Search Results
Results 551 - 600 of 1228
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D'Orleans-Juste, Pedro - - 2010
Hartman, J. - - 2010
To evaluate potential mechanisms of clinical hepatotoxicity, 4 endothelin receptor antagonists (ERAs) were examined for substrate activity and inhibition of hepatic uptake and efflux transporters in sandwich-cultured human hepatocytes. The 4 transporters studied were sodium-dependent taurocholate cotransporter (NTCP), organic anion transporter (OATP), bile salt export pump (BSEP), and multidrug resistance-associated ...
Rosano, Laura - - 2010
In human ovarian carcinoma, the endothelin-1 (ET-1)/endothelin A receptor ([ET.sub.A]R) axis is overexpressed, correlating with tumor grade. Moreover, [ET.sub.A]R activation by ET-1 affects cell proliferation, survival, angiogenesis, and invasion. [ET.sub.A]R blockade with zibotentan (ZD4054), a specific ETaR antagonist, significantly inhibits ovarian cancer growth in vitro and in vivo, underscoring the ...
Khodorova, Alla - - 2010
A profound tachyphylaxis of the acute nocifensive flinching (pain) response to subcutaneous injection of endothelin-1 (ET-1) into the hind paw footpad is shown by the reduced response to a second injection. Flinching from the second injection was 20% [+ or -] 5%, 57% [+ or -] 18%, 79% [+ or ...
Claudino, Rafaela - - 2010
This study evaluated the contribution of endothelins to changes in sensitivity to mechanical stimulation of the lower abdomen and hind paw associated with 2,4,6-irinitrobenzene sulfonic acid (TNBS)-induced colitis. The frequency of withdrawal responses to 10 consecutive applications of von Frey probes to the lower abdomen (0.07 g) or hind paw ...
Papadopoulos, Panayiota - - 2010
Increased levels of transforming growth factor-[[beta].sub.1], (TGF-[[beta].sub.1]) induce a vascular pathology that shares similarities with that seen in Alzheimer's disease, and which possibly contributes to the cognitive decline. In aged transgenic mice that overexpress TGF-[[beta].sub.1] (TGF mice), we previously found reduced dilatory function and selectively impaired endothelin-1 (ET-1)-induced contraction. Here ...
Kelland, N.F. - - 2010
Inactivation of endothelin B receptors ([ET.sub.B]), either through selective pharmacological antagonism or genetic mutation, increases the circulating concentration of endothelin-1 (ET-1), suggesting [ET.sub.B] plays an important role in clearance of this peptide. However, the cellular site of [ET.sub.B]-mediated clearance has not yet been determined. We have used a novel mouse ...
Cavasin, Maria - - 2010
Hepatic and circulating endothelin-1 (ET-1) are increased in patients with cirrhosis and in cirrhotic animals. However, the distinct roles of ET receptor subtypes [ET.sub.A] and [ET.sub.B] in cirrhosis and portal hypertension (PHT) have not been clearly elucidated. Thus, we studied the effects of selective ET-1 antagonists ([ET.sub.A]-ant or [ET.sub.e]-ant) and ...
Cellini, Mauro - - 2010
Retinitis pigmentosa (RP) is an inherited retinal disorder clinically characterized by a pale, waxy optic nerve head, attenuated retinal blood vessels, and bone spicule pigment in the retina. Hemodynamic studies have demonstrated that RP is associated with a reduction in the retinal and choroidal blood flow. Retinal hemodynamic impairment is ...
Kopp, Ulla - - 2010
Increasing renal pelvic pressure results in PGE2-mediated release of substance P, leading to increases in afferent renal nerve activity (ARNA) and natriuresis, that is, a renorenal reflex response. The renorenal reflexes are impaired in congestive heart failure (CHF). Impairment of the renorenal reflexes may contribute to the increased renal sympathetic ...
Sachidanandam, Kamakshi - - 2010
Vascular remodeling, characterized by extracellular matrix deposition and increased media-to-lumen (M/L) ratio, contributes to the development of microvascular complications in diabetes. We have previously shown in type 2 diabetic Goto-Kakizaki (GK) rats that selective [ET.sub.A] receptor blockade prevents medial thickening of mesenteric arteries via regulation of matrix metalloproteases (MMP), whereas ...
Wu, Yuexiu - - 2010
Upregulation of endothelin 1 (ET-1) causing blood How alteration and increased extracellular matrix production are characteristic features of diabetic angiopathy. Several glucose-induced signaling mechanisms cause ET-1 upregulation in diabetic angiopathy. Extracellular signal-regulated kinase 5 (ERK5) is a member of the MAPK family, which plays a key role in cardiovascular development. ...
Ozmen, Mine - - 2010
Within psychosomatic approach, patients are evaluated with a multifaceted holistic approach regarding his personality characteristics, his relations with social environment and psychiatric comorbidity in the context of a positive patient-physician relationship. There is a bi-directional relationship between the patients' minds and dermatological diseases; there are a wide variety of factors ...
Altunay, Ilknur - - 2010
Psychodermatology is a new developing area of dermatology. It has been long recognized that dermatologic disease may affect psychological functions in dermatology patient and thus, there is a close relationship between dermatology and psychosomatic medicine. Despite this, the development of scientific methods based on the evidence-based medicine and confirmation of ...
Cetin, Alptekin - - 2010
Dermatological drugs, mostly corticosteroids and isotretinoin, cause different psychiatric adverse effects. During steroid therapy, a wide range of psychiatric conditions, from minor clinical symptoms like insomnia and anxiety to serious psychiatric syndromes like psychosis and delirium might be seen. In medical literature, a causal connection is usually suggested between "isotretinoin", ...
Turan, Senol - - 2010
Although psychodermatologic diseases are diagnosed very easily, their treatment often poses a great deal since they are often associated with psychological conflicts and psychiatric disorders such as depression, anxiety disorders and delusional disorders. Therefore dermatological treatment modalities might be insufficient for psychodermatologic diseases. Associations between dermatological and psychiatric diseases and ...
Aydemir, Ertugrul - - 2010
This group of diseases are characterised with the aggravated types of stress releasing behaviors like scratching, picking, squeezing, and sucking. Lichen simplex chronicus, prurigo nodularis, neurotic excoriations, trichotillomani, and onychotillomani are the diseases in this group. Depression, anxiety, and obsesif compulsive disease are the main underlying psychologic diseases. They need ...
Altunay, Ilknur - - 2010
Psychodermatology is a working area dealing with the diseases involved by both psychiatry and dermatology. Although the essence of the discipline emerged in antiquity, its evolution and maturation have only been in recent years. Evolutional and maturational process of psychodermatology and its sphere on the basis of various classifications have ...
Mercan, Sibel - - 2010
Borderline personality disorder, addictions, sexual dysfunction disorder and eating disorders are other psychiatric problems which can been seen by dermatological illnesses. Borderline personality disorder, alcohol or drug addiction or eating disorder patients may give harm to their skin as dermatitis artefacta or smoking and alcohol may give harm to skin ...
Mercan, Sibel - - 2010
Psychiatric disorders are comorbid or secondary to dermatologic illnesses in these patients. Depression, anxiety and somatization disorders are most frequent psychiatric disorders accompanied with dermatological disorders. Biopsychosocial evaluation of dermatology patients will help to explain their problems in detail and increase therapeutic success with them. (Turkderm 2010; 44 Suppl 1: ...
Aydemir, Ertugrul - - 2010
Mercan, Sibel - - 2010
The etiology of these dermatological diseases is entirely psychiatric origin. These patients show overconcern to their skin or self inflicted dermatoses unconsciously instead of facing with their real problems. In this group, delusions, dermatitis artefacta, trichotillomania, body dysmorphic disorder can be seen. They use denial as defence mechanism to their ...
Altunay, Ilknur - - 2010
Psychoneuroimmunology is a new discipline which searches dynamic relationship between mind, neuroendocrin system and immune system that is organized via neuropeptides and hormones. It aims to investigate and explain how mental and psychic factors affect immune system and ultimately general health. The skin is an organ which has a critical ...
- - 2010
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