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- - 2009
Kelley, George - - 2009
Purpose: Estimate the costs of physical inactivity in West Virginia, a rural, Appalachian state of less than 2 million people. Design: Using the most recent year in which complete data were available and a previously developed algorithm, we estimated the costs of physical inactivity in the state of West Virginia. ...
Montjoy, Carol - - 2009
Malignant mesothelioma (MME) is an aggressive tumor of serosal surfaces resistant to current treatment options. MME is typically diagnosed in middle aged males exposed to asbestos in the workplace. However, MME is occasionally diagnosed at an earlier age without an obvious source of exposure. MME typically carries an average survival ...
Schmidt, John H., - - 2009
The role of hypothermia in the improvement of outcomes among patients suffering severe head injury remains controversial. The "National Acute Brain Injury Study: Hypothermia (NABIS:H)" is a series of prospective trials trying to determine if this therapy provides a beneficial effect. This report describes the case of a patient ejected ...
Sporck, F. - - 2009
Sebert, Stephen - - 2009
Zhou, Jing-Jun - - 2009
Extracellular anions enter into the pore of the cystic fibrosis transmembrane conductance regulator (CFTR) [Cl.sup.-] channel, interacting with binding sites on the pore walls and with other anions inside the pore. There is increasing evidence that extracellular anions may also interact with sites away from the channel pore to influence ...
Petrov, Theodor - - 2009
Endothelin 1 (ET-1) is one of the most powerful vasoconstrictors in the brain. Its expression is upregulated after traumatic brain injury (TBI) and is a major factor in the ensuing hypoperfusion. Attenuation of ET-1 effects has been mainly achieved by blockade of its receptors. The result of a direct blockade ...
Vohra, S. - - 2009
In preparation for a clinical trial on the efficacy of Echinacea products with a pediatric population, a rational method for selection of test products was developed, based on phytochemical and bioassay evaluation. Ten currently available commercial products of Echinacea angustifolia (EA) or Echinacea purpurea (EP) were selected, and 3 bottles ...
Mont, Meghan - - 2009
Calcium has been proposed as a primary influence on cell death during ischemic episodes in myocardial cells. One component of calcium entry into a cell is resting calcium influx. This basal movement of calcium is blocked by 100 [micro]mol/L gadolinium chloride (Gd[Cl.sub.3]) in cardiac myocytes. Therefore, Gd[Cl.sub.3] should be cardioprotective ...
Malek, Hala - - 2009
Acute ischemia-reperfusion JR) of the limbs initiates both local and systemic injuries by triggering a systemic inflammatory response. Cyclooxygenase-2 (COX-2), an endogenous inducible enzyme, rises in response to inflammation. The aim of this work is to investigate the role of celecoxib, a selective COX-2 inhibitor, in abrogating remote organ dysfunction ...
Mokaleng, B.B. - - 2009
Normal tissue toxicity resulting from chemoradiotherapy is of significant clinical concern. This study used normal Chinese hamster fibroblasts from lung (V79) and ovary (CHO-Kl) to assess the modulation of cellular response to photons and neutrons by cisplatin, vinblastine, and bleomycin. Based on the colony formation assay, the drug concentration corresponding ...
Redzic, Zoran - - 2009
Increased adenosine concentration inhibits gastric acid secretion in rat via adenosine Al and A2A receptors, whereas achlorhydria suppresses Al and A2A receptor gene expression. This study aimed to examine the effects of omeprazole-induced achlorhydria on the expression and functional activity of nucleoside transporters in rat gastric mucosa. Wistar rats were ...
Harron, Scott - - 2009
Cells regulate their volume in response to changes in the osmolarity of both their extracellular and their intracellular environments. We investigated the ability of the human airway epithelial cell line Calu-3 to respond to changes in extracellular osmolarity. Although switching Calu-3 cells from an isosmotic to a hyperosmotic environment resulted ...
Black, J. - - 2009
We examined the interaction of smooth muscle myosin with [alpha]-actin and [beta]-actin isoforms during the contraction of A7r5 smooth muscle cells and rat aortic smooth muscle. The techniques of confocal microscopy and fluorescence resonance energy transfer (FRET) analysis were utilized in examining A7r5 cells and rat aortic rings contracted with ...
Shen, Mei - - 2009
To examine the comparative effects of different frequencies of electrical stimulation (ES) on angiogenesis and gene expression, New Zealand white rabbits with femoral artery ligation in one hindlimb and electrode implantation on the sciatic nerve of the same hindlimb were randomly assigned to 4 groups: control group, 1 Hz group, ...
- - 2009
Sundaram, Hema - - 2009
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