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Results 401 - 450 of 829
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Gilchrist, James - - 2010
We investigated calpain activation in the heart during ischemia-reperfusion (I-R) by immunologically mapping the fragmentation patterns of calpain and selected calpain substrates. Western blots showed the intact 78 kDa large subunit of membrane-associated calpain was autolytically fragmented to 56 and 43 kDa signature immunopeptides following I-R. Under these conditions, the ...
Bouallegue, Ali - - 2010
Endothelin-1 (ET-1) is a potent vasoactive peptide that exeits hypertrophic, migratory, and mitogenic effects in vascular smooth muscle cells. ET-1-induced activation of several signaling events has been shown to mediate the cellular effects of ET-1. In the past several years, transactivation of growth factor receptor has gained much recognition in ...
McNicol, Archibald - - 2010
The oral cavity is inhabited by over 500 different bacterial species that normally exist in ecological balance both with each other and with the host. When this equilibrium is disturbed, an overgrowth of individual organisms can occur, which, in turn, can lead to the onset of pathological processes, notably dental ...
Fang, Wentong - - 2010
Prostaglandin [E.sub.1] ([PGE.sub.1]) is a member of the prostaglandins and has a variety of cardiovascular protective; effects. Increasing attention has been paid to the anti-inflammation activity of [PGE.sub.1], but little direct evidence has been found. We investigated the effects of [PGE.sub.1] on cell adhesion and inflammation and the mechanisms responsible ...
Li, Li - - 2010
A recent study showed that resveratrol, a polyphenol found in many plant species, exerts dual effects on gastric mucosal injury. By using the model of ethanol-induced gastric mucosal injury in the present study, we explored the effect of trans-3,5,4'-trimethoxystilbene (BTM-0512), a novel analog of resveratrol, on gastric mucosal injury and ...
Mehta, Anita - - 2010
We studied the effect of perindopril (1%) on intraocular pressure (IOP) and compared it with the effect of pilocarpine, a therapeutic agent used in experimentally induced acute and chronic models of glaucoma in rabbits. Acute glaucoma was induced by intravenous administration of 5% glucose. Pretreatment with topical perindopril (1%) and ...
Boxwalla, Mustufa - - 2010
Clonidine, an [[alpha].sub.2]-adrenergic agonist, has been demonstrated to produce significant analgesia and potentiate morphine analgesia. Endothelin ([ET.sub.A]) receptor antagonists have also been found to potentiate the antinociceptive response to morphine. Clonidine and ET have been reported to have cardiovascular interactions involving the sympathetic nervous system, but it is not known ...
Jiang, Youde - - 2010
Cardiovascular disease involves changes in inflammatory markers. Since insulin/insulin-like growth factor 1 receptor (IGF-1R) can activate vascular endothelial growth factor to promote vascular growth, reduced IGF-1R signaling in the type I diabetic heart could be detrimental, leading to reduced, collateral blood vessel growth. This study assessed whether diabetes can induce ...
Mellor, Kimberley - - 2010
A dramatic rise in the prevalence of insulin resistance has been paralleled by increasing dietary consumption of sugar. The use of added sweeteners containing fructose (sucrose and high-fructose corn syrup) has increased by 25% over the past 3 decades. High fructose intake has the potential to adversely influence systemic and ...
Bae, Soochan - - 2010
Exposure to tobacco smoke is known to have deleterious cardiovascular effects. In this study, we tested whether exposure to tobacco smoke exacerbates the severity of viral myocarditis in mice. Viral myocarditis was generated in 4-week-old male BALB/c mice by injection of Encephahmyocardilis virus (EMCV). Four groups were studied: (1) control ...
Boudjeltia, Karim - - 2010
Raloxifene (RLX), a selective oestrogen receptor modulator, has oestrogen-agonisi effects on bone, lipoproteins, and homocysteine and oestrogen-antagonist activity in the breast and uterus, positioning it as a potential drug for long-term prevention of coronary heart disease in postmenopausal women. To further evaluate its influence on cardiovascular risk factors, we studied ...
Hampasagar, S. - - 2010
McCulloch, T.J. - - 2010
Saranteas, T. - - 2010
Venous thrombosis of the upper extremities is becoming increasingly prevalent in the intensive care unit as a result of chronic in-dwelling central venous catheters. We report two rare cases in which combined transoesophageal echocardiography and vascular ultrasound examination aided in the identification of catheter-related thrombosis in two patients suffering from ...
Jain, G. - - 2010
We report a case where a patient presented with generalised tonic-clonic seizures secondary to nausea, vomiting and dehydration. She had suffered a postpartum haemorrhage six months previously. On laboratory assessment hyponatraemia and low hormone concentrations suggested pituitary failure. The diagnosis was confirmed by magnetic resonance imaging of the head, which ...
McIver, L.J. - - 2010
In the setting of severe acute asthma, electrocardiographic abnormalities are not uncommon and some patients will develop reversible systolic dysfunction. However, acute myocardial infarction and potentially fatal arrhythmias are rare. We report the case of a middle-aged indigenous male who suffered an ST-elevation myocardial infarction and then pulseless ventricular tachycardia ...
Ben-Meir, M. - - 2010
A case of hypoxaemia was concluded to be a pseudo-condition after investigation demonstrated that the hypoxaemia was not related to lung disease, but rather to the time expiring between obtaining and analysing blood samples and to a reduction in the magnitude of the patient's white cell count. Key Words: hypoxaemia, ...
Pacenta, H.L. - - 2010
An 18-year-old man with metastatic femoral osteosarcoma had inadequate pain control with gabapentin, naproxen and intravenous fentanyl. A tunnelled femoral nerve catheter was used to administer a continuous infusion of 0.2% ropivacaine and 4 [micro]g/ml clonidine (10 ml/hour) until his death 88 days later. During discharge from hospital, catheter disconnection ...
Wall, C.J. - - 2010
Acute limb compartment syndrome is a surgical emergency associated with significant morbidity if not diagnosed promptly and treated effectively. We describe a case of severe and eventually lethal acute limb compartment syndrome, which complicated veno-arterial extracorporeal membrane oxygenation in a previously well young woman who had suffered an unexplained cardiac ...
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