutations behave as a founder genetic lesion in AML, they could be an attractive target for therapeutic intervention. Here, ...
Hadi R - - 2011
Introduction: Anal Canal squamous cell carcinoma (SCC) accounts for nearly 2% of all cancers of the alimentary tract. Over the past few years, the management of anal canal cancer has changed from primary surgery to primary chemo-radiotherapy (CRT). Methods: A total of 83 patients' (pts) records (62 males, 21 females) ...
Uribe-Romo Fernando Javier - - 2011
Condensation of 2,5-diethoxyterephthalohydrazide with 1,3,5-triformylbenzene or 1,3,5-tris(4-formyl-phenyl)benzene yields two new covalent organic frameworks, COF-42 and COF-43, in which the organic building units are linked through hydrazone bonds to form 2-dimensional porous extended frameworks. Both materials are highly crystalline, display excellent chemical and thermal stability, and are permanently porous. These new ...
Ren Wen - - 2011
Herein graphene oxide/Ag nanoparticles hybrids (GO/AgNPs) were fabricated according to a self-assembly procedure. Using the obtained GO/AgNPs as SERS substrates, an ultra-sensitive and label-free detection of folic acid in water and serum was demonstrated based on the inherent SERS spectra of folic acid. The modified graphene oxide exhibited strong enrichment ...
Ayinla Rashidat O - - 2011
Intermolecular hydroamination of heteroatom-substituted allenes with a bulky arylamine was carried out using a bis(amidate) bis(amido) titanium(iv) complex (1) as a precatalyst. The reaction of 2,6-dimethylaniline with oxygen-substituted allene 2c or 2d in the presence of complex 1 gives the ketimine regioisomer as the exclusive product. Reduction of such ketimine ...
Warnan Julien - - 2011
The first trichromophoric sensitizer, consisting of covalently linked boradiazaindacene (BODIPY), zinc porphyrin (ZnP), and squaraine (SQ) units, has been synthesized by Heck alkynylation to obtain a panchromatic dye, for dye sensitized solar cells (DSSCs). Efficient intramolecular energy transfers (ET) were observed between all chromophoric subunits and enhance the overall conversion ...
Elahy Mina - - 2011
DNAzymes (DNA enzymes, deoxyribozymes) are synthetic, single-stranded DNA-based catalysts engineered to bind to their complementary sequence in a target messenger RNA (mRNA) through Watson-Crick rules for base-pairing and cleave the mRNA at predetermined phosphodiester linkages. Dz13, a DNAzyme that cleaves c-Jun mRNA, has been found to have efficacious effects against ...
Hebels Dennie G A J - - 2011
N-nitroso compounds (NOCs) are suspected human carcinogens and relevant in human exposure. NOCs also induce micronuclei (MN) formation in vivo. Since lymphocytic MN represent a validated biomarker of human cancer risk, establishing a link between NOC exposure and MN frequency in humans and concurrently investigating associated transcriptomic responses may provide ...
Lebowitz Kim R - - 2011
Previous research indicates the beneficial effects of humor among healthy adults. Little is known about the physical and psychological effects of sense of humor and laughter among patients with chronic obstructive pulmonary disease (COPD). Patients with COPD (n = 46; mean age ± SD, 66.9 ± 9.9 years) completed assessments ...
Patel Katir K - - 2011
SUMMARY AT A GLANCE: Assessment of 319 pediatric patients with chronic respiratory disease revealed a high prevalence of urogenital Mycoplasma species in their BAL fluid. Therefore, the presence of urogenital Mycoplasma species should not be underestimated, but evaluated in patients with chronic respiratory diseases, especially in those whose symptoms have ...
Engelken Florian Jan - - 2011
OBJECTIVE: To evaluate whether measurement of strain under static compression in tomosynthesis of a breast-mimicking phantom can be used to distinguish tumor-simulating lesions of different elasticities and to compare the results to values predicted by rheometric analysis as well as results of ultrasound elastography. MATERIALS AND METHODS: We prepared three ...
Assareh Hassan - - 2011
Precise identification of the time when a clinical process has changed, a control chart's signal, enables clinicians to search for a potential special cause more effectively. In this article, we develop a change point estimation method for Bernoulli processes in a Bayesian framework. We apply Bayesian hierarchical models to formulate ...
Zhu N - - 2011
Engineered scaffolds have been shown to be critical to various tissue engineering applications. This paper presents the development of a novel three-dimensional scaffold made from a mixture of chitosan microspheres (CMs) and poly(l-lactide) by means of the rapid freeze prototyping (RFP) technique. The CMs were used to encapsulate bovine serum ...
Javadi Firouzeh - - 2011
The subgenus Ceratotropis in the genus Vigna is widely distributed from the Himalayan highlands to South, Southeast and East Asia. However, the interspecific and geographical relationships of its members are poorly understood. This study investigates the phylogeny and biogeography of the subgenus Ceratotropis using chloroplast DNA sequence data. Sequence data ...
Farshchian Mehdi - - 2011
The incidence of keratinocyte-derived nonmelanoma skin cancers is increasing worldwide because of cumulative recreational exposure to sunlight. At present, no specific molecular markers are available for assessing the progression of premalignant actinic keratoses to invasive cutaneous squamous cell carcinoma (SCC). We examined the role of the Serpin family in skin ...
Wright Imelda - - 2011
Peripheral nerve blocks involve injecting local anesthesia near or around a nerve or nerve plexus. This form of anesthesia allows surgeons to perform more complex surgeries and provides extended postoperative analgesia for patients. Patients experience reduced postoperative pain and length of hospital stay and increased satisfaction with the outcome of ...
Aleman André - - 2011
Novel strategies are needed in the treatment of hallucinations as a subgroup of patients with pathological hallucinations (>30%) do not respond to antipsychotics or are not compliant with medication. We review recently developed biological and cognitive treatments. Repetitive transcranial magnetic stimulation concerns neuromodulation targeted at aberrant activity in regions shown ...
Chen Jian-Yong - - 2011
To explore the significance of colonic epithelial cell apoptosis and tumor necrosis factor α (TNF-α) changing in pathogenesis of melanosis coli (MC) in guinea pig and the molecular mechanism of rhubarb (Rhu) in inducing the disease, by means of using different dosages of Rhu to induce the disease. One hundred ...
Mohkam Masoumeh - - 2011
Introduction. Hypertension is one of the most common diseases in the world and a major risk factor for cardiovascular, renal, and neurologic diseases. It seems that hypertension and overweight in children are a growing epidemic. The aim of this study was to investigate the prevalence of hypertension in school-aged children ...
Brown Catana - - 2011
This study assessed phases one and two of a three-phase weight-loss program called RENEW--Recovering Energy Through Nutrition and Exercise for Weight Loss--among individuals with serious mental illness at four mental health centers. RENEW provides meal replacements twice daily and intensive instruction in nutrition and meal preparation, exercise, and goal setting ...
Hillmann Dierck - - 2011
Scanning optical coherence tomography (OCT) is limited in sensitivity and resolution by the restricted focal depth of the confocal detection scheme. Holoscopy, a combination of holography and Fourier-domain full-field OCT, is proposed as a way to detect photons from all depths of a sample volume simultaneously with uniform sensitivity and ...
Markov Andrey - - 2011
A type of a plasmonic waveguide has been proposed featuring an "open" design that is easy to manufacture, simple to excite and offers convenient access to a plasmonic mode. Optical properties of photonic bandgap (PBG) plasmonic waveguides are investigated experimentally by leakage radiation microscopy and numerically using the finite element ...
Emmons Karen M KM Dana-Farber Cancer Institute/Harvard School of Public Health, Boston, MA, USA. - - 2012
There is a growing emphasis on the role of organizations as settings for dissemination and implementation. Only recently has the field begun to consider features of organizations that affect dissemination and implementation of evidence-based interventions. This manuscript identifies and evaluates available measures for five key organizational-level constructs: (a) leadership, (b) ...
Bürgmann Helmut - - 2011
The microbial population and physicochemical process parameters of a sequencing batch reactor for nitrogen removal from urine were monitored over a 1.5-year period. Microbial community fingerprinting (automated ribosomal intergenic spacer analysis), 16S rRNA gene sequencing, and quantitative PCR on nitrogen cycle functional groups were used to characterize the microbial population. ...
Pelossof Gilad - - 2011
Thiolated nucleic acid hairpin nanostructures that include in their stem region a "caged" G-quadruplex sequence, and in their single-stranded loop region oligonucleotide recognition sequences for DNA, adenosine monophosphate (AMP), or Hg(2+) ions were linked to bare Au surfaces or to Au nanoparticles (NPs) linked to Au surfaces. The opening of ...
Fadda Guido - - 2011
DESIGN: Fine-needle aspiration biopsy (FNAB) is the most reliable diagnostic tool in the diagnosis of thyroid nodules. A cytologic diagnosis of follicular neoplasm with also atypical cells of undetermined significance (FN/AUS) implies that the selection of patients between surgery and follow-up is difficult. In this setting immunocytochemical stainings might be ...
Pataro André Luiz - - 2012
Recent studies have shown that being overweight or obese is associated with a higher risk of periodontitis. However, the literature offers an insufficient number of published reports regarding the effect of bariatric surgery on oral health. As such, the present study aims to determine the association between periodontal status and ...
Löfström Björn - - 2011
OBJECTIVE: Patients with rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE) have an increased risk of diffuse large B cell lymphoma (DLBCL). The cytokine A PRoliferating-Inducing Ligand (APRIL) is strongly expressed in DLBCL in the general population and is detected in high concentrations in sera from subgroups of patients with ...
Khaykin Yaariv - - 2011
We report a case of a patient with long-standing persistent atrial fibrillation (AF) who had rapid formation of spontaneous echo-contrast in the left atrium during pulmonary vein antrum isolation set off by a vagally mediated pause despite standard anticoagulation protocol. Spontaneous echo contrast resolved with ventricular pacing, representing visual evidence ...
Wasyl Dariusz - - 2011
The prevalence of Escherichia coli with putative extended-spectrum cephalosporin resistance was assessed in cattle, pigs, broilers, layers, and turkey slaughtered in Poland. The occurrence of random E. coli isolates recovered from MacConkey agar plates with non-wild-type minimal inhibitory concentrations for cefotaxime and ceftazidime reached 0.6% in layers, 2.3% in turkey, ...
Sathiyan S - - 2011
The purpose of this study is to examine the plan quality and monitor unit with sliding window IMRT and RapidArc (RA) treatment plans using American Association Physicists in Medicine TG119 test suite DICOM-RT images and structure sets. The structure set includes multi-target (superior, central, inferior), prostate, head and neck and ...
Marzouk Asma - - 2011
The formation and structure of a novel species, a disuperoxo-cobalt dioxide complex (CoO6), has been investigated using matrix isolation in solid neon and argon, coupled to infrared spectroscopy and by quantum chemical methods. It is found that CoO6 can be formed by successive complexation of cobalt dioxide by molecular oxygen ...
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