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Sui, Xu-Xia - - 2010
Previous studies have proposed that the forkhead transcription factor FOXO3a is involved in cell cycle arrest and apoptosis and that it may also repress follicular development by inducing cell cycle arrest in ovaries. We have recently demonstrated that FOXO3a induces oocyte apoptosis of neonatal rat ovaries under in vitro conditions. ...
Guo, Wen-Ping - - 2010
Neuregulin-1 (NRG-1) is a member of the epidermal growth factor family. Our previous study showed that NRG-1 protected neurons from apoptosis following focal cerebral ischemia by the inhibition of caspase-3 and TNF-a expression. However, the molecular signaling mechanisms for this action of NRG-1 following cerebral ischemia are not fully understood. ...
Hauff, Kristin - - 2010
Barth syndrome is a rare X-linked disease in which mild hypocholesterolemia is observed in some patients. We investigated cholesterol biosynthesis in lymphoblasts from a normal and age-matched Barth syndrome patient. Control and Barth syndrome ([DELTA]TAZ1) lymphoblasts were incubated in the presence or absence of serum to induce cholesterol synthesis and ...
Li, Zhiguo - - 2010
Diabetic nephropathy (DN) is one of the most important complications of diabetic patients and is characterized histologically by an accumulation of extracellular matrix (ECM) protein in the glomerular mesangium. Therefore, mesangial cells likely play an important role in the development of diabetic nephropathy. Here, we employed proteomic techniques to investigate ...
Xu, Zhigang - - 2010
Celecoxib is a selective inhibitor of cyclooxygenase-2 (COX-2). It may reduce the risk of cancer formation by affecting the metabolism of arachidonic acid (AA), which has been implicated in the development of cancer. Accordingly, this study was designed to determine the effects of celecoxib on the AA pathway in mouse ...
Niu, Jianqin - - 2010
Haloperidol is a commonly used, typical, antipsychotic drug (APD) that acts strongly against positive symptoms, but has fewer therapeutic effects on, or may even aggravate, negative symptoms and cognitive deficits in patients with schizophrenia. Loss of oligodendrocytes has been suggested as a factor associated with the negative symptoms of schizophrenia. ...
LeBlanc, Marissa - - 2010
Saccharomyces cerevisiae remains an ideal organism for studying the cell biological roles of lipids in vivo, as yeast has phospholipid metabolic pathways similar to mammalian cells, is easy and economical to manipulate, and is genetically tractable. The availability of isogenic strains containing specific genetic inactivation of each non-essential gene allowed ...
Wu, Gengshu - - 2010
Choline kinase (CK) was discovered in 1953. Progress in understanding the function of CK was slow until its purification in 1984. The subsequent cloning and expression of the cDNA led to the description of the gene structures. Two genes encode choline kinase, Chka and Chkb, and 3 isoforms of the ...
Dallar, Yildiz - - 2010
Introduction: Child abuse and neglect is a very important problem in our country as it also is in the world. There is a high possibility of child abuse by mothers who suffer depression after birth. Here, a newborn that was physically abused by a mother diagnosed with depression after birth ...
Aslan, Eyup - - 2010
Introduction: Alkaptonuria is a disease caused by deficiency of homogentisate 1-2 dioxygenase, which is associated with thyrosine metabolism in the liver. Deficiency of this enzyme is caused by mutation in homogentisic acid oxidase gene. This is a rare otosomal recessive disease. The most prominent symptom in childhood is darkening of ...
Yildiz, Meral - - 2010
Son yillarda yenidogan yogun bakim unitelerinin yayginlasmasi ve yenidogan bakimindaki gelismelere paralel olarak tum dunyada premature retinopati insidansinda bir artis izlenmektedir. Bu durum taranmasi gereken prematur bebek sayisini ve tedavi edilmesi gereken goz sayisini arttirmaktadir. Bu derlemedeki amacimiz premature retinopati tedavisindeki guncel yenilikleri degerlendirmektir. Tedavi alaninda lazer ve kriyoterapiye alternatif ...
Akcan, A. - - 2010
Family of natriuretic peptides (NP), consists of eight or more peptides associated with each other. These are, atrial natriuretic peptide (ANP) prohormone consisting of 126 amino acids; brain natriuretic peptide (BNP) prohormone consisting of 108 amino acids; C-type natriuretic peptide (CNP) prohormone consisting of 126 amino acids. Although recently identified, ...
Karacan, Mehmet - - 2010
Introduction: The aim of this study was to assess the frequency of undiagnosed congenital and acquired heart diseases among school-aged children.
Ozkan, Hilal - - 2010
Introduction: The aim of this study was to evaluate the characteristic features and both early and late term prognosis of premature infants who were followed-up with NEC in the neonatal intensive care unit.
Demir, Korcan - - 2010
Introduction: In this study, it was aimed to assess the frequency and associated factors of diabetic ketoacidosis (DKA) at diagnosis in patients with newly diagnosed type 1 diabetes who were admitted to pediatric endocrinology clinics in tertiary referral hospitals in Izmir and Manisa provinces.
Babaoglu, Kadir - - 2010
Introduction: Mucopolysaccharidoses (MPS) are an important group of lysosamal storage diseases. Commonly reported cardiac involvements are mitral leaflet thickening and accompanying prolapsus, regurgitation and rarely stenosis. In this study, it was aimed to evaluate cardiac in involvements in patients with MPS.
Potter, Polyxeni - - 2010
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