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Dang Yunkun Y Department of Physiology, ND13.214A, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd., Dallas, TX 75390-9040, USA. - - 2011
Small RNA molecules of about 20 to 30 nucleotides function in gene regulation and genomic defense via conserved eukaryotic RNA interference (RNAi)-related pathways. The RNAi machinery consists of three core components: Dicer, Argonaute, and RNA-dependent RNA polymerase. In fungi, the RNAi-related pathways have three major functions: genomic defense, heterochromatin formation, ...
Shi Liang - - 2011
Shewanella oneidensis MR-1 possesses a periplasmic [NiFe]-hydrogenase (MR-1 [NiFe]-H(2)ase) that has been implicated in H(2) production and oxidation as well as technetium [Tc(VII)] reduction. To characterize the roles of MR-1 [NiFe]-H(2)ase in these proposed reactions, the genes encoding both subunits of MR-1 [NiFe]-H(2)ase were cloned and then expressed in an ...
Cacicedo José M - - 2011
Exercise can prevent endothelial cell (EC) dysfunction and atherosclerosis even in the absence of improvements in plasma lipids. However, the mechanisms responsible for these effects are incompletely understood. In this study we examined in mice whether an acute bout of exercise activates enzymes that could prevent EC dysfunction, such as ...
Thompson Wesley K - - 2011
Characterization of developmental trajectories across the lifespan is integral to understanding the prodromal course of many neuropsychiatric illnesses and the significant risk factors for disease onset or unfavorable outcomes. However, the standard experimental designs used in psychiatric research are not ideal for this purpose. The authors review the limitations of ...
Jaffers Gregory J - - 2011
Purpose: The incidence of ulcerated, bleeding, autologous, hemodialysis fistulas has been felt to be increasing in recent years. This review was undertaken to examine our experience with patients who presented with episodes of spontaneous bleeding in the presence of an ulcerated lesion over their autologous dialysis accesses. Methods: A database ...
Moran Colleen M - - 2011
Papaverine has been associated with transient cranial nerve dysfunction after topical application during craniotomy. The authors report similar dysfunction after the use of papaverine affected brainstem structures. Two patients undergoing craniotomy for clipping of an aneurysm experienced bilateral depression of cortical somatosensory evoked potentials to both median and tibial nerve ...
Luo Shenglin - - 2011
The development of multifunctional agents for simultaneous tumor targeting and near infrared (NIR) fluorescence imaging is expected to have significant impact on future personalized oncology owing to the very low tissue autofluorescence and high tissue penetration depth in the NIR spectrum window. Cancer NIR molecular imaging relies greatly on the ...
Castillo C - - 2011
The aim of this investigation was to evaluate whether, in the nutritional management of commercial feedlots, copper (Cu) supplementation is justified to maintain the physiological requirements. This study compared beef calves fed concentrates with an average Cu basal content of 5 and 8mg/kg in growing and finishing periods (10 animals) ...
Chen Shi-Gui - - 2011
A novel type of chiral layered supramolecular copolymers of high molecular weight has been assembled from a hydrogen bonded C6-symmetric zinc porphyrin hexamer and chiral C3-symmetric pyridine hexadentates driven by multivalent zinc porphyrin-pyridine coordination. UV-vis, circular dichroism and static light scattering experiments reveal that the formation of the layered supramolecular ...
Sakamoto Keiko - - 2011
Phenylacetic acid (PAA) is a common intermediate in the catabolic pathways of several structurally related aromatic compounds. It is converted into phenylacetyl coenzyme A (PA-CoA), which is degraded to general metabolites by a set of enzymes. Within the genome of the extremely thermophilic bacterium Thermus thermophilus HB8, a cluster of ...
Douda David Nobuhiro - - 2011
Neutrophils release DNA-based extracellular traps to capture and kill bacteria. The mechanism(s) and proteins that promote neutrophil extracellular trap (NET)-mediated bacterial trapping are not clearly established. Surfactant protein D (SP-D) is an innate immune collectin present in many mucosal surfaces. We hypothesized that SP-D can bind both the pathogens and ...
Bensamoun Sabine F - - 2011
To date, non-invasive methods to detect kidney malignancies and mild tumors remain a challenge. The purpose of this study was to establish the proper imaging protocol to determine kidney stiffness and its spatial distribution within the various kidney compartments such as the renal sinus, medulla, and cortex. Here, we have ...
Kitahara Maki - - 2011
Strains of Gram-negative anaerobic rods were isolated from chinchilla (Chinchilla lanigera) faeces, and three strains, ST161T, ST33 and ST37T, were investigated taxonomically. Based on the phylogenetic analyses and specific phenotypic characteristics, the three strains belonged to the genus Bacteroides. Phylogenetic analyses of their 16S rRNA gene sequences revealed that strain ...
Ruder Thomas D - - 2011
OBJECTIVES: Minimally invasive or virtual autopsies are being advocated as alternative to traditional autopsy, but have limited abilities to detect coronary artery disease. It was the objective of this study to assess if the occurrence of chemical shift artifacts (CSA) along the coronary arteries on non-contrast, post-mortem cardiac MR may ...
Lefthériotis Georges - - 2011
Pseudoxanthoma elasticum (PXE) is an inherited metabolic disease characterized by elastic fiber fragmentation and calcification in the cutaneous, ophthalmologic, and vascular tissues. Cardiovascular manifestations such as peripheral arterial disease (PAD) are frequent in PXE. Because of the changes in the elastic properties and medial calcification of the arterial wall in ...
North Simon J - - 2012
In allergic diseases such as asthma, eosinophils, basophils and mast cells, through release of preformed and newly generated mediators, granule proteins and cytokines, are recognized as key effector cells. While their surface protein phenotypes, mediator release profiles, ontogeny, cell trafficking and genomes have been generally explored and compared, there has ...
Etchells Edward - - 2011
Background For patients with critical laboratory abnormalities, timely clinical alerts with decision support could improve management and reduce adverse events. Methods The authors developed a real-time clinical alerting system for critical laboratory abnormalities. The system sent alerts to physicians as text messages to a smartphone or alphanumeric pager. Decision support ...
Trèves R R Service de gynécologie-obstétrique et médecine de la reproduction, hôpital Antoine-Béclère, AP-HP, 157, rue de Porte-de-Trivaux, 92141 Clamart, - - 2011
Over the past two decades, major advances in diagnostic modalities and treatment have markedly improved rates of cure for adult cancers. As a consequence, the number of long-term survivors is increasing, and fertility preservation has become a major issue for young patient about to start treatment for cancer. Whether fertility ...
Keller Paula A PA University of Wisconsin Center for Tobacco Research and Intervention, Madison, Wisconsin, - - 2011
Smoking prevalence among Medicaid enrollees is higher than among the general population, but use of evidence-based cessation treatment is low. We evaluated whether a communications campaign improved cessation treatment utilization. Quasi-experimental. Wisconsin. Enrollees in the Wisconsin Family Medicaid program. The average monthly enrollment during the study period was approximately 170,000 ...
- - 2011
AbstractA 36-year-old male with a history of chronic asthma presented to an emergency department with shortness of breath consistent with an asthma exacerbation. He had persistent tachypnea following inhaled bronchodilator treatment; thus, the workup and differential diagnosis were expanded. He was found to have a mixed respiratory alkalosis and metabolic ...
Young-Hughes Sadie - - 2011
The purpose of this study was to compare the costs of providing specialty wound care to spinal cord injury/disorder (SCI/D) veterans by teleconsultation and traditional care. A retrospective design was used to conduct this descriptive, correlational study. A convenience sample of 76 SCI/D veterans (2 women, 74 men) met inclusion ...
Induru Raghava R - - 2011
For a variety of reasons, cancer pain is often undertreated, adversely affecting the quality of life for patients and caregivers. To manage cancer pain effectively, physicians need to understand its pathogenesis, how to assess it, how to treat it, and, in particular, how to optimize opioid treatment. We discuss common ...
Jenkins Michael P - - 2011
Conventional open surgical repair, endovascular treatment, and the hybrid technique constitute the three treatment options for patients with type IV thoracoabdominal aortic aneurysms (TAAAs). Treatment is advocated to prevent rupture but yields significant risk for spinal cord ischemia, cardiovascular, and renal and respiratory complications, including death. Refinements in open surgical ...
Zada Gabriel - - 2011
The aim of this paper is to provide a comprehensive review of clinical, imaging, and histopathological features, as well as operative and nonoperative management strategies in patients with Rathke cleft cysts (RCCs). A literature review was performed to identify previous articles that reported surgical and nonsurgical management of RCCs. Rathke ...
Hill Clare P - - 2011
Balamuthia amebic encephalitis is rarely reported in infants. To the best of our knowledge, amebic encephalitis complicated by a mycotic aneurysm was only described once. We report on an 8-month-child with laboratory-confirmed Balamuthia mandrillaris meningoencephalitis, complicated by a mycotic aneurysm of the middle cerebral artery.
Anil Kumar V - - 2011
Salmonellosis is a common infection in systemic lupus erythematosus patients. The present study reports on two such cases of Salmonella typhimurium septic arthritis among the 102 patients seen during a four-year period.
Granzow Nicolai - - 2011
We report a hybrid chalcogenide-silica photonic crystal fiber made by pressure-assisted melt-filling of molten glass. Photonic bandgap guidance is obtained at a silica core placed centrally in a hexagonal array of continuous centimeters-long chalcogenide strands with diameters of 1.45 μm. In the passbands of the cladding, when the transmission through the ...
Pégard Nicolas C - - 2011
We demonstrate a method to optimize the reconstruction of a hologram when the storage device has a limited dynamic range and a minimum grain size. The optimal solution at the recording plane occurs when the object wave has propagated an intermediate distance between the near and far fields. This distance ...
Naumann Fiona - - 2011
BACKGROUND: Cancer and its treatments produce lingering side-effects that undermine the quality of life (QOL) of survivors. Exercise and psycho-therapies increase QOL among survivors, however, research is needed to identify intervention characteristics most associated with such improvements. OBJECTIVE: This research aimed to assess the feasibility of a 9 week individual ...
Goode Ellen L EL Department of Health Sciences Research, Mayo Clinic College of Medicine, Rochester, MN 55905, USA. - - 2011
Invasive ovarian cancer is a significant cause of gynecologic cancer mortality. We examined whether this mortality was associated with inherited variation in approximately 170 candidate genes/regions [993 single-nucleotide polymorphisms (SNPs)] in a multistage analysis based initially on 312 Mayo Clinic cases (172 deaths). Additional analyses used The Cancer Genome Atlas ...
Choudhary Vivek V Charlie Norwood VA Medical Center, Georgia Health Sciences University, Augusta, Georgia, - - 2011
Androgen and androgen receptors (AR) play critical roles in the proliferation of prostate cancer through transcriptional regulation of target genes. Here, we found that androgens upregulated the expression of dynamin-related protein 1 (Drp1), which is involved in the induction of mitochondrial fission, a common event in mitosis and apoptosis. Clinical ...
Porat Ron - - 2011
BACKGROUND: The traditional guava variety cultivated in Israel, 'Ben Dov', emits a very strong odour, whereas some newly bred varieties have a mild odour. In this study the aroma profile composition of the high-aromatic 'Ben Dov' variety was compared with those of four new low-aromatic varieties. RESULTS: Overall, using gas ...
Maeda Hiroaki - - 2011
Linear and branched Fe(tpy)(2) complex oligomer wires were quantitatively formed on hydrogen-terminated silicon wafers by means of hydrosilylation of ethynylterpyridine and following stepwise coordination reactions, and the redox property of surface-attached species and its photosensitivity can be controlled by the doping density of the silicon wafers.
Silva John-Paul JP Division of Cell and Molecular Biology, Imperial College London, London SW7 2AZ, United - - 2011
Latrophilin 1 (LPH1), a neuronal receptor of α-latrotoxin, is implicated in neurotransmitter release and control of presynaptic Ca(2+). As an "adhesion G-protein-coupled receptor," LPH1 can convert cell surface interactions into intracellular signaling. To examine the physiological functions of LPH1, we used LPH1's extracellular domain to purify its endogenous ligand. A ...
Sela Meirav - - 2011
Cooperatively assembled signalling complexes, nucleated by adaptor proteins, integrate information from surface receptors to determine cellular outcomes. In T and mast cells, antigen receptor signalling is nucleated by three adaptors: SLP-76, Gads and LAT. Three well-characterized SLP-76 tyrosine phosphorylation sites recruit key components, including a Tec-family tyrosine kinase, Itk. We ...
Verma Ravi - - 2011
Background The nucleotide-binding oligomerization domain1 (NOD1) gene encodes a pattern recognition receptor that senses pathogens. NOD1/CARD4 signaling leads to activation of nuclear factor-kB, and plays an important role in innate immunity. Certain polymorphisms and mutations in NOD1/CARD4 may result in dysfunctional innate immune response during bacterial recognition which may have ...
Wharam J Frank - - 2011
BACKGROUND:: Although pay-for-performance (P4P) compensation is widespread, questions have arisen about its efficacy in improving health care quality and consequences for vulnerable patients. OBJECTIVE:: To assess perceptions of general internists and P4P program leaders regarding how to implement fair and effective P4P. METHODS:: Qualitative investigation using in-depth interviews with P4P ...
Bzdok Danilo - - 2012
Face-derived information on trustworthiness and attractiveness crucially influences social interaction. It is, however, unclear to what degree the functional neuroanatomy of these complex social judgments on faces reflects genuine social versus basic emotional and cognitive processing. To disentangle social from nonsocial contributions, we assessed commonalities and differences between the functional ...
Groeneveld Iris F IF VU University Medical Center/EMGO+ Institute, Department of Public and Occupational Health, Van der Boechorststraat 7, Amsterdam, Noord Holland 1081 BT, The Netherlands. - - 2011
Evaluate counselors' adherence to an intervention protocol, counselors' competence, and the associations between three process indicators and body weight at follow-up in a 6-month individually based lifestyle intervention for construction workers. Process evaluation with qualitative and quantitative data. Occupational health service. A total of 408 male construction workers with an ...
Fulkerson Daniel H - - 2011
Object Pediatric intracranial aneurysms are rare lesions that differ from their adult counterparts. Aneurysms involving the middle cerebral artery (MCA) are particularly challenging to treat in children, as they are often fusiform and cannot undergo direct clipping alone. The authors recently treated a patient with a heavily calcified, dysplastic, left-sided ...
Malone Ian B IB Cavendish Laboratory, University of Cambridge, Cambridge, United - - 2011
Modeled attenuation correction (AC) will be necessary for combined PET/MRI scanners not equipped with transmission scanning hardware. We compared 2 modeled AC approaches that use nonrigid registration with rotating (68)Ge rod-based measured AC for 10 subjects scanned with (18)F-FDG. Two MRI and attenuation map pairs were evaluated: tissue atlas-based and ...
Ghinea Razvan - - 2011
This study deals with the influence of surface roughness on the color of resin composites. Ten resin composites (microfilled, hybrid, and microhybrid) were each polished with 500-grit, 1200-grit, 2000-grit, and 4000-grit SiC papers. The roughness parameter (R(a)) was measured using a Plμ confocal microscope, and field-emission scanning electron microscope (Fe-SEM) ...
Chen Lijuan - - 2011
We reported an efficient laser-diode (LD) end-pumped CW dual-wavelength Nd:YAG crystal laser operating at 1074 and 1112 nm simultaneously, for the first time to our knowledge. The maximum output power was 3.15 W with an optical conversion efficiency of 23.6%. Considering the broad absorption of carbonylhemoglobin and hemoglobin located at about 538 ...
Pegolo N T - - 2011
The interest in the effect of genotype by environment interaction (GEI) is increasing because animal breeding programs have become geographically broader. Climate changes in the next decades are also expected to challenge the present breeding goals, increasing the importance of environmental sensitivity. The aim of this work was to analyze ...
Kip Nardy - - 2011
Sphagnum peatlands are important ecosystems in the methane cycle. Methane-oxidizing bacteria in these ecosystems serve as a methane filter and limit methane emissions. Yet little is known about the diversity and identity of the methanotrophs present in and on Sphagnum mosses of peatlands, and only a few isolates are known. ...
Novinscak A - - 2011
In this study, we evaluated the effect of soil clay content on RNA isolation and on quantitative reverse transcription-PCR (qRT-PCR) quantification of microbial gene transcripts. The amount of clay significantly altered RNA isolation yields and qRT-PCR analyses. Recommendations are made for quantifying microbial gene transcripts in soil samples varying in ...
Abhishek Abhishek - - 2011
INTRODUCTION: The objectives were to ascertain the incidence of teriparatide prescription in the UK stratified by region and sex, examine the association between National Institute for Health and Clinical Excellence (NICE) and European Medicines Agency approval and geographic variation in teriparatide prescription, and compare the regional rates of teriparatide and ...
Béliveau François - - 2011
The type II transmembrane serine protease TMPRSS6 (also known as matriptase-2) controls iron homeostasis through its negative regulation of expression of hepcidin, a key hormone involved in iron metabolism. Upstream of the hepcidin-regulated signaling pathway, TMPRSS6 cleaves its target substrate hemojuvelin (HJV) at the plasma membrane, but the dynamics of ...
Touma Zahi - - 2011
OBJECTIVE: To assess whether the Lupus Quality of Life (LupusQoL) questionnaire contributed additional information not obtained using the Medical Outcomes Study Short-Form 36 questionnaire (SF-36) in a cohort of patients with systemic lupus erythematosus (SLE). METHODS: Forty-one patients seen at a single center were followed at monthly intervals for 12 ...
Martínez-Ortega José M - - 2011
OBJECTIVES: To identify demographic or clinical factors associated with frequent admissions in a sample of patients admitted to an acute psychiatric hospitalization unit, controlling for potentially confounding factors. METHODS: Socio-demographic variables, diagnosis, and the legal status, date and length of admission were collected for 1,722 consecutively admitted psychiatric patients during ...
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