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Hughes, Breedagh - - 2009
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Blankenship, Karen - - 2009
Duffy, Maureen - - 2009
Gezginci-Oktayoglu, Selda - - 2009
Glucagon-like peptide-1 (GLP-1) ameliorates the symptoms of diabetes through stimulation of insulin secretion. We have investigated the possible components of cellular mechanism triggered by exendin-4, a potent GLP-1 receptor agonist, in streptozotocin (STZ) induced diabetic mice pancreas. BALB/c male mice were divided into four groups for this investigation. The first ...
Aouida, Mustapha - - 2009
Saccharomyces cerevisiae Opt2 is a member of the oligopeptide transporter family that was initially identified to transport tetra- and pentapeptides. Mutants deleted for the OPT2 gene exhibit no growth defects under normal culture conditions. We identified OPT2 from a high-throughput screen that when deleted results in mutants that displayed sensitivity ...
Arslan, Pharhad - - 2009
Fibrillation of the Alzheimer [beta]-amyloid peptide (AP) and (or) formation of toxic oligomers are key pathological events in Alzheimer's disease. Several strategies have been introduced to identify small molecule aggregation inhibitors, and based on these methods, a number of aggregation inhibitors have been identified. However, most of these methods use ...
N'-soukpoe-Kossi, C.N. - - 2009
We studied the interaction between tRNA and three polyamine analogues (1,11-diamino-4,8-diazaundecane*4HC1 (333), 3,7,11,15-tetrazaheptadecane*4HC1 (BE-333), and 3,7,11,15,19-pentazahenicosane*5HC1 (BE-3333)) using FTIR, UV-visible, and CD spectroscopic methods. Spectroscopic evidence showed that polyamine analogues bound tRNA via guanine N7, adenine, uracil 02, and the backbone phosphate ([PO.sup.-.sub.2]) groups, while the most reactive sites for ...
Majumder, Syamantak - - 2009
Cadmium, a ubiquitous heavy metal, interferes with endothelial functions and angiogenesis. Bradykinin is a Ca-mobilizing soluble peptide that acts via nitric oxide to promote vasodilation and capillary permeability. The objective of the present study was to explore the Cd implications in bradykinin-dependent endothelial functions. An egg yolk angiogenesis mod el ...
Gu, Jinyang - - 2009
One of the greatest challenges in the attempt to create functional bioartificial liver designs is the maintenance of porcine hepatocyte differentiated functions in vitro. Co-cultivation of hepatocytes with nonparenchymal cells may be beneficial for optimizing cell functions via mimicry of physiological microenvironment. However, the underlying mechanisms remain to be elucidated. ...
Villagomez, Maria - - 2009
Cell adhesion is regulated by a variety of [Ca.sup.2+]-regulated pathways that depend on [Ca.sup.2+]-binding proteins. One such protein is calreticulin, an ER-resident protein. Calreticulin signalling from within the ER can affect processes outside the E R, such as expression of several adhesion-related genes, most notably vinculin and fibronectin. In addition, ...
Hikita, Atsuhiko - - 2009
Tumor necrosis factor-a (TNF-[alpha]) is initially synthesized as a membrane-bound protein and converted into a soluble form by proteolytic cleavage. Although a disintegrin and metalloproteinase 17 (ADAM17) is considered to be the primary sheddase for TNF-[alpha], it is not known whether ADAM17 is solely responsible for that process in any ...
Krawetz, Roman - - 2009
The mouse F9 embryonal carcinoma cell line is ideally suited to study the epithelial-to-mesenchymal transition accompanying the differentiation of primitive to parietal extraembryonic endoderm. In F9 cells, the application of exogenous agents including retinoic acid or activation of signal transduction cascades downstream of G-proteins triggers widespread changes in gene expression ...
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