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Yazici, Hasan - - 2010
Halsted R. Holman, in a 1994 Arthritis & Rheumatism editorial, discusses how "thought barriers" can make our understanding of rheumatic diseases more difficult. The medical teaching-practice has traditionally been centered on acute disease; however, most rheumatic diseases are chronic. There is also the prevailing notion of a single lesion for ...
Boers, Maarten - - 2010
The first definition of remission in rheumatoid arthritis was proposed by Pinals and colleagues in 1981. Although its development process was of high quality, the definition proved unfeasible and was not often applied. Subsequently many other definitions appeared, either as variations or as cutpoints of disease activity indices. The American ...
Pincus, Theodore - - 2010
Modern medical care is based largely on laboratory advances, such as microbiological cultures giving rise to antibiotics and hemoglobin A1c leading to "tight control" of diabetes, among many others. Development of a "gold standard" laboratory test has appeared attractive for care of patients with rheumatoid arthritis (RA) since rheumatoid factor ...
Yazici, Yusuf - - 2010
Informed consent is a legal document that summarizes what will take place in a study in a language the study subjects can understand and is the process by which a person decides whether or not to participate in a study. The document is not limited to explaining the intervention or ...
Boyer, Jason - - 2010
Surgical repair of the anterior cruciate ligament is a fairly common necessity in knee injuries, usually with good to excellent outcomes. However a successful repair and return to activities for a subpopulation of patients, 10% to 30%, remain elusive. Additionally, some athletes have arthritic changes, even with ligament repair. These ...
Quach, Tony - - 2010
Three percent of all biceps tendon ruptures occur at the distal aspect, where the tendon inserts into the radial tuberosity. Distal bicep tendon ruptures typically occur in middle-aged males after an eccentric extension load is applied to the elbow. Patients usually complain of a sudden, sharp, and painful tearing sensation ...
Jensen, Jamie - - 2010
I present a learning cycle that explores different biotechnologies using the process of in situ hybridization as a platform. Students are presented with a cyclopic lamb and must use biotechnology to discover the mechanism behind the deformity. Through this activity, students learn about signal transduction and discover the processes of ...
Palmer, Laura - - 2010
This lesson uses characters from the Harry Potter series of novels as a "hook" to stimulate students' interest in introductory forensic science. Students are guided through RFLP (restriction fragment length polymorphism) analysis using inexpensive materials and asked to interpret data from a mock crime scene. Importantly, the lesson provides an ...
Offner, Susan - - 2010
The Y chromosome is of great interest to students and can be used to teach about many important biological concepts in addition to sex determination. This paper discusses mutation, recombination, mammalian sex determination, sex determination in general, and the evolution of sex determination in mammals. It includes a student activity ...
Billingsley, James - - 2010
Do our genes exclusively control us, or are other factors at play? Epigenetics can provide a means for students to use inquiry-based methods to understand a complex biological concept. Students research and design an experiment testing whether dietary supplements affect the lifespan of Drosophila melanogaster over multiple generations.
Alozie, Nonye - - 2010
How can science instruction help students and teachers engage in relevant genetics content that stimulates learning and heightens curiosity? Project-based science can enhance learning and thinking in science classrooms. We describe how we use project-based science features as a framework for a genetics unit, discuss some of the challenges encountered, ...
Halverson, Kristy - - 2010
Phylogenetic trees, such as the "Tree of Life," are commonly found in biology textbooks and are often used in teaching. Because students often struggle to understand these diagrams, I developed a simple, inexpensive classroom model. Made of pipe cleaners, it is easily manipulated to rotate branches, compare topologies, map complete ...
Colon-Berlingeri, Migdalisel - - 2010
Epigenetics involves heritable changes in gene expression that do not involve alterations in the DNA sequence. I developed an active-learning approach to convey this topic to students in a college genetics course. I posted a brief summary of the topic before class to stimulate exchange in cooperative groups. During class, ...
Lee, David - - 2010
Flannery, Maura - - 2010
Offner, Susan - - 2010
The beta hemoglobin protein is identical in humans and chimpanzees. In this tutorial, students see that even though the proteins are identical, the genes that code for them are not. There are many more differences in the introns than in the exons, which indicates that coding regions of DNA are ...
Chan, Hue - - 2010
Mercer, R.C.C. - - 2010
It had been thought that vertebrates synthesize the same isoform of sarcomeric actin in all skeletal muscles. The present work demonstrates the existence of a unique variant, accounting for all of the sarcomeric actin in the slow skeletal trunk muscle of Atlantic herring. The primary structure has been inferred from ...
Barette, J. - - 2010
Bovine spongiform encephalopathy in cows, scrapie in sheep, and Creutzfeldt-Jakob disease in humans are all examples of the degenerative neuropathies known as prion disease. According to the protein-only hypothesis of propagation, the infectious agent responsible for prion disease is a misfolded form of the prion protein (PrP), known as PrP ...
Tremblay, M.-L. - - 2010
The chemical shift index is a simple method used to assess protein secondary structure in nuclear magnetic resonance (NMR) spectroscopy. With this method, a "secondary chemical shift" is defined as the difference between the chemical shift for a random coil (RC) peptide and the experimentally observed protein/peptide chemical shift. Specific ...
Dill, K. - - 2010
We are interested in capturing principles of equilibrium and kinetic properties of proteins in simple analytical models. First, to study the cooperativity in reversible folding equilibria, we have focused on helix-bundle proteins. By treating folding as a combined process of helix formation and chain collapse, we can explore the coupling ...
Kopito, R. - - 2010
Sequence-specific nucleated protein aggregation is closely linked to the pathogenesis of most neurodegenerative diseases, and constitutes the molecular basis of prion formation. Here, we report that fibrillar polyglutamine peptide aggregates can be internalized by mammalian cells in culture, where they gain access to the cytosolic compartment and become cosequestered in ...
Forman-Kay, J. - - 2010
The regulation of complex biology is often mediated by interactions of disordered protein regions that are sites of phosphorylation. While many of the disordered regions undergo global disorder-to-order transitions (folding) upon binding to targets, others appear to be only transiently and locally ordered, existing in a dynamic complex with protein ...
Vocadlo, D. - - 2010
Pathological hyperphosphorylation of the microtubule-associated protein tau is characteristic of Alzheimer disease (AD) and the tauopathies. Recently, it has emerged that tau is also modified with 2-acetamido-2-deoxy-_-D-glucopyranose residues O-linked (O-GlcNAc) to serine and threonine residues. This O-GlcNAc modification of nucleocytoplasmic proteins is a common post-translational modification found in higher eukaryotes. ...
Kelly, J. - - 2010
The physical chemical information within the sequence comprising a given protein, post-translational modifications, and the interactions of the polypeptide with proteostasis network components (e.g., chaperones and folding enzymes) determine whether a given member of the proteome will fold and function, remain intrinsically unstructured, be degraded, or aggregate and create additional ...
Stathopulos, P.B. - - 2010
Stromal interaction molecule-1 (STIM1) activates storeoperated [Ca.sup.2+] entry (SOCE) in response to diminished luminal [Ca.sup.2+] levels. We have recently determined the solution structure of the [Ca.sup.2+]-sensing region of STIM1, consisting of the EF-hand and sterile a motif (SAM) domains (EF-SAM) (Stathopulos et al. Cell 2008; 135: 110-122). The canonical EF-hand ...
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